Testing Board - Центр тестування при ... · Krok 1 Pharmacy (англомовнi студенти) 2017 рiк 1 1. In a child-rearing facility there was an outbreak

MINISTRY OF PUBLIC HEALTH OF UKRAINE

Department of human resources policy, education and science

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Test items for licensing examination

Krok 1PHARMACY

(російськомовний варіант)

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Authors of items: Akimova Z.I., Andronov D.Yu., Azarov O.S., Berezhna T.A., Blinder O.O.,Bobyr V.V., Bodnarchuk O.V., Bodrov V.P., Bohatyrova O.V., Bolotov V.V., Bondarenko N.M.,Borodina N.I., Bratenko M.K., Brytska V.S., Buchko O.V., Bylov I.Ye., Cherneha H.V., Cherpak O.M.,Deineka S.Ye., Diachenko I.V., Didenko O.V., Dutka N.M., Fedorovych I.P., Fedushchak N.K.,Filipets N.D., Halkevych I.Y., Halynska V.I., Havryliuk H.S., Havryliuk I.M., Holubieva M.H.,Hrekova T.A., Hryhorieva N.P., Hrytsan L.D., Hulay O.I., Hulko R.M., Huminska O.Yu., Ivankiv O.L.,Ivanova S.A., Katsev A.M., Kava T.V., Khmelnykova L.I., Kishchuk B.M., Klepa T.I., Klopotsky H.A.,Klymenko A.O., Klymniuk S.I., Kobylinska L.I., Koldunov V.V., Kolesnikova T.O., Kolisnyk S.V.,Komlevoy O.M., Korniyevsky Yu.I., Kosareva A.Ye., Kostiuk L.S., Kosuba R.B., Kremenska L.V.,Krushynska T.Yu., Kuras L.D., Kuzmina A.V., Leochko N.S., Lisnycha A.M., Lopastinsky M.M.,Lozynska R.V., Lukianchuk V.D., Lukovych I.M., Lychko V.H., Lychyk H.Z., Maksymchuk T.P.,Matviyenko A.H., Melnyk O.Ya., Meshchyshyn I.F., Mikhieiev A.O., Mikhieieva N.H.,Mishchenchuk V.V., Mishyn V.V., Mykhailova I.V., Mylnikova O.O., Nedostup A.T., Nizhenkovska I.V.,Nykyforchyn R.M., Oleshchuk O.M., Osiychuk O.V., Peleshenko H.B., Pokryshko O.V., Polinkevych S.H.,Potikha N.Ya., Prysiazhniuk P.V., Pylyponova V.V., Reva T.D., Rohovy Yu.Ye., Romanukha V.V.,Romanyshyna L.M., Rykalo N.A., Rylska T.A., Shemchuk L.A., Sheremeta L.M., Shevelova N.Yu.,Shevtsov I.I., Shono N.A., Shumeiko O.V., Shvets V.M., Siedov V.I., Sira L.M., Skladaniuk R.V.,Slobodian K.V., Sokolovska L.V., Soloviova I.V., Stakhmych T.V., Starchykova I.L., Stepanchuk V.V.,Stetskiv A.O., Stoliarchuk E.V., Stolietov Yu.V., Streltsova N.Yu., Struchaieva H.I., Strumenska O.M.,Taller O.Yu., Tkachenko V.H., Tkachuk N.I., Tokaryk H.V., Tomarovska T.O., Trzhetsynsky S.D.,Tursunova Yu.D., Uhryn O.M., Ulizko I.V., Varynsky B.O., Vasiuk S.O., Vasyleva A.H., Vasylyk L.V.,Velyka A.Ya., Vivchar D.P., Volkova N.O., Volotovska N.V., Vronska L.V., Vynnytska R.B.,Yashchyshyn Z.M., Yushchenko T.I., Zahrychuk H.Ya., Zhuravel T.O. and Committees of professionalexpertise.

Item reviewers. Anisimov V.Yu., Cherpak O.M., Deineka S.Ye., Ersteniuk H.M., Filimonova N.I.,Herush O.V., Hlushachenko O.O., Holdobina O.V., Hontova T.M., Hryhorieva N.P., Ivanets L.M.,Kaluhina S.M., Kaplaushenko A.H., Kobylinska L.I., Kononenko N.M., Korniyevska V.H., Kostina T.A.,Kraidashenko O.V., Lisnycha A.M., Liubinets L.A., Makoid O.B., Minarchenko V.M., Mykhalkiv M.M.,Oliynyk N.M., Shanaida M.I., Shemchuk L.A., Shtryhol S.Yu., Tomarovska T.O., Vasiuk S.O.,Yushchenko T.I., Zahaiko A.L., Zahrychuk H.Ya.

The book includes test items for use at licensing integrated examination “Krok 1. Pharmacy” andfurther use in teaching.

The book has been developed for students of pharmaceutical faculties and academic staff of highermedical educational establishments.

Approved by Ministry of Public Health of Ukraine as examination and teachingpublication based on expert conclusions (Orders of MPH of Ukraine of14.08.1998 №251, of 27.12.1999 №303, of 16.10.2002 №374, of 29.05.2003 №233).

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General InstructionEvery one of these numbered questions or unfinished statements in

this chapter corresponds to answers or statements endings. Choose theanswer (finished statements) that fits best and fill in the circle with thecorresponding Latin letter on the answer sheet.

Krok 1 Pharmacy (англомовнi студенти) 2017 рiк 1

1. In a child-rearing facility there wasan outbreak of measles. What speci-fic urgent prophylaxis should be admi-nistered to contact UNVACCINATEDchildren?

A. Gamma globulin against measlesB. Measles virus vaccine liveC. DPT vaccineD. Medical screening of the childrenE. Isolation and treatment of infectedchildren

2. Bouguer-Lambert-Beer law is thebasis of molecular absorption analysis.According to this law, optical density of asolution is:

A. Directly proportional to layer thi-ckness and concentration of a substanceB. Directly proportional to layer thi-ckness and absorption coefficientC. Inversely proportional to layer thi-ckness and concentration of a substanceD. Directly proportional to concentrationand inversely proportional to layer thi-cknessE. Directly proportional to concentrationand inversely proportional to absorptioncoefficient

3. Within folded parenchyma of a firneedle there are cavernous structuresfilled with galipot and lined with livethin-walled secretory cells. Name thesestructures:

A. Resin ductsB. LaticifersC. HydatodesD. GlandulesE. Nectar glands

4. A chemotherapeutic agent hasbactericidal effect against streptococci,staphylococci, bacilli, and clostridia.According to its action spectrum thisdrug belongs to the following group:

A. Broad spectrum antibacterial agentsB. Narrow spectrum antibacterial agentsC. Broad spectrum antifungal agentsD. Antiviral agentsE. Antituberculous agents

5. Stem thickening occurs due to functi-oning of the following structures:

A. Lateral meristemB. Apical meristemC. Wound meristemD. Intercalary meristemE. Endoderm

6. To determine mass fraction of sodiumchloride in a drug, the Fajans methodshould be applied. Titration is to beperformed in the presence of the followi-ng indicator solution:

A. FluoresceinB. Methyl redC. Potassium chromateD. Ammonium iron (III) sulfateE. Phenolphthalein

7. Sulfanilamide drugs contain primaryaromatic amides in their structure. Speci-fy the method of quantitative determi-nation of these compounds:

A. NitritometryB. IodometryC. DichromatometryD. PermanganatometryE. Cerimetry

8. Microbe survival within environmentis facilitated by spore formation. Whatmicroorganisms of those listed below arespore formers:

A. ClostridiaB. BacteroidesC. StaphylococciD. PeptococciE. Peptostreptococci

9. Synthesis of a medicinal substanceoccurs in an isolated system. What isa direction criterion of spontaneousprocesses?

A. Entropy changeB. Gibbs energyC. Helmholtz energyD. Intrinsic energyE. Enthalpy

10. Dissociation degree in 0,01 Mwater solution is the same for all thestrong electrolytes listed below. Namethe substance with the highest boilingtemperature of such solution:


A. Al2(SO4)3B. KClC. Na3PO4D. Cu(NO3)2E. K3PO4

11. Proteins are of great importancefor vital functions. What value of pHresults in zero electrophoretic mobilityof gelatin (gelatin isoelectric point equals4,7)?

A. 4,7B. 7,0C. 14,0D. 5,5E. 9,4

12. Enzymes are widely used as drugsin pharmacy. What is the main di-fference that separates enzymes fromnon-biological catalysts?

A. High specificity and selectivityB. High universalityC. Low universalityD. High dispersionE. High homogeneity

13. Chloroform and sodium nitrite soluti-on were added into the acidulous investi-gated solution. The chloroform layercolored red-violet, which indicates thepresence of:

A. Iodide ionsB. Carbonate ionsC. Chloride ionsD. Sulfate ionsE. Fluoride ions

14. The following should be used forsterilization of laboratory glassware ina microbiological laboratory:

A. Hot-air sterilizerB. Bacteria-excluding filtersC. Koch’s steam sterilizerD. DisinfectantE. Bactericidal lamps

15. Parents of a 10-year-old child havemade an appointment with an endocri-nologist due to complaints of the chi-ld’s low height. The child’s appearanceis corresponding with that of a 5-year-old. What hormone causes such changesin physical development, if its secretionis disturbed?

A. Somatotropic hormoneB. Adrenocorticotropic hormoneC. ThyroxinD. TestosteroneE. Insulin

16. Dry residue received after evaporati-on of the investigated solution turnspreviously colorless burner flame yellow,which is observed as violet through blueglass. What cations are there in the dryresidue?

A. Na+, K+

B. �a2+, K+

C. Na+ , Sr2+

D. Li+, Ba2+

E. Na+, Ca2+

17. A smear of purulent excharge fromurethra contains gram-negative bean-shaped diplococci with both extra- andintracellular positions. Make the provisi-onal microbiological diagnosis:

A. GonorrheaB. SyphilisC. ChlamydiosisD. TrichomoniasisE. Candidiasis

18. Under isobaric-isothermal condi-tions the possibility and direction ofspontaneous processes can be predictedthrough change of:

A. Gibbs energyB. Helmholtz energyC. EnthalpyD. EntropyE. Intrinsic energy

19. Investigated solution containspotassium and ammonium ions. Speci-fy the reagent that can indicate thepresence of potassium ions in this soluti-on:

A. Potassium tetraiodomercurateB. Sodium chlorideC. Sodium acetateD. Potassium hexacyanoferrate (II)E. Uranyl zinc acetate

20. An injured person exhibits thefollowing signs at the site of trauma:skin redness, throbbing small arteries,elevated local temperature, increased ti-ssue turgor. What local blood circulationdisorder are these presentations typicalof?


A. Arterial hyperemiaB. Venous hyperemiaC. ThrombosisD. EmbolismE. Ischemia

21. During investigation of bacterialcontamination of air it is necessary totake into account both total amountof microorganisms in a certain volumeand qualitative content of microflora.What microorganisms are the sanitaryindicators of air contamination withinenclosed spaces?

A. Staphylococcus aureusB. ColibacillusC. Hay bacillusD. Yeast fungiE. Mold fungi

22. Purine ring biosynthesis occursin ribose-5-phosphate through gradualaccumulation of nitrogen and carbonatoms and closing of the rings. Thesource of ribose phosphate is the processof:

A. Pentose phosphate cycleB. GlycolysisC. GlyconeogenesisD. GluconeogenesisE. Glycogenolysis

23. Number of freedom degrees at thepoint of intersection of liquidus withY-axis on the fusibility chart of a two-component system would equal:

A. 0B. 2C. 3D. 4E. 1

24. In the process of qualitative analysisto determine strontium ions, so-called”gypseous water” is used. This substancecan be defined as:

A. Concentrated aqueous solution ofCaSO4B. Solution of Ca(OH)2C. Concentrated aqueous solution of CO2D. Aqueous solution of Ba(NO3)2E. Solution of ��(OH)2

25. Which of the ligands is bidentate?

A. EthylenediamineB. Thiocyanate ionC. Cyanide ionD. PyridineE. Hydroxide ion

26. Name the pH value, under whichoccurs the most intense color change ofan indicator:

A. pT valueB. pK valueC. Color change intervalD. Equivalence pointE. Titration end point

27. What compound produces phthalicacid during oxidation?

A.

B.

C.

D.

E.

28. To distinguish between phenol andsalicylic acid the following reagent isused:


A. Sodium bicarbonate solutionB. Iron (III) chloride solutionC. Sodium hydroxide solutionD. Sodium chloride solutionE. Bromine solution

29. Reaction of benzaldehyde withchlorine produces:

A.

B.

C.

D.

E.

30. Bacterial culture obtained from pati-ent DOES NOT grow when exposed tooxygen. Conditions suitable for bacterial

culture growth can be created in:

A. Anaerobic culture jarB. Serum-supplemented mediumC. Pasteur ovenD. Krotov apparatusE. Oxidative medium

31. Specify the number of electronsthat participate in creation of closedconjugated system within the pyrimidi-ne molecule:

A. 6B. 4C. 10D. 2E. 8

32. An oncological patient was prescri-bed fluorouracil that is a competitiveinhibitor of thymidine synthase. It inhi-bits the process of:

A. Pyrimidine nucleotides synthesisB. Carbohydrate disintegrationC. Purine nucleotides synthesisD. Purine nucleotides disintegrationE. Lipids synthesis

33. During feces analysis of a 3-month-old child with signs of enteric infection,numerous dark-red colonies has grownon Endo agar. What microorganisms canbe the cause of such enteric infection?

A. EscherichiaB. StreptococciC. GonococciD. SalmonellaeE. Shigella

34. Sedimentation analysis has beenapplied for assessment of air purity inan aseptic unit of a phamacy. The testresulted in growth of the small colonieswith areas of hemolysis. What mediumwas used for inoculation?

A. Blood agarB. Levine’s agar (Eosin Methylene Blueagar)C. Endo agarD. Ploskirev’s agarE. Egg-yolk salt agar

35. Reaction of urea with nitrous acid


produces the following:

A. CO2 + N2 + H2OB. CO2 + NO2 + H2OC. CO + NH3 + CO2D. CO2 + NO + NH3E. CO2 + NH3 + NO2

36. Surface tension is an importantcharacteristic of a liquid. What substancehas maximal surface tension?

A. WaterB. EthanolC. BenzeneD. AcetoneE. Chloroform

37. What standard solution can be used tostandardize the solution of I2?

A. Sodium thiosulfate solutionB. Potassium iodide solutionC. Potassium dichromate solutionD. Potassium permanganate solutionE. Sodium nitrite solution

38. Catalysts are widely used in producti-on of drugs. How can reaction accelerati-on in the presence of a catalyst be explai-ned?

A. Activation energy decreasesB. Total collision frequency increasesC. Activation energy increasesD. Collision frequency decreasesE. Molecule speed increases

39. Microorganisms in the environmentare being affected by various physi-cal factors. What is the effect of hightemperature on a microbial cell?

A. Irreversible degradation of all cellularstructuresB. Mutagenic effectC. Transition into anabiosis stateD. AlbuminolysisE. Fats saponification

40. A person has been stung by a bee.The stung area developed redness andedema. What is the main mechanism ofedema development?

A. Increased permeability of the capillari-esB. Decreased oncotic blood pressureC. Increased hydrostatic blood pressureD. Decreased osmotic blood pressureE. Disturbed lymphatic efflux

41. During identification of fruits ofDatura family they were determined tobe a:

A. Thorned quadrivalve capsuleB. Glossy black berryC. Urceolate capsule with a lidD. Juicy globular cynarodiumE. Berry in an orange cup

42. During examination of a patient withintestinal infection, inoculation in Endomedium resulted in multi-colored coloni-es: red and colorless. According to itspurpose this medium can be determinedas:

A. Differential diagnosticB. UniversalC. SpecialD. SelectiveE. -

43. Formation enthalpy equals zero forthe following substance:

A. O2B. H2O2C. H2SO4D. CaCO3E. �O2

44. Nicotinic acid amide fulfills importantmetabolic function. What disorderdevelops, when it is deficient in theorganism?

A. PellagraB. RicketsC. AnemiaD. XerophthalmiaE. Beriberi

45. At the triple point of the water phasediagram:

A. f=0B. f=2C. P=3; f=1D. f=1E. P=3; n=1

46. Reaction of benzene sulfonationproduces:


A.

B.

C.

D.

E.

47. Choose the reaction of ester producti-on among those listed below:

A.

B.

C.

D.

E.

48. Select the formula of diazonium salt:

A.

B.

C. C6H5 − N = OD. C6H5 − NH − C(O) − CH3E. (CH3)2N − N = O

49. A patient was delivered into a resusci-tation unit with signs of alcohol poisoni-ng. The patient developed hypoxia of thefollowing pathogenesis:

A. TissueB. HypoxicC. HemicD. CirculatoryE. Mixed

50. Select the compound withamphoteric properties (which reacts bothwith acids and bases and produces salts):


A.

B.

C.

D.

E.

51. Since 2005 in Asian and Europeancountries there was recorded unusuallyhigh avian flu morbidity. Such spread ofepidemic process can be determined as:

A. PandemiaB. EpidemicC. EndemiaD. SporadicE. Epizooty

52. Pharmacopoeia reaction to determi-ne benzoate ions requires interaction wi-th the solution of:

A. Iron (III) chlorideB. Potassium chlorideC. ResorcinD. Acetic anhydrideE. Diphenylamine

53. Tricarboxylic acid cycle is a generalway of carbohydrates, amino acids, andfatty acids oxidation. Specify the acid wi-th which acetyl-CoA reacts first in tri-carboxylic acid cycle:

A. OxaloaceticB. CitricC. IsocitricD. FumaricE. Malic

54. Specify the substance that resultsfrom the following reaction:

CH ≡ CHHOH, Hg2+

−−−−−−−→?

A. EthanalB. EthanolC. PropanalD. PropanoneE. Acetic acid

55. Choose the indicator and titrati-on method to determine hydrogencarbonate ions in a drug:

A. Methyl-orange, acidimetryB. Phenolphthalein, acidimetryC. Methyl-orange, alkalimetryD. Phenolphthalein, alkalimetryE. Murexide, acidimetry

56. Pharmacopoeia reaction to determi-ne phosphate ions is a reaction withmagnesia mixture. It results in producti-on of white crystalline precipitate�gNH4PO4. Magnesia mixture consistsof the following:

A. MgCl2, NH3 · H2O, NH4ClB. MgCl2, NaOH , NaClC. MnCl2, NH3 · H2O, NaClD. MgCl2, MnSO4, NH4ClE. MgCl2, NH4Cl

57. An ophthalmologist has detectedincreased time of dark adaptation ina patient. What vitamin deficiency canresult in such symptom?

A. AB. CC. KD. B1E. B6

58. Prolonged taking of cytostatic agentsresulted in development of necrotictonsillitis in the patient. It can be associ-ated with the following changes in theleukocyte content:

A. AgranulocytosisB. Neutrophilic leukocytosisC. LymphopeniaD. EosinopeniaE. Lymphocytosis

59. During photosynthesis within plantcell chloroplasts there is short-term retai-ned starch being produced, which rapi-dly hydrolyzes into glucose. This starch iscalled:


A. PrimaryB. SecondaryC. TransitoryD. ResistantE. Reserve

60. A patient with type I diabetesmellitus developed hyperketonemiccoma. What acid-base imbalance will beobserved in the patient?

A. Nongaseous acidosisB. Gaseous acidosisC. Nongaseous alkalosisD. Gaseous alkalosisE. There will be no acid-base imbalances

61. Reaction rate constant of a hypotheti-cal reaction is measured as s−1. What isthe order of this reaction?

A. First-orderB. Zero-orderC. Second-orderD. Third-orderE. Fractional-order

62. Species character of Thymusserpyllum includes: apical inflorescences(flower heads), dark punctate glands onthe inferior surface of a leaf, long hairsalong the edge of leaf base, and:

A. Creeping stemsB. ThornsC. Stems with pricklesD. Climbing stemsE. Short decumbent stems

63. Natural peptides can perform variousfunctions. What bioactive peptide is amajor antioxidant and fulfills coenzymefunctions?

A. GlutathioneB. BradykininC. OxytocinD. LiberinE. Anserine

64. Gout develops when purine nucleoti-de metabolism is disturbed. A doctorprescribed the patient allopurinol thatis a competitive inhibitor of:

A. Xanthine oxidaseB. Succinate dehydrogenaseC. Alcohol dehydrogenaseD. Lactate dehydrogenaseE. Hexokinase

65. Specify the indicator of the protectiveproperties of high-molecular compoundsof body, which promote the retentionof calcium, phosphate and carbonate inblood plasma:

A. Protective valueB. Coagulation thresholdC. Critical micelle concentrationD. Hydrophilic-lipophilic balanceE. Volume of sol coagulated by 1 mol ofthe electrolyte substance

66. In a research center there is a livevaccine against dysentery being created.What property of attenuated vaccinestrain should coincide with the properti-es of original virulent strain of dysenterybacillus?

A. Antigenic structureB. MorphologyC. Biochemical activityD. Antibiotic susceptibilityE. Toxin production

67. Plantago major inflorescence growsat the apex, its rachis is long, with sessileflowers. Name this type of inflorescence:

A. SpikeB. PanicleC. SpadixD. CapitulumE. Thyrse

68. Microbiological investigation of vagi-nal suppositories determined them tobe CONTRARY to the Pharmacopoeiademands. What microflora was detectedin the suppositories, resulting in such aconclusion?

A. Blue pus bacillusB. SarcinaC. MicrococcusD. TetracoccusE. Citrobacter

69. A number of hereditary diseasesis caused by mutations in gene areasthat determine beginning or end of anintron. What process results in removalof introns and joining of exons?

A. SplicingB. TranscriptionC. RecombinationD. ReplicationE. Translation

70. Hyperlipemia can be observed in 2-


3 hours after eating fatty food. 9 hourslater lipid content normalizes again. Howcan this condition be characterized?

A. Alimentary hyperlipemiaB. Transport hyperlipemiaC. Hyperplastic obesityD. Retention hyperlipemiaE. Hypertrophic obesity

71. Name the mercurimetry titrant:

A. 0,1 М solution of Hg2(NO3)2B. 0,1 М solution of NaNO2C. 0,1 М solution of AgNO3D. 0,1 М solution of KSCNE. 0,1 М solution of NH4SCN

72. What inflorescences are characteristicof Cruciferae (Brassicaceae) family?

A. Raceme or panicleB. Capitulum or corymbC. Capitulum or umbelD. Corymb or spikeE. Spadix or panicle

73. What cation of the 4th analyticalgroup is present in a solution, if its reacti-on with the group reagent results information of yellow precipitate?

A. Cr3+

B. Zn2+

C. Sn2+

D. Al3+

E. Sn(IV )

74. A patient presents with icteric scleraand mucous tunics; urine is dark; fecesare light-colored. Blood content of directand indirect bilirubin is increased, urinecontent of direct bilirubin is increased.What pathology can be characterized bythese signs?

A. Obstructive jaundiceB. Hemolytic jaundiceC. Hepatocellular jaundiceD. Jaundice of the newbornE. Atherosclerosis

75. The patient presents with rapidgrowth of a tumor node and its progressi-ng malignization. What stage of tumorgrowth can be characterized by thesepresentations?

A. ProgressionB. Promotion (activation)C. TransformationD. ExudationE. Inactivation

76. You are studying a silvery downyplant of Asteraceae family, which is richwith essential oils and bitters. Harvestedare apical sprouts with panicle of smallround flower heads. This plant is:

A. Artemisia absinthiumB. Arctium lappaC. Bidens tripartitaD. Calendula officinalisE. Chamomilla recutita

77. Among dosage forms there arenumerous disperse systems. Specify thefree disperse system:

A. EmulsionB. GelC. JellyD. DiaphragmE. Membrane

78. A 55-year-old man, who had beensuffering from mitral insufficiency formany years, developed acute heart fai-lure. What pathophysiological type ofheart failure can be observed in thiscase?

A. Due to cardiac overloadB. Due to hypoxic damage to the heartC. Due to coronarogenic damage to theheartD. Due to neurogenic damage to theheartE. Due to acute cardiac tamponade

79. Cataract (lenticular opacity) hasdeveloped in a 52-year-old woman withdiabetes mellitus. Lenticular opacity wascaused by intensification of the followingprocesses:

A. Protein glycosylationB. LipolysisC. KetogenesisD. Protein proteolysisE. Gluconeogenesis

80. During practice in the laboratory thestudents had been investigating in vi-tro, how malonate affects enzymes oftricarboxylic acid cycle. They detectedaccumulation of the following metaboli-te:


A. SuccinateB. MalateC. IsocitrateD. FumarateE. Succinyl-CoA

81. Aqueous solution of the followingsubstance will have the smallest surfacetension, if all the listed solutions aretaken in the same concentration:

A. Sodium stearateB. EthanolC. Sodium chlorideD. Sodium hydroxideE. Sucrose

82. A 45-year-old woman, who fortwo weeks has been taking neodi-coumarin (ethyl biscoumacetate) due totrombophlebitis, during a regular exami-nation was detected to have decreasedblood content of prothrombin, in uri-ne there is microhematuria. What drugshould be administered as a neodi-coumarin antagonist?

A. Vicasol (Menadione)B. Protamine sulfateC. Sodium citrateD. HeparinE. Aminocapronic acid

83. A patient complaining of dry mouth,photophobia, and visual impairment hasbeen delivered into an admission room.The skin is hyperemic and dry; pupilsare dilated; tachycardia is observed. Thepatient was diagnosed with belladonnaalkaloids intoxication. What drug wouldbe advisable?

A. ProserinB. AceclidineC. PilocarpineD. ArminE. Dipiroxim

84. A child accidentally took a drink fromthe vial of grandmother’s medicine forglaucoma. The medicine was identifiedas pilocarpine hydrochloride. What drugcan be used as an antidote?

A. AtropineB. CarbacholC. AceclidineD. Benzohexonium (Hexamethonium)E. Pentamin (Azamethonium bromide)

85. A woman suffering from neurosis hasdisturbed sleep. What drug is optimal for

insomnia treatment?

A. NitrazepamB. PhenobarbitalC. Aethaminalum-natrium (Pentobarbi-tal)D. BromisovalE. Valerian tincture

86. What antiprotozoal drug can berecommended to a woman with tri-chomoniasis?

A. MetronidazoleB. PrimaquineC. ChloridineD. Solusurminum (Sodium sti-bogluconate)E. Chiniofon

87. Select the halogenated antiseptic thatwould be preferable for a child to pack inthe first aid kit, when going to a summercamp:

A. Iodine alcoholic solutionB. Brilliant greenC. Copper sulfateD. Methylene blueE. Formaldehyde solution

88. Name the most typical symptom ofatropine poisoning:

A. Dilated pupils unresponsive to lightB. Constricted pupils unresponsive tolightC. Excessive sweatingD. BradycardiaE. Low intraocular pressure

89. A patient consulted an ophthalmologi-st about deterioration of twilight visionand xerophthalmus. What drug shouldthe doctor prescribe?

A. RetinolB. PyridoxineC. TocopherolD. Ascorbic acidE. Cocarboxylase

90. A woman with hypertension came toa doctor complaining of dry cough thatdeveloped against the background of hertherapy. What antihypertensive drug wasshe taking?


A. LisinoprilB. AtenololC. NifedipineD. FurosemideE. Dichlothiazide (Hydrochlorothiazide)

91. Decreased absorption of tetracycli-nes, if they are taken simultaneously withantacids, is an example of their:

A. Pharmacokinetic incompatibilityB. Pharmaceutical incompatibilityC. Pharmacodynamic incompatibilityD. SynergismE. Functional antagonism

92. A patient after craniocerebral traumahas been prescribed piracetam. Whatpharmacological group does this drugbelong to?

A. Nootropic agentsB. Non-narcotic analgesicsC. TranquilizersD. General anestheticsE. Antipsychotics

93. Recommend the patient withglaucoma an M-cholinomimetic agent:

A. Pilocarpine hydrochlorideB. Ephedrine hydrochlorideC. Sulfacyl-sodium (Sulfacetamide)D. Atropine sulfateE. Levomycetin (Chloramphenicol)

94. A patient with hypertensionwas prescribed a nonselective beta-adrenergic blocking agent. Name thisdrug:

A. Anaprilin (Propranolol)B. PrazosinC. ProserinD. Adrenalin hydrochlorideE. Labetalol

95. In the course of bronchi-tis pharmacotherapy a patienthas developed dyspeptic disorders,photodermatitis and hepatic failure.What drug can cause such disorders?

A. DoxycyclineB. ParacetamolC. Ascorbic acidD. AcetylcysteineE. Codeine phosphate

96. A 25-year-old woman with signs ofacute morphine intoxication was admini-stered naloxone, which rapidly improved

her condition. What is the mechanism ofaction of this drug?

A. Opioid receptor blockadeB. GABA receptor blockadeC. Serotonin receptor blockadeD. Dopamine receptor blockadeE. Benzodiazepine receptor blockade

97. Name the ability of a drug toaccumulate within the patient’s body:

A. CumulationB. AntagonismC. SynergismD. HabituationE. Allergy

98. What pharmacological effect ofacetylsalicylic acid allows its applicationin patients with ischemic heart diseasefor prevention of thromboses?

A. AntiaggregantB. AnalgesicC. AntipyreticD. UlcerogenicE. Anti-inflammatory

99. A patient developed herpetic rashes.What drug should be prescribed in thiscase?

A. AcyclovirB. GentamicinC. ClotrimazoleD. BenzylpenicillinE. Biseptol (Co-trimoxazole)

100. A woman complaining of sleep di-sturbance, fearfulness, and anxiety cameto a neurologist. What drug should beprescribed in this case?

A. DiazepamB. LevodopaC. NitroglycerineD. OxytocinE. Lisinopril

101. A man developed cardiac arrest dueto thoracic trauma. Name the drug thatshould be introduced into the cavity ofthe left ventricle in this case:

A. Adrenalin hydrochlorideB. SalbutamolC. LisinoprilD. ProserinE. Metoprolol

102. A patient with acute heart failure


was administered corglycon. What effectof this drug results in improvement of thepatient’s condition?

A. Increased heart forceB. Decreased heart forceC. Coronary vessels dilatationD. Increased heart rateE. Decreased oxygen demand ofmyocardium

103. Explain to an intern, what isthe mechanism of analgesic action ofmorphine hydrochloride:

A. Opiate receptors stimulationB. Histamine receptors blockadeC. Phosphodiesterase blockadeD. Adenylate cyclase stimulationE. Choline esterase blockade

104. What pharmacological effect of di-azepam allows its application for termi-nation of convulsions?

A. AnticonvulsantB. AnalgesicC. AntipyreticD. Anti-inflammatoryE. Hypnotic

105. A patient suffers from hyperchromicB12-deficiency anemia. What vitaminpreparation should be prescribed in thiscase?

A. CyanocobalaminB. RiboflavinC. Vicasol (Menadione)D. Thiamine chlorideE. Retinol acetate

106. A man is diagnosed with Parkinson’sdisease. What drug should be prescribedin this case?

A. LevodopaB. NitrazepamC. ParacetamolD. AminazineE. Anaprilin (Propranolol)

107. Direct titration CANNOT beapplied for quantitative determinati-on of calcium chloride by means ofpermanganatometry, because:

A. The investigated substance does notinteract with the titrantB. The reaction runs very quicklyC. It is impossible to select the indicatorto determine titration end pointD. Side reactions are possibleE. The reaction runs slowly

108. Colored or white component ofdouble perianth, which consists of petals,is a:

A. CorollaB. Flower cupC. AndroeciumD. GynoeciumE. Perigonium

109. A 54-year-old man requested apharmacist’s advice on drug prescripti-on. The patient has 4-year-long history ofchronic glomerulonephritis and 2-year-long history of persistent hypertension.What substance synthesized in the ki-dneys has important role in developmentof arterial hypertension?

A. ReninB. Nitric oxideC. AldosteroneD. HistamineE. Catecholamines

110. A patient complains of generalweakness, muscle weakness in theextremities (if the patient is asked tomake a fist several times in a row, forexample, the patient is capable of doingit only once), facial muscles are weak,swallowing is disturbed. Administrationof acetylcholinesterase drugs removesthese disturbances to a certain degree.Determine the pathology:

A. MyastheniaB. ParalysisC. ParesisD. HemiplegiaE. Monoplegia

111. A drug solution sterilized bymeans of boiling was tested for sterili-ty. Inoculation on Kitt-Tarozzi mediumrevealed clostridia. Clostridia survivedthe boiling because they are:

A. Spore-formersB. ThermophilicC. AnaerobicD. PrototrophicE. Acid-fast


112. A 71-year-old woman developedmechanical jaundice due to obstructionof the bile duct with a chololith. Decreaseof blood pressure and bradycardia aredetected. These changes in functioningof the patient’s cardiovascular system arecaused by increased blood content of thefollowing substance:

A. Bile acidsB. Direct bilirubinC. Indirect bilirubinD. UrobilinE. Stercobilin

113. A sanitary-epidemic stationemployee has been poisoned whenthe premices were processed wi-th an organophosphorous insectici-de. What enzyme is inhibited byorganophosphorous compounds?

A. AcetylcholinesteraseB. Lactate dehydrogenaseC. Xanthine oxidaseD. CatalaseE. Pepsin

114. Indican excretion is a diagnostic cri-terion of intencified protein putrefactionin the intestine. Name the end productof tryptophan ”decay” occurring in thelarge intestine:

A. IndoleB. PutrescineC. Benzoic acidD. MercaptanE. Hydrogen sulfide

115. The second stage of detoxificati-on involves joining certain chemicalcompounds with functional groups oftoxines. Select one such compound:

A. Glucuronic acidB. Higher fatty acidsC. CholesterolD. GlucoseE. Pyruvate

116. Actinomorphic apopetalous corollainclude:

A. CruciformB. FunnelformC. CampanulateD. TubularE. Ligulate

117. Selective medium can be used toseparate various species of bacteria in a

bacteriological laboratory. What mediumof those listed below can be determinedas selective?

A. Alkaline peptone waterB. Meat infusion brothC. Meat infusion agarD. Hiss’ serum water mediumE. Endo agar

118. A 5-year-old child presents wi-th abdominal distension, abdominalcramps, and diarrhea occurring 1-4 hoursafter drinking milk. Described symptomsare caused by the lack of enzymes thatbreak up:

A. LactoseB. GlucoseC. MaltoseD. SaccharoseE. Fructose

119. If pH of a solution is lower than itsisoelectric point, it means in this solution:

A. Cation forms of amino acids areprevalentB. Anion and cation forms of amino acidsare balancedC. Certain protein aggregates are formedD. Irreversible protein precipitationoccursE. Anion forms of amino acids areprevalent

120. Avidin - an egg white protein -inhibits reception of biotin (carboxylasecoenzyme) by the body. What reactionwill be blocked by avidin administration?

A. CO2 attachment to pyruvateB. NH3 attachment to glutamateC. NH3 detachment from glutamineD. Detachment of phosphate residualsE. Beta-oxidation of fatty acids

121. During mercurimetric titration ofhalogenide ions in the presence of di-phenylcarbazone, at the titration endpoint the precipitate is produced. Thisprecipitate will be colored:

A. BlueB. RedC. YellowD. GreenE. Brown

122. When determining oxidizing agentsby means of iodometry in the presenceof starch the following phenomenon can


be observed at the titration end point:

A. Blue coloring disappearsB. Red coloring appearsC. Green coloring of precipitate appearsD. Green coloring of solution disappearsE. White precipitate occurs

123. To obtain exotoxins of some mi-croorganisms, these microorganisms areinoculated into liquid nutrient medium,where microbial cultivation occurs andtoxins are produced. At a certain stage itis necessary to remove the microbial cellsfrom the medium, that is, to separatethe toxins from microbes. What methodshould be applied in this case?

A. Bacteria-excluding filtersB. BoilingC. AutoclavingD. Ultraviolet irradiationE. Disinfectants (chloramine)

124. A plant producing essential oil hassquare stem, bilabiate corolla, coenobi-um fruit. These features are characteri-stic of:

A. LamiaceaeB. PapaveraceaeC. PolygonaceaeD. SolanaceaeE. Scrophulariaceae

125. A plant under investigationhas compound uniform monopodiuminflorescence - compound umbel. Whatplant is it characteristic of?

A. Anethum graveolensB. Allium cepaC. Sorbus aucupariaD. Rosa caninaE. Centaurea cyanus

126. During field practice a student wastasked with making a morphologicalcollection of coenocarpous fruits. Whattype of fruit belongs to this group?

A. HesperidiumB. Aggregate-accessory fruitC. FragariaD. CynarodiumE. Drupe

127. A patient with gingivitis was prescri-bed oral cavity irrigation with 0,02%potassium permanganate solution. Whatgroup of antiseptics does this drug belongto?

A. OxidantsB. DyesC. DetergentsD. AlcoholsE. Nitrofurans

128. To relieve dry cough a patient wi-th bronchitis was prescribed a drug thatis an alkaloid of yellow horned-poppy.Name this drug:

A. Glaucine hydrochlorideB. Codeine phosphateC. Libexin (Prenoxdiazine)D. OxeladinE. Codterpin

129. Hydrochloric acid was added intothe solution under investigation. Theresulting precipitate was filtered, thenthis filter cake was processed with hotwater; after the filtrate cooled, KI soluti-on was added into it. What cation waspresent in the solution, if the precipitatewas colored yellow?

A. Pb2+

B. Ag+

C. Hg2+

D. Ca2+

E. Ba2+

130. When cations are divided intoanalytical groups according to the acid-base classification, group reagents can beacids or bases. What acids can be used asgroup reagents?

A. HCI , H2SO4B. HNO3, CH3COOHC. H3PO4, H2C2O4D. HCIO4E. H2CO3

131. Main process of ammonia neutrali-zation occurs in the liver. Argininedecomposition reaction that producesurea as a result is catalyzed with argi-nase. What group of enzymes does argi-nase belong to?

A. HydrolasesB. SynthetasesC. OxidoreductasesD. TransferasesE. Isomerases

132. Connection between plant cellprotoplasts and their metabolic functionis provided by thin cytoplasmic threads


that pass through pores in the cell walls.Name these threads:

A. PlasmodesmaB. FibrilsC. MicrotubulesD. MicrofilamentsE. Cytoskeleton

133. On autopsy there are numeroussuppurative foci within many of theinternal organs. What pathologicalprocess is it characteristic of?

A. SepticopyemiaB. SepticemiaC. SepsisD. BacteriemiaE. Toxemia

134. Isotonicity is required of infusi-on solutions. What phenomenonoccurs when a hypertensive solution isintroduced into blood plasma?

A. PlasmolysisB. OsmosisC. HemolysisD. DenaturationE. Thixotropy

135. The third analitycal group of cations(acid-base classification) includes Ca2+,Sr2+, Ba2+. What acid can function asa precipitator agent (group reagent) forthese cations?

A. H2SO4B. HNO3C. HCID. CH3COOHE. HCIO4

136. During routine preventive exami-nation the local pediatrician noti-ced a boy of short stature. Mentaldevelopment of the child corresponds wi-th his age. What endocrine disorder is it?

A. Pituitary nanismB. CretinismC. AcromegaliaD. GigantismE. Rickets

137. Eicosanoids synthesis begins withfreeing polyene acids from membranephospholipids by means of a specificphospholipase. Name this enzyme:

A. Phospholipase A2B. CyclooxygenaseC. Phospholipase CD. Protein kinaseE. Arginase

138. Thermal analysis is used inpharmacy to identify drugs and determi-ne drug purity. What coordinates arenecessary to build a cooling curve?

A. Temperature-timeB. Pressure-timeC. Volume-temperatureD. Volume-timeE. Temperature-volume

139. Both scientific and folk medicineuses medicinal plant Glycyrrhiza glabraL. What part of the plant is harvested?

A. Roots and rhizomesB. FoliageC. InflorescenceD. GrassE. Seeds

140. Choose the formula of nonionicsurfactant among those listed below:

A. CH3(OCH2CH2)10OHB. C15H31COONaC. C11H23OSO3NaD. C6H13NH2COONaE. C2H5NH2 · HCl

141. A pregnant woman was diagnosedwith vaginal dysbacteriosis. What drugshould be prescribed in this case?

A. ProbioticB. AntibioticC. BacteriophageD. InterferonE. Polyvitamins

142. A patient has been receivingTheophylline (inhibitor of cyclic adenosi-ne monophosphate phosphodiesterase)for a week. What hormone can increaseits action due to such treatment andcause hyperglycemia?

A. GlucagonB. TestosteroneC. AldosteroneD. InsulinE. Estradiol

143. Reaction of sodium ions withpotassium hexahydroxoantimonate (V)in neutral medium produces precipitate.


Specify the color of this precipitate:

A. WhiteB. RedC. YellowD. GreenE. Blue

144. Reaction with potassium permanganateis used to detect reducing anions. Speci-fy the anion that decolorizes potassiumpermanganate:

A. SulfiteB. CarbonateC. TetraborateD. SulfateE. Arsenate

145. A 25-year-old-patient with the IIdegree thermal burns came to a doctor.Objectively: there are large blisters onthe upper limbs; the blisters are filled wi-th clear exudate containing mostly waterand albumines with isolated leukocytes.Name the type of the exudate:

A. SerousB. Catarrhal (mucous)C. FibrinousD. PurulentE. Hemorrhagic

146. Rhizome of an Asteraceae familyspecies is polycephalous, succulent, haslysigenous cavities, accumulates inulin.Such underground organ is characterisicof:

A. Inula heleniumB. Hyoscyamus nigerC. Digitalis grandifloraD. Sorbus aucupariaE. Helianthus annuus

147. Osmotic pressure is an importantcharacteristic of biological fluids. Semi-permeable membranes are necessary forpenetration of solvent molecules. Whatsubstance CANNOT be used as a semi-permeable membrane?

A. GlassB. Biological membraneC. Collodion filmD. ParchmentE. Gelatine

148. Specify the substance that can bedetermined by means of polarimetry:

A. GlucoseB. This method will suffice for anysubstanceC. Sulfuric acidD. Sodium chlorideE. Benzene

149. A local general practitionerrecommends taking interferon forinfluenza prevention. What is themechanism of action of this drug?

A. Blocks virus protein synthesisB. Blocks virus strippingC. Inhibits virion exit from cellsD. Prevents adsorption of virus in cellreceptorsE. Disrupts the process of virus assembly

150. What cation can be detected withChugaiev’s agent (Dimethylglyoxime)?

A. Ni2+

B. Ca2+

C. �+

D. Mn2+

E. Co2+

151. A solution of hydrogen peroxide inan acid medium was added into investi-gated solution, leading to blue coloringof the resulting solution. This analyti-cal effect indicates the presence of thefollowing anions:

A. Cr2O2−7

B. MnO−4

C. C2O2−4

D. NO−3

E. Cl−

152. A patient presents with hypoxia.What metabolic process activates whenoxygen supply is insufficient?

A. Anaerobic glycolysisB. Urea cycleC. Pentose-phosphate pathwayD. Oxidative decarboxylation of ketoacidsE. Tricarboxylic acid cycle

153. A child had been administered anti-diphtheric serum. What resistance wasformed in the child?


A. PassiveB. ActiveC. PrimaryD. PathologicE. Physiological

154. A patient with brain edema presentswith respiration that is characteri-zed by periods of several respiratorymovements of equal amplitude alternati-ng with periods of apnea. Whatpathologic respiration is it characteristicof?

A. Biot’s respirationB. Gasping respirationC. Apneustic respirationD. Cheyne-Stokes’ respirationE. Kussmaul’s respiration

155. A patient in the state of ketoacidoticcoma presents with loud rapid respi-ration: labored expiration with tensionof expiratory muscles occurs after deepinspiration. Name the type of pathologicrespiration:

A. Kussmaul’sB. Cheyne-Stokes’C. GaspingD. StenoticE. Biot’s

156. In a nursery-garden some medici-nal plants developed signs of a disease:there are yellow spots and necrotic focion the leaves. Sap of the diseased plantsremained infectious even after passingthrough a bacteria-excluding filter. Nomicroorganisms growth was detected onthe nutrient medium. What microorgani-sms could be the cause of this disease?

A. VirusesB. FungiC. Ray fungiD. BacteriaE. Mycoplasma

157. Bark of a thornless xylophyte of theRhamnaceae family has laxative effect.Name this plant:

A. Frangula alnusB. Aronia melanocarpaC. Hippophaё rhamnoidesD. Rubus idaeusE. Crataegus sanguinea

158. Different structures of a bacterialcell perform different functions. Whatdispensable component of a cell ensures

its survival within hostile environment?

A. SporesB. FlagellaC. CapsuleD. CiliaE. Inclusions

159. Total content of chloride, bromide,and iodide ions in the investigated soluti-on can be quantitatively determined withthe following titrant:

A. Silver nitrate solutionB. Potassium dichromate solutionC. Sodium thiosulfate solutionD. Potassium permanganate solutionE. Sodium nitrite solution

160. Specify the reaction product ofcomplete aniline hydrogenation:

A.

B.

C.

D.

E.

161. Name the isomer of diethyl etherfunctional group:CH3 − CH2 − O − CH2 − CH3:

A. ButanolB. EthanolC. ButanalD. Ethyl acetateE. Dimethyl ether

162. What substance can be identified wi-th aqueous solution of FeCl3?


A.

B.

C.

D.

E.

163. What reaction proves that phenolhas acidic properties?

A.

B.

C.

D.

E.

164. Gravimetry (precipitation method)is used for quantitative determinati-

on of sulfates in potable water. Whatsubstance should be used as precipitatorfor sulfates?

A. BaCI2B. KCIC. MgCI2D. NaCIE. NH4NO3

165. In 9 days after administration of atherapeutic serum the patient developedurticaria, itching, edemas, and lymphnodes enlargement. What type of allergicreaction has occurred in the patient?

A. Immune complexB. CytotoxicC. AnaphylacticD. StimulatingE. Cellular

166. Which of the listed compounds is analpha-amino acid?

A.

B.

C.

D.

E.

167. Exudation is characteristic ofinflammation. What factors causeexudation and local edema of theinflamed area?

A. Increased permeability of vessel wallB. HyperglycemiaC. IschemiaD. Leukocyte adhesion to endothelialcellsE. Decreased permeability of vessel wall

168. For cardiovascular disease preventi-


on the patient was recommended to takevitamin F . What is the chemical natureof this vitamin?

A. Complex of polyunsaturated fattyacidsB. Cholesterol derivativeC. Polysaccharide complexD. Amino acids complexE. Carotin derivative

169. Wetting occurs when a drop of a li-quid comes into contact with the surfaceof a solid substance. The degree of wetti-ng is measured through:

A. Contact angleB. Drop densityC. Surface tensionD. Drop sizeE. Work of adhesion

170. A perennial plant has white flowerheads grouped in compound corymbsand bipinnatisected or tripinnatisectedleaves. Name this plant:

A. Аchillea millefoliumB. Melilotus officinalisC. Potentilla erectaD. Phaseolus vulgarisE. Taraxacum officinale

171. What organic compounds areproduced in the result of intramoleculardehydration of monohydric alcohols?

A. AlkenesB. EstersC. AldehydesD. AlkanesE. Arenes

172. A group of children in thekindergarten (6-year-olds) receivedMantoux test; 15 children presented withnegative results. What measures shouldbe taken towards these children?

A. BCG vaccinationB. Tuberculosis antitoxinC. IsolationD. Repeat the testE. Referral for fluorography

173. Increased concentration of acti-ve oxygen forms is a mechanism ofpathogenesis in a number of diseases.To prevent this process, antioxidants areprescribed. Select an antioxidant fromthe list below:

A. Alpha-tocopherolB. GlucoseC. CalciferolD. CobalamineE. Glicerol

174. During excursion into a coniferforest the students noticed that bilberry(Vaccinium myrtillus) stems are lignifi-ed only partially in their lower part, theupper part of the stem retains the form ofcaulis. Therefore, this plant can be classi-fied as:

A. SuffrutexB. Annual grassC. LianaD. Perennial grassE. Tree

175. Antibiotics derived from variousspecies of actinomycetes are widely usedin medical practice. Point out these drugsamong those listed below:

A. Aminoglycosides (streptomycin,monomycin)B. Penicillin, cephalosporin, griseofulvinC. Polymyxin, bacitracinD. Chloreline, arenarinumE. Lysozyme, erytrinum

176. In a human body there occurnumerous reactions of direct interacti-on between substrate and molecularoxygen. What enzyme catalyzesattachment of two oxygen atoms to thesubstrate?

A. DioxygenaseB. CatalaseC. MonooxygenaseD. Superoxide dismutaseE. Glutathione reductase

177. Seeds of rye, corn, and other cropshave small corymb-shaped cotyledonand accumulate nutrients in the:

A. EndospermB. PerispermC. ShellD. GemmuleE. Embryo root

178. A 55-year-old man came to a doctorwith complaints of acute pain in his bigtoes. Meat and wine remain permanentlyin his diet. The doctor suspects gout.What substance must be measured in thepatient’s blood to confirm this diagnosis?


A. Uric acidB. UreaC. LactateD. BilirubinE. Ketone bodies

179. Isotonic glucose solution is widelyused as a solvent or infuson medium forintroduction of various drugs. What massfraction is characteristic of this solution?

A. 5%B. 10%C. 15%D. 20%E. 1%

180. Name the process of cell membranesaturation with a fat-like substance -suberin:

A. SuberizationB. LignificationC. MineralisationD. CutinizationE. Sliming

181. A man has been suffering fromrheumatoid arthritis for 10 years. Dueto its exacerbation he had been taki-ng acetylsalicylic acid and predni-solone. The patient complains ofstomachache, eructation, nausea, sensati-on of full epigastrium, and meteorism.On gastroscopy there was an erosion(0,5x0,5 cm) of gastric mucosa detected.What is the cause of gastric mucosadefect development?

A. Prolonged taking of aspirin andhormonesB. Immune-mediated destruction ofgastric mucosaC. Dysbacteriosis developmentD. Age-related changes of mucosaE. Prolonged hypersthenia of gastricmuscles

182. Treatment of a number of pathologicchanges in human body is based onthe peptization process, particularly di-sintegration of thrombi within bloodvessels. The most important conditionfor efficient peptization can be determi-ned as:

A. Timely introduction of anticoagulantB. Introduction of excessive solventC. Ultrasound effectD. ShakingE. Heating

183. The patient’s large-focal myocardialinfarction is complicated with pulmonaryedema. What disturbance of cardi-ohemodynamics contributed to thepulmonary edema development?

A. Acute left ventricular failureB. Acute right ventricular failureC. Autoimmune myocarditisD. Cardiogenic shockE. Reperfusion syndrome

184. The fruit is a thorned many-seededcapsule that opens into four flaps whenripe. It is characteristic of:

A. Datura stramoniumB. Papaver somniferumC. Hyoscyamus nigerD. Digitalis purpureaE. Linum usitatissimum

185. An interhospital pharmacy receiveda short-acting narcotic analgesic that is100 times more active than morphine.Name this drug:

A. FentanylB. NaltrexoneC. NaloxoneD. Analgin (Metamizole)E. Ketanov (Ketorolac)

186. Hemoglobin break-up begins in thecells of reticuloendothelial system. Whatenzyme catalyzes the reduction reactionof biliverdine into bilirubin?

A. Biliverdine reductaseB. Beta-glucuronidaseC. Xanthine oxidaseD. Heme oxygenaseE. Hexokinase

187. To stop diarrhea the doctor prescri-bed a drug that affects opiate receptorsof the intestine and decreases its peri-stalsis. Name this drug:

A. LoperamideB. HeparinC. LevorinD. Voltaren (Diclofenac)E. Tetracycline

188. What formula corresponds withalpha-nitropyrole?


A.

B.

C.

D.

E.

189. Essential oils are used both inpharmaceutical and cosmetic industry.To extract essential oils from herbalraw material the following technology isused:

A. Steam distillationB. CalorimetryC. ColorimetryD. PotentiometryE. Conductometry

190. Specify the mechanism of the givenreaction:

C2H5OHH+, t>170oC−−−−−−−−→ H2C = CH2+H2O

A. Е (elimination)B. SN (nucleophilic substitution)C. �N (nucleophilic attachment)D. SR (radical substitution)E. S� (electrophilic substitution)

191. What type of bonds participatesin creation of both linear and cycliccarboxylic acid associates in the form ofdimers?

A. Hydrogen bondsB. Ionic bondsC. Polar covalent bondsD. Nonpolar covalent bondsE. Donor-acceptor bonds

192. Specify the functional group ofisoniazide (an isonicotinic acid derivati-ve) molecule:

A. Hydrazide groupB. Amide groupC. Carboxyl groupD. Pyridine heterocyclic groupE. Ester group

193. What compound is synthesized bymeans of beta-picoline oxidation?

A. Nicotinic acidB. Benzoic acidC. Uric acidD. Barbituric acidE. Ascorbic acid

194. Specify quinoline among thecompounds given below:

A.

B.

C.

D.

E.

195. Name the substance B in the followi-


ng transformation:

CH ≡ CHHOH,Hg2+

−−−−−−−→ A[0]−→ B

A. Acetic acidB. EthanolC. PropanalD. PropanoneE. Ethanal

196. What substance produces ketone,when oxidized with potassiumpermanganate?

A.

B. CH3 − CH − CH2OHC. CH3 − CH2OHD.

E.

197. Among the given isomer pairschoose the position isomers of the functi-onal group:

A.

B.

C.

D.

E.

198. Among the given substances choosethe one that is used for oxidation oforganic compounds:

A. KMnO4B. CH3 − CH3C. NaOHD. HClE. NH2 − NH2

199. What substance will be produced asthe result of the following reaction:

�6�5 − N+ ≡ NCl− + KJto

−→?

A. �6�5JB. C6�5��

C. �6�6D. �6�5 − ClE. C6�5�K

200. What reagent can simultaneouslydetect aldehyde group and glycolfragment in a glucose molecule?

A. Cu(OH)2B. Br2C. AlCl3D. FeCl3E. KMnO4

INSTRUCTIONAL BOOK

Testing Board

TEST ITEMS FOR LICENSING EXAMINATION: KROK 1. PHARMACY.

Kyiv. Testing Board.(English language).

Approved to print 10.05./№66. Формат 60х84 1/8Offset paper. Typeface. Times New Roman Cyr. Offset print.Conditional print pages 24. Accounting publishing pages 20.Issue. 99 copies.

List of abbreviations

A/G Albumin/globulin ratioA-ANON Alcoholics anonymousACT Abdominal computed tomographyALT Alanin aminotranspheraseAP Arterial (blood) pressureAST Aspartat aminotranspheraseBP Blood (arterial) pressureBR Breathing ratebpm Beats per minuteC.I. Color IndexCBC Complete blood countCHF Chronic heart failureCT Computer tomographyDIC Disseminated intravascular coagulationDCC Doctoral controlling committeeDM-2 Non-Insulin dependent diabetes mellitusDTP Anti diphtheria-tetanus vaccineECG ElectrocardiogramESR Erythrocyte sedimentation rateFC Function classFEGDS Fibro-esphago-gastro-duodenoscopyGy GrayGIT Gastrointestinal tractHb HemoglobinHbA1c Glycosylated hemoglobinHct, Ht HematocritHDL High-density lipoproteinsIDDM Insulin dependent diabetes mellitusIHD Ischemic heart diseaseIU International unitMSEC Medical and sanitary expert committeeNIDDM Non-Insulin dependent diabetes mellituspCO2 CO2 partial pressurepO2 O2 partial pressurePm Per minutePs Pulse rateR RoentgenRBC Red blood countRh RhesusRR Respiratory rateS1 (S1) Heart sound 1S2 (S2) Heart sound 2TU Tuberculin unitU UnitUSI Ultrasound investigationV/f Vision fieldWBC White blood countX-ray Roentgenogram

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Testing Board - Центр тестування при ... · Krok 1 Pharmacy (англомовнi студенти) 2017 рiк 1 1. In a child-rearing facility there was an outbreak