The clinical research of early diagnosis and ultimately the treatment of Alzheimer’s disease

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Dementia

• Suffers memory difficulty• Can’t feed or dress themselves• Can’t recognize the person sitting next to

them have been their spouse for thirty or forty years

Dementia

• Unfortunately, this is the stage where we are typically doing our clinical trials. • There’s already been years of irreversible

brain damage.

Mild cognitive impairment (MCI)

• MCI = prodromo(?) Alzheimer’s• Not all will progress to Alzheimer’s disease• A significant risk factor, and 15 percent of them

will move toward Alzheimer dementia every year

Mild cognitive impairment (MCI)

• Have already started to do clinical trials at this stage of disease• However, even mild cognitive

impairment might still be too late

The Amyloid plaques

• We already know that Amyloid must play an important role in Alzheimer’s disease because the genetics drives us this way.• Unfortunately we don’t have all the

answers.

Why would one want to detect and find out that one’s gonna get Alzheimer’s

• Disease ten or twenty years before they do when there’s nothing we can do about it?• Look at other diseases: cancer, cardiovascular

disease, HIV-AIDS, diabetes, osteoporosis, stroke• We have successes when we treat before we

can see symptoms.