RTK
RTK
RTK
RTK
RTK
RTK
RTK
RTK
PDGF RTK
RTK
RTK
RTK
PDGF
RTK
EGF
EGF
RTK
RTK
PDGF
pp.
Kit
RTK
RTK
RTK
PDGF
KitSCF
Kit
SCF
Structural biology of receptor tyrosine kinase KitSatoru Yuzawa
and Joseph SchlessingerYale UniversitySchool of Medicine, Cedar
Street, New Haven, CT, U.S.A.
Kit
Kit
PDGF
PDGF RTK
RTK
NRTK RTK
RTK
PDGF III
RTKKitc-kitSCFCDCSF
colony-stimulating factorM-CSFc-fms
FltFms-like tyrosine kinase PDGFPDGFRPDGFR RTK RTK
Ig
JMRjaxstamembrane region
KIDkinase insertion domain
PDGF
SCFstem cell factor
RTK RTKEGFPDGFFGFVEGFIgLCRFnKIDkinase insertion domain
CSF FltLFltligand
small helical cytokine foldCSF
SCF FltL
SCF KitCSF CSF
FltL Flt
PDGFR
PDGF cytokine knot foldPDGF
ABC D
PDGF-AA-BB-CC-DDAB
PDGF
PDGFR PDGFR-PDGFR PDGFR-PDGFR PDGFR-PDGFRPDGF
RTK
RTK
SHSrc homology PTBphospho-
tyrosine bindingRTK
RTK
RTK
ligand-mediated
hGH-hGH EPO
erythropoietin-EPO
hGH EPO
Flt-VEGFR-
IgD
VEGF
VEGFR-
VEGFVEGF VEGFR-
VEGFVEGFR-
RTK
PDGF
VEGF Ig
D-D-D
D
PDGF VEGF
cytokine knot fold
PDGFVEGF
NGFnerve growth
factor-TrkA
PDGFPDGF SCFstem cell factorCSFcol-ony stimulating
factorFltLFms-like tyrosine kinaseligandPDGF-BBplatelet-derived
growth factor PDBEXZSCFHMCCSFETEFltLPDGPDGF-BB
Kit
PDGF Kit
GISTmas-
tocytosisAML
SCF Kit
D-D-D-D-D
Kit
D-D-D SCF
SCF-Kit
SCF SCF-Kit
Kit
SCFKit
IgD-D-D Ig
D-D
D-D-D
D-D
Kit D-D-D
SCF
Kit D-D-D
SCF
Kit D-D-D
SCF
SCF-Kit D-D-D
VEGF-VEGF D
Kit D-D-D
Tie
SCF-Kit
SCF KitSCFstem cell factor KitKit SCF IgDDD SCF SCF IgDDSCF
PDBECKitEWSCF-Kit
D BCSCF
D N
SCF D C-SCF
SCF-Kit
SCF-Kit
D D
DD
SCF-Kit SCF-SCF
SCF-KitSCF-KitSCF KitD D SCFD SCF Kit
SCF-KitSCF-Kit IgDD E F
D
PDGF
FltD
Kit PDGF
IgD
D
Kit PDGF
D
VEGF Ig
DPDGF D
VEGF VEGF
VEGF-VEGF
D
PDGF
Ig
VEGF Ig
PDGF
VEGF RTK
PDGF VEGF
Kit
D
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DDDD Kit D E FPDGFFlt VEGF Ig
Kit D
D D
GISTmastocytosis
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Ig D D
Kit D D
Ig
D D
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D D
D
RTK
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VEGF-VEGF D
Kit D
SCF Kit SCFa SCF-Kitb Kit DD DDD CSCF-KitDD DD
Ig
FGF Ig
FGF
FGF-
FGF
D
NRTK JAKJanus
kinase
JAK
gp
Fngp
IL- IL- IL- IL-
Fn
D
Kit
JMR N-
C-
N-ATP
ATPC-
ATP
A-activation segmentloop
A-
A-
A-
A-
JMR
PDGF JMR
Eph
JMR
PDGF
ATP
RTK
Kit
A-
JMR
A-
JMR
A-
JMR
JMR
Kit
A-
JMR
PDGF
JMR
JMR
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RTK
Kit A-
Kit A-
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Kit
RTK
PDGF
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Kit
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D
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KitKitab N- C-JMRjaxtamembrane regionA-KIDkinase insertion
domainADPJMRTyr Tyr A-JMR A-N- C-JMRTyr TyrA-JMRpTyr pTyr
PDBPKGT
JMR
JMR
RTK
KitPDGF
Kit
JMR
PDGF
VEGF RTK
RTK
D D
RTKD-D
D-D
RTK
Kit
Yarden Opatowsky
Zhongtao ZhangValsan Mandiyan Irit Lax
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