Pharmaceutical processings in ay

Anand

ChaudharyAssociate Professor

Department of Rasa ShastraFaculty of Ayurveda

Institute of Medical Sciences Banaras

Hindu UniversityVaranasi

email‐[email protected]

mailto:[email protected]

Questions /Contents

01‐

Are the principles of herbal drug processing and mineral

drug processing same ?

02‐Are there any parameters to know the physical change

in source material ?

03‐What are the reasons for selection of particular process

of particular drug ?

04‐What is the basis of selection of particular drugs for

particular formulations ?

CME for Teachers in Rasa Shastra

, College of Ayurveda ,Bharati

Vidyapeetha,Pune 25 July ,2011 3

Contd.

05 ‐What is the relevance of repetition cycles especially for

production of Bhasma

and Khalviya

rasa

kalpa

?

06‐Principles of Stability are based on what logic ?

07‐Is there any co relation between principles of

formulations applied to Ayurvedic drugs and modern

drugs ?




Herbal Drug – Ayurvedic

Medicine




Authoritative Authentication

Classical considerations

Contemporary contemplations




Sanitization & Storage

Separation

Segregation

Sustainable




Processing




Container Consensus

Primary dosage forms

Secondary dosage forms




Comminution

Size Reduction

Mechanical Pressure Solvency Procedures




Extraction

Universal Solvent

Other Solutions

Suspensions

Nano

suspensions




Energy Agenda




Solvents




Completion Criteria

As per different dosage forms




Procurement & Packing

As per Prepared Medicaments




Delivery & Dispensing

As per indications of Physicians




Mineral Drug – Ayurvedic

Medicine




Individualistic Identification

Conventional connotations

Current conjectures




Processing




Contd .




Adaptations

Modification –

Physical (Heterogeneous to homogenous)

Chemical Conversion

Enhancement



Vidyapeetha,Pune25 July ,2011 22

Impacts

Purification

Reduction in adverse effects

Induction of trace elements

Alteration in Constituencies




Metallographic findings

Metallographic figure of Raw Swarna Makshika (M= 400X).

Metallographic figure of Shodhita Swarna Makshika (M= 400X).




Initial Stride




Marana

•

Sukshmikaran

(Fine powdering)

•

Chakrika

Nirmana

(Pellet formation)‐

With other ingredients.

•

Samputi

Karana

(Sealing in earthen vessels)

•

Puta




Intrinsic Worth

•

Maximum Temperature range

•

Duration of Maximum temperature

•

Self Cooling

•

Repetition of process

1.

Hardness

2. Particle size3. Chemical Constituents




Vividness




Explicitness

0

200

400

600

800

1000

1200

1 4 7 10 13 16 19

time in min. (1 = 15 units)

tem

pe

ratu

re

Temperature(0C)




Magnitude

Conversion

Potentiation

Elimination

Safety




Makshika

SEM Feature of Raw S. M SEM Feature of Bhasma S. M




Lauha Bhasma



Vidyapeetha,Pune

Neetu Singh et al , Chemical Characterization of Lauha Bhasma by X-Ray Diffraction and Vibrating Sample Magnetometry International Journal of Ayurvedic Medicine, 2010, 1(3), 143-149

25 July ,2011 32

Rasa Sindoor

Transmission electron microscopy (TEM) images (a, b, and c) along with selected area electron diffraction pattern (SAED) pattern (d) showing the presence of sub-micron size, agglomerated, and crystalline particles in the drug Rasa-Sindoor. S K Singh et al 2011 ,dept of Physics, BHU




Rasa Sindoor

Scanning electron microscopy (SEM) image of the Rasa-Sindoor showing the plate like porous surface morphology. Inset to the figure shows the tiny voids presents in the material, S K Singh et al ,2011, Dept of Physics ,BHU




Miscellaneous

Procurement

Packing

Dispensing




Manufacturing

Characterization

Safety & Efficacy



Vidyapeetha,Pune

Recent Researches

25 July ,2011 36

Scientific Approach Stakeholders

Deptt

of AYUSH,GOI

Deptt

of DST,GOI

Academic Institutes

Research Organizations

???????

Observations




Characterizations

IIT ,Rooraki

Kumar A

IIT, Mumbai

Bellare

Jayesh

IIT ,Kharagpur

Roy Subrato




Safety

Schedule Y , D & C Rule

1945

Rule 170 , D & C Rule

1945 – 24 Dec , 2008




Rays of Radiance




Selective Selection

Artificial Addition Inherent Innate




Supervises Solubility

Developmental Doctrine Progressive Preferences




Probable Postulation

Bio accumulation Bio detoxification




Reductionist Relativity

Contour Conversion Eternal Endowment




Procedural Principal

Blending Thermodynamics




Assertive Assumptions

Visionary Validation Rational Realization




Extended Elegance

Explanation Elucidation




Prominent Paramount

Herculean Herbal Metamorphic Metal




Absolve Absorption

Organic Order Actual Accomplishment




Pragmatic Paradigms

Momentous Mercury Poise Parada




Authentic Authenticity




Bhasma as Nano‐medicine

Global Guidance Crucial Clause




Additional GMP Additional Certification

Stop Press




Enlighten Endorsement

Causative Consultation Comprehensive communication




Special Submission




Exigency in Education




Take Home Message

Indian Inheritance Authoritative Agenda




Conclusion

Ayurveda is Super Science!Rasa Shastra

is Super Chemistry!

All is Well

Dosage forms of Rasa Shastra

& Bhaishjya Kalpana

‐

Super Pharmaceutics ?




Acknowledgement

Prof A Wele

,Head , Dept of Rasa Shastra,

College of Ayurveda, Bharati

Vidyapeetha ,Pune

All Team Rasa Shastra

, BV ,Pune

All Scholastic Scholars of Rasa Shastra

at Pune

from 25/07/2011 to 30/07/2011




Thanks & All Good Wishes ‐‐ ‐‐‐


, College of Ayurveda

,Bharati
