Developmental Programming 2016. 9. 27

ContentsDevelopmental programming?

?

Vs.

?

5

? ( ?)

6

ProgrammingExposure to environmental stimuli or insults

Critical phases of developmentPermanent changes to physiology or metabolism

3034

In Human

Coronary heart diseaseObesityHypertensionDM

Fetus DevelopmentNutrition

(1991, David Barker, )

Developmental ProgrammingFetal ProgrammingNutritional ProgrammingDevelopmental Origins of Health and Disease (DOHaD)Developmental Programing of Chronic Disease

Developmental Programming

Barker et al., BMJ 1993; 307: 1519-24

1990, The Hunger Winter (1944.11~1945)Dutch famine, 6 months500~600 kcal/day 3: 250g , , , . 1: , , , 1) .2) .

Early adiposity rebound

, fat mass , insulin resistance 2 Rebound timing (BMI ) 4-5 : 9% vs. 8 : 2%Eriksson et al., Diabetologia. 2003

() ..? ?

2000,

Langley-Evans et al., J Anat. 2008

BMI(kg/m2) :