Clopivas (Clopidogrel Tablets)
Clopidogrel Tablets
Clearsky Pharmacy
Clopivas (Clopidogrel Bisulfate Tablets) is used to prevent
blood clots forming in hardened blood vessels (a process known as
atherothrombosis) which can lead to events such as stroke, heart
attack or death. It is used to treat the medical conditions Acute
Coronary Syndrome and Recent MI, Recent Stroke or Established
Peripheral Arterial Disease.
Clopivas Tablets
Clearsky Pharmacy
Clopivas Tablets are manufactured by Cipla Ltd., India.
(Website: www.cipla.com)
Clopidogrel Bisulfate Tablets Brand Names
Clearsky Pharmacy
Clopidogrel Bisulfate tablets are available as Plavix, Clopivas,
Ceruvin, Clavix, Clopilet, Deplatt and Plagril.
Active Ingredient
Clearsky Pharmacy
The active ingredient contained in Clopivas tablets is
Clopidogrel Bisulfate. Each film-coated Clopivas tablet contains 75
mg of Clopidogrel Bisulfate.
Chemical Structure
Clearsky Pharmacy
The structure of Clopidogrel Bisulfate is given below:
Uses of Clopivas Tablets
Clearsky Pharmacy
Clopivas tablets manufactured by Cipla Ltd., is a platelet
inhibitor and used to prevent blood clots in coronary artery
disease, peripheral vascular disease, and cerebrovascular disease.
Clopivas (Clopidogrel Bisulfate Tablets) is used to treat patients
with Acute coronary syndrome (unstable angina (UA)/non-ST-segment
elevation ACS (NSTEMI)& ST-elevation myocardial infarction
(STEMI) ), recent myocardial infarction (MI), recent stroke, or
established peripheral arterial disease.
Storage Instructions
Clearsky Pharmacy
Clopivas (Clopidogrel Bisulfate Tablets) have to be stored at
controlled room temperature i.e. 25C (68F ) with excursions
permitted between 15 to 30C (59 to 86F). Keep this as well as all
other medicines away from children and pets.
Warnings
Clearsky Pharmacy
The annual incidence of hemorrhage may be increased by the
co-administration of aspirin. use of non-steroidal
anti-inflammatory drugs is discouraged in those taking clopidogrel
due to increased risk of digestive tract hemorrhageCYP2C19
inhibitors: Avoid concomitant use of omeprazole or esomeprazole.
Bleeding: Plavix increases risk of bleeding. Discontinuation:
Premature discontinuation increases risk of cardiovascular events.
Thrombotic thrombocytopenic purpura (TTP) has been reported.
Cross-reactivity among thienopyridines has been reported
Warnings
Clearsky Pharmacy
Thienopyridines, including Clopidogrel, increase the risk of
bleeding. If a patient is to undergo surgery and an antiplatelet
effect is not desired, discontinue Clopivas (Clopidogrel Bisulfate
Tablets) five days prior to surgery that has a major risk of
bleeding. In cases of confirmed isolated activated partial
thromboplastin time (aPTT) prolongation with or without bleeding,
acquired hemophilia should be considered.Hypersensitivity,
including rash, angioedema or hematologic reaction, has been
reported in patients receiving clopidogrel, including patients with
a history of hypersensitivity or hematologic reaction to other
thienopyridines.
Clopivas Dosage
Clearsky Pharmacy
Acute coronary syndrome - Non-ST-segment elevation ACS
(UA/NSTEMI): 300 mg loading dose followed by 75 mg once daily, in
combination with aspirin (75-325 mg once daily)
Acute coronary syndrome - STEMI: 75 mg once daily, in
combination with aspirin (75-325 mg once daily), with or without a
loading dose and with or without thrombolytics
Recent MI, recent stroke, or established peripheral arterial
disease: 75 mg once daily
The adult dosage of Clopivas tablets (Clopidogrel Bisulfate) is
given below:
Clopivas Tablets
Clearsky Pharmacy
Contraindications
Clopivas is contraindicated in patients with a hypersensitivity
to or any other component of this medication. This medicine is also
contraindicated in patients that have active pathological bleeding,
such as peptic ulcer or intracranial hemorrhage. Also
contraindicated in cases of Severe liver impairment.
Clopidogrel Side Effects
Clearsky Pharmacy
Bleeding, including life-threatening and fatal bleeding, is the
most commonly reported side effect of Clopivas (Clopidogrel
Tablets).
Thrombotic Thrombocytopenic Purpura (TTP), sometimes fatal, has
been reported following use of Clopidogrel Tablets, sometimes after
a short duration.
Clopidogrel Overdose
Clearsky Pharmacy
Overdose following Clopivas (Clopidogrel Tablets) administration
can lead to prolonged bleeding time and subsequent bleeding
complications.
Clopivas Overdose
Clearsky Pharmacy
Appropriate therapy must be considered if bleedings are observed
due to Clopivas (Clopidogrel Tablets) overdose. No antidote to the
pharmacological activity of Clopidogrel has been found. In case a
fast correction of prolonged bleeding time is necessary, platelet
transfusion may reverse the effects of Clopidogrel tablets.
Clopidogrel During Pregnancy
Clearsky Pharmacy
Clopidogrel (Clopivas Tablets) has been classified by the US FDA
as Pregnancy Category B. Controlled studies reproduction studies
performed in animals revealed no evidence of impaired fertility or
fetotoxicity due to Clopidogrel. However, no adequate and
well-controlled studies with Clopidogrel have been conducted in
pregnant women. Since animal reproduction studies are not always
predictive of a human response, Clopivas should be used during
pregnancy only if clearly required.
Clopivas Tablets
For more details on Clopivas Tablets click here
Clearsky Pharmacy
Clopivas (Clopidogrel Bisulfate Tablets) by Cipla Limited,
India.
