Ménétrier Disease (Hypoproteinemia Hypertrophic Gastropathy)

OVERVIEW• Rare stomach condition, more common in men, usually

occurs between age 30-60.

• Cause unclear, linked to abnormally high levels of

transforming growth factor-alpha (TGF- )α .

• Involves enlarged stomach rugae due to overgrowth

of surface mucous cells (hypertrophy).

• Excess mucus secretion causing hypoproteinemia.

• Reduction in parietal cells causing decreased

stomach acid.

ANATOMY

ANATOMY

SIGNS & SYMPTOMS

Pain in abdomen

Nausea and frequent

vomiting

Swelling of the face,

abdomen, limbs,

and feet

Loss of appetite

Malnutrition

Extreme weight loss

Low blood protein

Anaemia

Diarrhoea

DIAGNOSIS DIAGNOSIS

Endoscopy

CT Scan

X-Ray

Stomach Biopsy

TREATMENT Pain relief medication

Nausea relief

medication

High protein diet

Gastrectomy (Stomach

Transplant).

REFERENCES http://radiographics.rsna.org/content/2

9/1/297.full?sid=d8389545-0cd2-48f6-9320-89cec7203229

http://digestive.niddk.nih.gov/ddiseases/pubs/menetrier/