生化室 2014 级科硕 柳霞. abstract RAS proteins are essential components of signalling...

生化室 2014 级科硕

柳霞

abstractRAS proteins are essential components of signalling pathways that emanate from cell surface receptors. Oncogenic activation of these proteins owing to missense mutations is frequently detected in several types of cancer. A wealth of biochemical and genetic studies indicates that RAS proteins control a complex molecular circuitry that consists of a wide array of interconnecting pathways. In this Review, we describe how RAS oncogenes exploit their extensive signalling reach to affect multiple cellular processes that drive tumorigenesis.

Oncogenic activation – themes and variations

RAS and the transformed phenotype

Promotion of proliferation

Suppression of apoptosis

Metabolism

Remodeling the microenvironment

Evasion of the immune response

Metastasis

The road ahead

Figure 1. Frequency of mutations at G12, G13 and Q61 in RAS isoforms

Figure 2. RAS effects on proliferation

Figure 3. RAS effects on apoptosis

Figure 4. Effect of RAS on energy metabolism in cancer cells: generating macromolecular precursors

Figure 5. RAS and angiogenesis

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