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Séminaire 2 E-santé: diagnostic anatomo-pathologique.
Du projet BWB vers la pathologie digitale Wallonie-Bruxelles
Biothèque Wallonie-Bruxelles www.biotheque-wallonie-bruxelles.be
Laurent Dollé Operating manager
Sabine Cornelis Operating manager assistant
Agenda
Main tasks and current achievements
Perspectives and valorization
Main challenges we are facing
BWB Context : “biobanking”
BWB project
What is a Biobank?
Biological resources
What is a Biobank?
Patient/Clinic Biobank Discovery
Fabienne George
Myriam Remmelink
Flavienne Sandras
What is a Biobank?
Storage size Nature of
samples
What is a Biobank?
provides the provision of the human body material exclusively for scientific research and is not intended for human application
with high quality control and respecting the legal* & ethical framework
*Le biobanking est régi par la Loi du 19/12/2008, relative à l'obtention et à l'utilisation de matériel corporel humain destiné à des applications médicales humaines ou à des fins de recherche scientifique. Cette loi qui répond à la directive européenne de 2005, impose le passage obligé du matériel biologique humain destiné à la recherche scientifique par une biobanque de matériel corporel humain qui en assure la gestion depuis l'obtention du matériel jusqu'à son utilisation.
receives, stores, processes, disseminates biological specimens (blood, tissue, urine, saliva etc.)
ensures storage of associated data from human body material (medical, epidemiological,
molecular, physiological, structural…)
BWB context: “biobanking”
Doable Partially doable Non-manageable
Encompasses the physical location and the full range of operational activities
Professional staff and a commitment to maintain and preserve specimens and records
Fabienne George
Flavienne Sandras
BWB context: challenges in biobanking
Get access
Certified quality
Find samples PP dialogue
Time Filling out
forms
BWB context: challenges in biobanking
BWB context: why biobanking?
To participate in the development of new diagnostic, prognostic and predictive tests
To enable the development of new drugs
To improve treatment for patients
To identify patients predisposed to a disease
To predict the response of a patient to a drug
There is no longer biomedical research without biobanks
Dominique Demonte
BWB’s mission is dedicated to supporting biomedical research for the benefit of patients by providing high-quality
specimens and associated medical and molecular data compliant with international quality standards and regulations
BWB Project: mission
● Create and implement a network to unify and make accessible human materials and scientific data managed by the biobanks of
Wallonia-Brussels’ territory
● Promoting effective collaboration between academia and industry in a common goal to give and enhance value of such data
BWB operates on a decentralized model with:
1. A virtual network
2. A constitution of a virtual catalog 3. An offer of services to academic and industrial users with a front-office
BWB Project: objectives
Organizational component
Technical component
Valorization component
BWB project: structure
January 2014 – December 2017
2009
2012
3,4M€
Stakeholders of BWB project
Steering committee extended
Management team (Laurent Dollé, Sabine Cornelis, Nicolas
Pitance, Jean-Marc Hausman)
HUB ULB
HUB UCL
HUB CHU-Lg/ULg
5 biobanks 2 biobanks 1 biobank
University of Namur
University of Mons
1 biobank 1 biobank
Front-office= single-point of contact
Samples management
=
Decentralized approach
(Albert King Institute, Mont-Godinne)
(Jules Bordet, Brugmann- Brutus, CBEU-Erasme, IPG, ISPPC-Charleroi)
(BHUL)
Steering committee (Laurent Dollé, Isabelle Salmon,
Etienne Marbaix, Jacques Boniver)
Organizational component
Who is in charge?
Nicolas Pitance IT
Jean-Marc Hausman Jurist
Laurent Dollé Operating manager
Management
Sarah De Clercq Biobank manager assistant
Sabine Cornelis Operating manager assistant
Organizational component
Who ensures its governance?
Steering committee
Laurent Dollé Operating manager Prof. Isabelle Salmon Prof. Étienne Marbaix Prof. Jacques Boniver Xavier Hulhoven Didier Flagothier
Organizational component
1. Quality book 2. Ethic charter 3. HMTA 4. Constitution of workflow for request 5. Human samples request form 6. Price list
Harmonization of the documents with:
Current achievements Organizational
component
Virtual catalogue
Organizational component Current achievements
HUB
Meta-HUB Expertise, know-
how… Front-office
Front-office: modus operandi
Sample request
Virtual catalogue
Request processing
Delivery
Follow-up satisfaction
publications
collaboration
Biobankers
Researcher
Researcher
Analysis
Biospecimen
form
Quotation
Confidentiality contract
HMTA
Scientific committee
Ethical committee
Biobankers
Organizational component
Biospecimen
preliminary
request form
Presentation
of the request
Phone
call
Visit
on site
Round
table
Biospecimen
definite
request form
File
Current achievements Technical
component
Nicolas Pitance
71 experts
15 national nodes
509 biobanks
65 million of samples
10 experts
3 networks
13 biobanks
1,5 million of samples
Current achievements Valorization component
Current achievements Valorization component
Number of requests
0
10
20
2015
2016 N=20
Academia 15%
private 70%
public 15%
Nature of the request
n= 14
n= 3 n= 3
Belgium 45%
UK 20%
France 15%
US 5%
Germany 5%
Canada 5%
Others 5%
Nationalities
n= 9
n= 4
n= 3
Activity indicators – First rewards
Prospective 60%
Retrospective10%
Mix 30%
Type of collection
n= 2
n= 12
n= 6
Activity indicators – First rewards
0
2
4
6
8
10
12
public industrie
1
11
Public Private 0
0,5
1
1,5
2
2,5
3
académie industrie
3 3
Academy Private
0 2 4 6 8
Serum/plasma
FFPE
Frozen tissue
Fresh tissue
Sputum/BAL/OP/NP
Urine
Feces
Others
Number of request
Activity indicators – First rewards
0 5 10 15 20
demographic data
clinical data
diagnostic data
genomic data
analytical data
relapse
death date
survival duration
track down pregnancy data
lifestyle data
Nombre de demandes
Other services
TMA block TMA slide
FFPE tissue samples
TMA design TMA construction TMA validation
Sarah De Clercq
BWB offers new services: Tissue Microarrays (TMAs) Digital pathology
Isabelle Salmon
Guilhem Mascré
Christine Decaestecker
Establish & reinforce the front-office
Continue harmonization of common procedures (HMTA, road book,
white book, application form, setting up tracking of demands…)
Scalable maintenance of the IT platform
Enrich the virtual catalog
Get full range of expertise
Be opened to partnerships, conventions, collaborations
Enrich the pipeline of the BWB
Perspectives & valorisation
Broad consent vs. specific consent
Empower & enrich the success stories
Determine Key Performance Indicators
Economics and sustainability
Stimulate the valorisation of the prospective collections
Legislation is evolving, new rules, new norms & new obligations
Continuity of integrating small biobanks into the network
Main challenges
Privacy, confidentiality (data security) vs. data sharing
A clear understanding of the expectations/needs of industry/academy
Alone we are smart, together we are brilliant!
Laurent Dollé Operating manager
Laurent.Dolle@erasme.ulb.ac.be
Thank you for your time!
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