The physiology and biochemistry of the Paleolithic Diet for weight reduction

The physiology and biochemistry of the Paleolithic Diet for weight reductionDavid C. Pendergrass, Ph.D.University of Kansas

Glycolysis to Lipogenesis

Sensory Neuron

monocyte

β- cell

Nociceptor

TRPV1 Hypothesis

TRPV1 – Physiological Mediator• Nociception• Inflammation• Infection• Immunity: Exposure to TRPV1 agonists• Keratinocytes PGE2 & IL-8• PBMC apoptosis

• Alimentary tract:• Metabolism• Hair growth regulation • Cancer development

• Reduced obesity• Smooth muscle cell regulation• Anorexigenic signaling

TRPV1 - • Agonists• Thermosensing >43C; pain• Protons (pH < 5.2)• Capsaicin• Depolarizing voltage > + 60 mv (outwardly rectifying)• Stretch

TRPV1 -• Sensitizing molecules

• 17-β-estradiol• Anandamide• Olvanil• Omega-3 polyunsaturated FA• 12-hydroperoxyeicosatetranoic acid (12-HPETE)• N-arachidonyl dopamine (NADA)• 2-aminoethoxydiphenyl borate (2-APB)• Inflammatory mediators

• Growth factors• Neurotransmitters: bradykinin, serotonin, histamine, prostaglandins• Peptides and small proteins• Lipids• Chemokines• Cytokines

• Intracellular phosphorylation• PKC• PKA• Tyrosine receptors kinases • Ca2+/CAM Kinase

TRPV1• Desensitizing molecules• PIP2

Sing-a-long

• If you’re healthy and you know it:

• If you’re healthy and you know it, Modern People gotta show it, if you’re healthy and you know it:

• Eat GOOD meat• Don’t eat wheat• Eat GOOD fish• Make the switch• Eat your greens• Buy new jeans

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