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Enrique Jaimovich
Instituto de Ciencias
Biomédicas,
Facultad de Medicina
Universidad de Chile
Acoplamiento Excitación-
Contracción
Axon
Muscle
Tendom
Bone
Joint
Brain
Spinal Cord
Motor neuron
Motor Unit
Unidades Motoras, Unión Neuromuscular
By John Heuser and Louise Evans
University of California, San Francisco
Neuromuscular junction
The scheme The structure at the e.m. level
End Plate Potential (EPP)
Outside
Inside
Muscle membrane
Presynaptic
terminal Mu
scle
Me
mb
ran
e
Vo
lta
ge
(m
V)
Time (msec)
-90 mV
VK
VNa
0
Threshold
Presynaptic
AP
EPP
The movement of Na+ and K+
depolarizes muscle membrane
potential (EPP)
ACh Receptor ChannelsVoltage-gated
Na ChannelsInward Rectifier
K Channels
Sarcolema
Myofibrill
Sarcoplasmic reticulum
Triad
Mitochondria
Structure and Function of Skeletal Muscle
Cells
Dolphin (2003) Pharmacol Rev 55:607
Cav1.1: Canal de calcio dependiente de potencial:
Receptor de dihidropiridinas: DHPR
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