Centum20 Review - Essentia120 Review

The most sophisticated health discovery in the worldOver 300 years in the making

Productdescription Manufacturing Mechanism of

Action Clinical StudiesKey

Competitive Advantages

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Product Description

The origin of the species is a plant of the genus Amorphophallus Propol, also know as elephant yam or Konjac 蒟蒻/菎蒻;(in Japanese)

Essentia-120 is extracted from the root of the plant. The root has been recognized for 1500 years as a medicinal food in Japan.

Further extraction in which the chemical structureis the purest and most highly concentrated form ofpropolmannan is what is used for Essentia-120™

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Scientifically Validated Beneficial Effects

Regulates extra-‐calorie absorption

Regulates cholesterol levels

Regulates appetite

Improves metabolism

Delays gastric emptying time

Enhances intestinal health

Enhances immune capacity

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Approved by European Food Safety Authority For:

Reduction of body weight

Reduction of post-‐prandial glycemic responses

Maintenance of normal blood glucose concentrations

Maintenance of normal (fasting) blood concentrations of triglycerides

Maintenance of normal blood cholesterol concentrations

Maintenance of normal bowel function

Decreasing potentially pathogenic gastro-‐intestinal microorganisms

Improvement of intestinal micro flora

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Essentia-120™ is the most purified and highest concentration form

Standard Konjac Flour

Refined Konjac

Glucomannan

Essentia-120

Need to take out enzyme and other impurities beforehumanconsumption

No ClinicalData MostlyHigh Sulfiteand Arseniclevels(Requirespre-‐processing before use)

Does Not Satisfy Criteria For Health ClaimsNo Clinical Data for Cholesterol, Diabetes,Weight Loss

Essentia -120™ the only form that meets claims for weight loss/Cholesterol

The only ingredient that can satisfy the criteria and specifications for EU EFSA health claims

As of January 2014, FFSC22000 Certified The highest level food certification in the world!

Over 100 Clinical studies -14 for safety300 year plantation know-how

• Extraction / polish technology• Molecular Weight Control• 518 Agro-‐Chemical free• Zero detection for SO2 and arsenic

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WHAT DIFFERENTIATES ESSENTIA-120™ FROM GLUCOMANNAN

Konjac glucomannan is a similar plant to Essentia-120™. They both are of the Amorphophallus genus that is used in Asian cuisine to thicken sauces, make fruit jellies, and to create konyaku, a stretchy noodle that is popular in Japan. Konjac glucomannan, however, does not yield the extraordinarily high quality material that makes Essentia-120™ so effective.

The Technology behind Essentia-120™ completely removes its catabolic enzyme resulting in highly soluble and highly viscous fiber that has the ability to remain intact in the digestive tract, where it can form a sponge that binds to bile acids and impede dietary fat absorption.

This sponge function not only decreases appetite, but delays the emptying of food from the stomach into the small intestines, slowing down the influx of carbohydrates and fats into the bloodstream. This slower rate of gastric emptying helps keep blood sugar levels more stable than the typical sharp peaks after carbohydrate foods are eaten.

Reducing postprandial (after-meal) glucose spikes promotes the beneficial expression of longevity genes observed in organisms that are calorie restricted.

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Partners: Manufacturing, Research & DevelopmentJapan & U.S.A.

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Proceeds with state of the art processing

Starts with Choice Selection Of An All Natural Organic Plant

And Finally the Highest Quality Assurance and Certifications in the world

300 years of proprietary technology

Essentia-120™ is The Highest Quality

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Essentia-120™ Particle Expands up to 200 times its original weight

•1Particle•Dry

•Add Water

• 2 Min’s10 Min’s

• Still Expanding

• At 5 Hr’s

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Essentia-120™ Mechanism Of Functionality

Satiety Signal

Slows Down

Digestion

Controlled Absorption

Speed

Extra Oil Absorption

Feel Full

Prolonged Satiety

Glycemic Control

Cholesterol Control

Fast All Natural Weight Loss – 78%

From Fat

0246

Satie

ty

Feeling of Fullness Evaluation of the actionof Essentia-120™

on metabolic parameters 30-day study n=30, EU

By maintaining its viscous structure throughout the digestive tract, Essentia-120™ can decrease appetite and help impede the absorption of ingested calories.



Fat Trapping Ability

The Oil-‐Trapping Demo

Hydrated Essentia-120™ mixed with OilMimics the movement in the stomach and in the intestines

No Oil Release in water!Oil and Fats are Trapped in the hydrated layerwith its micelle effect and « the fatty extras » willbe carried out of your body through the system 11

Oil Absorbing Property

Fat Trapping Magnet

No Extra Energy

Absorption


What does this translate into as far as weight loss?

In placebo-controlled human studies, those taking Essentia-120™ before meals lost 5.5 to 7.92 pounds after eight weeks without changing their diets.

The placebo groups in these studies showed no significant weight loss.

The Essentia-120™ groups also showed reductions in blood lipid/glucose levels with substantial reductions in waist circumferences.


Scientific Studies Backing Essentia-120™

There are so many questionable weight loss products claiming “miraculous” results however the reality is that Essentia-120™ is proven to accelerate weight loss and in the process, help normalize excess levels of lipids and glucose in the blood.

In a clinical study conducted on young obese individuals, subjects were not asked to make any changes in their diet except for the addition of 1 gram of Essentia-120™ with three meals. After eight weeks, subjects lost an average of 9.44 pounds. The placebo group only lost an average of 1.69 pounds. The Essentia-120™ group also whittled their waistlines by more than an inch.

Essentia-120 Placebo

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Scientific Studies Backing Essentia-120™ Cont.

Also in this adult study participants were not asked to alter their eating habits, those taking Essentia-120™ lost an average of 5.5 pounds after eight weeks, compared to no significant weight change in the placebo group.

In a similar study where subjects were allowed to eat anything they wanted, those taking Essentia-120™ lost 7.92 pounds compared to no significant weight changes in the placebo arm of the study.

These and other studies document that humans taking Essentia-120™ experience weight loss and improvements In blood lipids compared to those taking placebo.

In a second study, adults taking Essentia-120™ experienced significant reductions in blood lipid levels. Dropping cholesterol by 21.7 (mg/dL),triglycerides by 23.4 (mg/dL)and LDL by 15.0 (mg/dL). In the placebo group, cholesterol and LDL increased while triglycerides showed only a small decline. (See chart below.)

Cholesterol and Triglyceride improvement after 8 weeks of Essentia-120™ Supplementation 3 times a day.

8 Weeks Essentia-120™ 8 Weeks Placebo


The Role of Bile Acids in Dietary Fat Absorption

Bile acids are excreted from the liver into the small intestine where they facilitate the absorption of dietary fats into the bloodstream. The absorption of dietary fats is dependent on bile acids and the lipase enzyme. An intact soluble fiber binds to bile acids in the small intestine, thus helping to impede absorption of dietary fats (while simultaneously reducing serum LDL and cholesterol).

Specially processed, Essentia-120™ is a polysaccharide fiber that does

not break down in the digestive tract.

Published studies reveal Essentia-120™has the ability to not only increase the

amount of bile acids in the feces, but also reduce the rate of carbohydrate absorption and the subsequent glucose/insulin spike in

the blood. When Essentia-120™ is taken before meals, consistent and significant

reductions in blood triglyceride, LDL, and cholesterol are observed.

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Published Clinical Study #1.

Effects Of Essentia-120™ On Obese PatientsWalsh David E., Gaghoubian Gazgen, Behgorooz Ali; International Journal of Obesity; 289-‐293, 1983

Subjects 20 Obese Women

Methods - Double-‐blind placebo control study for 8 weeks

-‐ Active – 1 g (0.035 oz) of Essentia ™taken 1 hr prior to meals-‐ Placebo-‐ No Dietary Changes – Patients eat/drink whatever they like

Measurements - Body Weight-Triglycerides-‐ Serum Cholesterol-‐ LDL Cholesterol-‐ HDL Cholesterol

Results -‐ Significant Mean Weight Loss (5.5 lbs)

-‐ Significant Reduction of Serum Cholesterol (21.7 mg/dl)-‐ Significant Reduction of LDL Cholesterol (15.0 mg/dl)

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Weight Loss After 8 Weeks of Essentia-120 ® 1 g / meal3 g (0.106 oz)/day of Essentia-120

1.521

Cha

nge

inbo

dyw

eigh

t(lb

s)vs

ba

seBa

se li

ne

-0.4

0-1-2 4 Weeks

-3-4-5

8 Weeks

-4.9 -5.5

-6Essentia-120

Placebo

Significant Weight Loss

Published Clinical Study #1.Weight Loss Results

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Cholesterol and Triglycerides improvement after4 and 8 Weeks of Essentia-120®1g / meal

3 g (0.106 oz)/day of Essentia-120®

18.620

15

10

Cha

nge

inch

oles

tero

land

tri

glyc

erid

es(m

g/dl

)vs

base

line

5.94.7

-2.1

5.9

-2.6

-14.8 -15 -15.5

5

0

-5

4 weeks Essentia-1208 weeks Essentia-120

-10

-15

-20

-25

4 WeeksPlacebo

8 WeeksPlacebo

-20.9 -21.7 -23.4

Cholesterol LDLCholesterol

Triglycerides

Significant Well-‐balanced Improvements


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Effects of Essentia-120 on serum bile acids inhealthy subjects – Egg yolk loading test

with Essentia-120® without Essentia-120®

DECREASES

• Total Cholesterol by 9.7%

• LDL Cholesterol by 7.3 %

• Total Triglycerides by 21.0%

Essentia-120® is the solution that helpsyou to reduce Lipids significantly andsafely

Total Cholesterol changes in patients treated with Essentia-120® (A), Essentia-120® +

Triglycerides changes in patients treated with Essentia-120® (A),Essentia-120® +restricted calorie

regimen (B), Placebo (C) restricted calorie regimen (B), Placebo (C)


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Published Clinical Study 2: Double-‐blind Evaluation of Active Ingredient of Essentia-120 vs Placebo in Post infracted Patients after Cardiac

Rehabilitation

Reffo G.C., Ghiradi P.E., Forantini C., Current Therapeutic Research, Vol. 47; 753-758, 1990

28 Post infarcted cardiac patients after rehabilitation (24 men & 4 women –average age: 54)Double-‐blind placebo control study for 8 weeks

-‐ Active (15 subjects) – 1.5 g (0.053 oz) of Essentia-120 taken before

Subjects

Methods

breakfast and dinner-‐ Placebo (13 subjects)-‐ No Dietary Changes – Patients eat/drink whatever they like

Measurements -‐ Heart Rate-‐ Blood Pressure-‐ Cholesterol-‐ Body Weight

Results 0 Week 8 Weeks

Cholesterol 235 215

SBP 144.6 137.3



Published Clinical Study 3:

Essentia -120™ Hypertensive Outpatients: Pilot Clinical TrialReffo G.C, Ghardi, P.E., Forrantini C. Current Therapeutic Research Vol. 44;22-27,1988

Subjects Hypertensive Outpatientsn= 31 )males = 10; Females = 12) Average age 51.6 yrs.4-Week Placebo Controlled

Methods – Group A -1g(0.035 oz) of Essentia 120™ 1 each of 3 meals -Group B – Essentia-120™ + restricted calorie regimen-Group C – Placebo Control

Results Essentia-120™ is useful as a natural obstacle to nutrient intake in maintaining energy balance and the management of obesityWeight Decrease (2.4kg)Serum Cholesterol decrease (13%)Triglycerides decreased (36%)

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Published Clinical Study 4: Dietary Treatment of Severe Obesity

-‐ Group A:-‐ Group B:

4 g (0.141 oz) / day of Essentia-120 to be taken in 3 doses Placebo + Diet therapy

Subjects 50 obese Patients (15 men & 35 women – average age: 39)

Double-‐blind placebo control study for 8 weeksMethods

-‐ Group A+B: Prepared meals were offered

-‐ Body Weight-‐ Triglycerides

Measurements

-‐ Glycemic values-‐ Cholesterol-‐ Intestinal Function

Results … (Essentia-120 group)… had a more significant weight loss in relation to thefatty mass alone, an overall improvement in lipid status and carbohydratetolerance, and a greater adherence to the diet in the absence of any relevant side effects. »

… (Essentia-120 diet supplements) have been found to be particularly efficaciousand well tolerated even in the long-‐term treatment of severe obesity. »

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Published Clinical Study 5 (Child Obesity Study): Pharmacologic Intervention Program Childhood Obesity & Dislipidemias: Usefulness of Essentia-120™

Rodoriuez de Roa, Elsy et al., Jose Ignacio Baldo Hospital, Vargas Hopital, Gastroenterology Department Risk Factors Condulation (Unpublished Study)

Subjects 31 children & adolescents of age 9-‐19 years (4 men & 27 women – average age: 15.2)

8-‐Week Placebo Controlled Study-‐ Essentia-120 Group: 1 g 3 times a day at the meals-‐ Placebo Group-‐ Caloric ingestion was not decreased during the study

Methods

Results -‐ Weight decrease (4.29 kg)-‐ BMI decrease (1.89 units)-‐ Waist diameter decrease (2.75 cm)-‐ Cholesterol decrease (10.5 %)-‐ Triglycerides decrease (25.4 %)-‐ Fasting Glycemia decrease (9.8)

« The obtained results allow to recommend the use of … Essentia-120 in «obese and dislipidemic children and adolescents. » »



Published Clinical Study 6: Essentia-120 improves Glycemia and Other AssociatedRisk Factors for Coronary Hear Disease in Type 2 Diabetes

Vladimir Vuksan, David J.A. Jenkins et al., Diabetes Care, Vol 22, No.6: 913-919, 1999

Subjects 11 hyperlipidemic and hypertensive type 2 diabetic patients (5 men& 6 women – average age: 62 for men & 59 for women)

Double-‐blind placebo control study for 8 weeks (3 weeks; 2 weeks washout; 3 weeks)

-‐ Active: instructed (0.7 g/100 kcal, essentia-120) 3 times a day as a snackwith an 8-‐oz beverage-‐ Placebo: instructed (14 g/day placebo fiber) 3 times a day as a snackwith an 8-‐oz beverage-‐ NCEP Step 2 diet provided with 3 meals provided under metabolic conditions

Methods

Measurements -‐ Cholesterol-‐ Triglycerides

Glycemic level

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Rapid Cholesterol and Triglyceride Improvement After Only 3 weeks of Essentia-120™

-4.9 -4.8 -3.0 -3.0

-16

-25

-8.6

-14-5

-10

-15

-20

-25

3 Weeks Essentia-120™

3 Weeks Placebo

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Clinical Study 7: Glycemic Level Control

K. Doi, Lancet, p 987-988, May 1979 WPM Hopman et al., Gut, 198, 29 930-934

Significant Reduction of Glucose Levels after administration of Essentia-120

Individual Percentage Change In Fasting Blood-‐Glucose LevelsEffect of Essentia-120 on Urinary Excretion of 13 Diabetics After Administration

Significant decrease in Urinary / Glucose Excretion

Decrease in Fasting Blood Glucose by 29 % in 30 Days

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Clinical Study 7: Glycemic Level Control

Changes of postprandial blood glucose and serum insulin levels in normal subjects after test meals with or without Essentia-120

Changes of postprandial blood glucose after standard breakfast* with butter with or without Essentia-120

Plas

ma

gluc

ose

(mm

ol/l)

* Breakfast (3 slices of bread, 20 g butter -‐ with or without Stralean – 42 g marmelade, 10 g sugar, 100 ml tea and 150 ml milk) 88 g carbohydrates,18.5 g fat and 11 g proteins

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Clinical Study 8: Major determinants of Plasma Glucose-‐flattening activity of a Water-‐soluble Dietary Fiber: Effects of Essentia-120 on Gastric Emptying and

Intralminar Glucose-‐Diffusion

K.Ebihara et al., Nutrition Reports International June 1981, 23 No.6

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Published Clinical Study 9: Action of Essentia-120 on complaints inpatientsaffected with chronic constipation: A multi - centric clinical evaluation

S.Passaretti, M. Franzoni, U. Comin, R. Donzelli et al. Italian Journal of Gastroenterol 1991; 23:pp 421-425

Subjects 93 patients with chromic constipation (6+ months) 10 each from different hospitals – average age: 41.2, height:165 cm, weight: 62.6 kg

Methods 0.5 g x 2 capsules 2 times a day for 1 month. Non-‐controlled, open study3 g / day for the 1st month, 2 g / day for the 2nd month

Measurements -‐ Bowel movements-‐ Number of enemas performed

Results

-‐ Difficulty in evacuation and consistency of the stools Objective evaluation in « Visual Analogue Scale »

The treatment with essentia-120 improved all clinically evaluated subjective and objective parameters.

Average number of days per week with at least one bowel movement increased from 1.0 to 4within the first month, and the enemas reduced from 1.8 to 0.4.

These results seem much more important if it is considered that many patients wereaffected with a long-‐term stypsis and unresponsive to previous treatmants. Anotherremarkable result was the persistence of subjective and clinical improvement even duringthe maintenance phase, when essentia-120 was given at a reduced dose.

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Improved Bowel Movement for Severely Constipated Patients after 1 month of Essentia-120™

0

0.5

1

1.5

2

2.5

3

3.5

4

4.5

Bowel Movement WK Enemas Wk

Before TrialEssentia-120

3 Doses a day

Significant Improvements

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University of Connecticut Study

Body Composition significantly improved selectively on

« Effect of adding axercise to a diet containingglucomannan »W.J. Kraemer et al., University of ConnecticutMetabolism Clinical and Experimental 56 (2007)1149-‐1158

Lowering

1’500 mg intakeat 2 largest meals/day

-‐ Body Weight -‐ HDL Cholesterol

-‐ Body Fat % -‐ Abdominal % Fat

-‐ Total Fat Mass -‐ Abdominal Fat Mass

-‐ Leptin Levels -‐ Waist Circumference

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Summary of Clinical study results

• Loss 2.4 kg of pure fat for 4 weeks

• Reduction in waist circumference of 2.8 cm for 8 weeks

• Reduce of LDL ("bad") cholesterol by 20% in three weeks

• Reduction of blood glucose by 30% for 4 weeks

• Reduction of triglycerides in the blood and up to 36% for 8weeks

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GRAS(USA)

Food Ingredient

with Health Claim (Russia)

E Number (EU)

Official Functional Food

(Japan)

Food Chemicals Codex

Food/Food Additive (Japan)

Joint FAO/WHO Expert

Committee on Food Additives

EFSA (EU) Substantiation of Health Claims for

Cholesterol Improvement/Body

weight loss

The Global Registration Status of Essentia-120

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Essentia-120™ Key Competitive Advantages

Fat Loss• Proven by more than 100 worldwide clinical studies• Health claims related to Essentia-120™ confirmed by EFSA in 2010

Safety

• Proven by 14 strict pharmaceutical level complete safety studiesincluding:

• Dose Response, Toxicity, Acute Toxicity• GRAS Approved

Patented

• 3-stage purification process (high specialization)• Patented manufacturing (33 countries)• Other applications & technologies patented as well (USA, EU,

Japan & Central/South America)

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Essentia-120™ Key Competitive Advantages Part 2

Stability

• High temperature tolerance• Salt, sugar & pH stable• Non-binding with minerals & vitamins

HQ Standards

• 300 years technological know-how• Establishment of the mass-growing method & selection in order to

deliver the condensed pure quality ingredient• The specific species that delivers the functionality of Essentia-120

has been determined #1 in the world

100% All Natural

• Organic• Vegan

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Business

Centum20 Review - Essentia120 Review