從光電至生醫的 六脈神劍 - - 資訊

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從光電至生醫的 六脈神劍 - - 資訊. 主講人:吳 季 樺 光電博士 銘傳大學生醫系助理教授 中華民國九十七年十二月二十六日. 大綱. 1. 前言 2. 研究領域 ( 一 ): 光電系統 3. 研究領域 ( 二 ) 生醫電子 ( 光電 ) 4. 整合型的研究 ( 現在及未來 ) 5. 結論. 1. 前言. 人間處處有資訊 ---- 資訊氾濫 ( 網路電視最盛 ) 事物皆需資訊 --- 沒有資訊就沒有靈魂 要有資訊更要行動力 整合的時代早已來臨. 學 歷 : 國立中央大學光電博士 (89.9-94.6) - PowerPoint PPT Presentation

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  • - -

  • 1. 2.(): 3.()()4. ( )5.

  • 1. ----()---

  • (89.9-94.6)(73.9-75.6)(69.9-73.6)

  • (2008-)()()( )

  • 2.()CMOS 2.1 (Triangulation based laser range finder using a CMOS image sensor in automotive field) 2.2 (Electro-optical tilt sensor using a bowl shape lens) 2.3 ()(Non contact pulse measurement by laser triangulation )

  • 3.() 3. 1(The study of EEG and HRV with the stimulation of laser array ) 3.2 ()The pulse measurement with Moire and optical triangulation ) 3.3 3.4 () 3.5() 3.6 : ()

  • :1., M253858, 2004/12/12-2014/2/162., M254625, 2005/1/1-2013/11/103.M268054, 2005/6/21-2014/11/224.M268053, 2004/10/22-2014/10/215.I245473, 2004/3/9-2024/3/86.I2983022008/7/1-2026/7/11

  • 2.1 Triangulation based laser range finder using a CMOS image sensor in automotive field

    2. --

  • The circuit of the CMOS image sensor ,HV7131D, manufactured by Hynix

  • Photograph of this CMOS imager.

  • Laser driver and TE cooler circuit The laser module and TE cooler.

  • A photograph of the laser driver and TEC.

  • Configuration of a prototype laser range finder in pulsed mode.

  • Pulsed mode Real test image on a freeway at midday, (a) ET=20, (b)ET=02. (a)(b)

  • Photograph of CMOS image sensor and it was mounted on the rear-view mirror brace.

    *VC++ language and image processing* SOC

  • 2.2Electro-optical tilt sensor using a bowl shape lens

  • Measurement Principles :Light deviation caused by the tilted liquid. sin(is very small)n00= n11, n1=1(air) (5-1) =R1- R0 = R(n0-1) 0 = 0.36R0 (5-2)If n0=1.36 (alcohol)

  • Simulation by ZEMAX(Editor form)

  • 3-D Layout by ZEMAX

  • LED light spot imaged on the sensorDefocusFocus

  • Configuration of the electro-optical leveler.

  • Prototype of the electro-optical leveler. Experiment:MatlabReal Product:Embedded system (SOC)Or USB(Labview)

    Resolution :4.2arc sec.

  • 2.3Non contact pulse measurement by laser triangulation

  • IntroductionMeasurement methods

    *Palpation*Stethoscope*Sphygmomanometer*Electrocardiogram ( ECG )*Oximeter *Pressure transducer *Optical interferometer Doppler-based instrumentation*Optical triangulation

  • Three measuring points on wrist- Chun, Guan, and Chy in TCM

  • Geometrical layout of pulse measurement systemX=110mm L=100mm Z=148mm f=16mm

  • The photograph of the system*thickness measurement

  • Original data of centroid variation (a) without filter and with band pass filter (b) filtered signal was enlarged. (a)(b)

  • Full spectrum in frequency domain for a pulse measurement (a) without filter (b) with band pass filter.

    (a)(b)

  • Improvement of the Non contact pulse MeasurementResolution:
  • 3.1The study of EEG with the stimulation of laser array3.-- ()

  • (Brain wave and evoked potential)

  • 3.1.1 Hypothalamus()Pons()Medulla()Midbrain()Cerebellum()Corpus Callosum( )Cerebral Cortex()* wave (G.M. Shepherd, Neurobiology,2nd ed. Oxford University Press, New York, 1988,p513.)

  • 3.1.2 ---

  • 3.1.3 -- 14 Hz ~ fast activity--7.5 ~13 Hz --3.5 to 7.5 Hz ,slow activity136.0~7.5Hz --3 Hz or below

  • http://www.tbetter.com.tw/abrain.htm

  • Some suggested uses

  • 4

  • 3.1.5(evoked potential) (evoked potential)(visual evoked potential): LED(auditory evoked potential)(somatosensory evoked potential)(motor evoked potential)

  • 3.1.6

  • Before laser stimulating

  • After laser stimulating

  • Spectrum analysis

  • 3.2 () Moire pulse measurement system

  • Pigs pulse measurement

  • Measurement Result

  • The pulse measurement with optical triangulation

  • 3.3 ()

  • 3.4 ()Laser : 830 nm /30mW pulse rate: 10HzJih-Huah Wu, Hsin-Yang Chen, Yu-Ju Chang, Hung-Chien Wu, Wen-Dien Chang, Yi-Jing Chu, and Joe-Air Jiang*(2008).Study on Autonomic Nervous Activities of the Night Shift Workers Treated by Laser Acupuncture. Photomedicine and Laser Surgery (SCI, IF=1.23)(accepted)Jih-Huah Wu, Hsin-Yang Chen, Yu-Ju Chang, Hung-Chien Wu, Wen-Dien Chang, Yi-Jing Chu, and Joe-Air Jiang*(2008).Study on Autonomic Nervous Activities of the Night Shift Workers Treated by Laser Acupuncture. Photomedicine and Laser Surgery (SCI, IF=1.23)(accepted)

  • 3.4.1-

  • :

  • 3.4.2 (SA node)60-100(AV node)0.120.20

  • 1.3(Arrhythmia)

  • (Lead 1)

  • Lead I

  • 2046

  • 2046

  • 20

  • 46

  • 3.5 () 11

  • , 1111C0~C1011

  • HRV

  • (25)

  • 2120LabVIEW830nm10Hz30mW10

    52102102

  • 1.:(KFG-2-120-D1-11L50C2s) 2.:[22]1~10th

  • KYOWAKFG-2-120-D1-11L50C2s(120)

  • (Weatstone bridge)

  • V1V2CMRR

  • ()

  • ()

  • 3218-2332

    161620 .31 1.0820.25 1.39(cm)169 0.061720.06( kg)65.44 11.5869.88 12.68BMI( kg/m2 )22.72 3.2923.69 3.97

  • C0C1C2C3C4C5C6C7C8C9C10

    353440.2020.4911.6512.565.7364.1412.9841.2270.4300.596

  • C0C1C2C3C4C5C6C7C8C9C10540831.7821.8515.7414.315.0235.7083.3381.2090.5510.463

  • C0C1C2C3C4C5C6C7C8C9C106118.35.3419.149.98310.079.3364.5974.0433.9732.4781.020

  • C0C1C2C3C4C5C6C7C8C9C10

    1956.42.2120.9316.057.2805.0743.1691.6881.3511.2610.970

  • C0C1C2C4C3C5C6C7C8C9C102011.41.7315.5419.699.5104.623.9021.5981.4271.0780.877

  • C0c1c2c3c4c5c6c7c8c9c10200142.2817.6216.786.9284.5552.6881.7861.4302.2283.686

  • C1()C1

  • 3.6: () IC3.8.1 pic16F***/HT46R24 3.8.2 8051/52

  • 3.6.1 microprocessor PIC12C508(multi-colored light)

    DC-DC converterMode selection

  • 3.6.2 8051/52 LED

  • LED: 630nmLED 4mW/cm2(pulsed) , 8mW/cm2(CW)(IC555) ()

    3.6.3 LED()

  • :[630nm ~660nm]:

    :[400nm~420nm]::

  • LED2()LED(Portable)(Professional), : LEDLEDLED()LED()diffuser.()

  • 1. :()British Journal of Dermatology2000:142:973-978: (415nm)(660nm)(acne vulgaris) LED9%(anti-bacterial action)4.23 mW/cm2 15320 J/cm2 (anti-inflammatory action)2.67 mW/cm2 15202 J/cm2 2.67 mW/cm24.23 mW/cm2(dose),

  • 632nm LED(ASAP)

  • (632nm LED)(632nm LED)

  • 1

  • 2

  • :46

    1(15)3~521(15)3~52/1(15)12+2(15)232(15)23-52(15)23-41(15)12-31(15)3~52

  • LED3()

  • start

    no

    yes

    yes

    yes

    no

    no

  • PCB Layout

  • ()

  • 4. ().---!

  • :()1. Jih-Huah Wu, Hsin-Yang Chen, Yu-Ju Chang, Hung-Chien Wu, Wen-Dien Chang, Yi-Jing Chu, and Joe-Air Jiang*(2008).Study on Autonomic Nervous Activities of the Night Shift Workers Treated by Laser Acupuncture. Photomedicine and Laser Surgery (SCI, IF=1.32)(will be published in2009)2. Jih-Huah Wu , Cheng-Chung Pen and Joe-Air Jiang*(2008).Applications of the Integrated High-Performance CMOS Image Sensor to Range Finders from Optical Triangulation to the Automotive Field. Sensors, 8, 1719-1739.(SCI, IF=1.373) 3. Wen-Dien Chang, Jih-Huah Wu, Joe-Air Jiang*, Chun-Yu Yeh, and Chien-Tsung Tsai(2008). Carpal Tunnel Syndrome Treated with 830 nm Diodes Laser on Transverse Carpal Ligament: A Controlled Study. Photomedicine and Laser Surgery (SCI, IF=1.32)4. Jih-Huah Wu, Rong-Seng Chang, and Joe-Air Jiang* (2007).A Novel Pulse Measurement System by Using Laser Triangulation and a CMOS Image Sensor. Sensors, 7, 3366-3385.(SCI, IF=1.373)

  • 5. Jih-Huah Wu*, Kuo-Yang Horng, Shiuan-Leh Lin,Rong-Sen Chang (2006). A two-axis tilt sensor based on optics. Measurement Science and Technolog, 17, N9-N12. (SCI, IF=1.079)6. Jih-Huah Wu*, Shiuan-Leh Lin, Jun-Gi Chen, Rong-Sen Chang (2006). Electro-optical leveler using a bowl shape lens. Optical Engineering, 45 (4), 043603-1~5. (SCI, IF=0.75)7. Jih-Huah Wu*, Kuo-Yang Horng, Rong-Sen Chang (2006). Triangulation based laser range finder using a CMOS image sensor in automotive field. Optical Engineering, 45 (4), 044302-1~7. (SCI, IF=0.75)

  • :Joe-Air Jiang, Jih-Huah Wu, Wen-Dien Chang, Chien-Tsung Tsai, Chi-Hsiung Jung*, Effect of 830 nm Low Level Laser for Treatment of Pain and Symptom Caused by Carpal Tunnel Syndrome, submitted to Lasers in Medical Science, Manuscript Code: LIMS-S-08-00187(LIMS-361), submission date: 2008/10/13. (SCI, Impact Factor: 0.827; Rank = 96/139) Jih-Huah Wu, Wen-Li Lee, and Joe-Air Jiang*, An Improved Arterial Pulsation Measurement System Based on Optical Triangulation, submitted to Measurement Science and Technology, Article ID: MST/297953/DES/168620, submission date: 2008/11/5.(SCI, Impact Factor: 1.297; Rank = 10/67)Wen-Dien Chang, Jih-Huah Wu, Yi-Jing Chu, and Joe-Air Jiang*, Outcomes of 830 nm Low-level Laser Treatment for Closed Bone Fracture of Hand and Forearm, submitted to Photomedicine and Laser Surgery, Manuscript ID: PHO-2008-2466. Submission date: 2008/12/10. (SCI, Impact Factor: 1.230; Rank = 68/139)

  • THANK YOU FOR YOUR ATTENTION!

    *There are a lot of measurement methods or equipments for measuring the pulse of human being, including palpation, stethoscope---And this pulse measurement system based on optical triangulation we proposed here.