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從光電至生醫的 六脈神劍 - - 資訊. 主講人:吳 季 樺 光電博士 銘傳大學生醫系助理教授 中華民國九十七年十二月二十六日. 大綱. 1. 前言 2. 研究領域 ( 一 ): 光電系統 3. 研究領域 ( 二 ) 生醫電子 ( 光電 ) 4. 整合型的研究 ( 現在及未來 ) 5. 結論. 1. 前言. 人間處處有資訊 ---- 資訊氾濫 ( 網路電視最盛 ) 事物皆需資訊 --- 沒有資訊就沒有靈魂 要有資訊更要行動力 整合的時代早已來臨. 學 歷 : 國立中央大學光電博士 (89.9-94.6) - PowerPoint PPT Presentation
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1. 2.(): 3.()()4. ( )5.
1. ----()---
(89.9-94.6)(73.9-75.6)(69.9-73.6)
(2008-)()()( )
2.()CMOS 2.1 (Triangulation based laser range finder using a CMOS image sensor in automotive field) 2.2 (Electro-optical tilt sensor using a bowl shape lens) 2.3 ()(Non contact pulse measurement by laser triangulation )
3.() 3. 1(The study of EEG and HRV with the stimulation of laser array ) 3.2 ()The pulse measurement with Moire and optical triangulation ) 3.3 3.4 () 3.5() 3.6 : ()
:1., M253858, 2004/12/12-2014/2/162., M254625, 2005/1/1-2013/11/103.M268054, 2005/6/21-2014/11/224.M268053, 2004/10/22-2014/10/215.I245473, 2004/3/9-2024/3/86.I2983022008/7/1-2026/7/11
2.1 Triangulation based laser range finder using a CMOS image sensor in automotive field
2. --
The circuit of the CMOS image sensor ,HV7131D, manufactured by Hynix
Photograph of this CMOS imager.
Laser driver and TE cooler circuit The laser module and TE cooler.
A photograph of the laser driver and TEC.
Configuration of a prototype laser range finder in pulsed mode.
Pulsed mode Real test image on a freeway at midday, (a) ET=20, (b)ET=02. (a)(b)
Photograph of CMOS image sensor and it was mounted on the rear-view mirror brace.
*VC++ language and image processing* SOC
2.2Electro-optical tilt sensor using a bowl shape lens
Measurement Principles :Light deviation caused by the tilted liquid. sin(is very small)n00= n11, n1=1(air) (5-1) =R1- R0 = R(n0-1) 0 = 0.36R0 (5-2)If n0=1.36 (alcohol)
Simulation by ZEMAX(Editor form)
3-D Layout by ZEMAX
LED light spot imaged on the sensorDefocusFocus
Configuration of the electro-optical leveler.
Prototype of the electro-optical leveler. Experiment:MatlabReal Product:Embedded system (SOC)Or USB(Labview)
Resolution :4.2arc sec.
2.3Non contact pulse measurement by laser triangulation
IntroductionMeasurement methods
*Palpation*Stethoscope*Sphygmomanometer*Electrocardiogram ( ECG )*Oximeter *Pressure transducer *Optical interferometer Doppler-based instrumentation*Optical triangulation
Three measuring points on wrist- Chun, Guan, and Chy in TCM
Geometrical layout of pulse measurement systemX=110mm L=100mm Z=148mm f=16mm
The photograph of the system*thickness measurement
Original data of centroid variation (a) without filter and with band pass filter (b) filtered signal was enlarged. (a)(b)
Full spectrum in frequency domain for a pulse measurement (a) without filter (b) with band pass filter.
(a)(b)
3.1The study of EEG with the stimulation of laser array3.-- ()
(Brain wave and evoked potential)
3.1.1 Hypothalamus()Pons()Medulla()Midbrain()Cerebellum()Corpus Callosum( )Cerebral Cortex()* wave (G.M. Shepherd, Neurobiology,2nd ed. Oxford University Press, New York, 1988,p513.)
3.1.2 ---
3.1.3 -- 14 Hz ~ fast activity--7.5 ~13 Hz --3.5 to 7.5 Hz ,slow activity136.0~7.5Hz --3 Hz or below
http://www.tbetter.com.tw/abrain.htm
Some suggested uses
4
3.1.5(evoked potential) (evoked potential)(visual evoked potential): LED(auditory evoked potential)(somatosensory evoked potential)(motor evoked potential)
3.1.6
Before laser stimulating
After laser stimulating
Spectrum analysis
3.2 () Moire pulse measurement system
Pigs pulse measurement
Measurement Result
The pulse measurement with optical triangulation
3.3 ()
3.4 ()Laser : 830 nm /30mW pulse rate: 10HzJih-Huah Wu, Hsin-Yang Chen, Yu-Ju Chang, Hung-Chien Wu, Wen-Dien Chang, Yi-Jing Chu, and Joe-Air Jiang*(2008).Study on Autonomic Nervous Activities of the Night Shift Workers Treated by Laser Acupuncture. Photomedicine and Laser Surgery (SCI, IF=1.23)(accepted)Jih-Huah Wu, Hsin-Yang Chen, Yu-Ju Chang, Hung-Chien Wu, Wen-Dien Chang, Yi-Jing Chu, and Joe-Air Jiang*(2008).Study on Autonomic Nervous Activities of the Night Shift Workers Treated by Laser Acupuncture. Photomedicine and Laser Surgery (SCI, IF=1.23)(accepted)
3.4.1-
:
3.4.2 (SA node)60-100(AV node)0.120.20
1.3(Arrhythmia)
(Lead 1)
Lead I
2046
2046
20
46
3.5 () 11
, 1111C0~C1011
HRV
(25)
2120LabVIEW830nm10Hz30mW10
52102102
1.:(KFG-2-120-D1-11L50C2s) 2.:[22]1~10th
KYOWAKFG-2-120-D1-11L50C2s(120)
(Weatstone bridge)
V1V2CMRR
()
()
3218-2332
161620 .31 1.0820.25 1.39(cm)169 0.061720.06( kg)65.44 11.5869.88 12.68BMI( kg/m2 )22.72 3.2923.69 3.97
C0C1C2C3C4C5C6C7C8C9C10
353440.2020.4911.6512.565.7364.1412.9841.2270.4300.596
C0C1C2C3C4C5C6C7C8C9C10540831.7821.8515.7414.315.0235.7083.3381.2090.5510.463
C0C1C2C3C4C5C6C7C8C9C106118.35.3419.149.98310.079.3364.5974.0433.9732.4781.020
C0C1C2C3C4C5C6C7C8C9C10
1956.42.2120.9316.057.2805.0743.1691.6881.3511.2610.970
C0C1C2C4C3C5C6C7C8C9C102011.41.7315.5419.699.5104.623.9021.5981.4271.0780.877
C0c1c2c3c4c5c6c7c8c9c10200142.2817.6216.786.9284.5552.6881.7861.4302.2283.686
C1()C1
3.6: () IC3.8.1 pic16F***/HT46R24 3.8.2 8051/52
3.6.1 microprocessor PIC12C508(multi-colored light)
DC-DC converterMode selection
3.6.2 8051/52 LED
LED: 630nmLED 4mW/cm2(pulsed) , 8mW/cm2(CW)(IC555) ()
3.6.3 LED()
:[630nm ~660nm]:
:[400nm~420nm]::
LED2()LED(Portable)(Professional), : LEDLEDLED()LED()diffuser.()
1. :()British Journal of Dermatology2000:142:973-978: (415nm)(660nm)(acne vulgaris) LED9%(anti-bacterial action)4.23 mW/cm2 15320 J/cm2 (anti-inflammatory action)2.67 mW/cm2 15202 J/cm2 2.67 mW/cm24.23 mW/cm2(dose),
632nm LED(ASAP)
(632nm LED)(632nm LED)
1
2
:46
1(15)3~521(15)3~52/1(15)12+2(15)232(15)23-52(15)23-41(15)12-31(15)3~52
LED3()
start
no
yes
yes
yes
no
no
PCB Layout
()
4. ().---!
:()1. Jih-Huah Wu, Hsin-Yang Chen, Yu-Ju Chang, Hung-Chien Wu, Wen-Dien Chang, Yi-Jing Chu, and Joe-Air Jiang*(2008).Study on Autonomic Nervous Activities of the Night Shift Workers Treated by Laser Acupuncture. Photomedicine and Laser Surgery (SCI, IF=1.32)(will be published in2009)2. Jih-Huah Wu , Cheng-Chung Pen and Joe-Air Jiang*(2008).Applications of the Integrated High-Performance CMOS Image Sensor to Range Finders from Optical Triangulation to the Automotive Field. Sensors, 8, 1719-1739.(SCI, IF=1.373) 3. Wen-Dien Chang, Jih-Huah Wu, Joe-Air Jiang*, Chun-Yu Yeh, and Chien-Tsung Tsai(2008). Carpal Tunnel Syndrome Treated with 830 nm Diodes Laser on Transverse Carpal Ligament: A Controlled Study. Photomedicine and Laser Surgery (SCI, IF=1.32)4. Jih-Huah Wu, Rong-Seng Chang, and Joe-Air Jiang* (2007).A Novel Pulse Measurement System by Using Laser Triangulation and a CMOS Image Sensor. Sensors, 7, 3366-3385.(SCI, IF=1.373)
5. Jih-Huah Wu*, Kuo-Yang Horng, Shiuan-Leh Lin,Rong-Sen Chang (2006). A two-axis tilt sensor based on optics. Measurement Science and Technolog, 17, N9-N12. (SCI, IF=1.079)6. Jih-Huah Wu*, Shiuan-Leh Lin, Jun-Gi Chen, Rong-Sen Chang (2006). Electro-optical leveler using a bowl shape lens. Optical Engineering, 45 (4), 043603-1~5. (SCI, IF=0.75)7. Jih-Huah Wu*, Kuo-Yang Horng, Rong-Sen Chang (2006). Triangulation based laser range finder using a CMOS image sensor in automotive field. Optical Engineering, 45 (4), 044302-1~7. (SCI, IF=0.75)
:Joe-Air Jiang, Jih-Huah Wu, Wen-Dien Chang, Chien-Tsung Tsai, Chi-Hsiung Jung*, Effect of 830 nm Low Level Laser for Treatment of Pain and Symptom Caused by Carpal Tunnel Syndrome, submitted to Lasers in Medical Science, Manuscript Code: LIMS-S-08-00187(LIMS-361), submission date: 2008/10/13. (SCI, Impact Factor: 0.827; Rank = 96/139) Jih-Huah Wu, Wen-Li Lee, and Joe-Air Jiang*, An Improved Arterial Pulsation Measurement System Based on Optical Triangulation, submitted to Measurement Science and Technology, Article ID: MST/297953/DES/168620, submission date: 2008/11/5.(SCI, Impact Factor: 1.297; Rank = 10/67)Wen-Dien Chang, Jih-Huah Wu, Yi-Jing Chu, and Joe-Air Jiang*, Outcomes of 830 nm Low-level Laser Treatment for Closed Bone Fracture of Hand and Forearm, submitted to Photomedicine and Laser Surgery, Manuscript ID: PHO-2008-2466. Submission date: 2008/12/10. (SCI, Impact Factor: 1.230; Rank = 68/139)
THANK YOU FOR YOUR ATTENTION!
*There are a lot of measurement methods or equipments for measuring the pulse of human being, including palpation, stethoscope---And this pulse measurement system based on optical triangulation we proposed here.