Professor Jiangang SHEN ( 沈劍剛...1 Professor Jiangang SHEN (沈劍剛) Professor, Associate Director (Research) Chairman of Departmental Research Postgraduate Committee School

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Professor Jiangang SHEN (沈劍剛) Professor, Associate Director (Research) Chairman of Departmental Research Postgraduate Committee School of Chinese Medicine The University of Hong Kong, CONTACT INFORMATION Address: School of Chinese Medicine, University of Hong Kong,

10 Sassoon Road, Pokfulamm, Hong Kong Phone: (852) 3917 6429 Fax: (852) 2168 4259 E-mail: [email protected] ACADEMIC QUALIFICATION 1995.9-1998.7 Ph.D., Institute of Biophysics Chinese Academy of Science, China 1987.9-1990.7 Master of Medical Science in Integrated Medicine, Sun Yat-sen University of

Medical Science, China 1979.7-1984.7 M.B.B.S. in Chinese Medicine, Hunan Chinese Medical University, China 1998.9-1999.8 Postdoctoral Research fellow, Anesthesia Research Laboratories, Brigham and Women’s Hospital and Harvard Medical School, Boston, U.S.A. 1984.7-1987.8 Resident training, Internal Medicine and Traditional Chinese Medicine,

Nan-Fang Hospital, the First Military Medical University, Guangzhou, China

POSITIONS HELD 2014.8-present Associate Director (Research), School of Chinese Medicine, University of Hong

Kong, China 2012.12-2014.7 Professor, Assistant Director (Research), School of Chinese Medicine, University of

Hong Kong, China 2007.1-2012.11 Associate Professor, Assistant Director (Research), School of Chinese Medicine, University of Hong Kong, China 2005.11-2007.1 Assistant Professor, School of Chinese Medicine, Chinese University of Hong Kong,

Hong Kong, China 2004.8-2005.12 Assistant Professor, Associate Professor College of Pharmacy, Health Science Center,

University of New Mexico, USA 2001.9- 2004.9 Research Assistant Professor, Department of Medicine, the University of Hong

Kong, Hong Kong, China 1999.8- 2001.9 Research Scientist, National EPR Center, Department of Radiology, Dartmouth

Medical School, Hanover, USA 1995.7-1998.7 Associate Professor, Associate Director, Institute of Chinese Medicine, Nan-Fang Hospital, the First Military Medical University, China

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1990.7-1995.7 Lecturer, Institute of Chinese Medicine, Nan-Fang Hospital, the First Military Medical University, China

HONORARY PROFESSORSHIP 2011.11 Honor Overseas Scholarship, Hunan Chinese Medical University, China 2011.10 Associate Professor, College of Pharmacy, University of New Mexico, USA 2011.5 Honor Professor, Fudan Cancer Hospital, Fudan University, China 2010.11 Honorary Professor, Shenzhen Chinese Medical Hospital, China 2008.10 Honorary Professor, Wenzhou Medical College, China 2008.1 Honorary Professor, South China University of Technology, China 2006.9 Honorary Professor, Hunan Chinese Medical University, China 2005.7 Honor Professor, China West Hospital, Sichuan University, China CLINICAL POSITIONS HELD 1995-1998 Associate Professor, Department of Chinese Medicine,

Nan-Fang Hospital and the First Military Medical University, China 1990-1995 Attending Physician, Division of Cardiology, Institute of Chinese Medicine, Nan-Fang Hospital and the First Military Medical University, China HONORS AND AWARDS 2010 Scientific Achievement Award in Chinese Medicine, Guangdong Chapter, China 2009 National Scientific Achievement Award of Chinese Medicine (Third class), China 2002 Young Investigator Award, the 7th Medical Research Conference, Hong Kong 1998 National Military Medical Scientific Achievement Award (Second Class), PLA, China 1998 Dio Award, Chinese Academy of Science, China 1997 National Military Medical Scientific Achievement Award (Third Class), PLA, China 1997 Young Scientist Traveling Award of the Fifth International Meeting of Nitric Oxide Biology,

September 15-19, 1997 in Kyoto, Japan. 1997 Young Scientist Traveling Award of the First Asia – Pacific Symposium of EPR/ESR, January

17-20, 1997 in Hong Kong PROFESSIONAL SERVICES FOR ACADEMIC SOCIETIES Executive Council Member, Specity Committee of Chinese Medical Pharmacology , World

Federation of Chinese Medicine Society, 2012.9-2016.9 Executive Council Member, Specity Committee of Translation, World Federation of Chinese

Medicine Society, 2012.11-2016.11 Council Member, Standart Committee of Integrated Western and Chinese Medicine Society for

Neurological Diseases, China, 2012.8-2015.7 Member, Academic Advisory Board, External Advisory Board, Markey Cancer Center,

University of Kentucky, USA. 2012.4

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Consultant, Expert Group for Clinical Items (Chinese Medicine), Hospital Authority, Hong Kong, 2012.7

RESEARCH INTERESTS 1. Oxidative stress in aging-related diseases including cerebrovascular and cardiovascular diseases

and cancer 2. Herbal medicine for cerebral and cardiac vascular diseases and cancer, focusing on antioxidant

therapies RESEARCH DIRECTIONS 1. Molecular regulations of herbal medicine and antioxidant therapy on promoting neurogenesis for

brain repair in post-stroke and neurodegenative diseases 2. Molecular regulations of herbal medicine and antioxidant therapy on prevention of blood brain

barrier disruption in cerebral ischemia-reperfusion injury 3. Effects and mechanisms of natural antioxidants and herbal medicine in cancer treatment MAJOR EXTERNAL HIGH COMPETITIVE GRANTS (PRINCIPAL INVESTIGATORS) 1. Elucidating effects of APPL2 on regulating proliferation and cell fate decision of neural

stem/progenitor cells through activating Notch signaling pathway. (負責人 Principal Investigator), RGC GRF grant 香港研究資助局 No. 777313, Hong Kong, HK$779,429; 2014.1-2016.12

2. 過氧亞硝基調節腦缺氧缺血後神經再生及其信號通路的研究。Grant from National Natural Science Foundation of China 國家自然科學基金面上專案 80 萬人民幣 (香港大學深圳研究院, 負責人 Principal Investigator), 2013-2015

3. Elucidating peroxynitrite as a cellular signaling molecule for regulating proliferation and neuronal differentiation of neural stem/progenitor cells under hypoxic and ischemic conditions. (負責人Principal Investigator), RGC GRF grant, Hong Kong, 香港研究資助局 No. 776512M, HK$1,158,250.00; 2012.9-2015.8

4. Establishment of a novel platform for screening active components from herbal formula for controlling “stemness’ of cancer cancer and related signal pathways for extension of survivals of cancer patients. Grant from National Natural Science Foundation of China 國家自然科學基金面上專案, 55 萬人民幣. 2011-2014.

5. Molecular regulations of reactive nitrogen species inhibitors for preventing thrombolysis-induced blood brain barrier disruption and hemorrhagic transformation in experimental cerebral ischemia-reperfersion models. (負責人 Principal Investigator) RGC GRF grant, Hong Kong, 香港研究資助局, No. 777611M, HK$ 890,000; 2011-2014

6. Elucidating caveolin-1 as a negative modulating protein for proliferation and differentiation of neural stem/progenitor cells in post-ischemic brain. (負責人 Principal Investigator) RGC GRF grant, 香港研究資助局 No. 777610M, Hong Kong, HK$1,084,600; 2010-2013

7. Interactions of reactive nitrogen species, caveolins and matrix metalloproteinases: A novel signal mechanism in disruption of blood brain barrier during ischemic stroke. (負責人 Principal Investigator) RGC GRF grant, 香港研究資助局 No. 774408M, Hong Kong, HK$ 1,191,369; 2008-2011

8. Plasma membrane cholesterol homeostasis and oxidative stress: implication for neuronal oxidative damage in ischemia stroke. (負責人 Principal Investigator) RGC Competitive Earmarked Research Grant, Hong Kong 香港研究資助局 No. 749504M, HK$ 939,968; 2005-2007

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9. Effects of “Huang-Shan-Yao” on regulating lipid metabolism and protecting ischemic myocardium. (共同負責人 Co-Principal Investigator) National Natural Science Foundation of China 國家自然科學基金專案 RMB: 200,000; 2004-2006

10. Adiponectin as a novel diagnostic marker and therapeutic target for treatment of diabetes, steatohepatitis and other metabolic disorders. Innovation and Technology Fund of Hong Kong 香港創新科技署專案 (共同負責人 Co-Principal investigator) HK$ 3,000,000; 2004-2006

11. Molecular pharmacological study of Buyan Huangwu Decoction, a classic TCM formula, against cerebral ischemia damage. (負責人 Principal investigator) Grant from National Natural Science Foundation of China 國家自然科學基金專案 RMB: 140,000; 1999-2001

12. Serum pharmacological study of Yiqi Tongluo Pill against cardiomyocyte apoptosis in hypoxia-reoxygenation injury. (負責人 Principal investigator) Grant from Natural Science Foundation in Guangdong Province, China 廣東省自然科學基金專案, 人民幣: 100,000; 1998-2000

13. Protective mechanisms of a Chinese medicine “Yiqi Tongluo Pill” on myocardial ischemia-reperfusion injury. (負責人 Principal investigator) Grant from National Natural Science Foundation of China 國家自然科學基金專案 RMB: 60,000; 1994-1996

14. Study of stress and aging hyperlipidema. (合作者 Co-investigator) Grant from Military Medical Ministry of PLA, P. R. China RMB 100,000; 1992-1995

PATENTS 1. Reagents for highly specific detection of peroxynitrite, Patent: U.S. 11848-027-999 2. Diarylamine-Based Fluorogenic Probes for Detection of Peroxynitrite, WO2013113279 A1 PUBLICATIONS *corresponding author Peer-refereed and Invited Publications 1. Gu Y, Chen JP, Shen JG. Herbal Medicines for Ischemic Stroke: Combating Inflammation as

Therapeutic Targets. Journal of Neuroimmune Pharmacology DOI: 10.1007/s11481-014-9525-5, 2014 2. Hua YQ, Chen Z, Meng ZQ, Chen H, Shen JG, WANG K, Peng W, Shen YH, Liu LM. High expression

of erythropoietin‑ producing hepatoma cell line-B2 (EphB2) predicts the efficiency of the Qingyihuaji formula treatment in pancreatic cancer CFPAC‑ 1 cells through the EphrinB1‑ EphB2 pathway. Oncology Letters DOI: 10.3892/ol_xxxxxxxx

3. Yeung PK, Shen J, Chung SS, Chung SK. Targeted over-expression of endothelin-1 in astrocytes leads to more severe brain damage and vasospasm after subarachnoid hemorrhage. BMC Neuroscience 2013 Oct 25; 14(1): 131

4. Pan Y, Zhao L, Chen XM, Gu Y, Shen JG, Liu LM. The XRCC1 Arg399Gln genetic polymorphism contributes to hepatocellular carcinoma susceptibility: an updated meta-analysis. Asian Pac J Cancer Prev. 2013;14(10):5761-7

5. Xu MJ, Chen XM, Gu Y, Peng T, Yang D, Chang RC, So KF, Liu KJ, Shen JG. Baicalin can scavenge peroxynitrite and ameliorate endogenous peroxynitrite-mediated neurotoxicity in cerebral ischemia-reperfusion injury. Journal of Ethnopharmacology 150(1): 116-24, 2013

6. Chen Y, Nie YC, Luo YL, Lin F, Zheng YF, Cheng GH, Wu H, Zhang KJ, Su WW, Shen JG*, Li PB*. Protective effects of naringin against paraquat-induced acute lung injury and pulmonary fibrosis in mice. Food Chem Toxicol 58C: 133-140, 2013

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7. Yang LP, Shen JG*, Xu WC, Li J, Jiang JQ*. Secondary metabolites of the genus astragalus: structure and biological-activity update. Chemistry & Biodiversity 10(6): 1004-54, 2013

8. Du LB, Miao XX, Jiang YG, Jia HY, Tian Q, Shen JG*, Liu Y*. An effective strategy for the synthesis of biocompatible gold nanoparticles using danshensu antioxidant: prevention of cytotoxicity via attenuation of free radical formation. Nanotoxicology 7(3): 294-300, 2013

9. Sun H, Ge N, Shao M, Cheng X, Li Y, Li S*, Shen JG*. Lumbrokinase attenuates diabetic nephropathy through regulating extracellular matrix degradation in Streptozotocin-induced diabetic rats. Diabetes Research and Clinical Practice 100(1): 85-95, 2013

10. Wang ZY, Wang DM, Han SW, Wang N, Mo FZ, Loo TY, Shen JG, Huang H, Chen JP. Bioactivity-guided identification and cell signaling technology to delineate the lactate dehydrogenase A:Inhibition effects of spatholobus suberectus on breast cancer. PLoS One 8(2): e56613, 2013

11. Chen XM, Chen HS, Xu MJ, Shen JG*. Targeting reactive nitrogen species: A promising therapeutic strategy for cerebral ischemia-reperfusion injury. Acta Pharmacologica Sinica 34(1): 67-77; 2013

12. Wang Y, Shen JG, Wang XM, Fu DL, Chen CY, Lu LY, Lu L, Xie CL, Fang JQ, Zheng GQ. Scalp Acupuncture for acute ischemic stroke: a meta-analysis of randomized controlled trials. Evidence-based Complementary and Alternative Medicine 2012, Article ID. 480950

13. Hao CZ, Wu F, Shen JG, Lu L, Fu DL, Liao WJ, Zheng GQ. Clinical efficacy and safety of Buyang Huanwu decoction for acute ischemic stroke: A systematic review and Meta-analysis of 19 randomized controlled trials, Evidence-based Complementary and Alternative Medicine 2012, Article ID. 630124

14. Nie YC, Wu H, Li PB, Luo YL, Long K, Xie LM, Shen JG*, Su WW*. Anti-inflammatory effects of naringin in chronic pulmonary neutrophilic inflammation in cigarette smoke-exposed rats. Journal of Medicinal Food 15(10): 894-900, 2012.

15. Wang ZY, Wang N, Chen J*, Shen JG*. Emerging glycolysis targeting and drug discovery from Chinese Medicine in cancer therapy. Evidence-based Complementary and Alternative Medicine 2012, Article ID. 873175

16. Shen JG*. Reactive nitrogen species: Dual roles for blood brain barrier disruption and brain repairs in cerebral ischemia and reperfusion injury. Acta Biophysica Sinica 28 (4): 295-306, 2012

17. Nie YC, Wu H, Li PB, Xie LM, Luo YL, Shen JG*, Su WW*. Naringin attenuates EGF-induced MUC5AC secretion in A549 cells by suppressing the cooperative activities of MAPKs-AP-1 and IKKs-IκB-NF-κB signaling pathways. European Journal of Pharmacology 690: 207-213, 2012

18. Nie YC, Wu H, Li PB, Luo YL, Zhang CC, Shen JG*, Su WW*. Characteristic comparison of three rat models induced by cigarette smoke or combined with LPS: to establish a suitable model for study of airway mucus hypersecretion in chronic obstructive pulmonary disease. Pulmonary Pharmacology & Therapeutics 25(5): 349-358, 2012

19. Luo YL, Zhang CC, Li PB, Nie YC, Wu H, Shen JG*, Su WW*. Naringin attenuates enhanced cough, airway hyperresponsiveness and airway inflammation in a guinea pig model of chronic bronchitis induced by cigarette smoke. International Immunopharmacology 2012; 13(3): 301-307

20. Lau BW, Lee JC Lee, Li Y, Fung SM, Sang YH, Shen JG, Chang RC, So KF. Polysaccharides from wolfberry prevents corticosterone-induced inhibition of sexual behavior and increases neurogenesis. PLoS One 7(4): e33374, 2012

21. Li Y, Zhuang PW, Shen BR, Zhang YJ, Shen JG. Baicalin promotes neuronal differentiation of neural stem/progenitor cells through modulating p-stat3 and bHLH family protein expression. Brain Research 1429: 36-42, 2012

22. Gu Y, Zheng GQ, Xu MJ, Li Y, Chen XM, Zhu WZ, Tong Y, Chung SK, Liu KJ, Shen JG. Caveolin-1 regulates nitric oxide mediated matrix metalloproteinases activity and blood-brain barrier

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permeability in focal cerebral ischemia and reperfusion injury. Journal of Neurochemistry 20(1): 147-156, 2012

23. Wang ZY, Loo TY, Shen JG, Wang N, Wang DM, Yang DP, Mo SL, Guan XY, Chen JP. LDH-A silencing suppresses breast cancer tumorigenicity through induction of oxidative stress mediated mitochondrial pathway apoptosis. Breast Cancer Res Treat. 131(3): 791-800, 2012

24. Wang N, Wang ZY, Mo SL, Loo TY, Wang DM, Luo HB , Yang DP, Chen LY, Shen JG, Chen JP*. Ellagic acid, a phenolic compound, exerts anti-angiogenesis effects via VEGFR-2 signaling pathway in breast cancer. Breast Cancer Res Treat. 134(3): 943-55, 2012

25. Zhao H*, Ren CC, Chen XM, Shen JG. From rapid to delayed and remote postconditioning: the evolving concept of ischemic postconditioning in brain ischemia. Current Drug Targets 13(2): 173-187, 2012

26. Wang Z, Cheng Y, Wang N, Wang DM, Li YW, Han F, Shen JG, Yang DP, Guan XY, Chen JP. Dioscin induces cancer cell apoptosis through elevated oxidative stress mediated by downregulation of peroxiredoxins. Cancer Biology & Therapy 13(3), 138-147, 2012

27. Li Z, Yang D*, Huang M, Hu X, Shen JG, Zhao Z, Chen J. Chrysomya megacephala (Fabricius) larvae: A new biodiesel resource. Applied Energy 94: 349-354, 2012

28. Lee W, Xu M, Li Y, Gu Y, Chen J, Wong D, Fung PC, Shen JG. Free cholesterol accumulation impairs antioxidant activities and aggravates apoptotic cell death in menadione-induced oxidative injury. Arch Biochem Biophys. 514(1-2): 57-67, 2011

29. Li Y, Luo J, Zheng G, Fu S, Wang TT, Zeng HP, So KF, Chung SK, Tong Y, Shen JG. Caveolin-1 plays a crucial role in inhibiting neuronal differentiation of neural stem/progenitor cells via VEGF signaling-dependent pathway. PLoS One 6(8): e22901, 2011.

30. Xu WC, Shen JG*, Jiang JQ*. Phytochemical and biological studies of the plants from the genus daphne. Chemistry & Biodiversity 8: 1215-1233, 2011

31. Li Y, Lau WM, So KF, Tong Y, Shen JG. Caveolin-1 promotes astroglial differentiation of neural stem/progenitor cells through modulating Notch1/NICD and Hes1 expressions. Biochem Biophys Res Commun 407: 517-524, 2011

32. Li Y, Lau WM, So KF, Tong Y, Shen JG. Caveolin-1 inhibits oligodendroglial differentiation of neural stem/progenitor cells through modulating β-catenin expression, Neurochem Int 59(2): 114-121, 2011.

33. Zheng GQ, Zhao ZM, Wang Y, Gu Y, Li Y, Chen XM, Fu SP, Shen JG. Meta-analysis of scalp acupuncture for acute hypertensive intracerebral hemorrhage. J Altern Complement Med. 2011; 17(4): 293-299.

34. Gu Y, Dee CM, Shen JG. Interaction of free radicals, matrix metalloproteinases and caveolin-1 impacts blood-brain barrier permeability in cerebral ischemia and reperfusion injury. Frontier in Bioscience 3: 1216-1231, 2011.

35. Shen JG, Lee W.S., Chen J. and Yang D. Caveolin-3 Peptide Protects Cardiomyocytes from Apoptotic Cell Death via Preserving Superoxide Dismutase Activity and Inhibiting Caspase-3 Activation under Hypoxia-reoxygenation. American Journal of Biomedical Sciences 3(2): 126-144, 2011.

36. Wang ZY, Wang N, Shen JG, Wang DM, Yang DP, Loo TY, Mo SL, Fu JM, Guan XY, Chen JP. Spatholobus suberectus Dunn inhibits cancer angiogenesis through suppression of vascular endothelial growth factor signaling pathway. Journal of Ethnopharmacology133(2):751-8, 2011

37. Shen JG*, Gu Y, Yao Tong, PCW Fung, Tong L. Ginkgo biloba extract (EGb 761) prevents apoptosis in hypoxia-reoxygenated cardiomyocytes: involvement of mitochondria-dependent caspase pathway. Chinese Medicine 6: 8 , 2011

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38. Xu XC, Yang Y, Du LB, Shen JG*, Wang GQ, He Z, Tian Q, Liu Y. Autoxidation and prooxidation mechanism of Danshensu. Acta Physico-Chemica Sinica 26(7): 1737-1741, 2010.

39. Zhai JJ, Liu ZL, Li JM, Chen JP, Jiang L, Wang DM, Yuan J, Shen JG, Yang DP, Chen JQ. Different mechanisms of cis-9, trans-11- and trans-10, cis-12- conjugated linoleic acid affecting lipid metabolism in 3T3-L1 cells. Journal of Nutritional Biochemistry. 21(11): 1099-1105, 2010.

40. Zheng GQ, Li Y, Gu Y, Chen XM, Zhou Y, Zhao SZ, Shen JG*. Beyond Water Channel: Aquaporin-4 in Adult Neurogenesis. Neurochemistry International. 56(5): 651-654, 2010.

41. Yang D, Sun ZN, Peng T, Wang HL, Shen JG, Chen Y, Tam PK. Synthetic fluorescent probes for imaging of peroxynitrite and hypochlorous acid in living cells. Methods Mol Biol. 591: 93-103, 2010.

42. Shen JG, Sood R, Weaver J, Timmins GS, Schnell A, Miyake M, Kao JP, Rosen GM, Liu KJ. Direct visualization of mouse brain oxygen distribution by electron paramagnetic resonance imaging: Application to focal cerebral ischemia. Journal of Cerebral Blood Flow and Metabolism 2009; 29(10): 1695-703.

43. Mao WW, Wang TT, Zeng HP, Wang ZY, Chen JP, Shen JG*. The design, synthesis, and evaluation of novel substituted 5-hydroxycoumarin and pyranocoumarin derivatives exhibiting high antiproliferative activity. Bioorganic & Medicinal Chemistry Letters 19(16): 4570-4573, 2009

44. Ye XS, Feng YB, Tong Y, Ng KM, Tsao SW, Liu GK, Sze CW, Zhang YB, Tang J, Shen JG, Kobayashi S. Hepatoprotective and anti-oxidative effects of Coptidis Rhizoma aqueous extract on carbon tetrachloride-induced acute liver hepatotoxicity in rats. Journal of Ethnopharmacology 124(1): 130-6, 2009

45. Liu WL, Hendren J, Yuan ZR, Shen JG, Liu KJ. Normobaric hyperoxia attenuates early blood brain barrier disruption by inhibiting MMP-9-mediated occluding in focal cerebral ischemia. Journal of Neurochemistry 108: 811-820, 2009

46. Shen JG*, Lee WS, Lau CF, Ng KM, Fung ML, Liu KJ. Interaction of caveolin-1, nitric oxide, and nitric oxide synthases in hypoxic human SK-N-MC neuroblastoma cells. Journal of Neurochemistry 107: 478-487, 2008

47. Zeng HP, Wang, TT, Chen W, Wang CY, Chen DH, Shen JG*. Characterization of the chemical components in the Extracts from Si-wu decoction induce Proliferation of rat mesenchymal stem cells (rMSCs). Bioorganic & Medicinal Chemistry 16(9): 5109-14, 2008

48. Rong JH, Cheung CY, Lau AS, Shen JG, Tam PH, Cheng YC. Induction of heme oxygenase-1 by traditional Chinese medicine formulation ISF-1 and its ingredients as a cytoprotective mechanism against oxidative stress, International Journal of Molecular Medicine 21: 405-411, 2008

49. Shi J, Tong Y, Shen JG, Li HX. Effectiveness and safety of herbal medicines in the treatment of irritable bowel syndrome: A systematic review. World Journal of Gastroenterology 14(3):454-62; 2008

50. Rong JH, Titon R, Shen JG, Ng KM, Liu C, Tam PK, Lau AS, Cheng YC. Genome-wide biological response fingerprinting (BioReF) of the Chinese botanical formulation ISF-1 enables the eselection of multiple marker genes as a potential metric for quality control. Journal of Ethnopharmacology 113(1): 35-44, 2007

51. Cai GX, Liu BY, Liu W, Tan XH, Rong JH, Chen XM, Tong L, Shen JG*. Buyang Huanwu Decoction can improve recovery of neurological function, reduce infarction volume, stimulate neural proliferation and modulate VEGF and Flk1 expressions in transient focal cerebral ischaemic rat brains. Journal of Ethnopharmacology 113(2): 292-9, 2007

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52. Ren JY, Fung PC, Chang CQ, Shen GX, Chan FH, Shen JG*. A comparison study on blood and tissue nitric oxide concentration during renal ischemia-reperfusion injury with electron paramagnetic resonance spectroscopy. Applied Magnetic Resonance 32: 243-255, 2007

53. Miyake M, Shen JG, Liu SM, Shi HL, Liu WL, Yuan ZR, Pritchard A, Kao JPY, Liu KJ, Rosen GM. Acetoxymethoxycarbonyl nitroxides as EPR pro-imaging agents to measure O2 levels in mouse brain: A pharmacokinetic and pharmacodynamic study. Journal of Pharmacology and Experimental Therapeutics 318, 1187-1193, 2006.

54. Shen JG, Liu SM, Miyake M, Liu WL, Pritchard A, Kao JP, Rosen GM, Timmins GS, Tong Y, Liu KJ. Use of 3-acetoxymethoxycarbonyl- 2,2,5,5- tetramethyl-1 -pyrrolidinyloxyl as an EPR oximetry probe for measurement of tissue oxygenation in mouse brain. Magnetic Resonance in Medicine 55, 1433-1440, 2006

55. Yang D, Wang HL, Sun ZN, Chung NW, Shen JG.. A highly selective fluorescent probe for detection of peroxynitrite in living cells. Journal of The American Chemical Society 128(18):6004-5, 2006

56. Shen JG*, Ma S, Chan CP, Fung PC, Cheung RTF, Liu KJ. Nitric oxide down-regulates caveolin-1 expression in rat brains during focal cerebral ischemia and reperfusion. Journal of Neurochemistry 96; 1078-1089, 2006

57. Chen BY, Lam KS, Wang Y, Wu DH, Lam MC, Shen JG, Wong LC, Hoo RL, Zhang JL, Xu AM. Hypoxia dysregulates the production of adiponectin and plasminogen activator inhibitor-1 independent of reactive oxygen species in adipocytes. Biochemical and Biophysical Research Communications 341: 549-556, 2006

58. Chang CQ, Ren JY, Fung PCW, Hung YS, Shen JG, Chan FHY. Novel sparse component analysis approach to free radical EPR spectra decomposition. Journal of Magnetic Resonance 175: 242-255, 2005

59. Ren JY, Chang CQ, Fung PCW, Shen JG, Chan FHY. Free Radical EPR Spectroscopy Analysis using blind source separation. Journal of Magnetic Resonance 166(1): 82-91,2004

60. Shen JG, Khan N, Lewis LD, Ray A, Swartz H. Cellular respiration rates and oxygen concentration in lymphoblastic Molt-4 cells and there ρ0 derivative. Biophysical Journal 84(2): 1291-1298, 2003

61. Khan N, Shen JG, Chang TY, Fung PCW, Grinberg O, Swartz H. Plasma membrane cholesterol: a possible barrier to intracellular oxygen gradients in CHO cells. Biochemistry 42(1): 23-29, 2003

62. Shen JG, Qiu XS, Jiang B, Zhang DL, Xin WJ, Fung PC, Zhao BL. Nitric oxide and oxygen radicals induced apoptosis via bcl-2 and p53 pathway in hypoxia-reoxygenated cardiomyocytes. Science in China (Series C) 46(1): 28-39, 2002

63. Shen JG, Bottle S, Khan N, Micallef A, Swartz HM. Development of isoindoline nitroxides for EPR oxymetry in viable biological systems. Applied Magnetic Resonance 22: 357-368, 2002

64. Shen JG, Li M, Xin WJ, Zhao BL. Effects of chinonin on nitric oxide free radical, myocardial damage and arrhythmia in ischemia-reperfusion injury in vivo. Applied Magnetic Resonance 19: 9-19, 2000.

65. Shen JG, Quo X, Li M, Xin WJ, Zhao BL. Chinonin, a novel drug against cardiomyocyte apoptosis induced by hypoxia and reoxygenation. Biochimica et Biophysica Acta 1500: 217-226, 2000

66. Xu AG, Li SG, Liu JH, Shen JG, Jiang B, Gang AH. Correlation between apoptosis and proliferation in gastric pre-carcinomatic patients. Chinese Medical Journal 79(3): 185-186, 1999.

67. Shen JG, Wang J, Zhao BL, Hou JW, Gao TL, Xin WJ. Effects of EGb 761 on generation of nitric oxide, myocardial damage and arrhythmias in ischemia-reperfusion injury in vivo. Biochimica et Biophysica Acta 1406: 228-236, 1998

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68. Zhao B, Shen JG, Li M, Li MF, Wan Q, Xin WJ. Scavenging effects of Chinonin on NO and oxygen free radicals and its protective effects on the myocardium from the injury of ischemia-reperfusion. Biochimica et Biophysica Acta 1315: 131-137, 1996

69. Zhao BL, Shen JG, Hu J, Wan Q, Xin W. Synergic effects of NO and oxygen free radicals in the injury of ischemia-reperfused myocardium---ESR studies on NO free radicals generated from ischemia-reperfused myocardium. Science in China (Series C) 26, 491-500, 1996

70. Shen JG, Zhou D. Efficiency of Ginkgo biloba extract (EGb 761) in antioxidant protection against myocardial ischemia and reperfusion injury. Biochemistry and Molecular Biology International 35(1): 125-134, 1995

Book Chapters 1. Shen JG*, Gu Y. Insights into mechanisms of blood brain barrier permeability: Roles of free radicals,

matrix metalloproteinases and caveolin-1. Systems Biology of Oxidative Stress. (Eds. Ismail Laher), Springer 2013 (in press)

2. Shen JG*, Chen XM. Drug discovery from Traditional Chinese Medicine for neurogenesis: Implications for stroke and neurodegenerative diseases. Traditional Chinese medicine__ Scientific Basis for its Use. (Eds. James D. Adams, Jr.). Royal Society of Chemistry, Thomas Graham House , Cambridge CB4 0WF, UK 2013 SBN: 978-1-84973-661-9

3. Feng YB, Chen XM, Wang N, Shen JG. Current Progress on Medicinal Plants and their Biological Properties in Contemporary China. In J.N. Govil, Recent Progress in Medicinal Plants. Studium Press LLC, Houston, USA 529-588, 2009

4. Shen JG. Pharmacology and toxicology of Chinese herbal medicine for improving blood circulation. In: Yibin Feng, Pharamcology and Toxicology of Chinese Herbal Medicine. Commercial Press, Hong Kong 2009

5. Yang D, Sun ZN, Peng T, Wang HL, Shen JG, Chen Y, Tam PKH. Synthetic fluorescent probes for imaging of peroxynitrite and hypo chlorous acid in living cells. Live Cell Imaging Methods and Protocols. Series: Methods in Molecular Biology Vol 591 (Eds. Papkovsky DB ). Springer USA 2009

6. Shen JG., Liu S., Miyake M. and Liu K.J., Cerebral tissue oxygenation: transportation, metabolism, measurement, and significance in the ischemic brain, In: John Zhang, Hyperbaric Oxygen for Neurological Disorders. Flagstaff, Arizona, U.S.A., Best Publishing Co. 65-84, 2007

7. Shen JG, Zhao B, Li MF, Wan Q, and Xin W. Inhibitory effects of Ginkgo biloba extract (EGb 761) on oxygen free radicals, nitric oxide and myocardial injury in isolated ischemic-reperfused hearts. Proceedings of the International Symposium on Natural Antioxidant: Molecular Mechanisms and Health effects (Eds. Packer L, Traber MG & Xin W), American Oil Chemistry Society Press, Champaign, Illinois, 1996, pp453-465

8. Zhao B, Shen JG, Hou J, Xin W. Studies on NO free radical generated from ischemia-reperfusion tissue and polymorphonuclear leukocytes (PMN). Modern Applications of EPR/ESR from Biophysics to Material Science (Eds. Rudowicz CZ, Yu KN and Hiraoka H) Springer, 1997

9. Zhao B, Shen JG, Li M, Li M, Wan Q, and Xin W. Chinionin can scavenge NO free radicals and protect myocardia against ischemia-reperfusion injury. Proceedings of the International Symposium on Natural antioxidant: Molecular Mechanisms and Health effects (Eds. Packer L, Traber MG & Xin W), American Oil Chemistry Society Press, Champaign, Illinois, 1996, pp378-391

10. 細胞凋亡的基礎與臨床, 中國北京人民軍醫出版社, 1999 年

11. 新編中醫診斷學, 中國北京人民軍醫出版社, 1998 年

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12. 藥物新劑型及其臨床應用, 中國北京人民軍醫出版社, 1996 年

13. 醫學多媒體教學設計, 中國北京人民軍醫出版社, 1996 年 Chinese Journals 1. 朱文宗、鄭國慶、黃建平、金永喜、劉偉、沈劍剛。豁痰健脾法治療後半規管良性陣發性位置

性眩暈臨床研究。新中醫 45(2): 83-85, 2013. 2. 朱文宗、金永喜、黃建平、章國偉、吳紅專、沈劍剛。解痙合劑結合運動治療改善腦卒中後肌

痙攣及表面肌電圖分析。浙江中西醫結合雜志 45(2): 84-87, 2013. 3. 潘巖、花永強、劉魯明、沈劍剛。無血清培養法分離並鑒定胰腺癌細胞系 BxPC-3 中腫瘤幹細

胞。中國腫瘤 6; 441-445, 2012 4. 蘇彥雷、張驥、蔣建勤、林克江、沈劍剛。量子化學計演演算法分析蒙古黃芪中部分黃酮類化

合物抗氧化作用機制。中國藥科大學學報 18: 1-6, 2011 5. 塗天智、沈劍剛、蔣建勤。內蒙黃芪的化學成分研究。華西藥學雜誌 24 (5) : 466～468; 2009 6. 劉柏炎、沈劍剛、蔡光先、謝勇、陳雪梅、楊輝。補陽還五湯對局灶性腦缺血大鼠腦內

caveolin1、2 的影響。湖南中醫藥大學學報 28(1): 22-28, 2008 7. 劉柏炎、蔡光先、陳雪梅、楊輝、謝勇、沈劍剛。補陽還五湯對局灶性腦缺血大鼠神經元再生

的影響。中華神經醫學雜誌 2007: 6(8), 762-765(引用次數 3) 8. 佟麗、譚縣輝、沈劍剛。補陽還五湯及不同配伍組方對缺血性腦中風後大鼠神經增殖作用的對

比研究。中國中西醫結合雜誌 27(6): 519-22, 2007 (引用次數 2) 9. 魯剛。沈劍剛、游文龍、馮戩雲、朱建華。直結腸癌細胞線粒體超微結構與細胞凋亡的關係.。

中國誤診學雜誌 6(17): 3277-9, 2006 10. 張冬輝、魯剛、游文龍、沈劍剛、馮熾雲、朱建華。直結腸癌細胞線粒體研究中樣本的取材。

海南醫學院學報, 13(3): 259-260, 2007 11. 譚縣輝、曲宏達、彭康、陳育堯、佟麗、沈劍剛、朱傳武。補陽還五湯對缺血性腦中風後遺症

大鼠神經增殖作用的影響。南方醫科大學學報 26(2): 189-192; 2006 12. 曲宏達、佟麗、沈劍剛。補陽還五湯含藥血清對缺氧腦皮質神經細胞 p53 和 p21 基因表達的作

用。中國中西醫結合雜誌 24(2): 133-5, 2004 (引用次數 9) 13. 廖春來、佟麗、沈劍剛。補陽還五湯對小鼠腦缺血後 NOS 活性的影響。中藥藥理與臨床 19(4):

5-7, 2003 (引用次數 9) 14. 廖春來、佟麗、沈劍剛。補陽還五湯抗腦缺血的實驗研究進展。中國藥物與臨床 3(3): 176-178,

2003 15. 沈劍剛、丘幸生、薑泊、張德良、忻文娟、馮戠雲、趙保路。一氧化氮和氧自由基誘導缺氧再

給氧心肌細胞凋亡的 bcl-2 和 p53 信號通路研究。中國科學 C 輯 32(5): 436-446, 2002 16. 佟麗、沈劍剛、邱幸生、曲宏達、陳育堯。補陽還五湯抗缺氧再給氧乳鼠心肌細胞凋亡的實驗

研究。中國中西醫結合雜誌 22(7): 522-524, 2002 (引用次數 20) 17. 曲宏達、佟麗、沈劍剛、陳育堯。補陽還五湯對體外培養的大鼠皮層神經元缺氧凋亡的影響。

第一軍醫大學學報 22(1) : 35-37, 2002 18. 佟麗、曲宏達、陳育堯、沈劍剛。補陽還五湯對大鼠腦皮層神經元生長的影響。第一軍醫大學

學報 22(8): 711-712, 2002 19. 沈劍剛、佟麗、邱幸生、曲宏達、陳育堯。益氣通絡丹抗缺氧再給氧所致心肌細胞凋亡的研

究。第一軍醫大學學報 21(10): 743-745, 2001 (引用次數 3) 20. 許岸高、李韶光、劉集鴻、沈劍剛、甘愛華。黃參方劑治療胃癌中的細胞凋亡及一氧化氮機制

的研究。中華結核和呼吸雜誌 24(3) : 169, 2001

11

21. 邱幸生、陳素雲、沈劍剛、黃偉毅、陳凱。益氣通絡方對缺氧再給氧心肌細胞 bcl-2 基因表達影響的血清藥理學研究。中國中醫基礎醫學雜誌 7(3) : 38-40,2001(引用次數 3)

22. 陳素雲、曲宏達、陸力、沈劍剛。一氧化氮對大鼠皮層神經元缺氧凋亡的影響及其 bc1-2 機制。長春中醫學院學報 16(7) : 28-29, 2000

23. 邱幸生、沈劍剛、陳素雲、黃偉毅。益氣通絡丹抗缺氧再給氧心肌細胞凋亡的實驗研究。中國中醫藥科技 7(4): 213-215, 2000

24. 甘愛華、許岸高、劉集鴻、李韶光、沈劍剛. 薑泊。胃癌發生中增殖細胞核抗原與 bcl-2 和 p53蛋白表達的意義。臨床消化病雜誌 11(4): 160-161, 1999

25. 許岸高、李韶光、劉集鴻、沈劍剛。氟尿嘧啶和黃參液誘導胃癌細胞株凋亡的研究。中華消化雜誌 19(3): 202-203, 1999

26. 許岸高、劉集鴻、甘愛華、沈劍剛、鐘志強、黃志輝。5—氟尿嘧啶誘導人胃癌細胞的凋亡。現代消化及介入診療 1 : 48, 1999

27. 許岸高、沈劍剛、李韶光、劉集鴻。幽門螺桿菌感染所致胃粘膜上皮細胞凋亡與 p53 和 bcl—2表達的關係。現代消化及介入診療 1: 32-34, 1999

28. 劉集鴻、許岸高、沈劍剛。5-FU、絲裂黴素和表阿黴素誘導人胃癌細胞凋亡的體外研究。世界華人消化雜誌 4 : 365, 1999

29. 許岸高、李韶光、劉集鴻、沈劍剛、薑泊。胃癌前病變細胞凋亡和增殖的關係。中華醫學雜誌79. (3) : 185-186, 1999

30. 劉集鴻、許岸高、沈劍剛。 5-氟尿嘧啶、絲裂黴素和表阿黴素誘導人胃癌細胞凋亡的體外研究。廣東醫學 20(5): 327-328, 1999

31. 許岸高、劉集鴻、沈劍剛、甘愛華。黃參方劑治療胃癌中的細胞凋亡及一氧化氮改變。中國實用內科雜誌 4233-235, 2001

32. 郭志剛、沈劍剛、翁昌鴻、佟麗、陳玉堯、賈滿盈、劉伊麗。冠心病、高血壓病人血漿氧自由基、一氧化氮及纖溶活性的變化。第一軍醫大學學報 19(2) : 124-125, 1999 (引用次數 53)

33. 沈劍剛、郭志剛等。益氣通絡丹對冠心病、高血壓病患者不同中醫證型血液脂質過氧化、一氧化氮及纖溶活性的影響。中國中醫基礎醫學雜誌 4(3) : 37-39,1998

34. 趙保路、沈劍剛。用 DETC 鐵捕捉生物組織 NO 自由基的 ESR 波譜解析。波譜學雜誌 4:138-142,1998

35. 郭志剛、沈劍剛、佟麗、陳育堯、賈滿盈、劉伊麗、陳素雲。銀杏葉提取物對冠心病患者的氧自由基一氧化氮及纖溶活性的影響。嶺南心血管病雜誌 4(3) : 159-161, 1998

36. 趙保路、沈劍剛等。用 ESR 研究缺血再灌注組織和多形核白細胞產生 NO 自由基。波譜學雜誌 14(2) : 99-105,1997

37. 沈劍剛、郭志剛、佟麗、陳育堯、劉伊麗、賈滿盈、陳素雲、趙保路、忻文娟。益氣通絡丹對冠心病高血壓病人脂質過氧化、一氧化氮及纖溶活性的影響。中國中西醫結合雜誌 17(7) :410-413, 1997

38. 沈劍剛、郭志剛等。益氣通絡丹對心肌缺血再灌注大鼠脂質過氧化及纖溶活性的影響。中國病理生理雜誌 12(2) : 139-143, 1996 (引用次數 11)

39. 趙保路、沈劍剛、呼俊改、萬謙、忻文娟。NO 和氧自由基在心肌缺血再灌注損傷中的協同作用。中國科學 C 輯 26(4) : 331-338, 1996

40. 沈劍剛、趙保路、呼俊改、萬謙、忻文娟。益氣通絡丹對心肌缺血再灌注損傷 NO、氧自由基和心肌損傷的抑制作用。醫學生物物理學 8 : 7-11,1996

41. 郭志剛、沈劍剛等。冠心病高血壓病血漿 MDA、一氧化氮及組織型纖溶酶原啟動物的變化。中國迴圈雜誌 11(7) : 435, 1996

42. 佟麗、陳育堯、沈劍剛等。老年大鼠心肌缺血再灌注損傷及益氣通絡丹的保護作用。中國實驗方劑學雜誌 2(4) : 46-47, 1996

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43. 沈劍剛、郭志剛、佟麗、陳育堯、薑翼、許文學。益氣通絡丹對冠心病、高血壓病患者血液氧自由基、NO 及纖溶活性的影響。中藥藥理與臨床 3: 42-44, 1996

44. 賈鈺華、陳素雲、呂志平、許文學、崔志英、沈劍剛。舌色與心臟功能及血管功能的關係。中國中西醫結合雜誌 15(6): 331-333, 1995

45. 郭志剛、沈劍剛、劉伊麗、張榕華。小劑量美降之治療高膽固醇血症臨床觀察。第一軍醫大學學報 15(4): 299, 1995

46. 沈劍剛、侯燦等。高壓氧所致脂質過氧化損傷。基礎醫學與臨床 12(3) : 59-60, 1992 47. 沈劍剛、陳瑗等。Ebselen 抗高壓氧脂質過氧化作用。中國藥理學通報 8(2) : 160-161, 1992 48. 沈劍剛、陳瑗、周玫等。外源性 SOD 抗高壓氧脂質過氧化作用的實驗研究。中華醫學雜誌

71(11) : 642-644, 1991 49. 沈劍剛、陳瑗、周玫等。高氧靈和益氣通絡丹抗高壓氧脂質過氧化作用的實驗研究。中國中西

醫結合雜誌 (增刊) : 337-340, 1991 50. 沈劍剛、陳瑗、周玫等。高壓氧所致脂質過氧化反應的初步探討。第一軍醫大學學報 10(4) :

351-353, 1990 Last update: 6/2016

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沈劍剛教授香港大學中醫藥學院教授、副院長(科研) 研究生管理委員會主席聯絡方法地址: 香港薄扶林沙宣道 10 號香港大學中醫藥學院電話: (852) 3917 6429 傳真: (852) 2872 5476 電郵: [email protected] 學歷 1995 年 9 月- 1998 年 7 月中國科學院生物物理研究所博士學位 1987 年 9 月- 1990 年 7 月中山醫科大學中西醫結合碩士學位 1979 年 7 月- 1984 年 7 月湖南中醫學院醫療全科醫學學士學位工作經歷 2014 年 8 月-至今香港大學中醫藥學院副院長(科研) 2012 年 12 月-2014 年 7 月香港大學中醫藥學院教授、助理院長(科研) 2007 年 1 月- 2012 年 12 月香港大學中醫藥學院副教授、助理院長(科研) 2005 年 11 月-2006 年 12 月香港中文大學中醫學院助理教授 2005年3月- 2005年10月香港大學中醫藥學院助理教授 2004年8月- 2005年12月美國新墨西哥大學健康科學中心助理教授美國新墨西哥大學EPR研究中心中心主任 2001 年 9 月- 2004 年 8 月香港大學醫學院內科學系研究助理教授 1999 年 8 月- 2001 年 9 月美國達茨茅斯醫學院研究科學家 1998 年 9 月- 1999 年 8 月美國哈佛醫學院博士後研究員 1995 年 7 月- 1998 年 7 月中國第一軍醫大學中醫系副教授

中國南方醫院中醫科副主任醫師 1990 年 7 月-1995 年 7 月中國第一軍醫大學中醫系主治醫師

中國南方醫院中醫科講師 1984 年 7 月-1987 年 7 月中國第一軍醫大學中醫系助教

中國南方醫院中醫科/內科住院醫師客座教授 2013 年 11 月-迄今廣東省惠州市第一醫院客座教授 2013 年 10 月-迄今暨南大學客座教授 2011 年 9 月-迄今湖南中醫藥大學海外名師 2011 年 5 月-迄今復旦大學腫瘤醫院中西醫結合科客座教授 2008 年 9 月-迄今溫州醫學院客座教授 2007 年 5 月-迄今南理工大學客座教授 2006 年 9 月-迄今南中醫藥大學客座教授 2006年1月-迄今美國新墨西哥大學健康科學中心客座教授 2004年11月-迄今美國新墨西哥大學EPR研究中心中心主任(兼職) 2005年7月-迄今四川大學華西醫院客座教授

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2003年12月-迄今廣東醫學院客座教授

臨床經歷 2007 年-迄今香港大學中醫內科學臨床教學; 老年病(心腦血管病、惡性腫瘤)專家門診工作 2005 年-2006 年香港中文大學中醫內科學臨床教學 1995 年-1998 年從事老年病的專家門診工作和臨床研究 1990 年-1995 年南方醫院中西醫結合專科門診及病房工作及普通內科雜病的臨床診療工作 1984 年-1987 年內科學系住院醫師訓練(南方醫院中醫科、心血管科、呼吸科、消化內科、腫瘤、神經內科) 教學經歷 2007年-迄今香港大學的《中醫內科學》､《中醫診斷學》､《醫學統計學》課程教學 2005年-2007年香港中文大學的《中醫內科學》､《醫案及醫學論文寫作》課程教學 1995 年-1998 年負責中醫中藥本科生《中醫診斷學》、碩士研究生《臨床及基礎科研思路與方法學》的課程教學, 《中醫內科學》臨床見習和實習帶教工作 1990 年-1995 年先後負責中醫中藥本科生《中醫診斷學》、《中醫疾病防治學》及《中醫內科學》

及軍醫本科生《中醫診斷學》課程教學，以及碩士研究生之《臨床及基礎科研思路與方法學》的課程。

開展《中醫診斷學》之多媒體教學研究課題專案曾獲廣東省高教局教學二等獎。主編《中醫脈診》教學幻燈片獲第一軍醫大學電化教學二等獎。

1986 年-1987 年中醫中藥本科生《中醫診斷學》課程教學、《中醫內科學》臨床見習和實習帶教工作研究經歷學術榮譽 2002 年-迄今 Young Investigator Award, 7th Medical Research Conference, Hong Kong 2010 年-迄今補陽還五湯對缺血性中風後神經元保護及增殖作用的相關機制研究 2009 年

度中華中醫藥學會科學技術獎三等獎 1998 年-迄今廣東省自然科學基金中醫中藥組評審專家(終審) 1998 年-迄今獲中國人民解放軍總後勤部科技進步二等獎 1998 年-迄今獲中國科學院地奧獎一等獎 1997 年-迄今獲中國人民解放軍總後勤部科技進步三等獎 1997 年-迄今 Young Scientist Award of the Fifth International Meeting of Nitric Oxide Biology,

September 15-19th, 1997 in Kyoto, Japan. 1997 年-迄今 Young Scientist Award of the First Asia – Pacific Symposium of EPR/ESR,

January 17-20th, 1997 in Hong Kong 學會任職 2012年--迄今世界中醫藥聯合會中藥藥理學會常務理事 2012年--迄今世界中醫藥聯合會中醫翻譯專業委員會常務理事 2012 年--迄今中國中西醫結合學會中西醫結合神經醫學專業委員會學部委員承擔高競爭性及重點研究項目 15. Elucidating effects of APPL2 on regulating proliferation and cell fate decision of neural

15

stem/progenitor cells through activating Notch signaling pathway. (負責人 Principal Investigator), RGC GRF grant 香港研究資助局 No. 777313, Hong Kong, HK$779,429; 2014.1-2016.12

16. 過氧亞硝基調節腦缺氧缺血後神經再生及其信號通路的研究。Grant from National Natural Science Foundation of China 國家自然科學基金面上專案 80 萬人民幣 (香港大學深圳研究院, 負責人 Principal Investigator), 2013-2015

17. Elucidating peroxynitrite as a cellular signaling molecule for regulating proliferation and neuronal differentiation of neural stem/progenitor cells under hypoxic and ischemic conditions. (負責人Principal Investigator), RGC GRF grant, Hong Kong, 香港研究資助局 No. 776512M, HK$1,158,250.00; 2012.9-2015.8

18. Establishment of a novel platform for screening active components from herbal formula for controlling “stemness’ of cancer cancer and related signal pathways for extension of survivals of cancer patients. Grant from National Natural Science Foundation of China 國家自然科學基金面上專案, 55 萬人民幣. 2011-2014.

19. Molecular regulations of reactive nitrogen species inhibitors for preventing thrombolysis-induced blood brain barrier disruption and hemorrhagic transformation in experimental cerebral ischemia-reperfersion models. (負責人 Principal Investigator) RGC GRF grant, Hong Kong, 香港研究資助局, No. 777611M, HK$ 890,000; 2011-2014

20. Elucidating caveolin-1 as a negative modulating protein for proliferation and differentiation of neural stem/progenitor cells in post-ischemic brain. (負責人 Principal Investigator) RGC GRF grant, 香港研究資助局 No. 777610M, Hong Kong, HK$1,084,600; 2010-2013

21. Interactions of reactive nitrogen species, caveolins and matrix metalloproteinases: A novel signal mechanism in disruption of blood brain barrier during ischemic stroke. (負責人 Principal Investigator) RGC GRF grant, 香港研究資助局 No. 774408M, Hong Kong, HK$ 1,191,369; 2008-2011

22. Plasma membrane cholesterol homeostasis and oxidative stress: implication for neuronal oxidative damage in ischemia stroke. (負責人 Principal Investigator) RGC Competitive Earmarked Research Grant, Hong Kong 香港研究資助局 No. 749504M, HK$ 939,968; 2005-2007

23. Effects of “Huang-Shan-Yao” on regulating lipid metabolism and protecting ischemic myocardium. (共同負責人 Co-Principal Investigator) National Natural Science Foundation of China 國家自然科學基金專案 RMB: 200,000; 2004-2006

24. Adiponectin as a novel diagnostic marker and therapeutic target for treatment of diabetes, steatohepatitis and other metabolic disorders. Innovation and Technology Fund of Hong Kong 香港創新科技署專案 (共同負責人 Co-Principal investigator) HK$ 3,000,000; 2004-2006

25. Molecular pharmacological study of Buyan Huangwu Decoction, a classic TCM formula, against cerebral ischemia damage. (負責人 Principal investigator) Grant from National Natural Science Foundation of China 國家自然科學基金專案 RMB: 140,000; 1999-2001

26. Serum pharmacological study of Yiqi Tongluo Pill against cardiomyocyte apoptosis in hypoxia-reoxygenation injury. (負責人 Principal investigator) Grant from Natural Science Foundation in Guangdong Province, China 廣東省自然科學基金專案, 人民幣: 100,000; 1998-2000

27. Protective mechanisms of a Chinese medicine “Yiqi Tongluo Pill” on myocardial ischemia-reperfusion injury. (負責人 Principal investigator) Grant from National Natural Science Foundation of China 國家自然科學基金專案 RMB: 60,000; 1994-1996

28. Study of stress and aging hyperlipidema. (合作者 Co-investigator) Grant from Military Medical Ministry of PLA, P. R. China RMB 100,000; 1992-1995

專利 3. Reagents for highly specific detection of peroxynitrite, Patent: U.S. 11848-027-999

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4. Diarylamine-Based Fluorogenic Probes for Detection of Peroxynitrite, WO2013113279 A1 發表論文國際雜誌 71. Gu Y, Chen JP, Shen JG. Herbal Medicines for Ischemic Stroke: Combating Inflammation as

Therapeutic Targets. Journal of Neuroimmune Pharmacology DOI: 10.1007/s11481-014-9525-5, 2014 72. Hua YQ, Chen Z, Meng ZQ, Chen H, Shen JG, WANG K, Peng W, Shen YH, Liu LM. High expression

of erythropoietin‑ producing hepatoma cell line-B2 (EphB2) predicts the efficiency of the Qingyihuaji formula treatment in pancreatic cancer CFPAC‑ 1 cells through the EphrinB1‑ EphB2 pathway. Oncology Letters DOI: 10.3892/ol_xxxxxxxx

73. Yeung PK, Shen J, Chung SS, Chung SK. Targeted over-expression of endothelin-1 in astrocytes leads to more severe brain damage and vasospasm after subarachnoid hemorrhage. BMC Neuroscience 2013 Oct 25; 14(1): 131

74. Pan Y, Zhao L, Chen XM, Gu Y, Shen JG, Liu LM. The XRCC1 Arg399Gln genetic polymorphism contributes to hepatocellular carcinoma susceptibility: an updated meta-analysis. Asian Pac J Cancer Prev. 2013;14(10):5761-7

75. Xu MJ, Chen XM, Gu Y, Peng T, Yang D, Chang RC, So KF, Liu KJ, Shen JG. Baicalin can scavenge peroxynitrite and ameliorate endogenous peroxynitrite-mediated neurotoxicity in cerebral ischemia-reperfusion injury. Journal of Ethnopharmacology 150(1): 116-24, 2013

76. Chen Y, Nie YC, Luo YL, Lin F, Zheng YF, Cheng GH, Wu H, Zhang KJ, Su WW, Shen JG*, Li PB*. Protective effects of naringin against paraquat-induced acute lung injury and pulmonary fibrosis in mice. Food Chem Toxicol 58C: 133-140, 2013

77. Yang LP, Shen JG*, Xu WC, Li J, Jiang JQ*. Secondary metabolites of the genus astragalus: structure and biological-activity update. Chemistry & Biodiversity 10(6): 1004-54, 2013

78. Du LB, Miao XX, Jiang YG, Jia HY, Tian Q, Shen JG*, Liu Y*. An effective strategy for the synthesis of biocompatible gold nanoparticles using danshensu antioxidant: prevention of cytotoxicity via attenuation of free radical formation. Nanotoxicology 7(3): 294-300, 2013

79. Sun H, Ge N, Shao M, Cheng X, Li Y, Li S*, Shen JG*. Lumbrokinase attenuates diabetic nephropathy through regulating extracellular matrix degradation in Streptozotocin-induced diabetic rats. Diabetes Research and Clinical Practice 100(1): 85-95, 2013

80. Wang ZY, Wang DM, Han SW, Wang N, Mo FZ, Loo TY, Shen JG, Huang H, Chen JP. Bioactivity-guided identification and cell signaling technology to delineate the lactate dehydrogenase A:Inhibition effects of spatholobus suberectus on breast cancer. PLoS One 8(2): e56613, 2013

81. Chen XM, Chen HS, Xu MJ, Shen JG*. Targeting reactive nitrogen species: A promising therapeutic strategy for cerebral ischemia-reperfusion injury. Acta Pharmacologica Sinica 34(1): 67-77; 2013

82. Wang Y, Shen JG, Wang XM, Fu DL, Chen CY, Lu LY, Lu L, Xie CL, Fang JQ, Zheng GQ. Scalp Acupuncture for acute ischemic stroke: a meta-analysis of randomized controlled trials. Evidence-based Complementary and Alternative Medicine 2012, Article ID. 480950

83. Hao CZ, Wu F, Shen JG, Lu L, Fu DL, Liao WJ, Zheng GQ. Clinical efficacy and safety of Buyang Huanwu decoction for acute ischemic stroke: A systematic review and Meta-analysis of 19 randomized controlled trials, Evidence-based Complementary and Alternative Medicine 2012, Article ID. 630124

84. Nie YC, Wu H, Li PB, Luo YL, Long K, Xie LM, Shen JG*, Su WW*. Anti-inflammatory effects of naringin in chronic pulmonary neutrophilic inflammation in cigarette smoke-exposed rats. Journal of Medicinal Food 15(10): 894-900, 2012.

85. Wang ZY, Wang N, Chen J*, Shen JG*. Emerging glycolysis targeting and drug discovery from Chinese Medicine in cancer therapy. Evidence-based Complementary and Alternative Medicine 2012, Article ID. 873175

86. Shen JG*. Reactive nitrogen species: Dual roles for blood brain barrier disruption and brain repairs in

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cerebral ischemia and reperfusion injury. Acta Biophysica Sinica 28 (4): 295-306, 2012 87. Nie YC, Wu H, Li PB, Xie LM, Luo YL, Shen JG*, Su WW*. Naringin attenuates EGF-induced

MUC5AC secretion in A549 cells by suppressing the cooperative activities of MAPKs-AP-1 and IKKs-IκB-NF-κB signaling pathways. European Journal of Pharmacology 690: 207-213, 2012

88. Nie YC, Wu H, Li PB, Luo YL, Zhang CC, Shen JG*, Su WW*. Characteristic comparison of three rat models induced by cigarette smoke or combined with LPS: to establish a suitable model for study of airway mucus hypersecretion in chronic obstructive pulmonary disease. Pulmonary Pharmacology & Therapeutics 25(5): 349-358, 2012

89. Luo YL, Zhang CC, Li PB, Nie YC, Wu H, Shen JG*, Su WW*. Naringin attenuates enhanced cough, airway hyperresponsiveness and airway inflammation in a guinea pig model of chronic bronchitis induced by cigarette smoke. International Immunopharmacology 2012; 13(3): 301-307

90. Lau BW, Lee JC Lee, Li Y, Fung SM, Sang YH, Shen JG, Chang RC, So KF. Polysaccharides from wolfberry prevents corticosterone-induced inhibition of sexual behavior and increases neurogenesis. PLoS One 7(4): e33374, 2012

91. Li Y, Zhuang PW, Shen BR, Zhang YJ, Shen JG. Baicalin promotes neuronal differentiation of neural stem/progenitor cells through modulating p-stat3 and bHLH family protein expression. Brain Research 1429: 36-42, 2012

92. Gu Y, Zheng GQ, Xu MJ, Li Y, Chen XM, Zhu WZ, Tong Y, Chung SK, Liu KJ, Shen JG. Caveolin-1 regulates nitric oxide mediated matrix metalloproteinases activity and blood-brain barrier permeability in focal cerebral ischemia and reperfusion injury. Journal of Neurochemistry 20(1): 147-156, 2012

93. Wang ZY, Loo TY, Shen JG, Wang N, Wang DM, Yang DP, Mo SL, Guan XY, Chen JP. LDH-A silencing suppresses breast cancer tumorigenicity through induction of oxidative stress mediated mitochondrial pathway apoptosis. Breast Cancer Res Treat. 131(3): 791-800, 2012

94. Wang N, Wang ZY, Mo SL, Loo TY, Wang DM, Luo HB , Yang DP, Chen LY, Shen JG, Chen JP*. Ellagic acid, a phenolic compound, exerts anti-angiogenesis effects via VEGFR-2 signaling pathway in breast cancer. Breast Cancer Res Treat. 134(3): 943-55, 2012

95. Zhao H*, Ren CC, Chen XM, Shen JG. From rapid to delayed and remote postconditioning: the evolving concept of ischemic postconditioning in brain ischemia. Current Drug Targets 13(2): 173-187, 2012

96. Wang Z, Cheng Y, Wang N, Wang DM, Li YW, Han F, Shen JG, Yang DP, Guan XY, Chen JP. Dioscin induces cancer cell apoptosis through elevated oxidative stress mediated by downregulation of peroxiredoxins. Cancer Biology & Therapy 13(3), 138-147, 2012

97. Li Z, Yang D*, Huang M, Hu X, Shen JG, Zhao Z, Chen J. Chrysomya megacephala (Fabricius) larvae: A new biodiesel resource. Applied Energy 94: 349-354, 2012

98. Lee W, Xu M, Li Y, Gu Y, Chen J, Wong D, Fung PC, Shen JG. Free cholesterol accumulation impairs antioxidant activities and aggravates apoptotic cell death in menadione-induced oxidative injury. Arch Biochem Biophys. 514(1-2): 57-67, 2011

99. Li Y, Luo J, Zheng G, Fu S, Wang TT, Zeng HP, So KF, Chung SK, Tong Y, Shen JG. Caveolin-1 plays a crucial role in inhibiting neuronal differentiation of neural stem/progenitor cells via VEGF signaling-dependent pathway. PLoS One 6(8): e22901, 2011.

100. Xu WC, Shen JG*, Jiang JQ*. Phytochemical and biological studies of the plants from the genus daphne. Chemistry & Biodiversity 8: 1215-1233, 2011

101. Li Y, Lau WM, So KF, Tong Y, Shen JG. Caveolin-1 promotes astroglial differentiation of neural stem/progenitor cells through modulating Notch1/NICD and Hes1 expressions. Biochem Biophys Res Commun 407: 517-524, 2011

102. Li Y, Lau WM, So KF, Tong Y, Shen JG. Caveolin-1 inhibits oligodendroglial differentiation of neural stem/progenitor cells through modulating β-catenin expression, Neurochem Int 59(2): 114-121, 2011.

103. Zheng GQ, Zhao ZM, Wang Y, Gu Y, Li Y, Chen XM, Fu SP, Shen JG. Meta-analysis of scalp

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acupuncture for acute hypertensive intracerebral hemorrhage. J Altern Complement Med. 2011; 17(4): 293-299.

104. Gu Y, Dee CM, Shen JG. Interaction of free radicals, matrix metalloproteinases and caveolin-1 impacts blood-brain barrier permeability in cerebral ischemia and reperfusion injury. Frontier in Bioscience 3: 1216-1231, 2011.

105. Shen JG, Lee W.S., Chen J. and Yang D. Caveolin-3 Peptide Protects Cardiomyocytes from Apoptotic Cell Death via Preserving Superoxide Dismutase Activity and Inhibiting Caspase-3 Activation under Hypoxia-reoxygenation. American Journal of Biomedical Sciences 3(2): 126-144, 2011.

106. Wang ZY, Wang N, Shen JG, Wang DM, Yang DP, Loo TY, Mo SL, Fu JM, Guan XY, Chen JP. Spatholobus suberectus Dunn inhibits cancer angiogenesis through suppression of vascular endothelial growth factor signaling pathway. Journal of Ethnopharmacology133(2):751-8, 2011

107. Shen JG*, Gu Y, Yao Tong, PCW Fung, Tong L. Ginkgo biloba extract (EGb 761) prevents apoptosis in hypoxia-reoxygenated cardiomyocytes: involvement of mitochondria-dependent caspase pathway. Chinese Medicine 6: 8 , 2011

108. Xu XC, Yang Y, Du LB, Shen JG*, Wang GQ, He Z, Tian Q, Liu Y. Autoxidation and prooxidation mechanism of Danshensu. Acta Physico-Chemica Sinica 26(7): 1737-1741, 2010.

109. Zhai JJ, Liu ZL, Li JM, Chen JP, Jiang L, Wang DM, Yuan J, Shen JG, Yang DP, Chen JQ. Different mechanisms of cis-9, trans-11- and trans-10, cis-12- conjugated linoleic acid affecting lipid metabolism in 3T3-L1 cells. Journal of Nutritional Biochemistry. 21(11): 1099-1105, 2010.

110. Zheng GQ, Li Y, Gu Y, Chen XM, Zhou Y, Zhao SZ, Shen JG*. Beyond Water Channel: Aquaporin-4 in Adult Neurogenesis. Neurochemistry International. 56(5): 651-654, 2010.

111. Yang D, Sun ZN, Peng T, Wang HL, Shen JG, Chen Y, Tam PK. Synthetic fluorescent probes for imaging of peroxynitrite and hypochlorous acid in living cells. Methods Mol Biol. 591: 93-103, 2010.

112. Shen JG, Sood R, Weaver J, Timmins GS, Schnell A, Miyake M, Kao JP, Rosen GM, Liu KJ. Direct visualization of mouse brain oxygen distribution by electron paramagnetic resonance imaging: Application to focal cerebral ischemia. Journal of Cerebral Blood Flow and Metabolism 2009; 29(10): 1695-703.

113. Mao WW, Wang TT, Zeng HP, Wang ZY, Chen JP, Shen JG*. The design, synthesis, and evaluation of novel substituted 5-hydroxycoumarin and pyranocoumarin derivatives exhibiting high antiproliferative activity. Bioorganic & Medicinal Chemistry Letters 19(16): 4570-4573, 2009

114. Ye XS, Feng YB, Tong Y, Ng KM, Tsao SW, Liu GK, Sze CW, Zhang YB, Tang J, Shen JG, Kobayashi S. Hepatoprotective and anti-oxidative effects of Coptidis Rhizoma aqueous extract on carbon tetrachloride-induced acute liver hepatotoxicity in rats. Journal of Ethnopharmacology 124(1): 130-6, 2009

115. Liu WL, Hendren J, Yuan ZR, Shen JG, Liu KJ. Normobaric hyperoxia attenuates early blood brain barrier disruption by inhibiting MMP-9-mediated occluding in focal cerebral ischemia. Journal of Neurochemistry 108: 811-820, 2009

116. Shen JG*, Lee WS, Lau CF, Ng KM, Fung ML, Liu KJ. Interaction of caveolin-1, nitric oxide, and nitric oxide synthases in hypoxic human SK-N-MC neuroblastoma cells. Journal of Neurochemistry 107: 478-487, 2008

117. Zeng HP, Wang, TT, Chen W, Wang CY, Chen DH, Shen JG*. Characterization of the chemical components in the Extracts from Si-wu decoction induce Proliferation of rat mesenchymal stem cells (rMSCs). Bioorganic & Medicinal Chemistry 16(9): 5109-14, 2008

118. Rong JH, Cheung CY, Lau AS, Shen JG, Tam PH, Cheng YC. Induction of heme oxygenase-1 by traditional Chinese medicine formulation ISF-1 and its ingredients as a cytoprotective mechanism against oxidative stress, International Journal of Molecular Medicine 21: 405-411, 2008

119. Shi J, Tong Y, Shen JG, Li HX. Effectiveness and safety of herbal medicines in the treatment of irritable bowel syndrome: A systematic review. World Journal of Gastroenterology 14(3):454-62; 2008

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120. Rong JH, Titon R, Shen JG, Ng KM, Liu C, Tam PK, Lau AS, Cheng YC. Genome-wide biological response fingerprinting (BioReF) of the Chinese botanical formulation ISF-1 enables the eselection of multiple marker genes as a potential metric for quality control. Journal of Ethnopharmacology 113(1): 35-44, 2007

121. Cai GX, Liu BY, Liu W, Tan XH, Rong JH, Chen XM, Tong L, Shen JG*. Buyang Huanwu Decoction can improve recovery of neurological function, reduce infarction volume, stimulate neural proliferation and modulate VEGF and Flk1 expressions in transient focal cerebral ischaemic rat brains. Journal of Ethnopharmacology 113(2): 292-9, 2007

122. Ren JY, Fung PC, Chang CQ, Shen GX, Chan FH, Shen JG*. A comparison study on blood and tissue nitric oxide concentration during renal ischemia-reperfusion injury with electron paramagnetic resonance spectroscopy. Applied Magnetic Resonance 32: 243-255, 2007

123. Miyake M, Shen JG, Liu SM, Shi HL, Liu WL, Yuan ZR, Pritchard A, Kao JPY, Liu KJ, Rosen GM. Acetoxymethoxycarbonyl nitroxides as EPR pro-imaging agents to measure O2 levels in mouse brain: A pharmacokinetic and pharmacodynamic study. Journal of Pharmacology and Experimental Therapeutics 318, 1187-1193, 2006.

124. Shen JG, Liu SM, Miyake M, Liu WL, Pritchard A, Kao JP, Rosen GM, Timmins GS, Tong Y, Liu KJ. Use of 3-acetoxymethoxycarbonyl- 2,2,5,5- tetramethyl-1 -pyrrolidinyloxyl as an EPR oximetry probe for measurement of tissue oxygenation in mouse brain. Magnetic Resonance in Medicine 55, 1433-1440, 2006

125. Yang D, Wang HL, Sun ZN, Chung NW, Shen JG.. A highly selective fluorescent probe for detection of peroxynitrite in living cells. Journal of The American Chemical Society 128(18):6004-5, 2006

126. Shen JG*, Ma S, Chan CP, Fung PC, Cheung RTF, Liu KJ. Nitric oxide down-regulates caveolin-1 expression in rat brains during focal cerebral ischemia and reperfusion. Journal of Neurochemistry 96; 1078-1089, 2006

127. Chen BY, Lam KS, Wang Y, Wu DH, Lam MC, Shen JG, Wong LC, Hoo RL, Zhang JL, Xu AM. Hypoxia dysregulates the production of adiponectin and plasminogen activator inhibitor-1 independent of reactive oxygen species in adipocytes. Biochemical and Biophysical Research Communications 341: 549-556, 2006

128. Chang CQ, Ren JY, Fung PCW, Hung YS, Shen JG, Chan FHY. Novel sparse component analysis approach to free radical EPR spectra decomposition. Journal of Magnetic Resonance 175: 242-255, 2005

129. Ren JY, Chang CQ, Fung PCW, Shen JG, Chan FHY. Free Radical EPR Spectroscopy Analysis using blind source separation. Journal of Magnetic Resonance 166(1): 82-91,2004

130. Shen JG, Khan N, Lewis LD, Ray A, Swartz H. Cellular respiration rates and oxygen concentration in lymphoblastic Molt-4 cells and there ρ0 derivative. Biophysical Journal 84(2): 1291-1298, 2003

131. Khan N, Shen JG, Chang TY, Fung PCW, Grinberg O, Swartz H. Plasma membrane cholesterol: a possible barrier to intracellular oxygen gradients in CHO cells. Biochemistry 42(1): 23-29, 2003

132. Shen JG, Qiu XS, Jiang B, Zhang DL, Xin WJ, Fung PC, Zhao BL. Nitric oxide and oxygen radicals induced apoptosis via bcl-2 and p53 pathway in hypoxia-reoxygenated cardiomyocytes. Science in China (Series C) 46(1): 28-39, 2002

133. Shen JG, Bottle S, Khan N, Micallef A, Swartz HM. Development of isoindoline nitroxides for EPR oxymetry in viable biological systems. Applied Magnetic Resonance 22: 357-368, 2002

134. Shen JG, Li M, Xin WJ, Zhao BL. Effects of chinonin on nitric oxide free radical, myocardial damage and arrhythmia in ischemia-reperfusion injury in vivo. Applied Magnetic Resonance 19: 9-19, 2000.

135. Shen JG, Quo X, Li M, Xin WJ, Zhao BL. Chinonin, a novel drug against cardiomyocyte apoptosis induced by hypoxia and reoxygenation. Biochimica et Biophysica Acta 1500: 217-226, 2000

136. Xu AG, Li SG, Liu JH, Shen JG, Jiang B, Gang AH. Correlation between apoptosis and proliferation

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in gastric pre-carcinomatic patients. Chinese Medical Journal 79(3): 185-186, 1999. 137. Shen JG, Wang J, Zhao BL, Hou JW, Gao TL, Xin WJ. Effects of EGb 761 on generation of nitric

oxide, myocardial damage and arrhythmias in ischemia-reperfusion injury in vivo. Biochimica et Biophysica Acta 1406: 228-236, 1998

138. Zhao B, Shen JG, Li M, Li MF, Wan Q, Xin WJ. Scavenging effects of Chinonin on NO and oxygen free radicals and its protective effects on the myocardium from the injury of ischemia-reperfusion. Biochimica et Biophysica Acta 1315: 131-137, 1996

139. Zhao BL, Shen JG, Hu J, Wan Q, Xin W. Synergic effects of NO and oxygen free radicals in the injury of ischemia-reperfused myocardium---ESR studies on NO free radicals generated from ischemia-reperfused myocardium. Science in China (Series C) 26, 491-500, 1996

140. Shen JG, Zhou D. Efficiency of Ginkgo biloba extract (EGb 761) in antioxidant protection against myocardial ischemia and reperfusion injury. Biochemistry and Molecular Biology International 35(1): 125-134, 1995

專著 14. Shen JG*, Gu Y. Insights into mechanisms of blood brain barrier permeability: Roles of free radicals,

matrix metalloproteinases and caveolin-1. Systems Biology of Oxidative Stress. (Eds. Ismail Laher), Springer 2013 (in press)

15. Shen JG*, Chen XM. Drug discovery from Traditional Chinese Medicine for neurogenesis: Implications for stroke and neurodegenerative diseases. Traditional Chinese medicine__ Scientific Basis for its Use. (Eds. James D. Adams, Jr.). Royal Society of Chemistry, Thomas Graham House , Cambridge CB4 0WF, UK 2013 SBN: 978-1-84973-661-9

16. Feng YB, Chen XM, Wang N, Shen JG. Current Progress on Medicinal Plants and their Biological Properties in Contemporary China. In J.N. Govil, Recent Progress in Medicinal Plants. Studium Press LLC, Houston, USA 529-588, 2009

17. Shen JG. Pharmacology and toxicology of Chinese herbal medicine for improving blood circulation. In: Yibin Feng, Pharamcology and Toxicology of Chinese Herbal Medicine. Commercial Press, Hong Kong 2009

18. Yang D, Sun ZN, Peng T, Wang HL, Shen JG, Chen Y, Tam PKH. Synthetic fluorescent probes for imaging of peroxynitrite and hypo chlorous acid in living cells. Live Cell Imaging Methods and Protocols. Series: Methods in Molecular Biology Vol 591 (Eds. Papkovsky DB ). Springer USA 2009

19. Shen JG., Liu S., Miyake M. and Liu K.J., Cerebral tissue oxygenation: transportation, metabolism, measurement, and significance in the ischemic brain, In: John Zhang, Hyperbaric Oxygen for Neurological Disorders. Flagstaff, Arizona, U.S.A., Best Publishing Co. 65-84, 2007

20. Shen JG, Zhao B, Li MF, Wan Q, and Xin W. Inhibitory effects of Ginkgo biloba extract (EGb 761) on oxygen free radicals, nitric oxide and myocardial injury in isolated ischemic-reperfused hearts. Proceedings of the International Symposium on Natural Antioxidant: Molecular Mechanisms and Health effects (Eds. Packer L, Traber MG & Xin W), American Oil Chemistry Society Press, Champaign, Illinois, 1996, pp453-465

21. Zhao B, Shen JG, Hou J, Xin W. Studies on NO free radical generated from ischemia-reperfusion tissue and polymorphonuclear leukocytes (PMN). Modern Applications of EPR/ESR from Biophysics to Material Science (Eds. Rudowicz CZ, Yu KN and Hiraoka H) Springer, 1997

22. Zhao B, Shen JG, Li M, Li M, Wan Q, and Xin W. Chinionin can scavenge NO free radicals and protect myocardia against ischemia-reperfusion injury. Proceedings of the International Symposium on Natural antioxidant: Molecular Mechanisms and Health effects (Eds. Packer L, Traber MG & Xin W), American Oil Chemistry Society Press, Champaign, Illinois, 1996, pp378-391

23. 細胞凋亡的基礎與臨床, 中國北京人民軍醫出版社, 1999 年 24. 新編中醫診斷學, 中國北京人民軍醫出版社, 1998 年 25. 藥物新劑型及其臨床應用, 中國北京人民軍醫出版社, 1996 年

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26. 醫學多媒體教學設計, 中國北京人民軍醫出版社, 1996 年中國專業雜誌 51. 朱文宗、鄭國慶、黃建平、金永喜、劉偉、沈劍剛。豁痰健脾法治療後半規管良性陣發性位置

性眩暈臨床研究。新中醫 45(2): 83-85, 2013. 52. 朱文宗、金永喜、黃建平、章國偉、吳紅專、沈劍剛。解痙合劑結合運動治療改善腦卒中後肌

痙攣及表面肌電圖分析。浙江中西醫結合雜志 45(2): 84-87, 2013. 53. 潘巖、花永強、劉魯明、沈劍剛。無血清培養法分離並鑒定胰腺癌細胞系 BxPC-3 中腫瘤幹細

胞。中國腫瘤 6; 441-445, 2012 54. 蘇彥雷、張驥、蔣建勤、林克江、沈劍剛。量子化學計演演算法分析蒙古黃芪中部分黃酮類化

合物抗氧化作用機制。中國藥科大學學報 18: 1-6, 2011 55. 塗天智、沈劍剛、蔣建勤。內蒙黃芪的化學成分研究。華西藥學雜誌 24 (5) : 466～468; 2009 56. 劉柏炎、沈劍剛、蔡光先、謝勇、陳雪梅、楊輝。補陽還五湯對局灶性腦缺血大鼠腦內

caveolin1、2 的影響。湖南中醫藥大學學報 28(1): 22-28, 2008 57. 劉柏炎、蔡光先、陳雪梅、楊輝、謝勇、沈劍剛。補陽還五湯對局灶性腦缺血大鼠神經元再生

的影響。中華神經醫學雜誌 2007: 6(8), 762-765(引用次數 3) 58. 佟麗、譚縣輝、沈劍剛。補陽還五湯及不同配伍組方對缺血性腦中風後大鼠神經增殖作用的對

比研究。中國中西醫結合雜誌 27(6): 519-22, 2007 (引用次數 2) 59. 魯剛。沈劍剛、游文龍、馮戩雲、朱建華。直結腸癌細胞線粒體超微結構與細胞凋亡的關係.。

中國誤診學雜誌 6(17): 3277-9, 2006 60. 張冬輝、魯剛、游文龍、沈劍剛、馮熾雲、朱建華。直結腸癌細胞線粒體研究中樣本的取材。

海南醫學院學報, 13(3): 259-260, 2007 61. 譚縣輝、曲宏達、彭康、陳育堯、佟麗、沈劍剛、朱傳武。補陽還五湯對缺血性腦中風後遺症

大鼠神經增殖作用的影響。南方醫科大學學報 26(2): 189-192; 2006 62. 曲宏達、佟麗、沈劍剛。補陽還五湯含藥血清對缺氧腦皮質神經細胞 p53 和 p21 基因表達的作

用。中國中西醫結合雜誌 24(2): 133-5, 2004 (引用次數 9) 63. 廖春來、佟麗、沈劍剛。補陽還五湯對小鼠腦缺血後 NOS 活性的影響。中藥藥理與臨床 19(4):

5-7, 2003 (引用次數 9) 64. 廖春來、佟麗、沈劍剛。補陽還五湯抗腦缺血的實驗研究進展。中國藥物與臨床 3(3): 176-178,

2003 65. 沈劍剛、丘幸生、薑泊、張德良、忻文娟、馮戠雲、趙保路。一氧化氮和氧自由基誘導缺氧再

給氧心肌細胞凋亡的 bcl-2 和 p53 信號通路研究。中國科學 C 輯 32(5): 436-446, 2002 66. 佟麗、沈劍剛、邱幸生、曲宏達、陳育堯。補陽還五湯抗缺氧再給氧乳鼠心肌細胞凋亡的實驗

研究。中國中西醫結合雜誌 22(7): 522-524, 2002 (引用次數 20) 67. 曲宏達、佟麗、沈劍剛、陳育堯。補陽還五湯對體外培養的大鼠皮層神經元缺氧凋亡的影響。

第一軍醫大學學報 22(1) : 35-37, 2002 68. 佟麗、曲宏達、陳育堯、沈劍剛。補陽還五湯對大鼠腦皮層神經元生長的影響。第一軍醫大學

學報 22(8): 711-712, 2002 69. 沈劍剛、佟麗、邱幸生、曲宏達、陳育堯。益氣通絡丹抗缺氧再給氧所致心肌細胞凋亡的研

究。第一軍醫大學學報 21(10): 743-745, 2001 (引用次數 3) 70. 許岸高、李韶光、劉集鴻、沈劍剛、甘愛華。黃參方劑治療胃癌中的細胞凋亡及一氧化氮機制

的研究。中華結核和呼吸雜誌 24(3) : 169, 2001 71. 邱幸生、陳素雲、沈劍剛、黃偉毅、陳凱。益氣通絡方對缺氧再給氧心肌細胞 bcl-2 基因表達影

響的血清藥理學研究。中國中醫基礎醫學雜誌 7(3) : 38-40,2001(引用次數 3)

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72. 陳素雲、曲宏達、陸力、沈劍剛。一氧化氮對大鼠皮層神經元缺氧凋亡的影響及其 bc1-2 機制。長春中醫學院學報 16(7) : 28-29, 2000

73. 邱幸生、沈劍剛、陳素雲、黃偉毅。益氣通絡丹抗缺氧再給氧心肌細胞凋亡的實驗研究。中國中醫藥科技 7(4): 213-215, 2000

74. 甘愛華、許岸高、劉集鴻、李韶光、沈劍剛. 薑泊。胃癌發生中增殖細胞核抗原與 bcl-2 和 p53蛋白表達的意義。臨床消化病雜誌 11(4): 160-161, 1999

75. 許岸高、李韶光、劉集鴻、沈劍剛。氟尿嘧啶和黃參液誘導胃癌細胞株凋亡的研究。中華消化雜誌 19(3): 202-203, 1999

76. 許岸高、劉集鴻、甘愛華、沈劍剛、鐘志強、黃志輝。5—氟尿嘧啶誘導人胃癌細胞的凋亡。現代消化及介入診療 1 : 48, 1999

77. 許岸高、沈劍剛、李韶光、劉集鴻。幽門螺桿菌感染所致胃粘膜上皮細胞凋亡與 p53 和 bcl—2表達的關係。現代消化及介入診療 1: 32-34, 1999

78. 劉集鴻、許岸高、沈劍剛。5-FU、絲裂黴素和表阿黴素誘導人胃癌細胞凋亡的體外研究。世界華人消化雜誌 4 : 365, 1999

79. 許岸高、李韶光、劉集鴻、沈劍剛、薑泊。胃癌前病變細胞凋亡和增殖的關係。中華醫學雜誌79. (3) : 185-186, 1999

80. 劉集鴻、許岸高、沈劍剛。 5-氟尿嘧啶、絲裂黴素和表阿黴素誘導人胃癌細胞凋亡的體外研究。廣東醫學 20(5): 327-328, 1999

81. 許岸高、劉集鴻、沈劍剛、甘愛華。黃參方劑治療胃癌中的細胞凋亡及一氧化氮改變。中國實用內科雜誌 4233-235, 2001

82. 郭志剛、沈劍剛、翁昌鴻、佟麗、陳玉堯、賈滿盈、劉伊麗。冠心病、高血壓病人血漿氧自由基、一氧化氮及纖溶活性的變化。第一軍醫大學學報 19(2) : 124-125, 1999 (引用次數 53)

83. 沈劍剛、郭志剛等。益氣通絡丹對冠心病、高血壓病患者不同中醫證型血液脂質過氧化、一氧化氮及纖溶活性的影響。中國中醫基礎醫學雜誌 4(3) : 37-39,1998

84. 趙保路、沈劍剛。用 DETC 鐵捕捉生物組織 NO 自由基的 ESR 波譜解析。波譜學雜誌 4:138-142,1998

85. 郭志剛、沈劍剛、佟麗、陳育堯、賈滿盈、劉伊麗、陳素雲。銀杏葉提取物對冠心病患者的氧自由基一氧化氮及纖溶活性的影響。嶺南心血管病雜誌 4(3) : 159-161, 1998

86. 趙保路、沈劍剛等。用 ESR 研究缺血再灌注組織和多形核白細胞產生 NO 自由基。波譜學雜誌 14(2) : 99-105,1997

87. 沈劍剛、郭志剛、佟麗、陳育堯、劉伊麗、賈滿盈、陳素雲、趙保路、忻文娟。益氣通絡丹對冠心病高血壓病人脂質過氧化、一氧化氮及纖溶活性的影響。中國中西醫結合雜誌 17(7) :410-413, 1997

88. 沈劍剛、郭志剛等。益氣通絡丹對心肌缺血再灌注大鼠脂質過氧化及纖溶活性的影響。中國病理生理雜誌 12(2) : 139-143, 1996 (引用次數 11)

89. 趙保路、沈劍剛、呼俊改、萬謙、忻文娟。NO 和氧自由基在心肌缺血再灌注損傷中的協同作用。中國科學 C 輯 26(4) : 331-338, 1996

90. 沈劍剛、趙保路、呼俊改、萬謙、忻文娟。益氣通絡丹對心肌缺血再灌注損傷 NO、氧自由基和心肌損傷的抑制作用。醫學生物物理學 8 : 7-11,1996

91. 郭志剛、沈劍剛等。冠心病高血壓病血漿 MDA、一氧化氮及組織型纖溶酶原啟動物的變化。中國迴圈雜誌 11(7) : 435, 1996

92. 佟麗、陳育堯、沈劍剛等。老年大鼠心肌缺血再灌注損傷及益氣通絡丹的保護作用。中國實驗方劑學雜誌 2(4) : 46-47, 1996

93. 沈劍剛、郭志剛、佟麗、陳育堯、薑翼、許文學。益氣通絡丹對冠心病、高血壓病患者血液氧自由基、NO 及纖溶活性的影響。中藥藥理與臨床 3: 42-44, 1996

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94. 賈鈺華、陳素雲、呂志平、許文學、崔志英、沈劍剛。舌色與心臟功能及血管功能的關係。中國中西醫結合雜誌 15(6): 331-333, 1995

95. 郭志剛、沈劍剛、劉伊麗、張榕華。小劑量美降之治療高膽固醇血症臨床觀察。第一軍醫大學學報 15(4): 299, 1995

96. 沈劍剛、侯燦等。高壓氧所致脂質過氧化損傷。基礎醫學與臨床 12(3) : 59-60, 1992 97. 沈劍剛、陳瑗等。Ebselen 抗高壓氧脂質過氧化作用。中國藥理學通報 8(2) : 160-161, 1992 98. 沈劍剛、陳瑗、周玫等。外源性 SOD 抗高壓氧脂質過氧化作用的實驗研究。中華醫學雜誌

71(11) : 642-644, 1991 99. 沈劍剛、陳瑗、周玫等。高氧靈和益氣通絡丹抗高壓氧脂質過氧化作用的實驗研究。中國中西

醫結合雜誌 (增刊) : 337-340, 1991 100. 沈劍剛、陳瑗、周玫等。高壓氧所致脂質過氧化反應的初步探討。第一軍醫大學學報 10(4) :

351-353, 1990 最新更新: 6/2016

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Professor Jiangang SHEN ( 沈劍剛...1 Professor Jiangang SHEN (沈劍剛) Professor, Associate Director (Research) Chairman of Departmental Research Postgraduate Committee School