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multiple antioxidants Pietri S, 1997anti-amyloid aggregation Luo Y, 2002meta-analysis : Oken BS, 1998Cochrane review : Birks J, 2002

Patient : elderly people w/ normal cognitive fnIntervention : Ginkgo bilobaComparison : placeboOutcome : dementia incidence

: dementia, ginkgo, prevention : PubMed : Systematic review of RCT > RCT >... The Oxford 2011 Levels of Evidence: Treatment Benefits

(mild cog impairment) PICO

Vellas B et al 2012, Lancet20022854France76.35Beth ES et al 2009, JAMA20003069USA79.16.1DeKosky ST et al 2008, JAMA20003069USA79.16.1

RCT (randomised) (baseline characteristics) ITT (Intention-to-treat analysis) (blind) (dropped out rate)

ITTVellas B, 2012, LancetOOOOO64%Beth ES, 2009, JAMAOOOOO62%DeKosky ST, 2008, JAMAOOOOO94%

Ginkgo Biloba for Prevention of Dementia : A Randomized Controlled TrialDeKosky ST,Williamson JD,Fitzpatrick AL,Kronmal RA, Ives DG,Saxton JA,Lopez OL, Burke G,Carlson MC, Fried LP,Kuller LH,Robbins JA,Tracy RP,Woolard NF, Dunn L,Snitz BE,Nahin RL,Furberg CD; Ginkgo Evaluation of Memory (GEM) Study Investigators.JAMA, Vol. 300, No. 19, November 2008

1b ( RCT)

>756230696.1120mg bid