!

1

0 ��100

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6×4

1. ③ ！

！

！ ③③

A.

B.

C.

D.

2. The structure of HClO4•H2O was proved to be H3O+ClO4-. The following statement that can

BEST support this structure of HClO4•H2O is:

A HClO4•H2O is a strong acid

B HClO4•H2O is a strong oxidant

C HClO4•H2O decomposes at high temperature

D Four identical bonds are present in HClO4•H2O

3. ③

!

2

A B C

4.

！ −OBs −OC6H4Br

A. B. C. D.

!

3

5. Bullvalene Cope

13C

etc

A. 1 B. 6 C. 12 D. 45

6. Calicheamicin DNA “

Calicheamicin

~

A. B. C. D.

16

1. ③ DNA

2. EDTA EDTA

EDTA ③

EDTA EDTA

3. Nature

III 2b CO2 ！

!

4

4.

DNA

DNA T U

60

1. 6,8- -1,3- DHP RV 1 1

pH ） pH

RV DHP

!!

!!

!!

!!

!!

!

5

1.1

1.2 pH

2. 》

2.1 C-O （

（

2.2

2.3 -OCH3 -NO2

3. Ingenol SI-15 Hecker Euphorbia ingens

in, out-[4.4.1]

HIV FDA

ingenol 2- -2-

ingenol “ 2013

Scripps P. S. Baran (+)- (+)-ingenol

14

3.1 ingenol in, out

3.2 SI-10 SI-11

BF3

3.3 1999 ingenol

vinylogous retro-pinacol rearrangement

!

6

4.

！

③

1,2-

A 4.1 A

2

4.1

4.2 A

4.3 A

4.4 4.2

4.1 A 4.2 A

5. DHFR Glu17 Ile115

4- -L- 1 L-(7- -4- )

2

!

7

5.1 1 2

5.2 DHFR

5.1 DHFR

mRNA ！ ； DHFR 。

DHFR

1 2 Glu17 Ile115 DHFR 6

5.2 5.3 DHFR

0.5 µM pH = 8.0

Glu17

1 2

1 DHFR I DHFR1

2 DHFR II DHFR2

DHFR3 DHFR4 DHFR

Ile115

!

8

5.2 I DHFR1 280 nm II DHFR I 280 nm

III IV DHFR 4 340 nm 280 nm

5.3 I DHFR3 II DHFR2 III DHFR II 280 nm

5.3 5.5

5.3 1 2

5.4 DHFR I DHFR II 280 nm DHFR

5.5 ， 5.2 II 5.3 III 4

I

II

III

IV

I

II

III

!

9

DHFR I DHFR II

5.6 TMP DHFR DHFR

DHFR II

6.4 TMP DHFR II

I II III IV TMP 0 2 4 6 µM

280 nm 5.3 5.5

TMP DHFR II

DHFR

I

II III

IV