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24
24
39
939940
10
H5N1
(24
) Hansens disease
24 B NDM-1
Q
TOCC T-Travel O-Occupation C-Contact C-Cluster
WWW.CDC.GOV.TW
-- 3500035000
(1850s(1850s--1950s)1950s) 19211921-- BCG live attenuated vaccineBCG live attenuated vaccine 19441944-- streptomycin ( Schatz A., streptomycin ( Schatz A., BugieBugie E. & E. & WaksmanWaksman S.)S.) 19501950-- isoniazidisoniazid & & pyrazinamidepyrazinamide 19801980-- TBTBHIVHIV
10% 10% HIVHIV1515-- 20%20%
35%30% 20%
2010 880 110
13% HIV 16%MDR-TB
2012
201520151010 (2007(2007 1448014480))
15042
16758
7500
11591
0
5000
10000
15000
20000
199619
9719
9819
9920
0020
0120
0220
0320
0420
0520
0620
0720
0820
0920
1020
1120
1220
1320
1420
15
54.5
Int J AA 2012;39:201-5.
2011 1. 12,634 54.5 2. 6382.8
2010 MDR-TB1.0% 2012
- 3000
, 5 3000
>> 3000
30%
4 65,,
,
N Engl J Med 2004;345:189-200.
HIV infection
Substance abuse
Recent infection
Chest radiograph findings suggestive of previous TB
Diabetes mellitus
Silicosis
Prolonged corticosteriod therapy
Other immunosuppressive therapy
Cancer of the head and neck
Hematologic and
reticuloendothelial diseases
End-stage renal disease
Intestinal bypass or
gastrectomy
Chronic malabsorption
syndromes
Low body weight (10% or
more below the ideal)
Clinical and laboratory predictors of patients with tuberculosis
Shen GH, et al. Int J Antimcrob Agents, 2012; 39: 201-205.
PAPR
1.1.
(())
2.2.
: :
198019801212 Dr Gottlieb (UCLA) Dr Gottlieb (UCLA) 3131Oral Oral candidiasiscandidiasis and PCP and PCP
pneumoniapneumonia
19811981Ms Ford (CDC)Ms Ford (CDC)
32
0
500
1000
1500
2000
2500
3000
3500
84' 85' 86' 87' 88' 89' 90' 91' 92' 93' 94' 95' 96' 97' 98' 99' 00' 01' 02' 03' 04' 05'
1988
(HIV- 1 Ab)
1990
1989
(MSM,SW..)
1991
1995HIV- 1/2 (HIV-1/2 Ab)
1997
2000
2003
2004
2005
1. 2. I-CHECK
22171/ 1699
10 3
10 3
Complicated Influenza:
(
)
( )
:
2012115262245 AH3(AH3N2)2524AH3 AH3
2012.11.9888 60127372 1
1030115:78 41
WHO
2011:21:313-22.
2011:21:313-22.
Clinical course of dengueWHO
2011:21:313-22.
Lin CY, et al. JFMA 2012
: 3() :
critical phase
warning signs
NSAIDS
:
- 201510 18 19 20Clinical and laboratory predictors of patients with tuberculosis 23 24 25 28: 31 32 33Complicated Influenza 37 39 40 41 42Clinical course of dengue 44 45 46