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第九章 核苷酸的代谢 Nucleotide Metabolism. 本章将主要讨论的问题. 核苷酸有哪些重要生理功能? 食物中核酸如何消化、吸收? 体内核苷酸如何代谢 ( 合成与分解 ) ? 核苷酸代谢障碍对机体有什么影响? 核苷酸代谢类似物有何临床作用?. 食物核蛋白. 核酸 (RNA or DNA). 蛋白质. RNA 酶. ( 磷酸二酯酶 ). 胰核酸酶. DNA 酶. 单核苷酸. 胰、肠核苷酸酶. ( 磷酸单酯酶 ). 排出,很少利用. 核苷. 磷酸. ( 水解或磷酸解 ). 核苷酶. 戊糖或磷酸戊糖. 碱基. 核酸的消化. - PowerPoint PPT Presentation
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Nucleotide Metabolism
()
(RNA or DNA)RNADNA()()()
--------cAMP, cGMP----NADFADCoA---UDPG, CDP-DG, SAM ATP----GTP---- UTP----CTP----
() CO2() ,
Bases/Nucleosides/Nucleotides BaseBase + Sugar=NucleosideBase + Sugar + Phosphate=NucleotideAdenineDeoxyadenosineDeoxyadenosine 5-triphosphate(dATP)
()CO2Asp()(), ,CO2
R-5-PPRPP synthetasePP-1-R-5-P(PRPP)AMP
5-5-PR11IMPIMPCO25-IMPAMPGMP
IMP(11) 3 A:(1) B:(2-- 6) C:IMP(7--11) AMPGMP
AMP10
()(1) IMP(11)R-5-PAMPPRPPPP-1-R-5-P(PRPP)5-
PP-1-R-5-PGlnGlu3: H2N-1-R-5'-PGly3 ATP, Mg2+(GAR)PRA
FH4(GAR)HN=Glu(FGAR)(FGAM)
AIRATP,Mg2+,K+H2O(FGAM)5-(AIR)5--4-(CAIR)
Asp5--4-(CAIR)5--4-(N-)-(SAICAR)
5--4-(N-)-(SAICAR)5--4-(AICAR)
5--4-(AICAR)5--4-(FAICAR)N10FH4FH4
5--4-(FAICAR)H2O(IMP)
(2) IMPAMPSAsp, Mg2+,GTP
(AMPS)(AMP)
IMPNADH+H+XMPIMP
GlnGluXMPGMP
AMPADPATPGMPGDPGTP
::
----- PRPPKGPATATP5- PRPPIMP -----ATPGMP GTP GTPATP
6:AMPGMPIMPPRPPKGPAT2:AMPASSGMPIMPD
2. : 222
2IMPAMPSXMPAMPADPGMPGDPGTPATPATPGTP
Adenine phosphoribosyl transferaseAPRT) - (Hypoxanthine-guanine phosphoribosyl transferaseHGPRT) (Adenosine kinase)
()(1) PRPPPRPPPPiAPRTHGPRTAPRT
+1-+Pi(2) 1-, +ATP+ADP
------. 1. (.) 2. (.)
: (,)Lesch-Nyhan -,-----X:
() AMPGMPXMPAMPSIMP
() ()NADPH+H+NADP+ +H2OdNDPNDP
NDPdNDPNADP+NADPH+H+-(SH)2,Mg2+(FAD)
NDPdNDPADPdADPGDPdGDPUDPdUDPCDPdCDPTDPdTDP
dNDP+ATPdNTP+ADPdCDP+ATPdCTP+ADPdUDP+ATPdUTP+ADPdGDP+ATPdGTP+ADPdADP+ATPdATP +ADPdTTP?dNDPdNMP+Pi
, . , ()
1. :8-6-
AMPIGMPGX
() 3 (1) (2) 1-1- 5-5- (3)
PiNH3PiNH3
1-
NADP+NH3Pi1-NH3
0.12-0.36mmol/L : 0.27mmol/L:0.21mmol/L , 0.48mmol/L(8mg%), , (,
PRPP
CO2
1. 1 CO2
(2)
CO26 UMP
UMP
(3)
UMP
(4) TMP
III()()N-UMP()(CPS-I)(CPS-II)
() 1. (1) ----6HCO3_+Gln
+Asp
(OMP)(UMP)
ATP(2) (CTP)UDPUMPADPUTPGln, ATP Glu, ADP+Pi ATPADPCTP
dCMPdUDPPiNH3dUMPdTMPATPdTDPADPdTTPATPADPdTMP(3) (dTMPTMP)
(5) :ATP--- PRPP---
2 ---4A:CPS UMPB:(CAT) UMPCTPC:OPRT ADPGDPD:CTP(CTPS)CTP CTP,CTPCTP
2.
1 +PRPP UMP + Ppi
2
+1- +Pi+ATP Mg2+ UMP + ADP
2. ATP+CO2+GlnPRPPPRPPATP+ 5'-OMPUMPUTPCTP31CPS-II23PRPPAsp
() +PRPP+PPi+ATPUMP+ADP,TK
. 21R1132R21R13R1C222R2R14R15NADPH
1. 2. ,3. 2() 4. ,1. 5'-P -R2. IMP3. IMPAMPGMP1. 5'-P-R2. UMP3. UMP, CTP, dTMP
5'-P-RPRPPIMPdAMPGMPdGMPAMPdADPGDPdGDPADPdATPGTPdGTPATPUMPCMPdUMPUDPCDPdUDPUTPCTPdUTPdTMPdCMPdTDPdCDPdTTPdCTPCO2+GlnH2N-CO-POMPdCMP
. -----
1 PRPP x- HGPRT Lesch-Nyhan HGPRT x- ,, B, (ADA) (PNP) APRT 28- 2
() :5-
NH3NADP+H2OCO2+NH3H2N-CH2-CH2-COOH-
NADP+CO2+NH3--H2O
-
? A. B. C. D. E.
2. 5-A. DNAB. C. D. E.
3. A. B. C. D. E.
4. A. B. 6-C. 1-D. 1,6-E. 5-
5. A. B. C. D. E.
6. , ?A. B. C. D. E.
7. -CMPAMPTMPUMPIMP
, ?GTP-
9. PRPP, A. R-5-PPRPPB. C. PRPPD. IMPAMPE. IMPGMP
10. A. 5-B. FH4C. D. E.
11. The main tissue of de nove synthesis of purine nucleotide in vivo isA. thymus glandB. villous coat of small intestineC. liverD. spleenE. marrow
12. The main end product of purine nucleotide katabolic metabolism in human body isA. ureaB. creatineC. CreatinineD. uric acidE. -alanine
13. The methyl of thymine come fromN10-CHO FH4N5,N10=CH-FH4N5,N10-CH2-FH4N5-CH3FH4N5-CH=NHFH4
14. 6-mercapto-purine nucleotide doesnt suppressA. IMPAMPB. IMPGMPC. PRPP amide transferaseD. Purine phosphoribosyltransferaseE. Pyrimidine phosphoribosyltransferase
15. A B CO2C D E
16. PRPPA B C D NMPNDPNTP
17. A B C D
18. A B C
19. The compound which can produce feedback suppression of purine nucleotide synthesis is A IMPB AMPC GMPD uric acid
20. Which compound produce uric acid as its decomposed metabolism end product ?A AMPB UMPC IMPD TMP