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: S099009
99 10 01 100 09 30
: S099009
------------------------------------------------------ 1
------------------------------------------------------------------ 2
------------------------------------------------------------------------ 3
1. --------------------------------------------------------------------------- 3
2. --------------------------------------------------------------------------- 3
3. --------------------------------------------------------------------------- 4
4. --------------------------------------------------- 4
--------------------------------------------------------------------- 5
1. --------------------------------------------------------------------------- 5
2. ------------------------------------------------------------------------ 5
3. ------------------------------------------ 7
4. --------------------------------- 8
5. ------------------------------- 12
6. ------------------------- 14
7. ------- 16
8. (2.0 kg) ---------------------- 18
---------------------------------------------------------------------- 19
: S099009
1 ------------- 7
2YP-100817AYP-100817B --------------------- 9
3YP-100817A ----------- 10
4YP-100817B ----------- 12
5YP-101019 -
-----------------------------------------------------------------------------------------14
6 ------------------------------------ 15
7YP-101019
--------------------------------------------------------------------------------- 16
8YP-101019
------------------------------------------------------------------ 18
: S099009
1 ------------------------------------- 7
2 ------------------------------------------------------- 8
3 ---------------------------------------------- 8
4YP-100817A ----------------------------- 10
5YP-100817A() ------------------- 10
6YP-100817B ----------------------------- 11
7YP-100817B() ------------------- 11
8YP-101019 ------------------------------------- 12
9YP-101019 ---------------------------- 13
10YP-101019 --------------- 13
11 -------------------------------------- 14
12YP-101019 ------ 15
13YP-101019()
------------------------------------------------------------------------------------ 16
14YP-101019
() ------------------------------------------------------------------ 17
15YP-110105 ------------------------------------ 18
: S099009 : 3
()
1.
(Androdia cinnamomea)
(Cinnamomum kanehirai)
(YUNG PENG BIOTECHNOLOGY. CO., LTD)
(biomass)
2.
/
98
(translational research)
: S099009 : 4
3.
2009
4.
99 100 10 11 12 1 2 3 4 5 6 7 8 9
1
2
3
4
5
6 (2.5 Kg)
4
1 2
3 6
: S099009 : 5
1.
antcin Kantcin Czhankuic acid Czhankuic acid Adehydrosulphurenic
acid dehydroeburicoic acid YP-
100817AYP-100817BYP-101019 YP-110105
(TW 098104772US 12/538,549TW 098107047 US 12/552,115)
2.
2010 08 17 YP-100817A 3 kg 2010 08 17 YP-100817B 3 kg 2010 10 19 YP-101019 2.5 kg 2011 01 05 YP-110105 2 kg
TW 098104772
US 12/538,549 TW 098107047
US 12/552,115
: S099009 : 6
O
HO OHHO
COOH
H
H
H
OH
O
O
COOH
H
H
H
antcin K antcin C
COOH
O
O
HO
OH
H
H
H
COOH
O
O
OH
H
H
zhankuic acid C zhankuic acid A
HO
HOOC
OH
H
H HO
HOOC
H
H
dehydrosulphurenic acid dehydroeburicoic acid
: S099009 : 7
3.
(ergostane)
(lanostane) 20.4%
1 antcin K ( 1a 1b)
antcin C ( 2a 2b)zhankuic acid C ( 3a 3b) zhankuic acid A
( 5a 5b) dehydrosulphurenic acid (
4) dehydroeburicoic acid ( 6) 1 5
89.9% 92.17%
1
1
(min) (%) (%)
antcin K 1a 1b 5.783 5.929
4.12 7.55
11.87 19.84
antcin C 2a 2b 22.703 24.741
5.86 5.66
4.53 4.31
zhankuic acid C 3a 3b 25.348 26.512
5.04 6.78
3.89 4.60
dehydrosulphurenic acid 4 39.849 16.41 11.95
zhankuic acid A 5a 5b 46.025 46.721
15.94 12.70
11.88 9.72
dehydroeburicoic acid 6 79.119 9.84 9.58 10.1 7.83 100.00 100.00
Minutes
0 10 20 30 40 50 60 70 80 90 100
mA
U
0
10
20
30
40
1: 254 nm, 8 nmAC-FEA-2-0106 \AC-FEA-2-0106
1a
1b
2a 2b 3b
3a
4 5a
5b 6
: S099009 : 8
4.
2010 08 17
2 3 YP-100817A 3
kg YP-100817B 3 kg YP-100817B
dehydrosulphurenic acid
() dehydroeburicoic acid (YP01)
2
( YP-100817A YP-100817B)
3
( YP-100817A YP-100817B)
: S099009 : 9
2 YP-
100817A 3 22.67%22.50% 23.16%
YP-100817B 2 24.66% 22.80%
YP-100817A YP-100817B
2 YP-100817A YP-100817B
(g) (%)
(g)
(mL)
YP-100817-A ( 1) 25.14 250 4.14 1.11 0.45 5.70 16.47 4.42 1.79 22.67
YP-100817-A ( 2) 25.08 250 4.16 1.13 0.39 5.68 16.60 4.50 1.40 22.50
YP-100817-A ( 3) 25.00 250 4.20 1.22 0.37 5.79 16.80 4.88 1.48 23.16
YP-100817-B ( 1) 25.10 250 4.61 1.08 0.50 6.19 18.37 4.30 1.99 24.66
YP-100817-B ( 2) 25.04 250 4.23 1.13 0.35 5.71 16.90 4.50 1.40 22.80
( YP-100817A YP-100817B)
YP-100817A YP-100817B
YP-
100817A 54.06% 4 5
3 YP-100817A antcin Kantcin C
zhankuic acid C zhankuic acid A
dehydrosulphurenic acid dehydroeburicoic acid
3
: S099009 : 10
4 YP-100817A
5 YP-100817A ()
3 YP-100817A
(min) (%) (%)
antcin K 1a 1b 5.692 5.824
10.21 13.37
23.51 31.63
antcin C 2a 2b 22.305 24.348
7.75 5.19
3.60 2.58
zhankuic acid C 3a 3b 24.961 26.122
6.57 8.00
3.29 3.83
dehydrosulphurenic acid 4 39.595 7.57 3.87
zhankuic acid A 5a 5b 45.786 46.475
4.15 2.78
2.22 1.53
dehydroeburicoic acid 6 78.763 9.38 6.69 25.03 17.25 100.00 100.00
Minutes
10 20 30 40 50 60 70 80 90 100
mA
U
0
20
40
60
1: 254 nm, 8 nmCLOUD-FEA-0106 \CLOUD-FEA-0106
1a
1b
2a 2b
3a 3b 5a 5b
4
6
Minutes
0 10 20 30 40 50 60 70 80 90 100
mA
U
0
5
10
15
1: 254 nm, 8 nmCLOUD-FEA-0106 \CLOUD-FEA-0106
1a
1b
2a
2b
3a 3b
5a
5b
4
6
: S099009 : 11
YP-100817B 42.20%
6 7 4 YP-100817B antcin K
antcin Czhankuic acid C zhankuic acid A
dehydrosulphurenic acid dehydroeburicoic acid
4
6 YP-100817B
7 YP-100817B ()
Minutes
0 10 20 30 40 50 60 70 80 90 100
mA
U
-10
0
10
20
30
1: 254 nm, 8 nmYP-FEA-0106 \YP-FEA-0106
1a
1b
2a 2b 3a
3b 5a 5b
4
6
Minutes
0 10 20 30 40 50 60 70 80 90 100
mA
U
0.0
2.5
5.0
7.5
10.0
12.5
15.0
1: 254 nm, 8 nmYP-FEA-0106 \YP-FEA-01061a 1b
2a 2b
3a 3b
5a 5b
4 6
: S099009 : 12
4 YP-100817B
(min) (%) (%)
antcin K 1a 1b 5.713 5.849
4.18 6.04
10.71 12.63
antcin C 2a 2b 22.583 24.655
1.79 1.29
1.08 0.71
zhankuic acid C 3a 3b 25.085 26.245
0.69 1.12
0.46 0.59
dehydrosulphurenic acid 4 39.606 11.51 6.90
zhankuic acid A 5a 5b 46.088 46.813
0.69 0.27
0.37 0.15
dehydroeburicoic acid 6 79.341 11.90 9.81 60.52 56.59 100.00 100.00
5.
2010 10 19
8 YP-101019 2.5 kg
8 YP-101019
YP-101019
9 25.10 g 1 cm2
34.46%
: S099009 : 13
9 YP-101019
YP-101019 56.55%
10 5 YP-101019
antcin Kantcin Czhankuic acid C zhankuic acid A
dehydrosulphurenic acid
dehydroeburicoic acid
5
10 YP-101019
Minutes
0 10 20 30 40 50 60 70 80 90 100
mA
U
0
5
10
15
20
25
1a
1b
2a 2b
3a 3b 5a
4 6
5b
: S099009 : 14
5 YP-101019
antcin K 1a 1b 6.490 6.797
8.58 11.80
16.49 21.93
antcin C 2a 2b 25.017 27.080
5.48 4.57
3.81 2.59
zhankuic acid C 3a 3b 27.732 28.901
4.83 5.53
3.29 3.56
dehydrosulphurenic acid 4 41.569 16.76 12.88
zhankuic acid A 5a 5b 47.452 48.121
4.54 3.26
3.26 2.33
dehydroeburicoic acid 6 79.220 13.23 12.12 21.42 17.74 100.00 100.00
6.
YP-101019
11
11
()
6 2
28.73% 28.27%
: S099009 : 15
6
(g) (%)
(g)
(mL)
YP-101019-FB-1 ()
10.20 500 1.90 0.81 0.22 2.93 18.63 7.94 2.16 28.73
YP-101019-FB-2 ()
10.08 500 1.90 0.75 0.20 2.85 18.85 7.44 1.98 28.27
YP-101019 ()
58.08% 12 13 7
antcin Kantcin Czhankuic acid C zhankuic acid A
dehydrosulphurenic acid
dehydroeburicoic acid
7
12 YP-101019
Minutes
0 10 20 30 40 50 60 70 80 90 100
mA
U
0
20
40
60
801: 254 nm, 8 nmYPFB-FEA-0106-1 \YPFB-FEA-0106-1
1a
1b
2a 2b
3a 3b 5a 5b 4
6
: S099009 : 16
13 YP-101019
()
7 YP-101019
(min) (%) (%)
antcin K 1a 1b 6.341 6.636
13.34 16.27
22.76 27.25
antcin C 2a 2b 24.024 26.002
9.71 7.19
6.23 4.01
zhankuic acid C 3a 3b 26.661 27.792
5.89 7.18
3.76 4.33
dehydrosulphurenic acid 4 40.538 2.48 1.73
zhankuic acid A 5a 5b 46.374 47.043
5.44 3.62
3.66 2.53
dehydroeburicoic acid 6 78.676 5.99 5.26 22.89 18.48 100.00 100.00
7.
YP-101019 250 g
57.18g
22.87%
Minutes
0 10 20 30 40 50 60 70 80 90 100
mA
U
0
5
10
15
20
25
1: 254 nm, 8 nmYPFB-FEA-0106-1 \YPFB-FEA-0106-1
1a
1b
2a
2b 3a
3b 5a
5b
4
6
: S099009 : 17
1 g
1 g 54.06% 14
8 YP-101019
antcin Kantcin Czhankuic acid C zhankuic acid A
dehydrosulphurenic acid
dehydroeburicoic acid
8
14 YP-101019
Minutes
0 10 20 30 40 50 60 70 80 90 100
mA
U
0
10
20
30
40
50
1a
1b
2a 2b
3a 3b 5a 5b
4 6
: S099009 : 18
8 YP-101019
antcin K 1a 1b 5.952 6.111
9.60 13.05
22.98 29.46
antcin C 2a 2b 24.032 26.170
6.49 5.03
3.46 2.39
zhankuic acid C 3a 3b 26.843 28.049
5.25 6.01
2.79 3.04
dehydrosulphurenic acid 4 41.334 10.49 6.35
zhankuic acid A 5a 5b 47.312 47.993
4.58 3.15
2.60 1.89
dehydroeburicoic acid 6 79.248 10.68 8.03 25.67 17.01 100.00 100.00
8. (2.0 kg)
2011 01 05
15 YP-110105 2.0 kg
15 YP-110105
YP-110105 2.0 kg
435.78 g
21.79%
: S099009 : 19
1 g
(TW 098104772US
12/538,549TW 098107047 US 12/552,115)
1.
2.