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17ο Πανελλήνιο Καρδιολογικό Συνέδριο ΚΕΒΕ
Θεσσαλονίκη, 24-26 Μαϊου 2018
Στρογγυλό τραπέζι: Κλινικά προβλήματα στην πνευμονική υπέρταση
Φωτεινή Α. ΛαζαρίδουΕπιμελήτρια Α’Γενικό Νοσοκομείο ‘ Αγιος Παύλος’ , Θεσσαλονίκη
Right heart
RV: Triangular shape in frontal plane RV: crescent shape in the transversal plane
RV The muscle mass of the RV is about one-sixth that of the LV.
The RV pumps the same stroke volume as does the LV, but with about 25% of the stroke work due to the low resistance of the pulmonary vasculature.
Longitudinal shortening is a greater and more important contributor to RV stroke volume than is circumferential shortening.
The RV is linked to the LV in several ways: by a shared wall (via the septum), by reciprocally encircling epicardial fibers, by sharing the pericardial space, and by the attachment of RV free wall to the anterior and posterior septum.
Arch Cardiovasc Imaging. 2015 November; 3(4):e35717.
RV contraction physiology
Regarding RV contraction physiology, three individual components lead to normal contraction:
I. the inward motion of the free wall;
II. longitudinal shortening; and
III. the traction of the free wall, secondary to LV contraction .
In consequence, RV contraction relies mostly on LV-RV interactionand longitudinal deformation.
Difficulties in RV assessment RV does not have a symmetrical, well-defined shape and does not lend itself
to simplified formulas.
the position of the RV directly behind the sternum can impair adequate visualization of all segments of the RV.
visualization of the RV inflow-outflow tract is difficult to perform on echocardiograms.
there are no clear landmarks to address standardization of views.
Different angulations can result in very different measurements.
Clinical Cardiology. 2017;40:542–548.
RV has three wall segments: anterior wall, inferior wall and lateral wall
Standard RV views by echo
RV inferior wall;
inflow and apical RV, RV lateral wall, interventricular septum, and s/p leaflets
RV crescent shape, eccentricity index, IVS septum motion;
RV anterior wall prox part of RVOT
anterior & inferior RV walls,RV inflow tracttwo leaflets
basal part of RV anterior wall, RVOT,two leaflets , pulmonary valve PA
Kardiologia Polska 2016; 74, 6: 307–322
Qualitative assessment Eccentricity index >1 at end diastole is highly suggestive for RV volume overload, and
at end systole or during the whole cardiac cycle — for RV pressure overload
Visual assessment of the RV size may be performed from the apical 4C view : the area of normal RV should not exceed two-thirds of the LV (aprox).
Evaluation of the RV walls’ structure and motion (aneurysm, hypo/a-kinesia)
Surkova, 2016
RV focused view
Avoid underestimation• Rotate the transducer until the maximal plane is obtainedAvoid overestimation• Ensure that the RV is not foreshortened and that the LVOT is not opened up (avoid the apical 5-chamber view)
J. Am. Soc. Echocardiogr. 23 (7) (2010) 685–713.J. Am. Soc. Echocardiogr. 28 (1) (2015) 1–39.
RVOT size
The PSAX distal RVOT diameter, just proximal to the pulmonary annulus, is the most reproducible and should be generally used
J. Am. Soc. Echocardiogr. 23 (7) (2010) 685–713.J. Am. Soc. Echocardiogr. 28 (1) (2015) 1–39.
RV wall thickness
RV wall thickness important in pts with RV pressure overload, biventricular hypertrophic cardiomyopathies, and storage diseases.
It is recommended to use the zoomed image of the RV free wall
Transoesophageal echo Some segments of the RV, such as the RVOT contributing up to 25– 30% of the RV volume, could be
overlooked when using standard transthoracic 2DE (TTE)
Transesophageal echocardiography (TEE) with the midesophageal inflow–outflow view can evaluate RVOT .
TEE is essential in the peri- and intraoperative settings and allows continuous monitoring of right heart function during noncardiac surgery
In addition to standard TEE views, five additional deep transgastric views have been suggested to provide additional information on the RV inflow tract, free wall, outflow tract and the right-sided valves .
International Journal of Cardiology 214 (2016) 54–69
3D echo 3D echo limitation: poor lateral resolution in right ventricular cavity dilatation
3DE tends to underestimate RV volumes compared CMR
Overall, women have smaller 3D echocardiographic RV volumes, despite indexing to BSA, and higher EFs.
Also, older age is associated with smaller volumes (expected decrements of 5 mL/decade for EDV and 3 mL/decade for ESV) and higher EF (an expected increment of 1% per decade)
Kardiologia Polska 2016; 74, 6: 307–322;J Am Soc Echocardiogr, 2015; 28:1–39.e14.
RV shape- 3DE –RV regional curvature
The curvature of the RV inflow tract was a more robust predictor of death than RVEF, RV volumes, or other regional curvature indices
Surkova et al; Kardiologia Polska 2016Addetia et al ; JASE 2017Surkova et al; International Journal of Cardiology 214 (2016)
RV systolic function
RV systolic function is a reflection of contractility, afterload, and preload.
RV performance is also influenced by heart rhythm, synchrony of ventricular contraction, RV force interval relationship, and ventricular interdependence.
J Cardiovasc Ultrasound 2016;24(3):183-190
Circulation 2008;117:1436-48.
RV systolic function assessment“RV systolic function should be assessed by at least one or combination of the following: FAC, S’ Wave, TAPSE or RIMP.” –ASE JASE 2015
RV function The assessment of RVEF using
2DE is no longer recommended due to its inaccuracy
a number of surrogate echocardiographic parameters :RV fractional area change, tricuspid annular plane systolic excursion, peak S wave velocity of the lateral tricuspid annulus by tissue Doppler imaging [TDI], and RV myocardial performance index) have been proposed for clinical use .
J Am Soc Echocardiogr, 2015; 28:1–39.e14
Dp/dt
Fractional area change
FACAdvantages of FAC for RV Systolic Function Established prognostic value RV FAC is found to be an independent predictor of:
Heart Failure Sudden Death Stroke Mortality in patients after pulmonary embolectomy
Longitudinal and radial components of RV contraction Correlates with CMR
Limitations of FAC Neglects contribution of RVOT to overall RV function Limited inter-observer reproducibility
TAPSE and S’ Wave limitations
The 3 main limitations are:
Angle dependency
Load dependency
Do not fully represent RV global function and therefore may over or underestimate global RV function
This study shows that the TAPSE(longitudinal RV fiber shortening) vs PASP (force generated by the RV ) relationship is shifted downward in nonsurvivors with a similar distribution in HFrEF and HFpEF, and their ratio improves prognostic resolution.
RV mechanics –RV longitudinal strain Being extremely load dependent, RVEF is a
partial indicator of the RV systolic function RV longitudinal strain : either TDI or 2DSTE
techniques . The correlation between Doppler-derived and
2DSTE-derived RV longitudinal strain appears to be moderate
abnormality threshold for the RV free-wall longitudinal strain : –20%
The term “global” RV longitudinal strain is commonly used for average values calculated from three segments of the RV free wall and three segments of the IVS from apical four-chamber view, even though the contribution of other walls and RVOT is neglected
relatively low repeatability of regional RV strain represents a relative weakness of both echocardiographic techniques limiting their routine use for an individual patient follow-up of segmental function
Kardiologia Polska 2016; 74, 6: 507–522
RV tissue characterisation RV freewall strain may be an accurate echocardiographic marker of the extent
of RV myocardial fibrosis correlating with patients’ functional capacity (end stage HF pts)
JACC Cardiovasc. Imaging 8 (5) (2015) 514–522.
RV dyssynchrony
a cutoff value of 18 ms was introduced as a criterion for RV dyssynchrony
J Am Coll Cardiol Cardiovasc Imaging, 2015; 8: 642–652Kardiologia Polska 2016; 74, 6: 507–522.
RV evaluation
• TAPSE, RVFAC, and RVEF can change with a change in load without any true change in myocardial contractility and therefore do not reflect innate myocardial function. • RIMP can be falsely low in conditions associated with elevated RA pressures, which will shorten the IVRT.
Clinical Cardiology. 2017;40:542–548.J Am Soc Echocardiogr 2015;28:1-39.
RV diastolic function
Grades of RV diastolic function
Impaired relaxation E/A<0.8
Pseudonormal filling 0.8< E/A <2.1 and E/E’ >6
Restrictive filling E/A >2.1 and DcT<120msRudski et al JASE 2010Kardiologia Polska 2016; 74, 6: 507–522;
E/e’ values > 6 have a sensitivity of 79% and a specificity of 73% for the detection
of right atrial pressure > 10 mm Hg.
During acute RV pressure overload, RV diastolic function is not affected
The assessment of RV diastolic function includes: evaluation of the RV inflow by pulsed wave Doppler sampling at the tips of the TV leaflets; measuring the TDI velocities of the Tr annulus at RV free wall; evaluation of right atrial, IVC, and hepatic vein size and function
Right Atrium • Smooth walled myocardium, except for appendage
• Three inlets: SVC, IVC, and coronary sinus • Visible fetal remnants: Eustachian valve / Chiari network • Normal pressure ranges from 0-5 mmHg
The right atrium not only acts as a conduit to fill the RV passively but also optimizes RV filling actively during late diastole.
Anatomical deformities of the spine and chest can alter the right atrium and project larger dimensions.
Echo : 4C apical views are used to evaluate the RA and the subcostal views to evaluate the IVC
J Cardiovasc Ultrasound 2016;24(3):183-190
RA dimensions Maximal long axis distance
Abnormal >5.3cm
Mid-RA minor distance:
Abnormal >4.4cm
RA area*
Abnormal >18cm2
RA volume index
Abnormal :Women >33ml/m2
Abnormal: Men >39ml/m2
*In patients with primary pulmonary hypertension right atrial area is a predictor of transplantation or mortality. J Am Soc Echocardiogr 2010;23:685-713;
RV pressures
Rudski et al JASE 2010
PA pressures
Right atrial pressure
Elevated right atrial pressure On the left, a normal waveform pattern is demonstrated showing S/D >1
One the right, an abnormal waveform pattern is demonstrated showing S/D <1 :
Indication of elevated RAP
https://www.cardioserv.net/hepatic_vein_right_heart/
Hepatic vein systolic filling fracture
Elevated PASP – RVOT AccT
IJC Heart & Vasculature 12 (2016) 45–51
Elevated PASP : Sm, SmVTI
Sm velocity < 12 cm/s and SmVTI < 2.5 are highly suggestive of elevated PASP
Elevated PASPrIVRT
rIVRT of >75 ms reliably predicts pulmonary hypertension while an rIVRT of <40 ms has a high negative predictive value for pulmonary hypertension
Pulmonary pressure : echo assessment
S/D ratio Calculation of the systolic to diastolic
duration ratio (S/D ratio) is another means of assessing RV adaptation.
An increase in the S/D ratio reflects a certain degree of RV dysfunction, with longer systole and abnormal cardiac performance; it is one of the strongest independent predictors of death in a population with Eisenmenger’s syndrome and independently predicts lung transplantation and death in paediatricPAH (cut-off1.4)
Screening for pulmonary hypertension Although not diagnostic of pulmonary hypertension, a number >35
mm Hg warranted further studies.
An incorrect estimation of RA pressure caused half of the overestimation of pulmonary pressures in one study comparing echocardiographic estimates of pulmonary artery systolic pressure to right-heart catheterization measurements.
Among patients with chronic thromboembolic pulmonary hypertension RV basal free wall strain appeared to show the best correlation with mean pulmonary artery pressure on right-heart catheterization.
DUTTA AND ARONOW , Clinical Cardiology. 2017;40:542–548.
Int Heart J. 2015;56:100–104.
Pre- vs Postcapillary PH
J Am Soc Echocardiogr 2015;28:108-15
60/60 sign for acute pulmonary embolism PASP <60 mmHg
PAT (pulmonary acceleration time)<60ms
McConnell’s Sign or Acute regional RV Dysfunction (PE)
akinesia of the mid free wall
Echocardiographic parameters of RV failure
Paul Cézanne:
“Il faut réfléchir, l'oeil ne suffit pas, il faut la réflexion ”
“Το μάτι δεν είναι αρκετό. Είναι απαραίτητη και η σκέψη”
Montagne Sainte-Victoire - Paul Cézanne
ευχαριστώ
Montagne Sainte-Victoire - Paul Cézanne