paracetamol Paracetamol (acetaminophen)

paracetamol (osteoarthritis) (NSAIDs) paracetamol paracetamol

paracetamol paracetamol (hepatotoxicity) paracetamol (acute liver failure) 4 (U.S. Food and Drug Administration; USFDA) .. 1998-2003 paracetamol 48 5 paracetamol 56,000 26,000 458

toxic metabolite NAPQI 650-1,000 4-6 4 5 paracetamol USFDA paracetamol 650 2,600 paracetamol paracetamol

USFDA paracetamol

paracetamol

paracetamol (toxic metabolite) paracetamol 2.5 glutathione toxic metabolite NAPQI

paracetamol

(flu-like symptoms) paracetamol

paracetamol paracetamol paracetamol narcotics paracetamol

paracetamol paracetamol

paracetamol

(enzyme inducer) cytochrome P450 2E1 paracetamol paracetamol cytochrome P450 2E1 paracetamol toxic metabolite NAPQI enzyme inducer cytochrome P450 2E1 phenytoin, carbamazepine, rifampin

paracetamol USFDA

paracetamol paracetamol paracetamol paracetamol

USFDA paracetamol 325 1 paracetamol

Paracetamol 5

1. Drug Safety and Risk Management Advisory Committee. Acetaminophen Overdose and Liver Injury Background and Options for Reducing Injury. Available at http://www.fda.gov/downloads/AdvisoryCommittees/CommitteesMeetingMaterials/Drugs/DrugSafetyandRiskManagementAdvisoryCommittee/UCM164897.pdf. Accessed 1 June 2010.

2. Acetaminophen. In: DRUGDEX Evaluations. [Online]. 2010 Jun 1. Available from: MICROMEDEX Healthcare Series; 2010. [cited 2010 Jun 1].

3. Navarro, VJ. and Senior, JR. Drug-Related Hepatotoxicity. N Engl J Med. 2006; 354: 731-9.

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