8/10/2019 Aging GEY3601 Spring 15 (1).pdf

1/18

Aging.

What is it?

A number? A disease? What is aging?

8/10/2019 Aging GEY3601 Spring 15 (1).pdf

2/18

AGING

Edward G. Lakata, MDThe Reality of Aging Viewed from the Arterial Wall

NIH/NIA Intramural Research Program/Nathan W. Shock Laboratories/Laboratory of CardiovascularScience

Lakata, E. G. (2013). The reality of aging viewed from the arterial wall. Paper presented at the GerontologicalSociety of America, New Orleans, LA.

A shift in our reality!

8/10/2019 Aging GEY3601 Spring 15 (1).pdf

3/18

What is reality?

8/10/2019 Aging GEY3601 Spring 15 (1).pdf

4/18

Life is order

8/10/2019 Aging GEY3601 Spring 15 (1).pdf

5/18

So what is aging?

Perhaps is only a progressive disorder of an

interaction between DNA and the

environment over time?

Decrease: order, complexity, clock thythmicity,

molecular density

Increase in entropy, post-translational

modifications/disordered molecular interactions

8/10/2019 Aging GEY3601 Spring 15 (1).pdf

6/18

Whats

happening?

8/10/2019 Aging GEY3601 Spring 15 (1).pdf

7/18

Developmental changes most evident in

later stages of life lead to:decreasing ability of the body to maintain internal balance

Internal balance of the body (normal body temperature, blood

sugar, blood pressure etc.) is referred to as___________

8/10/2019 Aging GEY3601 Spring 15 (1).pdf

8/18

What is meant by physical aging?

Physical Aging - aka Biological Aging:

Aging in the physical structures and functioning of the body that

affects the bodys ability to survive

Developmental stages1. _______________ (development before birth)

2. _______________(child to adult)

3. Aging

8/10/2019 Aging GEY3601 Spring 15 (1).pdf

9/18

Other types of aging:

Chronological Aging Cosmetic Aging

Social Aging

Psychological Aging

Economic Aging

8/10/2019 Aging GEY3601 Spring 15 (1).pdf

10/18

People become more diverseas they grow older

THEY AGE DIFFERENTLY

Factors that may contribute to people becoming

more diverse:

Heredity Diet

Exercise

Past illnesses

Environment

Education

Occupation

8/10/2019 Aging GEY3601 Spring 15 (1).pdf

11/18

0%

50%

100%

150%

200%

250%

AllA

ges

Under25

Over65

Over85

Percent increase of the US

population: 1960-1990

http://www.prb.org/Articles/2011/agingpopulationclocks.aspx

8/10/2019 Aging GEY3601 Spring 15 (1).pdf

12/18

How do you see yourself at 75 years of age?

The top 7 causes of death in USA between 2006-2010 and 2011

preliminary data are:

1. Diseases of the heart

2. Malignant neoplasms

3. Chronic lower respiratory diseases4. Cerebrovascular diseases

5. Accidents (unintentional injuries)

6. Alzheimers disease

7. Diabetes mellitus

8/10/2019 Aging GEY3601 Spring 15 (1).pdf

13/18

Aging is nota disease, although it increases therisk of disease and death

Medical advancements longer___________

New research findings, health promotion/education

disease prevention longer___________

8/10/2019 Aging GEY3601 Spring 15 (1).pdf

14/18

Important Terms

Gerontology

Geriatrics

8/10/2019 Aging GEY3601 Spring 15 (1).pdf

15/18

More terms

Life Span

Life expectancy

E.g., born in 1999females 79.4 yrs., males 73.9 yrs.

Healthy life expectancy

8/10/2019 Aging GEY3601 Spring 15 (1).pdf

16/18

Check out the

http://youtu.be/jc4yK0zZ-cQ

What is aging?

http://vimeo.com/74033442

http://youtu.be/jc4yK0zZ-cQhttp://vimeo.com/74033442http://vimeo.com/74033442http://vimeo.com/74033442http://youtu.be/jc4yK0zZ-cQ

8/10/2019 Aging GEY3601 Spring 15 (1).pdf

17/18

Take home message

Aging is an inevitable part of living

Older people are more likely to live with disease

and disability. HOWEVER, old age does not mean

disease and disability!

8/10/2019 Aging GEY3601 Spring 15 (1).pdf

18/18

Thank you!