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Curriculum Vitae

اسقائی مریم

پزشکی شناسی ویروس تخصصی دکتری

دانشیار :علمی رتبه

11230718120:تماس تلفن

esghaei.m@iums.ac.ir, maryam.esghaei@gmail..com

Education:

Ph.D degree: Medical Virology Tehran University of Medical Sciences, 2006-2012

Master degree: Medical Virology, Tehran University of Medical Sciences, 1998- 2001 Bachelor

: Microbiology , Tehran University ,1992-1996

Thesis:

1-Title of thesis for PhD degree:

Cloning and expression of M2 gene of influenza virus type A in eukaryotic cells.

2- Title of thesis for MS degree: Investigation of the prevalence of HSV by PCR in CSF of patients with encephalaitis in Tehran

1999-2000

Other trainings:

1- The lecture course “Clinical and Applied Virology, 2010- 2011. Department of virology, HAARTMAN Institute

University of Helsinki, Finland

2- - Medical Virology Methods (The methods include virus culture, polymerase chain reaction, microarray,

neutralization test, and plaque reduction neutralization test) on December 22, 2010- until June 21, 2011.National

Influenza Center, Helsinki, Finland.

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Journal Publications:

1. Eshaghi M, Bibalan MH, Rohani M, Esghaei M, Douraghi M, Talebi M, Pourshafie MR. Bifidobacterium

obtained from mother's milk and their infant stool; A comparative genotyping and antibacterial analysis.

Microbial Pathogenesis. 2017 Oct 1;111:94-8.

2. Keyvani H, Niya MH, Esghaei M*, Bokharaei-Salim F, Monavari SH. Presence of human herpesvirus 8 (HHV-8)

DNA sequences in patients with lymphoproliferative diseases and chronic blood disorders. Microbial

Pathogenesis. 2017 Oct 1;111:431-4.

3. Tavakoli A, Niya, MHadiK , Keshavarz M, Ghaffari H, Esghaei M*, Mechanisms Involved in Immuno

pathogenesis of influenza virus infection. Journal of Fasa University of Medical Sciences 7 (2), 162-171

4. Bibalan MH, Eshaghi M, Rohani M, Esghaei M, Darban-Sarokhalil D, Pourshafie MR, Talebi M. Isolates of

Lactobacillus plantarum and L. reuteri display greater antiproliferative and antipathogenic activity than

other Lactobacillus isolates. Journal of Medical microbiology. 2017 Sep 13.

5. Dehghani‐Dehej F, Sarvari J, Esghaei M, Hosseini SY, Garshasbi S, Kalantari S, Monavari SH, Fakhim A,

Keyvani H, Bokharaei‐Salim F. Presence of Different Hepatitis C Virus Genotypes in Plasma and Peripheral

Blood Mononuclear Cell Samples of Iranian Patients with HIV Infection. Journal of Medical Virology. 2017

Aug 28.

6. Vahabpour R, Bokharaei-Salim F, Kalantari S, Garshasbi S, Monavari SH, Esghaei M, Memarnejadian A,

Fakhim A, Keyvani H. HIV-1 genetic diversity and transmitted drug resistance frequency among Iranian

treatment-naive, sexually infected individuals. Archives of Virology. 2017 Jun 1;162(6):1477-85.

7. Esghaei M *, Khodayari A.h. Study of Refinement of Groundwaters of Viral Contaminants Using Clay. Journal

of Water and Sustainable Development. 2017, Vol.4, No.1, Pages 31-36. DOI: 10.22067/jwsd.v4i1.52220

8. Pouya Moradi, Hossein Keyvani, Seyed-Ali Javad Mousavi, MHKarbalaie Niya, Maryam Esghaei *:

Investigation of viral infection in idiopathic pulmonary fibrosis among Iranian patients in Tehran; Microbial

Pathogenesis, March 2017, Pages 171–174

9. Farah Bokharaei-Salim, Mostafa Salehi-Vaziri, Farzin Sadeghi, Khadijeh Khanaliha, Maryam Esghaei: Genetic

Variation in Interleukin-28B and Response to Peg-IFNα-2a/RBV Combination Therapy in Patients with

Hepatitis C Virus Infection; Jundishapur Journal of Microbiology: 2016/12

10. F Afsharzadeh, F Bokharaei-Salim, M Esghaei: The Presence of Autoantibodies to Cytoplasmic Rod and Ring

Particles in the Serum of Patients with Chronic Hepatitis C Virus Infection; Hepatitis Monthly, 2016

11. Khashayar Hesami-Zadeh, Hossein Keyvani, Farah Bokharaei-Salim, Maryam Esghaei*: Molecular

Epidemiology of Kaposi’s Sarcoma-Associated Herpes Virus, and Risk Factors in HIV-infected Patients in

Tehran, 2014. 06/2016;. DOI:10.5812/ircmj.32603

12. Mohammad Hadi Karbalaie Niya, Farah Bokharaei Salim, Ahmad Tavakoli, Maryam Esghaei, Hossein

Keyvani: Varicella zoster virus genotyping in chickenpox patient's clinical isolates from Iran. Future Virology

06/2016; DOI:10.2217/fvl-2016-0050

13. Samira Karimaei, Javad Sadeghi, Mahla Asadian, Maryam Esghaei, Mohammad Reza Pourshafie, Malihe

Talebi: Antibacterial potential and genetic profile of Enterococcus faecium strains isolated from human

normal flora. Microbial Pathogenesis 05/2016; 96. DOI:10.1016/j.micpath.2016.05.004

14. Mohammad-Navid Bastani, Farah Bokharaei-Salim, Hossein Keyvani, Maryam Esghaei, Seyed Hamidreza

Monavari, Mojtaba Ebrahimi, Saba Garshasebi, Shahin Fakhim: Prevalence of occult hepatitis C virus

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infection in Iranian patients with beta thalassemia major. Archives of Virology 04/2016;

DOI:10.1007/s00705-016-2862-3

15. Farah Bokharaei-Salim, Mostafa Salehi-Vaziri, Farzin Sadeghi, Maryam Esghaei, Seyed Hamidreza Monavari,

Seyed Moayed Alavian, Shahin Fakhim, Hossein Keyvani: The Association of Substitutions in the Hepatitis C

Virus Subtype 1b Core Gene and IL28B Polymorphisms With the Response to Peg-IFNα-2a/RBV Combination

Therapy in Azerbaijani Patients. Hepatitis Monthly 04/2016; In Press(In Press).

DOI:10.5812/hepatmon.35597

16. T. Narimani, M. Douraghi, P. Owlia, A. Rastegar, M. Esghaei, M. Nasr, M. Talebi: Heterogeneity in resistant

fecal Bacteroides fragilis groupcollected from healthy people. Microbial Pathogenesis 03/2016; 95.

DOI:10.1016/j.micpath.2016.02.017

17. Rouhollah Vahabpour, Mohammad Reza Aghasadeghi, Mostafa Salehi-Vaziri, Nasir Mohajel, Hossein

Keyvani, Maryam Nasimi, Maryam Esghaei, Seyed Hamidreza Monavari: Prevalence of Merkel Cell

Polyomavirus in Tehran: An Age-Specific Serological Study. 02/2016; . DOI:10.5812/ircmj.26097

18. Farah Bokharaei-Salim, Hossein Keyvani, Maryam Esghaei, Shohreh Zare-Karizi, Sahar-Sadat Dermenaki-

Farahani, Khashayar Hesami-Zadeh, Shahin Fakhim: Prevalence of occult hepatitis C virus infection in the

Iranian patients with human immunodeficiency virus infection. Journal of Medical Virology 01/2016;

DOI:10.1002/jmv.24474

19. Zahra Shabani, Maryam Esghaei, Hossein Keyvani, Fateme Shabani, Fateme Sarmadi, Hamidreza Mollaie,

Hamidreza Monavari: Relation between parvovirus B19 infection and fetal mortality and spontaneous

abortion. Medical journal of the Islamic Republic of Iran 04/2015; 29(197).

20. Ali Ahmadi, Farzaneh Khodaei, Maryam Esghaei, Gholamreza Irajian, Malihe Talebi: Differentiation of

Penicillin Susceptible and Nonsusceptible Streptococcus pneumoniae.

21. Farah Bokharaei Salim, Hossein Keyvani, Seyed Hamidreza Monavari, Maryam Esghaei: Distribution of

Hepatitis B Virus Genotypes in Azerbaijani Patients With Chronic Hepatitis B Infection. Hepatitis Monthly

12/2014; 14(12). DOI:10.5812/hepatmon.25105

22. Fatemeh Fotouhi, Behrokh Farahmand, Behnaz Heidarchi, Maryam Esghaei, Sima Rafati, Masoumeh,

Tavassoti Kheiri: In Vitro Evaluation of Influenza M2 and Leishmania major HSP70 (221-604) Chimer Protein.

Jundishapur Journal of Microbiology 09/2014; 7(9). DOI:10.5812/jjm.11812

23. Hossein Keyvani, Farah Bokharaei-Salim, Seyed Hamidreza Monavari, Maryam Esghaei, Mohssen Nassiri

Toosi, Shahin Fakhim, Zohreh Azita Sadigh, Seyed Moayed Alavian: Occult Hepatitis C Virus Infection in

Candidates for Liver Transplant With Cryptogenic Cirrhosis. Hepatitis Monthly 08/2013; 13(8).

DOI:10.5812/hepatmon.11290

24. M Esghaei, F Fotouhi, M Tavassoti-Kheiri, M Tabatabaian, Sh Shamsi-Shahrabadi, SHR Monavar: Preparation

of Plasmid DNA-Based Vaccine against Influenza A Subtypes; Iranian Journal of Virology, 2013/8/6.

25. Maryam Esghaei, Seyed Hamid Reza Monavari, Masoumeh Tavassoti-Kheiri, Mahmoud Shamsi-Shahrabadi,

Behnaz Heydarchi, Behrokh Farahmand, Maryam Saleh, Fatemeh Fotouhi: Expression of the influenza M2

protein in three different eukaryotic cell lines. Journal of virological methods 11/2011; 179(1).

DOI:10.1016/j.jviromet.2011.10.016

26. Seyed Hamidreza Monavari, Ali Kargar, Hamidreza Mollaie, Mehdi Fazlalipour, Hossein Keyvani, Maryam

Esghaei, Farah Bokharaei-Salim: Congenital rubella infection in neonatal cord blood samples of newborns in

hospitals affiliated to Tehran University of Medical Sciences.

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27. F Fotouhi, MT Kheiri, M Esghaei, B Heydarchi, B Farahmand, V Mazaheri: Expression of a chimerical pcDNA

encoding influenza virus M2 protein and HSP70 gene in eukaryotic cell lines. BMC proceedings 01/2011;

5(Suppl 1). DOI:10.1186/1753-6561-5-S1-P2

28. Seyed Hamidreza Monavari, Ali kargar moakhar,Maryam Esghaei. Congenital rubella infection in neonatal

cord blood samples of newborns in hospitals affiliated to Tehran University of Medical Sciences. Canadian

Journal on Medicine 2011;2(4):104-112.

29. Noor Mohamadian L ,Monavari H.R, Asghaei M. Prevalence of Conjunctivitis Infection by HSV-1 in Patients

Referring to Hospitals Affiliated to Iran University of Medical Sciences in 2009.Qom University of Medical

Sciences Journal. 2012; 05(3):45-49.

30. S.H. Monavari , A. Kargar Kheirabadi , M. Asghaie, M. Azizi. Serological Status of Rubella Virus in Cord Blood

Samples of Newborn in Hospitals Affiliated to Tehran University of Medical Sciences. Sci J Hamadan Univ

Med Sci 2012; 19 (1):16-21

31. S Nourbakhsh , H Tonkaboni, M Asghaee, et all. Detection of Herpes Virus Infection Frequency in Aseptic

Meningitis in Children Admitted to Rasoul-e-Akram & Mofid Hospitals. RJMS 2004, 11(42): 659-665

32. R.Seyedi Rashti ,M.Esghaei, T Mokhtari. Diagnosis and determination of the frequency of HSV by PCR in CSF

of patients with encephalaitis in Tehran 1999-2000. Iranian Journal of Infectious Diseases and Tropical

Medicne 2003; 8 (20):33-35

33. M.Mohraz, M.Esghaei, R.Nategh.Preliminary investigation of the prevalence of HSV by PCR. Iranian Journal

of Infectious Diseases and Tropical Medicne 2000; 4 (10)

Congress Presentations (Oral & Posters):

1. Maryam Esghaei; Farah Bokharaei-Salim; Hossein Keyvani; Seyed Hamidreza Monavari; Kaposi's

sarcoma-associated herpesvirus among patients with lymphoproliferative diseases and chronic blood

disorders. 5th World Hematologists Congress, (2016) , London, UK

2. M.Esghaei, , Esa Ronkko and Thedi Ziegler.Little evidence for herpes virus viremia in pregnant women.

Annual Congress of Virology in Finland (2012) . Helsinki, Finland.

3. M.Esghaei, The preliminary preparation of plasmid DNA-based vaccine against influenza A, subtypes.4th

Vaccine and ISV Annual Global Congress (2010),Vienna, Austria.

4. M.Esghaei, Study of congenital rubella syndrome (CRS) after vaccination against rubella in Iran. 4th

Vaccine and ISV Annual Global Congress (2010),Vienna, Austria.

5. F.Fotouhi, M.Esghaei, Construction of a chimerical pcDNA carrying Influenza virus M2 protein and

HSP70gene as a potent DNA vaccine.4th Vaccine and ISV Annual Global Congress (2010),Vienna, Austria.

6. M.Esghaei, Detection of herpes infection.1st Iranian congress of Virology (2002), Tehran,Iran.

7. M.Esghaei, Diagnosis and determination of the frequency of HSV of patients with encephalitis in

Tehran.2nd Iranian congress of Virology (2004), Tehran,Iran.

8. M.Esghaei, Determination of frequency of CMV by PCR in CSF, .2nd Iranian congress of Virology (2004),

Tehran,Iran.

9. M.Esghaei, Molecular cloning and expression M2 protein of human influenza A (H1N1) virus as a vaccine

target.4th Congress of Laboratory and Clinic (2012),Tehran ,Iran.

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10. M.Esghaei, Preparation of plasmid DNA-based vaccine of influenza virus M2 protein.20th Congress on

infectious disease and tropical medicine (2012), Tehran ,Iran.

11. M.Esghaei,Analysis of M2 protein influenza virus A construct using a transfection mammalian cell

system.5th Congress of Clinical Microbiology(2011),Shiraz,Iran.

12. M.Esghaei, Fatemeh Fotouhi b Seyed Hamid Reza Monavari. A full length cDNA clone for producing

influenza M2 gene DNA–based vaccine and expression in COS-7 cell line. The 6th Iranian Congress of

Virology 2012,Tehran,Iran.

13. M.Esghaei, , Esa Ronkko and Thedi Ziegler.Little evidence for herpes virus viremia in pregnant women.

The 6th Iranian Congress of Virology 2012,Tehran,Iran.

14. M.Esghaei, F.Fotou,hi, MT Kheiri. Using expression information to find new vaccine targets in the

influenza A. The Second International Congress of Immunology, Asthma and Allergy, February

2013,Tehran,Iran.

15. M.Esghaei,F.Bokharaei.Teaching of medical ethics to health care team when confronting with HIV carrier

pregnant women. 14th National Congress on Medical Education.2013. Tehran,Iran.

16. M.Esghaei,F.Bokharaei.Oncolytic Viruses: Appropriate tools for application in cancer therapy. Third

Iranian Congress of Medical Genetics,2013.Tehran.Iran.

17. M.Esghaei,Thedi Ziegler. Diagnose seven herpes viruses in one microarray test. The 5th International

Congress of Laboratory & Clinic.January, 2013. Tehran, Iran.

18. M.Esghaei, SHR. Monavari , F.Bokharaei .Development of in vitro method for studying of the asthmatic

disease due to respiratory syncytial virus (RSV) , 12th international congress of immunology and allergy

of IRAN, 2014. Tehran, Iran.

19. Maryam Esghaei , Farah bokharaei-salim,Seyed Hamidreza Monavari,Effect of green tea extraction on

Rotavirus infection in cell culture, The 16th Iranian and International Congress of Microbiology 25 - 27

August, 2015,Tehran, Iran

20. Maryam Esghaei , Mona Khodayari,The correlation between respiratory syncytial virus infections and

the symptomatic cardiac disease in children,7th International congress on clinical and

laboratory,2015,Tehran,Iran

21. Farah bokharaei-salim, Hossein Keyvani, Seyed Hamidreza Monavari , Maryam Esghaei ,Coinfection of

Human Immuno deficiency Virus- and Hepatitis C virus in Iranian patients with established HIV Infection.

First International Congress and the Fifth National Congress on HIV / AIDS ,2014,Tehran,Iran

22. Farah bokharaei-salim, Hossein Keyvani, Seyed Hamidreza Monavari , Maryam Esghaei , Shahin Fakhim,

Distribution of Hepatitis B Virus Genotypes in Azerbaijani Hepatitis B Chronic Infected Patients,7th

International congress on clinical and laboratory,2015,Tehran,Iran

23. KHashayar Hesamizadeh , Maryam Esghaei , Hossein Keyvani , Farah Bokharaei-Salim , Seyed Hamidreza

Monavari , Frequency of Human Herpesvirus-8 infection in Iranian Human Immuno deficiency Virus-

infected patients, ,7th International congress on clinical and laboratory,2015,Tehran,Iran

Teaching experience:

1- Medical Virology course (2000-Now). Faculty of medicine, Iran University of Medical Sciences

2- Virology course, (2007-2009), School of Biology, Faculty of Science, Tehran University.

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:تالیف کتاب

بهمن ماه(-1131عنوان کامل کتاب: واکسن های ویروسی )تاریخ چاپ -1

بهمن ماه( -1131عنوان کامل کتاب: همه چیز در مورد ویروس ابوال )تاریخ چاپ -2

:فعالیت های اجرایی

ویروس شناسیمعاون اجرایی گروه -1

نماینده تحصیالت تکمیلی گروه ویروس شناسی -2

عضو انجمن ویروس شناسی -1

:مجری طرح های پژوهشی

طرحهای پایان یافته:

مثبت HIV تعیین فراوانی عفونت هرپس ویروس انسانی تیپ هشت در بیماران .1

عصاره گیاهان نعنا و چای سبز بر روی تکثیر روتاویروس بر روی کشت سلولی بررسی اثر مهاری .2

درافراد مبتال به عفونت تنفسی پس از بازگشت A (H3N2) بررسی فراوانی و تعیین تایپ مولکولی ویروس آنفلوانزای .3

33-1332 -زائران حج، تهران

ماران فیبروز ریوی ایدیوپاتیک مراجعه کننده به تعیین فراوانی نسبی آدنوویروس، بوکاویروس و انتروویروس در بی .4

1334ایران، سا ل -، تهران (بیمارستان رسول اکرم )ص

تنفسی در فیبروز ریوی ایدیوپاتیک غیر بررسی فراوانی ویروسهای .5

فراوانی عفونت هرپس ویروس انسانی تیپ هشت در بیماران مبتال به اختالالت لنفوپرولیفراتیوتعیین .6

مارستان رسول اکرم ، سا ل بررسی فراوانی ویروسهای تنفسی در فیبروز ریوی ایدیوپاتیک دربیماران مراجعه کننده به بی .7

1334

طرحهای در حال انجام:

وس انسانی تیپ هشت در بیماران مبتال به سیروز کریپتوژنیک تعیین فراوانی عفونت هرپس ویر .1

ررسی فراوانی عفونت ویروس واریسال زوستر در بیماران مبتال به مالتیپل اسکلروزیس دریافت کننده فینگولیمود ب .2

ا و بررسی حضور ژنوم ویروس اپشتاین بار انسانی و ویروس پاپیلومای انسانی در نمونه های تومور رتینوبالستوم .3

ژنوتیپینگ نمونه های پاپیلوما مثبت

:همکار طرح های پژوهشی

ررسی توزیع فراوانی ژنوتیپهای ویروس هپاتیت ب در مبتالیات به هپاتیت ب در کشور آذربایجانب .1

در سیستم بیانی MCPyV VP1 به کمک بیان پروتئین ( MCPyV) تولید پارتیکل شبه ویروسی مرکل سل پولیوما .2

باکولوویروسی

سرمی در بیماران cccDNA و سطح B بررسی ارتباط بین سطح بار ویروسی، میزان آنتی ژن سطحی ویروس هپایتت .3

مبتال به عفونت مزمن هپاتیت

1333بررسی فراوانی عفونت مخفی با ویروس هپاتیت سی در بیماران تالسمی ماژور در سال .4

7

تعیین ژنوتایپ ویروس واریسال زوستر در نمونه های بالینی بیماران مبتال به آبله مرغان .5

( در سال HIVدر بیماران مبتال به عفونت ویروس نقص ایمنی انسانی ) Cبررسی فراوانی عفو نت مخفی با ویروس هپاتیت .6

1333

سیتوپالسمیک در سرم بیماران (Rods and Rings) حلقوی-نتی بادی علیه ذرات میله ایبررسی ارتباط بین حضور اتوآ .7

سی مبتال به عفونت مزمن هپاتیت

ریباویرین در بررسی ارتباط موتاسیون وژن کور ویروس هپاتیت سی وپاسخ به درمان ترکیبی توسط اینترفرون پگیله .8

بیماران مبتال به عفونت هپاتیت سی

و داروی ضد ایدز ماراویروک برموش های مدل آنسفالیت خود ایمن تجربی HIV-1ویروس TATوتئین بررسی اثرات پر .3

مقایسه اثر گیاه آرنبیااکروما باترکیب )گیاه آرنبیااکروما+ پرده آمنیون( و روغن کنجد،روغن زیتون،موم زنبور عسل بر .11

لولیدر محیط کشت س Aتکثیر هرپس ویروس تیپ یک ،روتاویروس وآنفلوانزا

اولویت ها پژوهشی:

بررسی بدخیمی های ناشی از هرپس ویروسها ی انکوژنیک -1

مطالعه ویروسهای تنفسی موثر در عفونت های مزمن ریوی -2

مطالعه در حوزه پیشگیری و درمان بیماریهای ویروسی با نگرش به تولید واکسن های نسل جدید و شناسایی ترکیبات -3

دارویی آنتی وایرال.