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Cytology of Body Fluid. Edmund S, Cytology, Chapter 4: Pleural, pericardial, and peritoneal fluid Richard M DeMay, The art & science of cytopathology, Chapter 8: Fluid Leopold G.Koss, Koss’ diagnostic cytology, Chapter 26: Effusion in the presence of cancer. Speaker : 黃筱琪 - PowerPoint PPT Presentation
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Cytology of Body FluidSpeaker : Advisor : Date : 3.15.2006Edmund S, Cytology, Chapter 4: Pleural, pericardial, and peritoneal fluid Richard M DeMay, The art & science of cytopathology, Chapter 8: FluidLeopold G.Koss, Koss diagnostic cytology, Chapter 26: Effusion in the presence of cancer
OutlineRepresentation of the three body cavitiesCollection and preparation of specimen Benign elementsNon-neoplastic conditionsMalignant effusions---primary tumors ---metastatic tumorsDifferences Between Adenocarcinoma and Mesothelioma
Schematic representation of the three body cavities
Accumulation of fluids in body cavities
Differences Between a Transudate and an ExudateFeature Transudate ExudateGross appearance Watery, clear Cloudy, reddishSpecific gravity 1.015Protein 3.0 g/dlClots No YesCells Few; usually benign Many; can be malignant
Collection and preparation of specimen
Benign elementsMesothelial cells
Non-neoplastic conditionsEosinophilic pleural fluid
Tuberculous pleuritisMultinucleated macrophages
Systemic lupus erythematosus Cytology preparation: Lupus erythematosus cell (LE cell)LE cell
Malignant effusions---primary tumors
More and bigger cells, in more and bigger clustersCell-in-cell pattern
Malignant effusions---metastatic tumors
F4.27F4.28
Non-Hodginkin lymphomaLarge cell lymphoma Nuclei large than histiocyte Eccentric nuclei Abundant blue cytoplasm Best appreciated in Diff-QuikFollicular lymphoma Irregular nuclear contours Scant cytoplasm
lymphoblastic lymphoma Small to medium sized lymphocytes Fine powdery chromatin Scant cytoplasm
Differences Between Adenocarcinoma and Mesothelioma
C: cytoplasm; M: membrane; N: nuclear +++++++++++--------++---
E-cadherin
BerEP4
B72.3
Calretinin