Fatemeh_Pourrajab

7/28/2019 Fatemeh_Pourrajab

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IN THE NAME OF GOD

FIRST NAME: Fatima

LAST NAME: Poorrajab

PHONE NUMBER: +98-351-8202660, +98-9123070076

POSTAL ADDRESS: No. 503, Block C1, Venous Building, Emam Ali Sq. Yazd, Iran,

8944118193.

E. MAIL: [email protected]

Present Position; Lecturing Molecular Biology, Biochemistry

PhD in Molecular Biochemistry September 2009

Biochemistry and Biophysics Institute (I.B.B.), faculty of science, University of Tehran,

Iran. With the average of 18.5 out of 20 and project excellent grade of 19.8 out of 20.

Thesis subject:

• Investigation on leishmanicidal activities of some new synthetic thiadiazole

compounds and their mechanism of action,

Under supervising of Professor Susan K. Ardestani, [email protected] .

Master of Science in Molecular Biochemistry June 2006

Biochemistry and Biophysics Institute (I.B.B.), faculty of science, University of Tehran,

Iran. With the average of 17.98 out of 20.

Thesis Subject:

• Effect of lead (Pb) on Chromatin components specially Histone Proteins and

PARP, DNA strand breaks - sensor enzyme,

Under supervising of Professor Azra Rabbani, [email protected] .

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mailto:[email protected]






Bachelor of Science in Cellular & Molecular Biology June 2004

Biology department, faculty of science, University of Tehran, Iran.

Thesis Subject:

• Cancer and Environment, Literature survey and investigating the effect of some

agents on polyten chromosomes of drosophila melanogaster, with the average of

17.5 out of 20.

Under supervising of Dr. Farideh sayedyazdani [email protected] .

ABSTRACTS & ARTICLES

• Mina Begrouzi-F., Fatemeh Poorrajab, et al. Synthesis and in vitro anti-

leishmanial activity of 1-[5-(5-nitrofuran-2-yl)-1,3,4-thiadiazol-2-yl]- and 1-[5-(5-

nitrothiophen-2-yl)-1,3,4-thiadiazol-2-yl]-4-aroylpiperazines, Bioorg Med Chem.

(2008).

• Fatemeh Poorrajab, Sussan K. Ardestani, et al. Nitroimidazolyl-1,3,4-

thiadiazole -based anti-leishmanial agents: synthesis and in vitro biological

evaluation. Eur J Med Chem. (2008).

• Fatemeh Poorrajab, Alireza Foroumadi. Sussan K. Ardestani, et al. Selective

leishmanicidal effect and mechanism of action of thiadiazole derivatives against

Leishmania species, Exp. Para. (2008).

• Babak H. ALIZADEH, Alireza FOROUMADI, Susan K. ARDESTANI3,

Fatemeh Poorrajab. Synthesis and Leishmanicidal Evaluation of Novel 4-

Substituted-2,2-Dimethyl-7-(prop-2-ynyloxy)Chromenes. Turk. J. Chem.(2009).

• Babak Heidary Alizadeh, Alireza Foroumadi, Susan K. Ardestani, Fatemeh

Poorrajab, and Abass Shafiee. Leishmanicidal Evaluation of Novel Synthetic

Chromenes. Arch. Pharm. Chem. (2008).

And three are submitted under subjects of :

• Cell death features induced in Leishmania major by 1, 3, 4-thiadiazole

derivatives, Fatemeh Poorrajab, Sussan K. Ardestani, et al.

• In Vivo Toxicity of New 1, 3, 4-Thiadiazole Derivatives with Leishmanicidal

Activity, Fatemeh Poorrajab, Sussan K. Ardestani, et al.

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• In Vivo Efficacy and Immunomodulatory Effects of 1, 3, 4-Thiadiazole

Derivatives for Treatment of Leishmaniasis in BALB/c mice, Fatemeh

Poorrajab, Sussan K. Ardestani, et al.

• Novel antileishmanial chalconoids: Synthesis and biological activity of 1- or 3-

(6-chloro-2H-chromen-3-yl)propen-1-ones, Zohreh Nazarian, Saeed Emami,

Fatemeh Poorrajab et al. (2010). Euro. J. Medic. Chem.

• Chromene-Based Synthetic Chalcones as Potent Antileishmanial Agents:

Synthesis and Biological Activity. Alireza Foroumadi, Saeed Emami, Fatemeh

Poorrajab, et al. (2010). Chem Biol Drug.

• Synthesis and antileishmanial activity of 5-(5-nitroaryl)-2-substituted-thio-

1,3,4-thiadiazoles. (2010). Eskandar Alipour, Saeed Emami, Fatemeh Poorrajab,

et al. Journal of Enzyme Inhibition and Medicinal Chemistry.

• Fatemah Poorrajab, Mina Behrouzi-Fardmoghadam, Antileishmanial activity of

some new synthetic thiadiazole components, 33rd FEBS Congress & 11th IUBMB

Conference, June 28th – July 3rd , 2008, Athens.

• Azra Rabbani, Fatemeh Poorrajab, The Effects of Lead Nitrate on Chromatin

Components of Alveolar Macrophages, 31st FEBS Congress, June 24-29, 2006,

Istanbul.

• Sussan K. Ardestani, Fatemeh Poorrajab, Alireza Foroumadi, Saeed Emami,

Amina Kariminia, Mina Behrouzi-Fardmoghadam, Abbas Shafiee

Antileishmanial Activity of 1, 3, 4-thiadiazoles with Nitroheteroaryl Substitutions,

4th Congress of world wiled Leishmania, Jan, 2009, Lacknow, India.

• Azra Rabbani, Fatemeh Poorrajab, Marziyeh Masbough, Time - course study of

Lead effect on Histone proteins from alveolar macrophages, 2nd International

Biological Congress, 2006, Tarbiat Modarres Univ. Tehran.

• Contributing in the writing of Molecular Genetics book, publishing in Tehran,

Iran, (2008).

• Sussan K. Ardestani, Fatemeh Poorrajab, Alireza Foroumadi, Saeed Emami,

Amina Kariminia, Mina Behrouzi-Fardmoghadam, Abbas Shafiee,

Antileishmanial Activity of 1, 3, 4-thiadiazoles with Nitroheteroaryl Substitutions

(2009), Nanotechnology Congress, Yazd.

• Fatemeh Poorrajab, Sussan Kabudanian Ardestani, Alireza Foroumadi, Amina

Kariminia, Mina Behrouzi-Fardmoghadam, Abbas Shafiee,

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• Cell death in Leishmania major induced by 1, 3, 4-thiadiazole derivatives:

apoptosis or necrosis?, Keystone Symposia B3 Antibiotics and Resistance , Santa

Fe, New Mexico, USA , 13 th - 19th feb, 2010.Awarded to attend in the

Keystone Symposia, Santa Fe/Historic Plaza, Santa Fe, USA.

• Viruses as Nanobiocarriers for Gene therapy, (2011). The 1st national conference

on Nano Science and thecnology. Fatemeh Pourrajab, Atef Atefi, Javad Mohiti

Ardakani.

EXperiences

• Cell culture and Viability assays , Apoptosis or necrosis assay

• DNA laddering and TUNEL assay

• In vivo experiments on BALB/c mice, rat alveolar and mouse peritoneal lavaging

and Giemsa staining for macrophages

•

Immunology assays; ELIS, Immunoblotting and gel electrophoresis• DNA proteins extractions and topoisomerase activity assay

• Some work on drosophila melanogaster polyten chromosomes in Genetic lab.

• PCR, DNA extraction experiences in Molecular Biology lab.

INTERESTS and LITRETURE SURVY

• Molecular mechanism of Cell cycle and Cancer.

• Drug investigation for Antimicrobial and anticancer agents and cellular targets

• Molecular mechanism of Cell death; necrosis and apoptosis (PARP & DNA

damage)

• Immunomodulatory mechanisms for cancer therapy

• MicroRNAs and mechanism of actions.

REFERENCES

• Dr. Sussan K. Ardestani, [email protected] . Immunology lab, Institute of

Biochemistry and Biophysics, Department of Biochemistry University of Tehran,

P.O. Box: 13145-1365, Tehran, Iran. Tel: +98-21- 66956978, Fax: +98-21-

66404680.

• Professor Abdol Ali Ziaee, [email protected], Institute of Biochemistry and

Biophysics, Department of Biochemistry University of Tehran, P.O. Box: 13145-

1365, Tehran, Iran. Tel: +98-21- 66956975, Fax: +98-21-66404680.

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mailto:aamailto:[email protected]


mailto:aamailto:[email protected]



• Dr. Aliresa Foroumadi, [email protected]. Pharmaceutical Chemistry lab,

Department of Medicinal Chemistry, Faculty of Pharmacy & Pharmaceutical

Sciences Research Center, University of Tehran of Medical Sciences, Tehran

14174, Iran. Tel: +98-21-66954708.

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Fatemeh_Pourrajab