Hale TUFAN, M.D, Ph.D(Assoc. Prof. in Pharmacology)

Mobile: +90 (533) 361 70 81E-mail: haletufan@yahoo.com

Address: Alkent 2000 Mah. Mehmet Yeşilgül Blv. Pelican Hill Residence,Messina B-5 Blok No 18, Büyükçekmece 34500 İSTANBUL /TURKEY

PERSONAL DETAILS:Date of Birth : 20.08.1967Place of Birth : Kastamonu / TURKEYCitizenship : Turkish RepublicSexuality : FemaleMarital Status : Single

EDUCATION:2012 Associate Professor in Pharmacology

2009 – 2011 Post Doc Fellow (in Dr. Martin Morad’s Lab)Cardiac Signaling Center (of University of South Carolina, Medical University of South Carolina and Clemson University), South Carolina, USA

2008 – 2009 Visiting Scientist (in Dr. Martin Morad’s Lab)Cardiac Signaling Center (of University of South Carolina, Medical University of South Carolina and Clemson University), South Carolina, USA

1993 – 1997 PhD in PharmacologyGazi University, Health Sciences Institute, Department of Pharmacology, ANKARA / TURKEY. General pharmacology Peptide autacoids Experimental Methods in Pharmacology Biostatistics Pharmacology of Central Nerve System Pharmacology of the autonomic nervous system Eicosanoids Pharmacology of the endocrine system Related compounds from endothelium Cardiovascular pharmacology

Dissertation : The comparison of the effects of levcromakalim and some vasodilator agents on normal and preeclamptic human umbilical arteries (Supported by Gazi Univ., Research Foundation (GU SBE 11/94-19) and Turkish Scientific Research Association (TUBITAK) ( TBAG, AY D 116)

1984 – 1991 Medical Doctor (M.D)

Ankara University, School of Medicine, ANKARA / TURKEY.

APPOINTMENTS AND PROFESSIONAL ACTIVITIES:2016 Vice Chairman,

Turkish Pharmacological Society, Cellular Therapy and Regenerative Medicine Working Group, ANKARA / TURKEY.

2015 – 2016 Associate Professor and Chair, Department of Pharmacology, School of Medicine, Fatih University, ISTANBUL / TURKEY.

2012 – 2015 Manager of Quality Management UnitAnkara University Stem Cell Institute, ANKARA / TURKEY.

2003 - 2009 Vice Chair, Department of Pharmacology, School of Medicine, Baskent University, ANKARA / TURKEY.

2003 - 2009 Member of the Ethics Committee of Animal Research Facilities, Baskent University, ANKARA / TURKEY.

2001 - 2009 Assistant Professor in Pharmacology, Department of Pharmacology, School of Medicine, Baskent University, ANKARA / TURKEY.

2000 - 2009 Member of Experimental and Clinical Research Committee, Baskent University, ANKARA / TURKEY.

1999 - 2001 Academic Staff (Researcher and Lecturer), Department of Pharmacology, Baskent University, ANKARA / TURKEY.

1999 - 2009 Member of the Ethics Committee of Clinical Research Facilities, Baskent University, ANKARA / TURKEY.

1999 - 2009 Head of the Experimental Research Center, Baskent University, ANKARA / TURKEY.

1991 - 1999 MD – Practitioner, Emergency Rooms, Ankara Numune Hospital, ANKARA / TURKEY.

MEMBERSHIPS:Turkish Pharmacological SocietyTurkish Medical AssociationMiddle East Society for Organ TransplantationCardiac Muscle SocietyBiophysics Society

RESEARCH INTERESTS:

Cardiovascular pharmacologyCell culturing and co-culturing (Various stem cells and cardiac myocytes) Cardiac electrophysiology (Whole cell – patch clamp)Intracellular calcium imaging (Confocal Ca2+ - imaging)Intracellular signal transduction of the smooth muscle and endotheliumResponses of organ / tissue to ischemia – reperfusion

PERSONAL ABILITIES:Pharmacology trainingLaboratory data analyzingScientific writing and presentationLaboratory management (Research and GMP labs)Department management (Academic and Research Center)Good communication skills and problem solvingEthical considerations

WORKSHOP INSTRUCTIONS:School of Medicine

2005 – 2006 Effects of Bradykinin on cardiovascular system2004 – 2005 Effects of Endothelin – 1 on vascular system2003 – 2004 Gastric Acid Secretion2002 – 2003 The role of calcium on the vascular smooth muscle contraction2001 – 2002 Hypertension2001 – 2002 The role of the Nitric Oxide on cardiovascular system2000 – 2001 The mediators of the feutoplacental circulation1999 – 2000 Importance of the apolipoproteins in lipid metabolism1999 – 2000 Examination of the ECG, heart and respiratory rate on anesthetized rats.

TEACHING EXPERIENCES:1. Medical Students:

Basic principles of pharmacologyAutonomic drugsCardiovascular drugsRenal drugsVasoactive peptides, autacoidsPharmacology of the central nervous systemDrugs used at hematological diseasesEndocrine drugsAntibioticsToxicologyRational Pharmacotherapy

2. MSc and PhD Students:Mechanisms of drug actionMedical ethicsComputer-based application of pharmacological parametersAnesthesia on laboratory animalsMetabolism and introduction of pharmacologyClinical development of drugs and biologicsDrug metabolism and toxicology

Hematopoietic stem cells and ion channels

TRAINING AND ATTENDED SEMINARS:Stem Cell Research and Bioethics Meeting Turkish Academy of Sciences (TUBA), February 2015, ANKARA/TURKEY.

Workers’ Health and Work Safety Training Meeting,Ankara University, June 2014, ANKARA/TURKEY.

ARTIBEL, Internal Quality Audit Training (Internal Auditor Certificate),Ankara University, Stem Cell Institute, June 2014, ANKARA/TURKEY.

ARTIBEL, ISO 9001: 2008 Quality Management System Basic Training,Ankara University, Stem Cell Institute, May 2014, ANKARA/TURKEY.

ARTIBEL, ISO 9001: 2008 Quality Management System Internal Audit Training,Ankara University, Stem Cell Institute, May 2014, ANKARA/TURKEY.

ARTIBEL, ISO 13485 Medical Devices Quality Management System Basic Training,Ankara University, Stem Cell Institute, May 2014, ANKARA/TURKEY.

ARTIBEL, ISO 13485 Medical Devices Quality Management System Internal Audit Training,Ankara University, Stem Cell Institute, May 2014, ANKARA/TURKEY.

IEMA Training and Consultancy, GMP, GLP and 17025 Laboratory Accreditation Course, Ankara University, Stem Cell Institute, March 2014, ANKARA/TURKEY.

Trainees on Workshops for Undergraduate Students, Baskent University, October 2005, ANKARA/TURKEY.

Rational Pharmacotherapy, Turkish Pharmacological Society, September 2005, İZMİR/TURKEY.

Ethics Committees and Systematic Examination of Ethics Committee Submissions, Turkish Pharmacological Society, November 2002, ISTANBUL/TURKEY.

Training on the Graduate Education, Baskent University, June 2001, ANKARA / TURKEY.

Experimental Research Workshop, Birmingham University and Erciyes University., May 2000, KAYSERI / TURKEY.

Postgraduate Training Program “Emergency Medicine”, Turkish Medical Association, Ankara Hospital, Sep 1995, ANKARA / TURKEY.

SEMINARS:

Electrophysiological properties of serine / threonine kinase transfected cardiac progenitor cells and interactions with cardiac myositis in co-culture medium, Turkish Pharmacological Society, Intergenerational Scientific Interaction Seminars in Pharmacology Education, 7 – 9 March 2012, KAYSERI/TURKEY.

Changes in drug effect in liver and kidney failure, “Life Quality Program” Channel B Television, 2008, ANKARA/TURKEY.

Mechanisms of Drug Action, “Life Quality Program” Channel B Television, 2006, ANKARA/TURKEY.

Ethics Considerations of Research Facilities on Laboratory Animals, Baskent University School of Medicine, 2005, ANKARA / TURKEY

Geriatric Pharmacotherapy, “Life Quality Program” Channel B Television, 2005, ANKARA/TURKEY.

Pharmacodynamics of Neuromuscular Blocking Agents, Baskent University School of Medicine, Department of Anesthesiology, 2004, ANKARA / TURKEY

Drugs Used in Pregnancy, “Life Quality Program” Channel B Television, 2004, ANKARA/TURKEY.

Role of Nitric Oxide and Endothelin on Hepatic Ischemia-Reperfusion Injury, Baskent University. School of Medicine, Division of Basic Sciences, 2003, ANKARA / TURKEY.

Pharmacology of the Drugs Used in Urology, Baskent University School of Medicine, Department of Urology, 2002, ANKARA / TURKEY

Pharmacokinetics of General Anesthetics, Baskent University School of Medicine, Department of Anesthesiology, 2001, ANKARA / TURKEY

The Function of the Umbilical Artery Smooth Muscle in Preeclampsia, Baskent University School of Medicine, Division of Basic Sciences, 1999, ANKARA / TURKEY.

Techniques of the General Anesthesia on Laboratory Animals, Baskent University Experimental Research Centre, 1999, ANKARA / TURKEY.

The Role of Endothelin and NO on the Hepatic Reperfusion Injury, Baskent University School of Medicine, 1999, ANKARA / TURKEY.

Potassium Channel Function in Preeclampsia, Gazi University Health Science Institute, Department of Pharmacology, 1997, ANKARA / TURKEY.The Role of Calcium on the Response of Vascular Smooth Muscle Cells,

Gazi University Health Science Institute, Department of Pharmacology, 1996, ANKARA / TURKEY.

Arteriosclerosis and Platelet Function, Gazi University Health Science Institute Department of Pharmacology, 1994, ANKARA / TURKEY.

RESEARCH EXPERIENCES:In vitro:

Isolated tissue bath studiesTissue isolations (Thoracic and abdominal aorta; carotid, femoral and superior

mesenteric artery; vena cava inferior; jugular and portal vein; heart; papillary muscle; sciatic nerve) in mouse, rat, guinea pig and rabbit. Human umbilical artery and vein; gastroepiploic, internal mammary and radial artery

Cardiac myocyte isolation in mice and rats (adult and newborn) Cell culturing and co-culturing (Stem cells, cardiac myocytes)“Whole-cell voltage-clamp” (with microperfusion system) Ca2+, Na+, K+, If, Cl- , NCX, hemichannel ion currents’ measuring Intercellular dye transfer (with or without patch clamping, simultaneously)İntracellular Ca2+ imaging using confocal microscope

In vivo:Catheterizations: carotid artery; femoral artery and vein; jugular vein, abdominal

aorta; vena cava inferior; choleduct (in rat); Invasive and non-invasive blood pressure measurements; SpO2; ECG, EEG; laser

Doppler flow meter (LDF, various tissues and vessels); EMG, neuronal conductivity measurements

Blood sampling (intracardiac, arterial and venous) in various animalsTissue sampling (lung, liver, spleen, stomach, intestine, kidney, uterus and brain) in

various animals Drug administrations (oral, intramuscular, intravenous, intra-arterial, intraperitoneal,

subcutaneous) in various animalsLaboratory Animal Models: Acute and chronic peptic ulcer, intestinal ulcer,

hypotension, intestinal ischemia – reperfusion induced Acute Lung Injury, intestinal obstruction, graft spasm, neointimal hyperplasia, wound healing.

OWN PROJECTS:Role of ETA receptors on ulcer healing. Baskent Univ. (DA 06/28)

In vitro effects of Endothelin-1 on vascular system. Baskent Univ. (DA 04/35)

Effects of ACE inhibitors on flap angiogenesis in rats. Baskent Univ. (DA 03/32)

The Role of Calcium in the Vascular Smooth Muscle Contraction. Baskent Univ. (DA03 / 03)

The Contractions of Umbilical Artery Smooth Muscle Induced by Depolarization in Ca-Free Medium. Baskent Univ. (DA00 / 07)

Effects of Ketamine and Thiopental on the Intestinal Ischemia – Reperfusion Induced Acute Respiratory Distress Syndrome. Baskent Univ. (DA99 / 10)

ATTENTED PROJECTS: Effects of intestinal milking on enteral functions and bacterial translocation. Baskent Univ. (DA 06/24)

Cytoprotective effects of amifostine on hepatic ischemia-reperfusion injury. Baskent Univ. (DA 06/16)

Effects of propofol and dexmedethomidine on cerebral reperfusion injury in rats. Baskent Univ. (DA 06/08)

Effects of systemic alpha-1 adrenergic antagonists on pupil diameter in rats. Baskent Univ. (DA 06/04)

Effects of peroxinitrite on Hecobacter pylori. Baskent Univ. (DA 05/31)

Tranilast embedded synthetic vascular grafts and neointimal hyperplasia. Baskent Univ. (DA 04/37)

Effects of cardioplegic solutions used long-term cardiac preservation on myocardial protection. Baskent Univ. (DA 04/31)

Experimental study of the effects of endothelin receptor antagonist on the patency rate of microvascular polytetrafluroentylene grafts. Baskent Univ. (DA 04/18)

The role of peroxynitrite on endothelium and calcium channel in vascular smooth muscle cells. Baskent Univ. (DA02/16 and DA02/17)

Acute renal failure induced by intestinal ischemia reperfusion: Renal arginase activity and oxidative stress. Baskent Univ. (DA01/14)

Arginase activity induced by oxidative stress in rat liver. Baskent Univ. (DA01/10)

Dose dependent effects of peroxynitrite on rat isolated thoracic aorta. Baskent Univ. (DA01/07)

Effect of stellate ganglion blockade on the blood flow of human radial and internal mammary artery during the coronary by-pass grafting. Baskent Univ. (KA01/56)

The effect of propofol on human umbilical vessels. Baskent Univ. (DA00/14)

Effects of dopamine on renal functions in normo- and hypotensive rats. Baskent Univ. (DA 99/08)

The role of potassium channels on the gastric acid secretion. Gazi Univ. (GU SBE11/96-8)

The function of potassium channels on normal and preeclamptic human umbilical and omental arteries. Gazi Univ. (GU SBE11/94-19) and TUBITAK (TBAG, AYD 116)

NATIONAL MEETING ABSTRACTS:1- Effect of potassium channel opener, levcromakalim, in internal mammary and

gastroepiploic arteryB.S. Uydeş-Doğan, H. Tufan, F. Akar, S. Aşlamacı, A. Arat, C. Köksoy, İ. KanzıkXII. National Congress of Pharmacology, 1994, ANTALYA / TURKEY.

2- Comparison of the vascular smooth muscle responses between normal and preeclamptic human umbilical arteryH. Tufan, B.S. Uydeş-Doğan, N. Danışman, B. Ayan-Polat, İ. Kanzık, F. AkarXIII. National Congress of Pharmacology, 1996, ANTALYA / TURKEY.

3- Effect of hemodilusion on renal function in rabbit with one kidneyE.A Akpek, H. Tufan, S. Candan, E. Ersoy, S. Arda, G. ArslanXXXIV. National Congress of Turkish Anesthesiology and Reanimation, 2000, KUŞADASI / TURKEY.(Best Oral Presentation Award)

4- Effect of low dose dopamine in renal function on hypotensive rats.H. Kaya Özdoğan, H. Tufan, G. ArslanXXXIV. National Congress of Turkish Anesthesiology and Reanimation, 2000, KUŞADASI / TURKEY.

5- A new option in the treatment of preeclampsia: Comparison of in vivo vasodilating effects of levocromakalim and nifedipineB. Polat, H. Tufan, G. Polat, A. Sargın, R. Karayalçın, N. DanışmanTurkish – Europe Gynecology Society 4th Congress, 2001, ANTALYA / TURKEY. Artemis, 2(1), 2001.

6- The effects of propofol in umbilical artery and veinE. Erol, Z. Kayhan, H. TufanXXXV. National Congress of Turkish Anesthesiology and Reanimation, 2001, ANTALYA / TURKEY.

7- Effect of diltiazem on cardiac arrest after respiratory arrestA. Torgay, H. Tufan, A. Kızılkan, G. ArslanXXXVI. National Congress of Turkish Anesthesiology and Reanimation, 2002, ANTALYA / TURKEY.

8- Başkent University, Experimental Research and Breeding Center for Laboratory Animals,

H. Tufan, D. Bacanlı, Z. Kayhan, N. Bilgin, M. Haberal2nd National Experimental Surgery Congress, 2003, ANKARA /TURKEY.

9- Effect of stellate ganglion block on internal mammary artery and radial artery contractions: In vitro control studyA. Dönmez, H. Tufan, Ç. Araz, A. SezginXXXVII. National Congress of Turkish Anesthesiology and Reanimation, 2003, ANKARA / TURKEY.

10- Influence of prefabricated flap expander and silicone leaf use on flab cascade 3 immunoreactivityB.Z. Salem, G. Take, H. TufanVII. National Histology and Embryology Congress, P-36, 2004, MERSİN /TURKEY.

11- Influence of the use of prefabricated flap expander and silicone leaf in the ultrastructure of the vessel B.Z. Salem, G. Take, H. TufanVII. National Histology and Embryology Congress,, P-91, 2004, MERSİN /TURKEY.

12- Immunohistochemical examination of the effect of the use of prefabricated flap expander and silicone leaf flab on angiogenesis B.Z. Salem, G. Take, H. TufanVII. National Histology and Embryology Congress, P-35, 2004, MERSİN /TURKEY.

13- Angiotensin-II - Captopril combination increases angiogenesis in rat skin flapH. Tufan, B.M. Zaki, M. Tecder Ünal, Ş.R. Erdem, G. Take 18th National Pharmacology Congressi, S7, 2005, IZMIR /TURKEY.

14- How does adrenomedullary tyrosine hydroxylase level change affect vascular adrenergic contractile responses? A stress study in ratsŞ.R. Erdem, M. Tecder Ünal, H. Tufan, S. Sarışık, F.B. Ataç18th National Pharmacology Congressi, P71, 2005, IZMIR /TURKEY.

15- Feedback to students after examinations improves the success of grade III students in Başkent University School of MedicineŞ.R. Erdem, M. Tecder Ünal, H. Tufan, B. Demirhan18th National Pharmacology Congressi, P81, 2005, IZMIR /TURKEY.

16- Investigation of the effects of peroxynitrite on Helicobacter pyloriM. Tecder-Ünal, F. Can, M. Demirbilek, G. Karabay, Ş.R. Erdem, H. Tufan, H. ArslanXII. National Clinical Microbiology and Infection Diseases Congress, 2005, ANTALYA / TURKEY.

17- Evaluation of neointimal hyperplasia in synthetic vascular grafts impregnated with tranilast: Experimental studyF. Karakayalı, N. Hasırcı, N. Haberal, H. Tufan, Ö. Başaran, A. Akdur, A. Kızıltay, M.HaberalNational Surgery Congress, 2006, ANTALYA / TURKEY.

18- The effect of triamcinolone acetonide on retinal endothelial cell proliferation in the in vivo rat model of premature retinopathyİ. Akkoyun, G. Yılmaz, S. Oto, N. Haberal, B. Kahraman, D. Bacanlı, H. Tufan, Y. Aydın AkovaTurkish Ophthalmology Society 40th National Congressi, S-TR-2-1, 2006, ANTALYA / TURKEY.

INTERNATIONAL MEETING ABSTRACTS:1- Potassium channel activators in the management of graft spasm

H. Tufan, B.S. Uydeş-Doğan, S. Aşlamacı, C. Köksoy, İ. Kanzık, F. AkarFirst European Congress of Pharmacology, 1995, Milan/ITALY.Pharmacological Research, 31 Supp. P183, 1995.

2- K+ channel active agents play a role in indomethacin – induced gastric mucosal injury in ratsH. Tufan, K. Buharalıoğlu, B.S. Uydeş-Doğan, İ. Kanzık, F. AkarX. International Conference of Prostaglandins and Related Compounds, 1996, Vienna/AUSTRIA.Prostaglandins Leukotriens and Essential Fatty Acids, 55 Supp. P260, 1996.

3- Tromboxane analogue U46619 – induced contractions of arterial grafts: its prevention and reversal by levcromakalim (BRL 38227)F. Akar, B.S. Uydeş-Doğan, H. Tufan, S. Aşlamacı, C. Köksoy, İ. KanzıkX. International Conference of Prostaglandins and Related Compounds, 1996, Vienna/AUSTRIA.Prostaglandins Leukotriens and Essential Fatty Acids, 55 Supp. P217, 1996.

4- Do prostaglandins and nitric oxide play a role in the relaxant responses of levcromakalim (BRL 38227) in arterial grafts?B.S. Uydeş-Doğan, H. Tufan, S. Aşlamacı, C. Köksoy, İ. Kanzık, F. AkarX. International Conference of Prostaglandins and Related Compounds, 1996, Vienna/AUSTRIA.Prostaglandins Leukotriens and Essential Fatty Acids, 55 Supp. P218, 1996.

5- The effects of vasodilator agents on normal and preeclamptic umbilical arteriesH. Tufan, F. Akar, B. Ayan-Polat, N. Danışman, İ. KanzıkXXXIII. International Congress of Physiological Sciences, 1997, St. Petersburg/RUSSIA.

6- Effect of intestinal ischemia/reperfusion on rat kidneyD. Aldemir, M. Tecder-Ünal, H. Tufan, E. Öğüş, S. Türkoğlu, Z. Kayhan25th Year in Renal Transplantation 2001, Ankara/TURKEY.

7- The effects of levcromakalim on KCl and 5-HT induce contractions of the human umbilical artery in calcium-free mediumH. Tufan, E. Erol, E. ÖğüşXXXIII. International Congress of Physiological Sciences, August – September 2001, Christchurch/NEW ZEALAND.

8- In-vitro effects of propofol on human umbilical vesselsE. Erol, H. Tufan, Z. Kayhan, E. ÖğüşXXXIII. International Congress of Physiological Sciences, August – September 2001, Christchurch/NEW ZEALAND.

9- The effect of intestinal ischemia – reperfusion on hepatic arginase activitiesH. Tufan, D. Akaydın-Aldemir, S. Türkoğlu, E. Öğüş, M. Tecder-Ünal

XXXIII. International Congress of Physiological Sciences, August – September 2001, Christchurch/NEW ZEALAND.

10- Renal arginase activity as a response to intestinal ischemia – reperfusionD. Akaydın-Aldemir, H. Tufan, S. Türkoğlu, E. Öğüş, M. Tecder-Ünal, Z. Kayhan27th Meeting of the Federation of European Biochemical Society, 2001, Lisbon/PORTUGAL.The FEBS Journal, 268 (Supp 1); 197, 2001.

11- Comparison the vascular effects of authentic peroxynitrite and SIN-1 in rat thoracic aortaM. Tecder-Ünal, H. TufanXIVth World Congress of Pharmacology, July 2002, Moscon Convention Center, San Francisco, California/USA.The Pharmaologist, 44(2) Supp 1, 2002.

12- The effect of ketamine and thiopenthal in ischemia/reperfusion induced adult respiratory distress syndrome in ratsM. Tecder-Ünal, H. Tufan, B. Bilezikci, Z.KayhanXIVth World Congress of Pharmacology, July 2002, Moscon Convention Center, San Francisco, California/USA.The Pharmaologist, 44(2) Supp 1, 2002.

13- Vascular reactivities of authentic peroxynitrite and SIN-1 in endothelium denudated rat thoracic aorta ringsM. Tecder-Ünal, H. TufanXIth Meeting of the Society for Free Radical Research International, july 2002, René Descartes University, Paris/FRANCE.Free Radical Biology & Medicine, 33 (Supp 1), 2002.

14- The vasoactive responses of peroxynitrite in coronary ischemia/reperfusion applied anesthetized rats.

M. Tecder-Ünal, H. TufanXIth Meeting of the Society for Free Radical Research International, july 2002, René Descartes University, Paris/FRANCE.Free Radical Biology & Medicine, 33 (Supp 1), 2002.

15- The hemodynamic effects of some radical scavengers on exogenously infused peroxynitrite in ischemia/reperfusion applied anesthetized rats.M. Tecder-Ünal, H. TufanXIth Meeting of the Society for Free Radical Research International, july 2002, René Descartes University, Paris/FRANCE.Free Radical Biology & Medicine, 33 (Supp 1), 2002.

16- KCl-induced contractions of human umbilical artery in the absence of intracellular calciumH. Tufan, M. Tecder-Ünal, B. Ayan-PolatXIth Meeting of the Society for Free Radical Research International, july 2002, René Descartes University, Paris/FRANCE.Free Radical Biology & Medicine, 33 (Supp 1), 2002.

17- Influence of thiopenthal sodium in edema and inflammation induced by adult respiratory distress syndromeH. Tufan, M. Tecder-Ünal, B. Bilezikci, P. Zeyneloğlu, Z. Kayhan XIth Meeting of the Society for Free Radical Research International, july 2002, René Descartes University, Paris/FRANCE.Free Radical Biology & Medicine, 33 (Supp 1), 2002.

18- Effect of propofol on vascular reactivity in isolated human umbilical vesselsE. Erol, H. Tufan, Z. KayhanEuropean Society of Anaesthesiologist, 10th ESA Anniversary Meeting and 24th EAA Annual Meeting, Euroanaesthesia 2002, April 2002, Nice/FRANCE.European Journal of Anaesthesiology, 19 (Supp 24), 2002.

19- The early effects of oxaliplatin and 5-fluorouracil on wound healing in experimental colon anastomosisE. Ersoy, S. Yıldırım, S. Arda, T.Z. Nursal, H. Tufan, M. Ünal, A. Pamir12th World Congress of the International Association of Surgeons and Gastroenterologist, Oct-Nov 2002, İstanbul/TURKEY.Hepato-gastroenterology, 49 (Supp 2), 2002.

20- Intestinal ischemia/reperfusion induced renal oxidative stress increase with age in ratsD. Aldemir, H. Tufan, M. Tecder-Ünal, S. Türkoğlu, E. Öğüş, Z. Kayhan, M. HaberalThe VIII. International Congress of the Middle East Society for Organ Transplantation, October 2002, Muscat/SULTANATE OF OMAN.

21- Effects of stellate ganglion blockade on the diameters of radial and internal mammarian arteries Doppler ultrasonographic and in-vitro resultsA. Dönmez, H. Tufan, N. Uslu, C. Araz, A. Sezgin, E. Karadeli, A. TorgaySociety of Cardiovascular Anesthesiologists, 26th Annual Meeting & Workshops, April 2004, Honolulu/HAWAII.Anesthesia And Analgesia, 98 (4): 47-47 Suppl. S, 2004

22- The effects of endothelium on vascular responses to authentic peroxynitrite and SIN-1 M. Tecder-Ünal, H. Tufan ve S. R. ErdemXIIth Meeting of the Society for Free Radical Research International, Buenos Aires/ARGENTINA, 2004.Free Radical Biology & Medicine, 36 (Supp 1), P9-288, 2004.

23- The principles of study and ethical approach to the animal welfare and research at Baskent UniversityD. Bacanlı, H. Tufan, S. Türkmen, K. Tokel, H. Özkardeş, Z. Kayhan, M. Haberal1st East Mediterranean Regional ICLAS Symposium on Laboratory Animal Science, May 2005, Athens/GREECE.

24- Baskent University – Breeding center for experimental animalsD. Bacanlı, S. Türkmen, H. Tufan, Z. Kayhan, M. Haberal1st East Mediterranean Regional ICLAS Symposium on Laboratory Animal Science, May 2005, Athens/GREECE.

25- Baskent University – Center for experimental research on animalH. Tufan, D. Bacanlı, Z. Kayhan, M. Haberal1st East Mediterranean Regional ICLAS Symposium on Laboratory Animal Science, May 2005, Athens/GREECE

26- Bacterial effect of peroxynitrite on Helicobacter pylori: A morphological studyM. Tecder-Ünal, F.Can, M. Demirbilek, G. Karabay, S.R. Erdem, H.Tufan, H. ArslanThe 15th World Congress of Pharmacology, July 2006, Beijing/CHINA.Acta Pharmacologica Sinica, 27 Supplement 1: P-56, 2006.

27- Discrepancy in the effect of adrenomedullary tyrosine hydroxylase increase on contractile responses to phenylephrine in rat aorta: A stress studyS.R. Erdem, M. Tecder-Ünal, H. Tufan, S. Sarışık, F. Belgin Ataç The 15th World Congress of Pharmacology, July 2006, Beijing/CHINA.Acta Pharmacologica Sinica, 27 Supplement 1: P-176, 2006.

28- Plasma endostatin levels after partial or salvage liver resection in miceD. Aldemir, M. Tecder-Ünal, A. E. Ünal, H. Tufan, S. Türkoğlu The 15th World Congress of Pharmacology, July 2006, Beijing/CHINA.Acta Pharmacologica Sinica, 27 Supplement 1: P-294, 2006.

29- Effects of high dose triamcinolone acetonide on proliferation of retinal endothelial cells in ROP-mouse-modelI. Akkoyun, G. Yılmaz, S. Oto, N. Haberal, D. Bacanlı, H. Tufan, Y. AkovaEuropean Vision and Eye Research (EVER), October 2006, Vilamoura/PORTUGAL.Acta Ophtalmologica Scandinavica, 84 (s239), 4242, 2006.

30- Use of a silicon sheet to improve the reliability of tissue expansionH. Borman, H. Tufan, B. Bilezikci, T. Bahar, M. DenizXIII. ISBI Congress, VII. FELAQ Congress, V. SBQ Congress, September 2006, Fortaleza/BRAZIL.BURNS, 33 Supplements 1: S53, 2007.

31- Ca2+ transients in pim-1 transfected cardiac stem cells co-cultured with rat neonatal cardiomyocytesH. Tufan, L. Cleemann, M. Sussman, M. MoradBiophysical Society 54th Annual Meeting, February 2010, San Francisco, California/USA.Biophysical Journal, vol. 98, issue 3, pp. 134a-134a

NATIONAL PUBLICATIONS:1- Peroksinitritin biyolojik sistemlerdeki rolü

M. Tecder-Unal, H. TufanTürkiye Klinikleri Kardiyoloji, 16; 110-8, 2003.

2- Hipotansif sıçan modelinde düşük doz dopamin infüzyonunun böbrek koruyucu etkisi: Deneysel Çalışma (The protective effect of low-dose dopamine on renal functions in hypotensive rats: an experimental study) H. Kaya, H. Tufan, M. Özdoğan, G. ArslanUlusal Travma ve Acil Cerrahi Dergisi (Turkish Journal of Trauma & Emergency Surgery), 12(3); 189-94, 2006.

3- Pretreatment with cypress cones’ water extract enhances survival of ischemically challenged skin flaps a preliminary study. B.G.Ulusal, H. Tufan, A.E. Ulusal, C. Haberal, T. Seyhan, H. Borman, M. Haberal Türk Plastik Rekonstrüktif ve Estetik Cerrahi Dergisi, 17(1); 25-29, 2009.

INTERNATIONAL PUBLICATIONS:

H-index: 7 (according to Google Scholar)Total citations: 149

1- The comparison of the responsiveness of human isolated internal mammary artery and gastroepiploic arteries to levcromakalim: An alternative approach to the management of graft spasmF. Akar, B.S. Uydeş-Doğan, H. Tufan, S. Aşlamacı, C. Köksoy, İ. KanzıkBritish Journal of Clinical Pharmacology, 44; 49-56, 1997.

2- Effect of intestinal ischemia – reperfusion on rat kidneyD. Aldemir, M. Tecder-Ünal, H. Tufan, E. Öğüş, S. Türkoğlu, Z. KayhanTransplantation Proceedings, 34; 2023-6, 2002.

3- Contractile responses of the human umbilical artery to KCl and serotonin in Ca-free medium and the effects of levcromakalimH. Tufan, B. Ayan-Polat, M. Tecder-Ünal, G. Polat, Z. Kayhan, E. ÖğüşLife Sciences, 72; 1321-9, 2003.

4- Age-related alternations of oxidative stress and arginase activity as a response to intestinal ischemia-reperfusion in kidney and liverD. Aldemir, H. Tufan, M. Tecder-Ünal, S. Türkoğlu, E. Öğüş, Z. Kayhan, M. HaberalTransplantation Proceedings, 35(7); 2811-2815, 2003.

5- In-vivo and in-vitro effects of stellate ganglion blockade on radial and internal mammary arteries A.Dönmez, H. Tufan, N. Tutar, C. Araz, A. Sezgin, E. Karadeli, A. Torgay Journal of Cardiothoracic and Vascular Anesthesia, 19(6); 729-33, 2005.

6- Propofol inhibits potassium chloride induced contractions of isolated human umbilical vesselsE. Calıskan, Z. Kayhan, H. TufanEuropean Journal of Anaesthesiology, 23(5); 411-7, May 2006.

7- The effects of systemic alpha-1 adrenergic antagonists on pupil diameter in ratsR. Altan-Yaycıoğlu, Ö. Yaycıoğlu, H. Tufan, Y. A. Akova, H. ÖzkardeşCurrent Eye Research, 32; 217-21, 2007.

8- Angiotensin II – Captopril Co-treatment Augments Angiogenesis in Abdominal Skin Flap in RatsH. Tufan, B. M. Zaki, M. Tecder-Ünal, Ş. R. Erdem, G. TakeAnnals of Plastic Surgery, 58(4); 441-8, April 2007.

9- Vasorelaxant effect of levcromakalim on isolated umbilical arteries of preeclamptic womenB. Polat, H. Tufan, N. DanışmanEuropean Journal of Obstetrics & Gynecology and Reproductive Biology, 134; 169-73, 2007.

10- Evaluation of Neointimal Hyperplasia on Tranilast-Coated Synthetic Vascular Grafts: An Experimental StudyF. Karakayalı, N. Haberal, H. Tufan, N. Hasırcı, Ö. Başaran, Ş. Sevmiş, A. Akdur, A. Kızıltay, M. HaberalJournal of Investigative Surgery, 20: 167-73, 2007.

11- The Bactericidal and Morphological Effects of Peroxynitrite on Helicobacter pylori.M. Tecder-Unal, F. Can, M. Demirbilek, G. Karabay, H. Tufan, H. Arslan Helicobacter, 13(1); 42-8, Feb 2008.

12- Fluid Resuscitation of Acute Hemorrhage in Uninephrectomized Rabbits: Effects on the Early Function of the Remnant KidneyE. A. Akpek, H. Tufan, P. Korkusuz, S. Candan, E. Aşan, S. Arda, A. Haberal, G. ArslanM.E.J. Anesth 19(4); 869 -84, 2008

13- Effect of manual bowel decompression (milking) in the obstructed small bowel.N. Törer, T. Z. Nursal, H. Tufan, F. Can, N. Bal, A. Tarim, G. Moray, M. HaberalAm J Surg. 195(6); 807-13, 2008.

14- Comparison of the protective effects of melatonin and amifostine on radiation-induced epiphyseal injury.E. Topkan, H. Tufan, A.A. Yavuz, D. Bacanli, C. Onal, S. Kosdak, MN YavuzInt. J. Radiat. Biol. 84; 796-802, 2008.

15- An alternative method of using an interpositional silicone sheet in tissue expansion.H. Borman, M. Deniz, T. Bahar, B. Bilezikci, H. Tufan, M. HaberalJ. Craniofac. Surg. 20; 905-8, 2009.

16- Cardiac Progenitor Cells Engineered with PIM-1 (CPCeP) develop cardiac phenotypic electrophysiological properties as they are co-cultured with neonatal myocytes. H. Tufan, X.H. Zhang, N. Haghshenas, M.A. Sussman, L. Cleeman, M. MoradJ. Mol. Cell Cardiol. 53(5); 695-706, 2012.

PhD Thesis:Experimental study of the effects of Endothelin Converting Enzyme Inhibitor and Endothelin Receptor Antagonist on the patency rate of microvascular polytetrafluoroethylene grafts (MD, PhD Thesis)

Dr. Hossam Abo Elatta, Ain Shams University, Department of Plastic and Reconstructive Surgery, Cairo/EGYPT, 2005.

Supervisors: Prof. Dr Ikram Ibrahiem Safe, Prof. Dr. Ayman Abu Elmakarem Shaker, Assist. Prof. Dr. Ashraf Maher Farid, Assist. Prof. Dr. Hale Tufan.