Immunoglobulins Handout

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    Ijjugkafkdufigx

    Cmixmf Ebm|id JL5 ^bL

    Cmhuf|y kc Jolihigo& _gisotxi|y kc @ktlmg

    Ijjugo xyx|oj Lo|oh|x mgl igmh|ism|ox cktoiag jkfohufox&situxox& dmh|otim mgl jihtkktamgixjx

    \qk hkj~kgog|x qi|b 4 x|tm|oaiox

    D Fyj~bkhy|ox "bujktmf ijjugo tox~kgxo)0

    Xkfudfo mg|idkliox "ijjugkafkdufigx)

    Xohto|ol dy ~fmxjm hoffx

    Tohkagipo mgl digl |k cktoiag jkfohufox'

    \ Fyj~bkhy|ox "hoffufmt ijjugo tox~kgxo)0 Eiffot hoffx |bm| lix~fmy cktoiag xudx|mghox kg

    |boit xutcmho

    _xo x~ohicih toho~|ktx kg |boit xutcmho

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    Ijjugkafkdufigx

    \bo digliga |k |bo cktoiag jkfohufox ix0 X~ohicih

    Biab mccigi|y

    Occoh|kt cugh|ikgx0 dikfkaihmf occoh|x |bm| toxuf|

    mx hkgxo}uogho kc mg|iaog digliga fieo

    Igmh|ism|ikg& loatmlm|ikg& fyxix

    Hmg tohkagipo mgl ig|otmh| qi|b cktoiag

    jkfohufox osog ic gk| oghkug|otol dockto

    Buao gujdot kc liccotog| eiglx "w=>2)

    Xyg|boxix ix x|ijufm|ol dy igsmxikg kc |bo dkly

    Cktjm|ikg kcijjugkafkdufigx "Ia) Mg|iaog

    * Cktoiag jkfohufox |k qbihb Ia diglx

    * Hmg ofihi| mg|idkly cktjm|ikg " ijjkugkaog)

    * Jmhtkjkfohufo5 ^tk|oig& ~kfyxmhhbmtilo& guhfoih mhil

    O~i|k~o

    ^mt|ihufmt xi|o kg mg|iaog |k qbihb mg|idkly diglx

    Mg|iaogih lo|otjigmg| Bm~|og

    xjmff jkfohufo& gk| mg mg|iaog

    Mg|iaog ic m||mhbol |k jmhtkjkfohufo

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    KB

    Ligi|tk~bogkfm xjmff jkfohufo

    M||mhb

    LG^ |k

    Dksigo Xotuj

    Mfdujig

    Cktjm|ikg kc mg|idkliox

    mamigx| xjmff jkfohufox

    Cktjm|ikg kc mg|idkliox mamigx| LG^ mc|ot

    ig`oh|ikg kc LG^*DXM |k tmddi|

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    Ixkfm|ikg kcmg|idkliox "MD) mamigx| LG^

    ctkj tmddi|

    Mg|ixotm0 \bo xotuj kd|migol qbihb hkg|migx

    |bo mg|idkliox "MD)

    MD cktjol hmg digl ctoo mgl m||mhbol bm~|og

    MD hmg do ~uticiol dy mccigi|y hbtkjm|katm~by

    MD kd|migol mto GK\ kgo eigl kc jkfohufox

    du| m jir|uto kc mg|idkliox qi|b |bo xmjox~ohicihi|y

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    Kgo eigl kc mg|idkliox

    ^tkluhol ctkj hfkgo

    kc kgo xigafo hoff

    Jkgkhfkgmf

    mg|idkliox

    ^tighi~fox kc ~to~mtm|ikg kc jkgkhfkgmf

    mg|idkliox

    Juf|i~fo Jyofkjm0 Jmfiagmg| atkq|b kc m

    xigafo eigl kc D fyj~bkhy|ox ig bujmg'

    Fmtao mjkug|x kc kgo eigl kc mg|idkliox mto

    ~tkluhol " du| ugegkqg x~ohicihi|y)'

    Jiho x|tmigx qi|b juf|i~fo jyofkjm mto

    msmifmdfo

    Hmg do |tmgx~fmg|ol ctkj kgo jkuxo |k

    mgk|bot'

    Xmjo eigl kc mg|idkly ix ~tkluhol'

    Hoffx hmg do huf|utol "hoff figo)

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    Mg|idkliox ~tkluhol

    Jkgkhfkgmf

    Fmtao mjkug|x

    Loxitol x~ohicihi|y

    X|tuh|uto kc mg|idkliox

    Ijjugkafkdufig A " IaA ) ix |bo jm`kt

    hfmxx kc mg|idkliox ig |bo ~fmxjm'

    =?> eLm

    \o|tmjot kc

    \qk bomsy hbmigx ?> eLm

    \qk fiab| hbmigx 4? eLm Hkggoh|ol dy lixufcilo dkglx

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    fiab| hbmig

    Bomsy

    hbmig

    IaA hmg digl mglhtkxx fige mg|iaogx

    qi|b juf|i digliga xi|ox

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    IaA ix gk| m tiail jkfohufo

    I| bmx xoajog|mf cforidifi|y

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    ^tk~ot|iox kc ijjugkafkdufig hfmxxox

    Jkgkjot=9>>'>?IaO

    Jkgkjot=2>8IaL

    ^og|mjot9>>=4>IaJ

    Lijot kt

    |tijot

    =1>*?>>4>>IaM

    Jkgkjot=?>=>>>IaA

    Hbmig

    x|tuh|uto

    Bomsy

    hbmig

    Jmxx

    eLm

    Hkghog|'

    ja+lf

    Hfmxx

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    IaA IaM IaJ IaL IaO

    Hfmxxox kc ijjugkafkdufigx

    ^tk~ot|iox kc ijjugkafkdufig hfmxxox

    M tkfo ig hkgcottiga ~tk|oh|ikg mamigx| ~mtmxi|ox

    Mffotaih tomh|ikgx

    IaO

    _gegkqg tkfoIaL

    \bo citx| hfmxx |k m~~omt ig xotuj mc|ot

    or~kxuto |k mg|iaog

    IaJ

    \bo jm`kt hfmxx ig or|otgmf xohto|ikgxIaM

    \bo biabox| ig hkghog|tm|ikg ig |bo xotujIaA

    Hfmxx

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    Hfomsmao kc IaA dy ~m~mig

    "Fiji|ol ~tk|okfyxix)

    Cmd ?> eLm

    Diglx mg|iaog

    Hmg| htkxx*fige

    Ch ?> eLm

    Tomlify htyx|mfypox

    Hmg| digl mg|iaog

    Mjigk mhil xo}uogho

    kc mg|idkliox

    4 F hbmigx 4? eLm 4=< MM

    4 B hbmigx ?> eLm

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    Mjigk mhil xo}uogho

    kc mg|idkliox

    MM xo}uogho B hbmig

    "juf|i~fo jyofkjm ~m|iog|x)

    =* ==8 smty ctkj kgo

    ~m|iog| |k mgk|bot

    ==<

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    Ijjugkafkdufig ckfl

    ^mit kc xboo|x

    Omhb duif| kc mg|i~mtmffof x|tmglx

    Hkggoh|ol dy lixufcilo

    \btoo fkk~x m| kgo ogl kc |bo x|tuh|uto

    By~otsmtimdfo x|to|hbox

    \bo digliga xutcmho hkj~fojog|mti|y

    lo|otjigiga toaikgx "HLT)

    \bo jkfohufmt dmxix kc Mg|idkliox

    lisotxi|y \bo Smtimdfo mgl hkgx|mg| toaikgx

    Juf|i~fo S smtimdfo aogox mto xo~mtm|o

    ctkj xigafo H aogo ig ojdtykgih LGM

    ojdtykgih hoff S=& S4& S8 ''Sg % H

    liccotog|im|ol hoff SH

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    Ltoyot * Doggo|| by~k|boxix

    SS

    SS

    S

    S

    SS

    S

    S

    SS

    S

    Tomttmgaiga S mgl H aogoxHS

    H

    Xigafo aotjfigo H aogo

    xo~mtm|o ctkj juf|i~fo S aogox

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    \bo jkfohufmt dmxix kc Mg|idkliox

    lisotxi|y

    Ijjugo xyx|oj hmg aogotm|o 7 =>2

    mg|idkliox ~tk|oigx

    Bujmg aogkjo hkg|migx w &>>> aogox -

    S aogox ig ojdtykgih hoffx lk gk|

    oghklo |bo og|ito smtimdfo aogo S aogoxoghklo |bo citx| 91 mjigk mhilx

    Mttmy kc xoajog|x

    @ aogox oghklo |bo fmx| =8 mjigk mhilx Mttmy kc ? xoajog|x gomt |bo H aogo

    S=& S4& ' S @=& @4& @? H

    S@

    S@H

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    Aogox oghkliga bomsy hbmigx mto ~toxog| kg

    hbtkjkxkjo =>

    Ckt 8> < : =4>

    Ckt B ?= 3 41 : 2434

    Hkjdigm|ikg kc 84> F mgl 2434 4'3 =>3

    Xkjm|ih ju|m|ikgx ightomxox |bo lisotxi|y

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    Hfmxx xqi|hbiga

    ^tk~ot ijjugo tox~kgxo0 Xohto|ol mg|idkliox jux|bmso m~~tk~tim|o occoh|kt cugh|ikg

    IaJ IaA kt IaM '''

    X~ohicihi|y ughbmgaol

    Fiab| hbmig ughbmgaol

    SB ughbmgaol

    HB ix hbmgaol

    Aogo tomttmgaojog|0 jksojog| kc SLA ctkj m xi|o

    gomt kgo H aogo |k m xi|o gomt mgk|bot H aogo

    Xbic|iga kc |bo tohkagi|ikg lkjmig liccotog|

    occoh|kt cugh|ikg ughbmgaol digliga x~ohicihi|y

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    Ijjugo xyx|oj hmg lix|igauixb

    do|qoog xofc mgl gkgxofc

    ^tk|oh|ikg ctkj igsmxikg dy cktoiag ktamgixjx

    ix |bo ~tijmty cugh|ikg kc ijjugo xyx|oj'

    M||mheiga bkx| hoffx ix mskilol'

    Bkq hmg ijjugo xyx|oj lix|igauixb

    Hoffx |bm| tomh| x|tkgafy qi|b xofc* mg|iaogx mto

    eiffol omtfy ig |bo losofk~jog| kc ijjugoxyx|oj

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    H*Tomhtiso ^tk|oig _glo|oh|mdfo ig bomf|by iglisilumfx

    Ig ~m|iog|x qi|b lisotxo igcfmjjm|kty

    lixomxox

    Mhu|o tboujm|ih cosot& dmh|otimf igcoh|ikg& aku| ''

    \ixxuo lmjmao

    Tomh|x qi|b H xudx|mgho " ~kfyxmhhbmtilo ig

    ^gujkhkhhi mgl jkfohufmt atku~x kg m qilosmtio|y kc dmh|otim