Biologic images obtained from Pharmacodia Co.,Ltd2020 sales data obtained from LePro PharmaCompass OPC Private Limited

Velcade Somatuline Nucala Keppra Tremfya Jakavi Copaxone Venclexta Lyrica Mirena Alecensa Lipitor Esbriet Vyndamax mmMeningococcal Vaccines Adempas mInsulin Isophane Galvus Group Bridion Gleevec

Lovenox Epclusa Samsca Brilinta Skyrizi Rotavirus Vaccines NovoMix Tafinlar Abraxane Afinitor Myrbetriq Xifaxan mmActivase/TNKase mInsulin Degludec Crestor Truvada Human Insulins Sandostatin DTaP Vaccines Rexulti

Xtandi Rituxan Herceptin Tagrisso Perjeta Darzalex Jardiance Soliris mmInfluenza Vaccines Cosentyx Victoza Gardasil Trikafta Tecfidera Entyvio Ozempic Invega Sustenna Lucentis Simponi Xolair

Humira Keytruda Eliquis Revlimid Imbruvica Stelara Eylea Opdivo Xarelto Dupixent Biktarvy Enbrel Avastin Prevnar 13 Insulin Glargine Ocrevus Trulicity Ibrance Remicade Prolia 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20(Adalimumab) (Pembrolizumab) (Apixaban) (Lenalidomide) (Ibrutinib) (Ustekinumab) (Aflibercept) (Nivolumab) (Rivaroxaban) (Dupilumab) (Bictegravir, Emtricitabine

& Tenofovir Alafenamide)(Etanercept) (Bevacizumab) (Pneumococcal 7-Valent

Conjugate)(Insulin Glargine) (Ocrelizumab) (Dulaglutide) (Palbociclib) (Infliximab) (Denosumab)

$20.947 Billion $14.38 Billion $14.117 Billion $12.106 Billion $9.442 Billion $7.972 Billion $7.938 Billion $7.899 Billion $7.806 Billion $7.501 Billion $7.259 Billion $6.828 Billion $6.503 Billion $5.85 Billion $5.666 Billion $5.665 Billion $5.404 Billion $5.392 Billion $5.163 Billion $5.138 BillionImmunology Oncology Cardiovascular Diseases Oncology Oncology Immunology Ophthalmology Oncology Cardiovascular Diseases Dermatology Infectious Diseases Immunology Oncology Vaccine Diabetes CNS & Anesthesia Diabetes Oncology Immunology Musculoskeletal

21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40(Enzalutamide) (Rituximab) (Trastuzumab) (Osimertinib) (Pertuzumab) (Daratumumab) (Empagliflozin) (Eculizumab) (Influenza Vaccine) (Secukinumab) (Liraglutide) (HPV Quadrivalent Vaccine) (Elexacaftor, Tezacaftor & Ivacaftor) (Dimethyl Fumarate) (Vedolizumab) (Semaglutide) (Paliperidone Palmitate) (Ranibizumab) (Golimumab) (Omalizumab)

$5.1 Billion $4.987 Billion $4.725 Billion $4.328 Billion $4.326 Billion $4.19 Billion $4.108 Billion $4.064 Billion $4.006 Billion $3.995 Billion $3.961 Billion $3.939 Billion $3.864 Billion $3.841 Billion $3.823 Billion $3.755 Billion $3.653 Billion $3.542 Billion $3.467 Billion $3.372 BillionOncology Oncology Oncology Oncology Oncology Oncology Diabetes Blood Disorders Vaccine Immunology Diabetes Vaccine Genetic Disorders CNS & Anesthesia Gastrointestinal Disorders Diabetes CNS & Anesthesia Ophthalmology Immunology Immunology

41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60Orencia Genvoya Januvia Triumeq Actemra Pomalyst Tecentriq Immunoglobulin Gilenya Insulin Aspart Veklury Symbicort Advate Insulin Lispro Neulasta Vyvanse DTaP-IPV-Hib vaccine Lynparza Entresto Aubagio(Abatacept) (Elvitegravir, Cobicistat, Emtricitabine

& Tenofovir Alafenamide)(Sitagliptin) (Abacavir, Dolutegravir

& Lamivudine)(Tocilizumab) (Pomalidomide) (Atezolizumab) (Immunoglobulin) (Fingolimod) (Insulin Aspart) (Remdesivir) (Budesonide & Formoterol) (Antihemophilic Factor

(Recombinant))(Insulin Lispro) (Pegfilgrastim) (Lisdexamfetamine) (DTaP-IPV-Hib vaccine) (Olaparib) (Sacubitril & Valsartan) (Teriflunomide)

$3.36 Billion $3.338 Billion $3.306 Billion $3.197 Billion $3.184 Billion $3.07 Billion $3.051 Billion $3.05 Billion $3.043 Billion $2.979 Billion $2.811 Billion $2.721 Billion $2.652 Billion $2.626 Billion $2.585 Billion $2.559 Billion $2.547 Billion $2.501 Billion $2.497 Billion $2.474 BillionImmunology Infectious Diseases Diabetes Infectious Diseases Immunology Oncology Oncology Immunology CNS & Anesthesia Diabetes Infectious Diseases Respiratory Disorders Blood Disorders Diabetes Blood Disorders CNS & Anesthesia Vaccine Oncology Cardiovascular Diseases CNS & Anesthesia

61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80Zytiga Ofev Hemlibra Sprycel Xeljanz Spinraza Alimta Cimzia Nexium Otezla Prezcobix Farxiga Spiriva Advair Tivicay Imfinzi Latuda Janumet Breo Ellipta Tasigna(Abiraterone Acetate) (Nintedanib) (Emicizumab) (Dasatinib) (Tofacitinib) (Nusinersen) (Pemetrexed) (Certolizumab pegol) (Esomeprazole) (Apremilast) (Darunavir & Cobicistat) (Dapagliflozin) (Tiotropium bromide) (Salmeterol) (Dolutegravir) (Durvalumab) (Lurasidone) (Metformin & Sitagliptin) (Fluticasone Furoate & Vilanterol) (Nilotinib)

$2.47 Billion $2.448 Billion $2.44 Billion $2.438 Billion $2.437 Billion $2.339 Billion $2.33 Billion $2.265 Billion $2.209 Billion $2.195 Billion $2.184 Billion $2.157 Billion $2.136 Billion $2.128 Billion $2.117 Billion $2.042 Billion $2.019 Billion $1.971 Billion $1.97 Billion $1.958 BillionOncology Respiratory Disorders Blood Disorders Oncology Immunology Genetic Disorders Oncology Infectious Diseases Gastrointestinal Disorders Dermatology Infectious Diseases Diabetes Respiratory Disorders Respiratory Disorders Infectious Diseases Oncology CNS & Anesthesia Diabetes Respiratory Disorders Oncology

81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100Tysabri Kadcyla Aranesp Vimpat Avonex MMR Vaccines Lenvima Descovy Leuprorelin Mavyret Jentadueto Abilify Maintena Taltz Pradaxa Xyrem Promacta Prograf Yervoy Odefsey Opsumit(Natalizumab) (Trastuzumab Emtansine) (Darbepoetin Alfa) (Lacosamide) (Interferon Beta-1a) (Measles, Mumps, Rubella

& Varicella Vaccine)(Lenvatinib) (Emtricitabine &

Tenofovir Alafenamide)(Leuprorelin) (Glecaprevir & Pibrentasvir) (Linagliptin & Metformin) (Aripiprazole) (Ixekizumab) (Dabigatran Etexilate) (Sodium Oxybate) (Eltrombopag) (Tacrolimus) (Ipilimumab) (Emtricitabine, Rilpivirine

& Tenofovir Alafenamide)(Macitentan)

$1.946 Billion $1.944 Billion $1.906 Billion $1.883 Billion $1.878 Billion $1.878 Billion $1.863 Billion $1.861 Billion $1.834 Billion $1.83 Billion $1.801 Billion $1.798 Billion $1.789 Billion $1.777 Billion $1.742 Billion $1.738 Billion $1.695 Billion $1.682 Billion $1.672 Billion $1.639 BillionCNS & Anesthesia Oncology Blood Disorders CNS & Anesthesia CNS & Anesthesia Vaccine Oncology Infectious Diseases Oncology Infectious Diseases Diabetes CNS & Anesthesia Immunology Blood Disorders CNS & Anesthesia Oncology Immunology Oncology Infectious Diseases Cardiovascular Diseases

101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120(Enoxaparin Sodium) (Sofosbuvir & Velpatasvir) (Tolvaptan) (Ticagrelor) (Risankizumab) (Rotavirus Vaccine) (Biphasic Insulin Aspart) (Dabrafenib & Trametinib) (Paclitaxel Protein Bound) (Everolimus) (Mirabegron) (Rifaximin) (Alteplase/Tenecteplase) (Insulin Degludec) (Rosuvastatin) (Emtricitabine & Tenofovir

Disoproxil Fumarate)(Human Insulin) (Octreotide) (Diphtheria, Tetanus Acellular,

and Pertussis Vaccine)(Brexpiprazole)

$1.634 Billion $1.599 Billion $1.597 Billion $1.593 Billion $1.59 Billion $1.572 Billion $1.567 Billion $1.542 Billion $1.539 Billion $1.535 Billion $1.492 Billion $1.482 Billion $1.472 Billion $1.459 Billion $1.458 Billion $1.448 Billion $1.443 Billion $1.439 Billion $1.424 Billion $1.42 BillionBlood Disorders Infectious Diseases Cardiovascular Diseases Cardiovascular Diseases Immunology Vaccine Diabetes Oncology Oncology Oncology Nephrology Infectious Diseases Cardiovascular Diseases Diabetes Cardiovascular Diseases Infectious Diseases Diabetes Oncology Vaccine CNS & Anesthesia

121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140(Bortezomib) (Lanreotide) (Mepolizumab) (Levetiracetam) (Guselkumab) (Ruxolitinib) (Glatiramer acetate) (Venetoclax) (Pregabalin) (Levonorgestrel) (Alectinib) (Atorvastatin) (Pirfenidone) (Tafamidis) (Meningococcal Vaccine) (Riociguat) (Insulin Isophane) (Vildagliptin) (Sugammadex) (Imatinib)

$1.389 Billion $1.386 Billion $1.378 Billion $1.359 Billion $1.347 Billion $1.339 Billion $1.337 Billion $1.337 Billion $1.313 Billion $1.308 Billion $1.292 Billion $1.291 Billion $1.29 Billion $1.288 Billion $1.269 Billion $1.261 Billion $1.26 Billion $1.199 Billion $1.198 Billion $1.188 BillionOncology Oncology Respiratory Disorders CNS & Anesthesia Immunology Oncology CNS & Anesthesia Oncology CNS & Anesthesia Urology Oncology Cardiovascular Diseases Immunology Cardiovascular Diseases Vaccine Cardiovascular Diseases Diabetes Diabetes CNS & Anesthesia Oncology

141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160NovoSeven Myozyme Insulin Detemir Trelegy Ellipta Kyprolis Creon Plavix Uptravi Ventolin Pneumovax 23 Ultomiris Forteo Cyramza Vectibix Cymbalta Pulmicort Diovan Group Benlysta Ingrezza Fabrazyme

$1.172 Billion $1.147 Billion $1.143 Billion $1.135 Billion $1.13 Billion $1.114 Billion $1.108 Billion $1.093 Billion $1.088 Billion $1.086 Billion $1.077 Billion $1.046 Billion $1.033 Billion $1.032 Billion $1.019 Billion $1.01 Billion $1.003 Billion $997 Million $993 Million $988 MillionBlood Disorders Rare Disorders Diabetes Respiratory Disorders Oncology Rare Disorders Cardiovascular Diseases Cardiovascular Diseases Respiratory Disorders Vaccine Blood Disorders Musculoskeletal Oncology Oncology CNS & Anesthesia Respiratory Disorders Cardiovascular Diseases Rare Disorders Neurology Rare Disorders

161 162 163 164 165 166 167 168 169 170 171 172 173 174 175 176 177 178 179 180Exforge Group Fasenra Edurant Nexgard Vraylar Repatha Nplate Zolgensma Chantix Verzenio Orkambi Zoladex Ilaris Bamlanivimab Isentress Cerezyme Ninlaro Toprol-XL Sutent YAZ(Amlodipine & Valsartan) (Benralizumab) (Rilpivirine) (Afoxolaner) (Cariprazine) (Evolocumab) (Romiplostim) (Onasemnogene Abeparvovec) (Varenicline) (Abemaciclib) (Lumacaftor & Ivacaftor) (Goserelin) (Canakinumab) (Bamlanivimab) (Raltegravir) (Imiglucerase) (Ixazomib) (Metoprolol Hydrochloride) (Sunitinib Malate) (Drospirenone & Ethinyl Estradiol)

$980 Million $969 Million $964 Million $958 Million $951 Million $930 Million $922 Million $920 Million $919 Million $913 Million $908 Million $888 Million $873 Million $871 Million $857 Million $835 Million $828 Million $821 Million $819 Million $810 MillionCardiovascular Diseases Respiratory Disorders Infectious Diseases Infectious Diseases CNS & Anesthesia Cardiovascular Diseases Immunology CNS & Anesthesia CNS & Anesthesia Oncology Respiratory Disorders Oncology Rare Disorders Infectious Diseases Infectious Diseases Rare Disorders Oncology Cardiovascular Diseases Oncology Urology

181 182 183 184 185 186 187 188 189 190 191 192 193 194 195 196 197 198 199 200Takhzyro Kalydeco Hepatitis Vaccines Invokamet Parasbiv Inlyta Restasis Vasostrict Aspirin Nexavar Eloctate Synthroid Takecab Acthar Azilva Erleada Anoro Ellipta Lamictal Adalat Strensiq (Lanadelumab) (Ivacaftor) (Hepatitis Vaccine) (Canagliflozin & Metformin) (Etelcalcetide) (Axitinib) (Cyclosporine) (Vasopressin) (Acetylsalicylic Acid) (Sorafenib) (Antihemophilic Factor (Recombinant),

Fc Fusion Protein)(Levothyroxine) (Vonoprazan) (Corticotropin) (Azilsartan) (Apalutamide) (Umeclidinium & Vilanterol) (Lamotrigine) (Nifedipine) (Asfotase Alfa)

$808 Million $803 Million $799 Million $795 Million $791 Million $787 Million $787 Million $786 Million $773 Million $773 Million $772 Million $771 Million $771 Million $768 Million $764 Million $760 Million $758 Million $744 Million $741 Million $732 MillionGenetic Disorders Respiratory Disorders Vaccine Diabetes Hormonal Disorders Oncology Immunology Nephrology Cardiovascular Diseases Oncology Blood Disorders Hormonal Disorders Gastrointestinal Disorders Immunology Cardiovascular Diseases Oncology Respiratory Disorders CNS & Anesthesia Cardiovascular Diseases Metabolic Disorders

(Coagulation Factor VIIa [Recombinant])

(Alglucosidase Alfa) (Insulin Detemir) (Fluticasone Furoate, Vilanterol & Umeclidinium)

(Carfilzomib) (Pancrelipase) (Clopidogrel) (Selexipag) (Albuterol) (Pneumococcal Vaccine Polyvalent)

(Ravulizumab) (Teriparatide) (Ramucirumab) (Panitumumab) (Duloxetine) (Budesonide) (Hydrochlorothiazide & Valsartan) (Belimumab) (Valbenazine) (Agalsidase Beta)

Key Oncology Cardiovascular Diseases Immunology Ophthalmology Dermatology Infectious Diseases Vaccine Diabetes CNS & Anesthesia Blood Disorders Respiratory Disorders Rare Disorders Miscellaneous

Top 200 Pharmaceuticals by Retail Sales in 2020M. Haziq Qureshi - The Njarðarson Group

The University of Arizona