Nghiên cứu và ứng dụng bêta-cyclodextrin làm chất mang thuốc ketoprofen

8/9/2019 Nghiên cứu và ứng dụng bêta-cyclodextrin làm chất mang thuốc ketoprofen

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LỜI CẢM ƠN

----------

Đầu tiên tôi xin bày tỏ lòng biết ơn sâu sắc đến GS. TSKH Nguyn !ông Hà"#

ng$%i T&ầy luôn gắn b' ()i *&"+ &,c# t-c tiế/ gi0ng 12y (à &$)ng 13n tôi t-"ng su4t

t&%i gi+n &,c t5/ (à ng&iên c6u t&c &i7n đ8 tài này. T&ầy đ9 t5n t:n& t-uy8n đ2t

n&;ng t-i t&6c *&"+ &,c uyên b<c# đ=ng t&%i đ9 luôn đ>ng (iên (à +n ?i tôi đ@ ($At

Bu+ n&;ng *&' *&Cn t-D ng2i t-"ng su4t t&%i gi+n làE đ8 tài.

!0E ơn c<c t&ầy cô K&"+ K&"+ &,c T n&iên F T-$%ng Đ2i &,c !ần T&ơ (à c<c

t&ầy cô công t<c t2i i7n !ông ng&7 H'+ &,c F i7n K&"+ &,c !ông ng&7 đ9 t-uy8nđ2t n&;ng *iến t&6c Bu b<u (à t5n t:n& &$)ng 13n tôi su4t *&'+ đà" t2" (I+ Bu+.

Tôi xin c0E ơn TS. ĐJng !& Hi8n# T&S. Nguyn T&àn& L+n& đ+ng công t<c

t2i M&òng !ông Ng&7 H"< L$Ac F i7n !ông ng&7 H'+ &,c đ9 n&i7t t:n& gi/ đO# t2"

đi8 *i7 & 5 l i đ@ ôi & à &à & l 5 C à

WWW.DAYKEMQUYNHON.UCOZ.COM



đi8 *i7 & 5 l i đ@ ôi & à &à & l 5 C à

MỤC LỤC

LỜI CẢM ƠN...................................................................................................................ii

MỤC LỤC.......................................................................................................................iii

1.1 KHÁI QUÁT VỀ β-CYCLODEXTRIN....................................................................3

1.1.1 Cấu !"# #$% β-#&#'()*+!i, ...................................................................................3

1.1. T,/ #/ấ #$% β-#&#'()*+!i,...................................................................................0

1.1..1 T,/ #/ấ ' 2 /% #$% β-#&#'()*+!i, .....................................................0

1.1.. 45# ,/ #$% β-#&#'()*+!i,......................................................................6

1.1..3 T,/ 7( 8/9#.............................................................................................:

1.1.3 ;,< )=,< #$% β-#&#'()*+!i,..................................................................................>

1.1.3.1 T!(,< #?,< ,</i@8 )AB# 8/.................................................................>

1.1.3. D, !u&F, /uG# /?,< u% ,< Ji,/ /#..............................................>




1..0.3 d 7( 8/9# )7,< f5 ,/j(1P>> ............................................................1

1..0.0 T!5, ' ,,<...............................................................................1

1..0.6 d k8 !i1..............................................................................................1

1..0.: T!5, h/?1P>>.........................................................................................13

1..0.> /A,< 8/S8 #/igu +7 'l i J,<............................................................13

1.3 KHÁI QUÁT CHUN VỀ HmT N^NO................................................................13

1.3.1 K/Si ,i@...............................................................................................................13

1.3. /, '(7i #$% /7 ,%,( ..........................................................................................10

1.3..1 /, '(7i /*( #/iFu #$% /@ /G,< ,%,(..................................................10

1.3.. /, '(7i /*( /n,/ /Si /#....................................................................16

1.3.3 T,/ #/ấ #$% /7 ,%,(...........................................................................................1:

1.3.0 CS# 8/A,< 8/S8 #/g 7( /7 ,%,( .......................................................................1>

1.3.0.1 /, S, 8('&*! /n,/ /,/ !Ao#.........................................................1>




..1 N<u&s, 'i@u /% #/ấ........................................................................................6

.. ioi /i@u J 'AB# F # i~ ,/ #/ấ #$% 5 JG ,<u&s, 'i@u...................:

...1 ^'<i,%*1P...............................................................................................:

... K*(8!(•*,1PP3 ..................................................................................>

.3 I€I THI|U dƠ LC VỀ CÁC THIvT yz d‚ DỤN......................................

.3.1 K,/ /i~, i i@, c uk1...................................................................................

.3. K,/ /i~, i i@, c !u&F, u%1...........................................................................

.3.3 MS& ?,< h/?........................................................................................................

.0 HƠN HÁ NHI{N C;U............................................................................

.0.1 Tƒ,< /B8 8/9# β-#&#'()*+!i,„h*(8!(•*,...........................................................

.0.1.1 Tƒ,< /B8 8/9# β-#&#'()*+!i,„h*(8!(•*, fp,< 8/A,< 8/S8 h/uấ& x

..............................................................................................................................

.0.1. Tƒ,< /B8 8/9# β-#&#'()*+!i,„h*(8!(•*, fp,< 8/A,< 8/S8 i J,<.3b




3. N^NO β-CYCLODEXTRIN2^LIN^TE............................................................03

3.3 N^NO β-CYCLODEXTRIN2^LIN^TE2KETORO…EN................................0:

3.3.1 K/e( JS † '@ β-#&#'()*+!i,‰%'<i,%*...................................................................0:

3.3. K/e( JS / 'AB,< h*(8!(•*, ...........................................................................0

3.0 4ŠC 4I‹M CZU TRŒC V[ HNH DmN CŽ^ H;C

β-CYCLODEXTRIN„KETORO…EN..........................................................................61

3.6 4ŠC 4I‹M CZU TRŒC V[ HNH DmN CŽ^ N^NO....................................61

3.6.1 C/u, f_ u ( dEM ( TEM.......................................................................61

3.6. 4# i~ #ấu !"# /n,/ )7,< #$% ,%,( β-#&#'()*+!i,2%'<i,%*.....................6

3.6.3 4# i~ #ấu !"# /n,/ )7,< #$% ,%,( β-#&#'()*+!i,2%'<i,%*2h*(8!(•*,. 6

3.: CÁC Ht IR............................................................................................................63

3.:.1 /ƒ IR #$% β-#&#'()*+!i,P 8/9# β-#&#'()*+!i,„h*(8!(•*,P h*(8!(•*,............63

ƒ β β β




3.1b KHẢ NN H}N THCH THU‘C06............................................................:0

0.1 QUY TRNH TH’C NHI|M...............................................................................::

0. y‘ TR TH NHI|M.............................................................................................:>

0..1 Tƒ,< /B8 8/9# β-#&#'()*+!i,„h*(8!(•*,...........................................................:>

0..1.1 /A,< 8/S8 h/uấ& x.............................................................................:>

0..1. /A,< 8/S8 i J,<...............................................................................:>

0.. Tƒ,< /B8 #S# ,%,(.................................................................................................:

0...1 N%,( β-#&#'()*+!i,2%'<i,%*.................................................................:

0... N%,( β-#&#'()*+!i,2%'<i,%*2h*(8!(•*,.............................................:

0.3 CÁC HƠN HÁ TtN H........................................................................:

0.3.1 Tƒ,< /B8 8/9# β-#&#'()*+!i,„h*(8!(•*, fp,< 8/A,< 8/S8 h/uấ& x.............:

0.3. Tƒ,< /B8 8/9# β-#&#'()*+!i,„h*(8!(•*, fp,< 8/A,< 8/S8 i J,<...............>

ƒ β




IR I,•!%!*) J8*#!(J#(8&

µ Mi#!(*

, N%,(*

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dC CO du8*!#!ii#%' #%!f(, )i(+i)*

dEM d#%,,i,< E'*#!(, Mi#!(J#(8*

Ty T!u,< fn,/

TEM T!%,JiJJi(, E'*#!(, Mi#!(J#(8&

TLC T/i, L%&*! C/!(%(<!%8/&

T d()iu !i8('&8/(J8/%




DANH MỤC CÁC BẢNG

ye,< 1 CS# ,/ #/ấ #$% β-#&#'()*+!i,1P0................................................................6

1:

ye,< D%,/ =# ,<u&s, 'i@u /% #/ấ j Jc )=,<.................................................6

ye,< 3 K/e( JS e,/ /A,< #$% † '@ h*(8!(•*,‰β-#&#'()*+!i, g, /i@u Juấ 7( 8/9#

β-#&#'()*+!i,„h*(8!(•*,...................................................................................3

ye,< 0 K/e( JS e,/ /A,< #$% /î <i%, 8/e, 9,< g, /i@u Juấ 7( 8/9#

β-#&#'()*+!i,„h*(8!(•*,...................................................................................30

ye,< 6 K/e( JS e,/ /A,< #$% ,/i@ 5 8/e, 9,< g, /i@u Juấ 7( 8/9#

β-#&#'()*+!i,„h*(8!(•*,...................................................................................3:

ye,< : K/e( JS e,/ /A,< #$% #?,< Juấ g, /i@u Juấ 7( 8/9#

β-#&#'()*+!i,„h*(8!(•*,...................................................................................3




DANH MỤC CÁC SƠ ĐỒ

d 1 Qu& !n,/ ƒ,< /B8 8/9# β-#&#'()*+!i,„h*(8!(•*, fp,<

8/A,< 8/S8 h/uấ& x.........................................................................................>b

d Qu& !n,/ ƒ,< /B8 8/9# fp,< 8/A,< 8/S8 i J,<.......................................>

d 3 Qu& !n,/ ƒ,< /B8 ,%,( β-#&#'()*+!i,2%'<i,%*............................................>6

d 0 Qu& !n,/ ƒ,< /B8 ,%,( β-#&#'()*+!i,2%'<i,%*2h*(8!(•*,........................>>




DANH MỤC CÁC HÌNH




DANH MỤC CÁC PHỤ LỤC

/= '=# 1 /ƒ IR #$% %'<i,%*

/= '=# /ƒ IR #$% β-#&#'()*+!i,

/= '=# 3 /ƒ IR #$% 8/9# β-#&#'()*+!i,„h*(8!(•*, –h/uấ& x—

/= '=# 0 /ƒ IR #$% 8/9# β-#&#'()*+!i,„h*(8!(•*, –i J,<—

/= '=# 6 /ƒ IR #$% ,%,( β-#&#'()*+!i,2%'<i,%*

/= '=# : /ƒ IR #$% ,%,( β-#&#'()*+!i,2%'<i,%*2h*(8!(•*,

/= '=# > /ƒ IR #$% h*(8!(•*,

/= '=# /ƒ IR #$% β-#&#'()*+!i,P 8/9# β-#&#'()*+!i,„h*(8!(•*,P h*(8!(•*,

/= '=# /ƒ IR #$% %'<i,%*P β-#&#'()*+!i,P ,%,( β-#&#'()*+!i,2%'<i,%*2




MT S! TỪ TIẾNG ANH D"NG

T#$NG LU%N V&N

^NOV^ /, #/ 8/A,< J%i

^,(% Ji,<'* •%#(! /, #/ 8/A,< J%i 5 &gu G

^*!%<* T!u,< fn,/

y*˜**, <!(u8J N<u ,/is,

C(*••. O• %!i%i(, H@ JG 8/A,< J%i

C(u, dG 'AB,<

D•‰ )*i%i(, yq# )(

…‰ …iJ/*! Tisu #/u, …iJ#/*! /# ,</i@

…-#!i‰ …iJ/*! #!i Tisu #/u, …iJ#/*! ' /u&g




LU“N VN THmC d› H}^ HœC - b1b

M' Đ(U

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h/i !ž * #Ÿ,< # /~ ™# f@,/. D( P ,/u #au iFu !_ fp,< h*(8!(•*, ' !ấ #%(.

K*(8!(•*, ' /uG# h/S,< is h/?,< J*!(i) –NdÎDJ— /u5# ,/ 8!(8i(,i# %#i)# S# )=,< <ie %u /7 JG. Tu& ,/is,P )( h*(8!(•*, # #/9% ,/ %#i) ,s, h/i

Jc )=,< 'iFu 'AB,< #%( J <& !% 5 JG S# )=,< 8/= e,/ /A,< #/$ &gu g, ,is

7# )7 )&P # /7i #/( <%, /q,.

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oi β-#&#'()*+!i,P 5 ('i<(J%##/%!i)* l,<. /9# ,& #/( 8/k8 ,/‡,< 8/, c ,

h*(8!(•*, AB# <iei 8/,< 5 #S#/ !is,< fi@ !(,< /@ isu /% /%& n )7,< i,/

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ig8 oi ,is 7# )7 )& <ie +uG,< ,s, ,<u& # <& is '(k )7 )& #Ÿ,< J <ie.

G ƒ ~ ấ F







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KHÁI UÁT VE FCCL$DT#IN CJ. +* */0 F**<5O+,6

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/, c β-#&#'()*+!i, #/9% fe& , _ α-D-<'u#(8&!%,(J* AB# 'is, hg fp,<

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f# fi h/u,< #%!f(, ,<u&s, c (+&<*, /u5# */*! #$% Aˆ,<.: V_ ! '¦ /ƒ,< /¢8

#$% β-#&#'()*+!i, # #S# ,/ /&)!(+&' fq# 5 AB# <i ' /9 ,/ấ. N<AB#

'7iP _ ! '¦ /ƒ,< !5,< #$% β-#&#'()*+!i, %,< #S# ,/ /&)!(+&' fq# /%i AB#

0P0

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8/ )( P # ' β-#&#'()*+!i, AB# ,</is, #9u G ,/ấ ,<Aî.1

1.1.2." Tính t#o $h%c

4# !A,< u%, !,< ,/ấ #$% β-#&#'()*+!i, ' # h/e ,¡,< 7( /,/ 8/9# #/ấ /,/ 8/a, ',< ,/%u !7,< /Si )u,< )_#/ !™,

–'(7i #/$ /~ 2 h/S#/ /~— oi 5 8/7 i !ấ !5,< #$% #S# #/ấ A% #/ấ fk( )7,< !™,P 'r,<P h/ fp,< /i@, AB,< 7( 8/9# 8/, c. 1:P1P6:

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β-#&#'()*+!i, # /~ f™ 'ấ& #S# 8/, c h/S#/ h¬ ,Ao# /#/ /B8 ( '¦ /ƒ,< h¬

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,</i@8 )@.0

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fo J h#/ /#/ )( /uG# <& !% <iấu Wi.6

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β ~







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' /B8 #/ấ f%(P 8/9# ,< <iP 8/9# #/ấP )7,< ™ 'Aoi 2 #'%/!%*.

P8g6 <f, a89* *8J+ +8368 a8b6 c67 680.

1.2.2.1 @h%c chất thnh $hAn l>ng nha =a $h<n tB 0

h&ng gian gi/ng như *;ng

N/ 8/, c #/$ ,& # !A,< fi J /q ' #/",< /n,/ /,/ S,< !(,<

)j& #$% #S# 8/, c /#/ /B8.

N/ #/ấ AB# fig ,/iFu /u5# '(7i ,& ' #S# /B8 #/ấ u!*%P /i(u!*%

J*'*,u!*%.> Ygu G u&g _,/ # /%& h/?,< 8/, c # /~ #u,< #ấ8 ,/A ' 8/, c

h/S#/ ' h/e ,¡,< #$% , h/o8 oi S,<.

h&ng gian gi/ng như l>ng





/n,/ /,/ #S# 8/9# #/u&~, i@, c oi i()i,*. N/iFu 8/, c #/$ # h/e ,¡,< /n,/

/,/ 8/9# #/ấ /,/ 8/a, ',< ,/%u '(7i ,& ,/A ' %&'(J*P %&'(8*#i,P i,u'i,P

•'%(,*P f%!fiu!i# %#i)P #(!iJ(,*P #(u%!i, #/('i# %#i).

1.2.2.8 @h%c chất thnh $hAn l>ng nha =#i $h<n tB 0

L(7i oi ,/ấ ,& #/9% #S# 8/, c #/$ # h#/ /Ao# 7i 8/, c. C/",< /n,/

/,/ f% #ấu !"# 7,< h/?,< <i%, !(,< #S# '¦ /ƒ,< AB# /n,/ /,/. D*+!%, '

7,< 7i 8/, c #$% 8('&J%##/%!i)* # h/e ,¡,< /(7 5,< ,/A ' 5 !& 8/, c.di'i#% <*' ' 7,< f% h/?,< <i%, h/?,< Fu #$% ,<u&s, c Ji'i#(, ,Gi oi ,<u&s, c

(+&<*,. C/",< ' #S# !& 8/, c oi 9# 5 #/, '# !ấ #%(.

] CX* +68 *8J+ */0 a89* *8J+ +8368 a8b6 c67 680.

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#S# 8/, c h/S#/ #/9% !(,< h/?,< <i%, /n,/ /# #$% 8/, c #/$ fp,< '# <i‡% #S#

8/, c &gu.6

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<ioi /7, #$% β-#&#'()*+!i, ,s, 8/ei Jc )=,< 'AB,< 'o, ,Ao#. K/e ,¡,< #/9%P /î

<i%, ,¡,< 'AB,< ~ ,u,< ,,< ' '7,/ # /~ ! /,/ &gu G #/i 8/ u%,

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)_#/P fi n 8/9# #$% β-#&#'()*+!i, fj( /( !(,< 8/% ,Ao#P 8/9# J hg i,/ /(# hg $% !% h/ri 8/% ,Ao#. CS# i,/ /~ β-#&#'()*+!i, J /l% %,

ig8 =# <i%i (7, fj( /l% !(,< 8/% ,Ao# ~ 7( /,/ 8/9# hg $% /(# hg i,/ !(,< <i%i (7, )_#/ ,Ao#. /9# ,& # /~ AB# /u /*( #S#/

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u i~ #/,/ #$% 8/A,< 8/S8 ,& ' <ie 'AB,< ,Ao# #a, /ig h#/

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1.2.8.M Tr!n Gh&1P>>

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8/A,< 8/S8 ,& AB# /# /i@, ,/i@ 5 8/l,< ' 5 fig, /~ #$% 8/A,< 8/S8

f5 ,/j(.

u i~ #/,/ #$% 8/A,< 8/S8 ,& ' h/?,< #a, /s ,Ao# (P !x <i%i (7,!c% AB# Jc )=,<.

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h/?,< AB# (, )i@, ), g, i@# 7( 8/9# h/?,< a& $ oi ,/iFu h/S#/ 5 )i

#$% /î <i%, ' #a, /ig.

1.2.8.K @hương $h;$ chiH x# lN vi óng

N<(i #S# 8/A,< 8/S8 #ƒ i~, !s,P ,<& ,%& ,<Aî % #l, Jc )=,< 8/A,<

8/S8 h/S# ~ 7( 8/9# ' 8/A,< 8/S8 #/igu +7 fp,< #S#/ Jc )=,< 'l i J,<. H¦, /B8 /uG#

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H@ /G,< ), !u&F, /uG# /7 ,%,( ' ,/‡,< #/ấ %,< , AB# Jc )=,< ~

), !u&F, /uG# /(# #S# 8/, c Ji,/ /#. Ni #/u,<P #S# #/ấ %,< , < # #S#

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1.".2.1 @h<n lo#i theo chi của h' th/ng nano

%. M5 #/iFu –'o8 8/$ fF r,<—

H@ /G,< 5 #/iFuP #/£,< /7, ,/A •i' r,< /(# #S# fF Je, +uấ.

f. H%i #/iFu

Ong nano carFon

‘,< ,%,( #%!f(, ' 5 /n,/ /9# oi #$% 8/, c #%!f(,. CS# G,< ,%,( ,&

# /~ # 5 'o8 )u& ,/ấ /(# ,/iFu 'o8 #$% != ,< !=# Aˆ,< h,/ ¡,< )a, /*(

!=# #/u,<.6>P

+<y nano





Pllerene

…u''*!*,* ' 8/, c AB# #ấu 7( /(, (, x #%!f(, –x g, ,/iFu /, 1bb

,<u&s, c #%!f(,—P # )7,< #$% /n,/ #au !¦,<P *''i8J(i) /(# G,<.

+endri*er

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ig,< H& L78 °±²³±´µ³¶ –8/S )*,)!(,—P )_#/ ' °#&¶. D*,)!i*! /Aˆ,< Gi +9,<

+u,< u%,/ '·iP /Aˆ,< /?,< u% 5 /n,/ /Si f% #/iFu /n,/ #au.: D*,)!i*! 7i

)i@, #/( 5 ,/ oi #$% #S# 8('&*! #ấu !"# # hi~ J(S oi h#/ /Ao# ,.

Qant* dot

Qu%,u )( ' 5 #/ấ fS, ), #S# *+i(, #$% , f_ <ioi /7, !(,< #e

h/?,< <i%, f% #/iFu. Qu%,u )( /~ /i@, 5 /n,/ /9# # fi@ #$% ,%,( i,/ /~/n,/ #au # Aˆ,< h,/ 1-1b ,.bP





HQ68 s N06< 8Q68 *b. m0n >3 606< 1R67 7R, men

4S ,%,( # ,/ấ 5 h#/ /Ao# x 1-1b , 8/, fG h#/ /Ao# /¢8.

Hn,/ #auP /n,/ u*P /n,/ JBi #/¯ ' 5 !(,< JG #S# /n,/ )7,< j AB# 8/S !i~,.

y5 ,%,( ' #S# h/Gi hg = #$% #S# /7 Jisu _,P #S# /7 ,%,( /(# S ,%,(.

CS# i,/ /~ , # h#/ /Ao# ,P /(# #S# /7 Jisu _, x !Aˆ,< ,P /Aˆ,<

AB# <i ' #S# ,%,( i,/ /~.P

]] T68 *8J+ */0 8f+ 606<


http://en.wikipedia.org/wiki/Powder_(substance)

http://en.wikipedia.org/wiki/Nanocrystal

http://en.wikipedia.org/wiki/Powder_(substance)

http://en.wikipedia.org/wiki/Nanocrystal




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CS# /7 ,%,( AB# iFu #/g /Aˆ,< +u&s, ,/ấ fp,< f% 8/A,< 8/S8‰ 11P> –1—

8/, S, 8('&*! /n,/ /,/ !Ao#ª –— !W,< /B8 (,(*!ª –3— J <*' /% i(, /(#

J = <i #$% 8('&*! A% ,Ao#. Tu& ,/is,P ,<& ,%& #l, Jc )=,< #S# 8/A,< 8/S8

h/S# ,/A h /uq #/ấ 'r,< Jisu oi /7,b J Si 7( /7 !(,< #S# u Ao33 ~ #/g

7( /7 ,%,(.

1.".8.1 @h<n t;n $oly*er hình thnh trưRc

/, S, 8('&*! /n,/ /,/ !Ao# ' h /uq 8/ƒ fig, AB# Jc )=,< ~ iFu

#/g #S# /7 ,%,( 8/, /u† Ji,/ /# x 8('&–%#i) '%#i#— –L^—ª 8('&–DP L-<'&#('i)*—

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K /uq ,& # /~ AB# Jc )=,< !(,< ,/iFu #S#/ h/S# ,/%u ,/A ? e )Aoi &.a. @hương $h;$ l* Fay hơi dng *&i

T!(,< 8/A,< 8/S8 ,& 8('&*! AB# /( %, !(,< )u,< ?i /‡u # ,/A '

)i#/'(!(*/%,P #/'(!(•(! /(# */&' %#*%* #Ÿ,< AB# Jc )=,< ,/A ' )u,< ?i ~

/l% %, /uG# h¬ ,Ao#. d%u P /¦, /B8 )u,< )_#/ 8('&*! /uG# AB# ,/Ÿ /%





,/Ÿ A,< ,Ao#„)au„,Ao# 8/9# 78 #a, 8/ei AB# /n,/ /,/ oi '(7i /uG# /l% %,

!(,< 8/% ,Ao# fs, !(,<.11P>

1.".8.2 @hương $h;$ tr?ng h($

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!(,< )u,< )_#/ ,Ao#. T/uG# AB# hg /B8 fp,< #S#/ /l% %, !(,< ?i !Aˆ,<

8('&*! /% /(# fp,< #S#/ /ấ8 8/= 's, #S# /7 ,%,( J%u h/i J 8('&*! /% /(,

/,/. d%u P /u&F, 8/W /7 ,%,( AB# i,/ #/g ~ '(7i fr #S# #/ấ ƒ, _,/ #/ấ/(7 5,< fF h/S# ,/%u Jc )=,< ~ 8('&*! /% fp,< #S#/ Jisu '& Si 7(

/u&F, 8/W #S# /7 !(,< ?i !Aˆ,< #/ấ /(7 5,< fF £,< !A,< )(.11P> K

/uq ,& j AB# fS( #S( ~ ' #S# /7 ,%,( 8('&–fu&'#&%,(%#!&'%*— /(#

8('&–%'h&'#&%,(%#!&'%*—.0P>P0> d /n,/ /,/ ,%,( ,< <i h#/ /Ao# /7 #$%

#/",< 8/= /u5# ( ,,< 5 #$% #/ấ /(7 5,< fF #/ấ ƒ, _,/ AB# Jc

)=,<.3

1.".8." @hương $h;$ gi3t tU hoIc gel hóa ion

N/iFu ,</is, #9u q8 !u,< ~ iFu #/g #S# /7 ,%,( fp,< #S#/ Jc )=,<





C/ấ 'r,< Jisu oi /7, # /~ AB# _,/ ,</`% ' 5 )u,< ?i ,/i@ 5 !s,

,/i@ 5 oi /7, #$% ,P #/ấ 'r,< ' 5 8/% )u& ,/ấ fấ h~ S8 Juấ. 3b CO Jisu

oi /7, –dC CO— ' #/ấ 'r,< Jisu oi /7, AB# Jc )=,< !5,< !ji ,/ấ fi n #S# iFuhi@, oi /7, s )_u #$% , –T # ¹ 31P1°CP # ¹ >3P f%!—P h/?,< 5#P h/?,< #/S& <iS

/ấ8. CS# h /uq #/g fig, 8/ƒ fig, ,/ấ 'is, u%, g, #/ấ 'r,< Jisu oi /7, ' 8/e,

)u,< ?i Jisu oi /7, –d^d— J , ,/%,/ #$% )u,< )_#/ oi /7, –REdd—.11P> QuS

!n,/ d^d Jc )=,< 5 )u,< ?i )7,< 'r,<P ,/A */%,('P # /~ !5, ', /(, (,

oi #/ấ 'r,< Jisu oi /7, –dC CO—P ~ /l% %, #S# #/ấ %, AB# i#!( /%ª 7i #S#

iFu hi@, #$% uS !n,/P fi n #/ấ %, ' h/?,< /l% %, !(,< #/ấ 'r,< Jisu oi /7,P

8/a, #/ig #$% )u,< ?i )7,< 'r,< fp,< #/ấ 'r,< Jisu oi /7, ), g, 'AB,< hg $%

9# /î #$% #/ấ %,P A% g, hg ue /n,/ /,/ #S# /7 ,%,(. b T/(* u8%

–bb6— fS( #S( i@# Jc )=,< 5 8/A,< 8/S8 d^d /%& ƒi ~ /n,/ /,/ #S# /7,%,( /uG# A% ,Ao# )*+%*/%J(,* 8/(J8/%* #/( =# #/ ,< 

REdd h/S# oi uS !n,/ d^d !(,< #/ấ %, AB# /l% %, !(,< #/ấ 'r,<

Jisu oi /7, –,/A */%,(' Jisu oi /7,— J%u )u,< )_#/ AB# , !5,< ,/%,/

#/,< /?,< u% 5 G,< /" ,/r ( W,< S8 Juấ /ấ8. Vn q&P 'AB,< )u,< ?i #$% #/ấ 'r,< Jisu oi /7, <ie





,/r /¦, /B8 */%,('‰,Ao# –† '@ 1‰1— AB# ,/( h ~ /u f5 ,/j(. d%u Jấ& h/?

#/, h/?,< ,/i@ 5 /Aˆ,<P J,< u% !& bP6 .

Qy trình tYng h($ $h%c β -cyclodextrinZdo*$eridone của \. D]a*i:

/9# 8/, S, #$% )(8*!i)(,* oi β-#&#'()*+!i, /&)!(+& 8!(8&' #*''u'(J*

oi † '@ 1‰1 AB# iFu #/g fp,< 8/A,< 8/S8 ,/(. LAB,< +ấ8 +¯ #$% β-#&#'()*+!i,

/&)!(+& 8!(8&' #*''u'(J* AB# /s ( )(8*!i)(,* !(,< #Gi <ij /¦, /B8 f5

AB# ' oi /~ #/ ,Ao# AB# ,/( h 'A,< fp,< #/& ~ /u /¦, /B8 ,/j(.d%u P * Jấ& h/? #/, h/?,< ,/i@ 5 8/l,<. /9# 8/, S, ƒ,< /B8 AB#

,</iF,P J,< u% !& bP6 AB# !‡ !(,< #(,%i,*! h, ~ !S,/ ~ !S,/ S,/

JS,< #/G,< #/( g, h/i Jc )=,<.

Qy trình tYng h($ $h%c β -cyclodextrinZcelecoxiF của ^. _. Dinha

>

β-C&#'()*+!i, AB# ' fp,< ,Ao# !(,< #Gi <ij #/( g, h/i /u AB# f5

,/j(. d%u P #*'*#(+if AB# /s ( f5 ,/j( AB# ,/( h/(e,< 1 <iˆ. LAB,<

,Ao# AB# /s ( ~ )u& !n 5 # /#/ /B8. y5 ,/j( AB# !c% fp,< )i*/&' */*!

~ '(7i fr /uG# h/?,< 7( 8/9#. d%u P Je, 8/ AB# Jấ& h/? #/, h/?,< 0b°C





Qy trình tYng h($ $h%c β -cyclodextrinZni*elide của +. 9athe]16

Du,< )_#/ β-#&#'()*+!i, AB# iFu #/g >6°C. LAB,< /uG# j AB# ,/

(S, /*( † '@ ,i*Ju'i)*‰β-#&#'()*+!i, –1‰bP6P 1‰1P 1‰— AB# /s ( )u,< )_#/P

x% ' '7,/ )u,< )_#/ ,& ,/i@ 5 8/l,< x% h/uấ&. T!(,< h/i ' '7,/P 8/9#

β-#&#'()*+!i,„,i*Ju'i)* !™, hg $%.

Qy trình tYng h($ $h%c β -cyclodextrinZnitroFenene của 9. Chen3

β-C&#'()*+!i, ,i!(f*,¤*,* AB# /l% %, ( ,Ao# #ấ /%i 'a, CH 3OHP

A,< 9,<. d%u P )u,< )_#/ ,i!(f*,¤*,* 2 CH 3OH AB# ,/r x x ( )u,< )_#/

,Ao# β-#&#'()*+!i, h/uấ&. QuS !n,/ h/uấ& AB# <i‡ !(,< 0 <iˆ ,/i@ 5

/Aˆ,<. i%i (7, #uGi #$% 8/e, 9,< 'AB,< 'o, hg $% )7,< i,/ /~ !™,<P 8/9# #$%

β-#&#'()*+!i,„,i!(f*,¤*,* AB# /u fp,< #S#/ '#. de, 8/ AB# !c% oi */%,(' ,Ao# oi 3 'a, '8 '7i. d%u P * Jấ& h/? #/, h/?,< 6b °C !(,< 0 <iˆ.

Qy trình tYng h($ $h%c β -cyclodextrinZGeto$roben `. . b

β-C&#'()*+!i, AB# /l% ( b */%,('-,Ao# :b°C 'AB,< A,< A,<







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AB# '(7i fr fp,< #S#/ ' f%& /i )Aoi S8 Juấ /ấ8. d%u P '& ~ '(7i fr 8/a,

#&#'()*+!i, h/?,< 8/e, 9,< * ?,< h/? /u Je, 8/.

o TNG UAN VE CÁC PHtƠNG PHÁP ĐIEU CHẾNAN$ TỪ ALGINAT

Qy trình =i chH h#t nano ch%a alginate:

>P6 L )u,< )_#/ #%'#iu #/'(!i)* AB# ,/r ( #G# #/9% 11>P6 L )u,< )_#/

%'<i,%* !(,< /î <i%, :b 8/". LAB,< i,Ju'i, A,< A,< AB# !5, ( )u,< )_#/%'<i,%* !Ao# h/i /s #%'#iu #/'(!i)* ~ <*' /% %'<i,%*. d%u P 6 L )u,< )_#/

#/i(J%, AB# /s ( <*' h/(e,< 1b 8/". 8H #$% )u,< )_#/ %'<i,%* #/i(J%, '

0P 0P: ~ 7( J 8/, S, h*( oi 8H #uGi ' 0P>. K/uấ& /s 3b 8/"P J%u '&

0°C /u /7 ,%,(.





4~ 8/, S, ,Ao# ( 8/% )auP 1bb L #/'(!(•(! AB# /s ( ,/Ÿ A,<

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%'<i,%* 8/, 'q8 !c% fp,< ,Ao# #ấP #/'(!(•(! AB# '(7i fr fp,< #S#/ /s 'AB,<

,Ao# '& . 4* ,%,(/&)!(<*' %'<i,%* /u AB# ?,< h/? /u Je, 8/.

β-C&#'()*+!i, j AB# Jc )=,< ,/A ' S )AB# !(,< )AB# 8/. 4j # ,/iFu

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http://vi.wikipedia.org/wiki/%C4%90i%E1%BB%87n_t%E1%BB%AD

http://vi.wikipedia.org/wiki/Th%E1%BA%A5u_k%C3%ADnh

http://vi.wikipedia.org/wiki/Quang_h%E1%BB%8Dc

http://vi.wikipedia.org/wiki/Ch%C3%A2n_kh%C3%B4ng

http://vi.wikipedia.org/wiki/%C4%90i%E1%BB%87n_t%E1%BB%AD

http://vi.wikipedia.org/wiki/Th%E1%BA%A5u_k%C3%ADnh

http://vi.wikipedia.org/wiki/Quang_h%E1%BB%8Dc

http://vi.wikipedia.org/wiki/Ch%C3%A2n_kh%C3%B4ng




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β-#&#'()*+!i,‰%'<i,%* ¹ 1‰1b h/i ¡,< )a, / 'AB,< h*(8!(•*, x 6-1b /n /i@u

Juấ Je, 8/ ¡,<. Tu& ,/is,P h/i ig8 =# ¡,< / 'AB,< h*(8!(•*, 's, g, 16

/n ,%,( ƒ,< /B8 AB# #/9% #S# /,/ 8/a, h/?,< ,< ,/ấ /i@u Juấ h/?,< ¡,< '7i <ie. Hi@u Juấ ,%,( /u AB# Gi % / 'AB,< h*(8!(•*, 1b.

]\ Đ”C ĐIM C_U T#–C VÀ HÌNH DjNG C—A PH^C

FCCL$DT#IN…KT$P#$‡N

Mu 8/9# β-#&#'()*+!i,„h*(8!(•*, ( dEM ' u AB# ƒ,< /B8 g, <i%i

(7, S#/ '& –j u% '& —.





]o Đl* 1,|d *J. +* >3 8Q68 5f67 */0 606< F**<5O+,6“

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HQ68 Ả68 SM */0 F**<5O+,6 m0nZ 07,60+O men >3

606< F**<5O+,6“07,60+O m*n

Kg ue ( dEM #/( /ấ& β-#&#'()*+!i, %'<i,%* Fu # h#/ /Ao# µ

,/A,< h/i hg /B8 oi ,/%u /n 7( /,/ Je, 8/ # h#/ /Ao# , [ình 22. H7

,%,( β-#&#'()*+!i,2%'<i,%* /u AB# # h#/ /Ao# /7 ,/r /, 1bb , h#/

0 e *





Qu%, JS e,/ TEM #$% ,%,( β-#&#'()*+!i,2%'<i,%*2h*(8!(•*, ƒ,< /B8

AB# [ình 2"F ,/q, /ấ& #S# /7 ,%,( ' ,/‡,< /7 # h#/ /Ao# h/(e,< :b->b ,.

]s CÁC PH I#

]s P8„ I# */0 F**<5O+,6Z a89* F**<5O+,6…;O+<a<pO6Z

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[ình 28 fi~u )i¨, 8/ƒ IR #$% 8/9# β-#&#'()*+!i,„h*(8!(•*,. Kg ue 8/ƒ IR

#/( /ấ& Ÿi )%( 5,< C¹O #$% ,/ %#i) ,/ h*(,* 'a, 'AB ' 1>33 # -1

1::6 #-1

. N/A q&P Ÿi )%( 5,< C¹O #$% ,/ %#i) )_#/ #/u&~, x 1:> #-1

g,1>33 #-1 –h/(e,< 3: #-1—. MŸi )%( 5,< C¹O #$% ,/ h*(,* )_#/ #/u&~, x 1:66

#-1 g, 1::6 #-1 –h/(e,< 1b #-1—. d )_#/ #/u&~, /%i Ÿi )%( 5,< C¹O )( A,<

S# <i‡% ,/ #%!f(+&'i# #$% h*(8!(•*, oi /&)!(+&' !s, β-#&#'()*+!i, ' /%&

ƒi a, JG )%( 5,< C¹O. T/s ( ,/ /&)!(+&' –-OH— ,/A ' 5 Ÿi !5,<

/ấ8 /u fAo# J,< 33:> #-1.

]s P8„ I# */0 07,60+OZ F**<5O+,6Z 606< F**<5O+,6“

07,60+OZ 606< F**<5O+,6“07,60+O“;O+<a<pO6Z ;O+<a<pO6

P8„ I# */0 07,60+O –/= '=# 1—

/ƒ IR #$% %'<i,%* AB# !n,/ f& hình 27 #/( /ấ& Ÿi )%( 5,< 1b3

#-1 A,< 9,< oi C-O-C # !A,< #/( #ấu !"# J%##/%!i)* #$% J()iu %'<i,%*.

T/s ( 8*%h 1:1> # -1 101 #-1 AB# ấ, _,/ Gi oi )%( 5,< /ấ8 /u

#$% ,/ #%!f(+&'%* fấ Gi +9,< Gi +9,< #$% uGi –-COO -—.





J,< #$% ,/ -COO- )_#/ #/u&~,. 4iFu #/9,< !p,< h*(8!(•*, j i ( 7,<

'Aoi 8('&*! #$% ,%,( β-#&#'()*+!i,2%'<i,%*. H, ,‡%P Ÿi )%( 5,< #$% ,/ C%-

O +uấ /i@, 8*%h h/(e,< 16 #-1

–!(,< h/i 8/ƒ IR #$% ,%,( β-#&#'()*+!i,2 %'<i,%* ' 1 #-1P )_#/ #/u&~, h/(e,< > #-1—.





C/u, f_ )u,< )_#/ u /c‰ T/s 1bb < u 8/9#

β-#&#'()*+!i,„h*(8!(•*, ( 6 L )i*/&' */*!. d%u P '# 'ấ& )_#/ #/ig. C/u, f_

1 L )_#/ #/ig ,& !i )W,< G,< %( ue, /" h/(e,< 1„ G,< #/ấ 's, fe, r,< ~#/7& J™# hP x J( JS,/ oi g #/ấ #$% )u,< )_#/ #/u,.

Du,< ?i <iei '& Jc )=,< ' 8*!('*u */*!‰*/&' %#*%* oi † '@ 1‰1.

C/ấ )u,< )_#/ #/u, )u,< )_#/ u /c 's, #W,< fe, r,<P #/7& <iei '&

oi /@ )u,< ?i !s,P !i J(i )Aoi ½, UV J /ấ& +uấ /i@, #S# g !s, fe, r,<.d%u h/i #/ấ 's, fe, r,3 d˜. +8q

[ình 2K fi~u )i¨, hg ue J™# h fe, r,< #$% )u,< )_#/ u /c )u,<

)_#/ h*(8!(•*, #/u,. Kg ue #/( /ấ& g #$% )u,< )_#/ u /c +uấ /i@, ,<%,<

fp,< oi g #$% )u,< )_#/ h*(8!(•*, #/u, !s, fe, r,<. D( # /~ hg 'uq,

!p,< !(,< u ,%,( β-#&#'()*+!i,2%'<i,%*2h*(8!(•*, ƒ,< /B8 AB# # J /i@,

)i@, #$% h*(8!(•*,.

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HQ68 [ G,W6 1c DSC */0 a89* F**<5O+,6…;O+<a<pO6

T/# /i@, ,</is, #9u 8/9# β-#&#'()*+!i,„h*(8!(•*, fp,< ,/i@ uk i J%i

[ình 2z #/( /ấ& ¯,/ /u ,/i@ #$% h*(8!(•*, ' 1P>°Cª ¯,/ /u ,/i@ #$%

β-#&#'()*+!i, ' >P3°C.

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T/# /i@, ,</is, #9u ,%,( β-#&#'()*+!i,2%'<i,%*2h*(8!(•*, fp,< ,/i@ uk

i J%i [ình 25 #/( /ấ& ¯,/ /u ,/i@ #$% h*(8!(•*, ' 1>P°Cª ¯,/ /u ,/i@ #$%

%'<i,%* ' >P6°C ¯,/ /u ,/i@ #$% β-#&#'()*+!i, ' :P°C.

Qu% hg ue 8/, #/ DdC #$% 8/9# β-#&#'()*+!i,„h*(8!(•*, ,%,(






- T/s b < h*(8!(•*, ( 6 L */%,(' #/( AB# )u,< )_#/ h*(8!(•*, 0

<„L )W,< ' u #/u,. C/u, f_ 1 L u #/u, ,& !Ao# h/i f (

S& u j AB# '# u% ,< i'i8(!*.- C/u, f_ 1 L u #/u, A,< ,/A !s, #/( #S# / 'AB,< <„LP 1

<„L bP6 <„L.

ye( ue, #S# )u,< )_#/ ,& ,/i@ 5 h/?,< uS 6 °C !S,/ S,/ JS,<.

Ch)n F dng dch =o *,

N< 1bb < #S# u ,%,( β-#&#'()*+!i,2%'<i,%*2h*(8!(•*, ,,< 5 6P

1bP 1 !(,< 6 L )i*/&' */*! h/(e,< 1- <iˆ ~ #/ig h*(8!(•*, # !(,< u.

NAo# '# u AB# uƒi )u,< ?i /u 5 #/ấ !™,. /% #/ấ !™, !(,< 1 L

*/%,(' '# )_#/ */%,(' u% ,< i'i8(!* !Ao# h/i f ( S&.

Ht 0E ch#y [@C

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Kg ue 8/, #/ HLC Gi oi )_#/ #/ig )i*/&' */*! /u x #S# u ,%,( j

ƒ,< /B8 Fu /ấ& +uấ /i@, 8*%h #$% h*(8!(•*, [ình "2. Kg ue #S# u 8/, #/

HLC # 'AB,< h*(8!(•*, 8/,< /#/ ' P 0P6 6 A,< 9,< oi 'AB,<h*(8!(•*, 6P 1b 1 j )W,< !(,< ƒ,< /B8 #S# u ,%,( β-#&#'()*+!i,2

%'<i,%*2h*(8!(•*,.

] KHẢ N&NG PHxNG TH™CH THU!C06

Ch)n F dng dch ='* $[ { 76w v $[ { K68

T/s >P < N%HO0 ( 1bbb L ,Ao# h/c i(, >1P1 < N% HO0.1HO

( 1bbb L ,Ao# h/c i(,.

@ha dng dch có $[ { 76w‰ C/( 1 L )u,< )_#/ N%HO0 ( 16b L )u,<

)_#/ N%HO0P /u AB# )u,< )_#/ # 8H ¹ 6Pb –iFu #/¯,/ fp,< S& iFu #/¯,/ 8H—.

@ha dng dch có $[ { K68‰ C/( 1 L )u,< )_#/ N%HO0 ( 1 L )u,<

)_#/ N%HO0 /u AB# )u,< )_#/ # 8H ¹ >P0.

+ng dch $h<n tích v dng dch ch)n AB# #/u, f_ A,< ,/A !Aˆ,<






- NP0.

C/u, f_ u A,< ,/A !Aˆ,< /B8 8H ¹ 6Pb.

Ht 0E =o =! $hóng thích

BW67 ] Ki+ r.W 1< 14 a8R67 +8*8 ;O+<a<pO6 +8O< +8‹, 7,06

T8‹, 7,06 m7,‹n Zo Z Z ]Z \Z m>ng =! Geto$roben *gZ* theo thi gian

8H ¹ 6Pb

8H ¹ >P0

1P

bP6

3P

1P:

6P6

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:P:

6P1

:P

6P>






Chương 8

THœC NGHIỆM----------

\ U T#ÌNH THœC NGHIỆM

/% #/g /% #/ấ ~ 8/=# = / ,</i@.

Tƒ,< /B8 8/9# β-#&#'()*+!i,„h*(8!(•*, fp,< 8/A,< 8/S8 h/uấ& x –h/e(

JS † '@ h*(8!(•*,‰β-#&#'()*+!i,P /î <i%, ,/i@ 5 8/e, 9,<— 8/A,< 8/S8 i

J,< –h/e( JS #?,< Juấ /î <i%, 8/e, 9,<—.

Tƒ,< /B8 ,%,( β-#&#'()*+!i,2%'<i,%* –h/e( JS † '@ β-#&#'()*+!i,‰%'<i,%*—

,%,( β-#&#'()*+!i,2%'<i,%*2h*(8!(•*, –h/e( JS † '@ β-#&#'()*+!i,‰%'<i,%*

/ 'AB,< h*(8!(•*,—.

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Lấ& ::3 < ¹ bP::3 < h*(8!(•*, /l% %, ( bb L )u,< )_#/ %'#(/('‰,Ao#

j AB# 8/% #/g !s,P % AB# bb L )u,< )_#/ h*(8!(•*, –3P316 <„L—.

\ B! T#™ TH™ NGHIỆM

CS# ,</i@ /9# AB# fG ! 5 #S#/ ,<u ,/is,.

\ T„67 8{a a89* F**<5O+,6…;O+<a<pO6

8.2.1.1 @hương $h;$ Ghấy t T8 678,kd K8W< zX+ W68 8ˆ67 */0 +‰ k ;O+<a<pO6Š F**<5O+,6 1i6

8,k. z.J+ +„67 8{a a89* F**<5O+,6…;O+<a<pO6

T/ ,</i@ AB# /# /i@, !s, 0 ,</i@ /9# –A,< 9,< oi #S# † '@

h*(8!(•*,‰β-#&#'()*+!i, ' 1‰1P 1‰6P 1‰ 1‰1b—P ¦i ,</i@ /9# AB# '8 '7i 3 'a,P#/, ,<u ,/is, 5 u !(,< ,</i@ /9# #/( /i@u Juấ ƒ,< /B8 8/9# ' #%( ,/ấ

~ ( IR.

T8 678,kd K8W< zX+ W68 8ˆ67 */0 +8‹, 7,06 a8W6 967 1i6 8,k. z.J+

+„67 8{a a89* F**<5O+,6…;O+<a<pO6








D% ( hg ue h/e( JS † '@ β-#&#'()*+!i,‰%'<i,%* –T/ ,</i@ >—P #/, †

'@ Gi Au ~ h/e( JS !s, 0 ,</i@ /9# –A,< 9,< oi #S# / 'AB,< h*(8!(•*, 6P

1bP 1 16—P ¦i ,</i@ /9# AB# '8 '7i 3 'a,P #/, ,<u ,/is, 5 u!(,< ,</i@ /9# #/( /i@u Juấ ƒ,< /B8 ,%,( β-#&#'()*+!i,2%'<i,%*2h*(8!(•*, '

#%( ,/ấ ~ ( IR #/=8 e,/ dEM.

q z} ,k.

CS# ,</i@ /9# AB# fG ! /(, (, ,<u ,/is, AB# S,/ <iS fp,< 8/a,F d%<!%8/i#J 8'uJP 5,< S,/ <iS 5 h/S# ,/%u <i‡% #S# ,</i@ /9# oi !™#

,</i@ fn,/ 8/A,< '% i,/ LdD 5 i, #q& ' 6Pb.

\] CÁC PHtƠNG PHÁP TNG H€P

\] T„67 8{a a89* F**<5O+,6…;O+<a<pO6 ež67 a8h67 a8Xa;8.J +u

Vi@# /n,/ /,/ 8/9# β-#&#'()*+!i,„h*(8!(•*, +e& !% !(,< 8/% ,Ao# h/?,<

# Jc )=,< ,/‡,< #/ấ 5# /7i.

Q





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K*(8!(•*,P h/e( JS † '@h*(8!(•*,‰β-#&#'()*+!i,

β-C&#'()*+!i,P h/e( JS † '@h*(8!(•*,‰β-#&#'()*+!i,

NAo# h/c i(,–1bb°C—

K/uấ& xP h/e( JS /î <i%, 8/e,9,3 ;O+<a<pO6

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β-#&#'()*+!i, ~ h/e( JS J e,/ /A,< #$% , g, /i@u Juấ ƒ,< /B8 8/9#. T† '@

h*(8!(•*,‰β-#&#'()*+!i, AB# h/e( JS ' 1‰1P 1‰6P 1‰ 1‰1b.

- D% ( hg ue h/e( JS † '@ h*(8!(•*,‰β-#&#'()*+!i,P #/, † '@ Gi Au ~

h/e( JS J e,/ /A,< #$% /î <i%, Gi oi /i@u Juấ 7( 8/9#. T/î <i%, 8/e, 9,<

AB# h/e( JS ' 3b 8/"P :b 8/"P b 8/" 1b 8/". N/i@ 5 AB# <i‡ h/?,< ƒi.

- Tx hg ue h/e( JS /î <i%, 8/e, 9,<P #/, /î <i%, Gi Au ~ h/e( JS Je,/ /A,< #$% ,/i@ 5 Gi oi /i@u Juấ 7( 8/9#. /e, 9,< AB# ig, /,/ #S#

,/i@ 5 h/S# ,/%u b°CP 1bb°CP 1b°C 10b°C. T† '@ h*(8!(•*,‰β-#&#'()*+!i,

AB# <i‡ #G _,/.

\] T„67 8{a a89* F**<5O+,6…;O+<a<pO6 ež67 a8h67 a8Xa >,

zR67

Qy trình tYng h($ $h%c β -cyclodextrinZGeto$roben

β-C&#'()*+!i,

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β-C&#'()*+!i, AB# /l% %, !(,< ,Ao# h/c i(, –1bb°C—. K*(8!(•*, AB#

/s (P /¦, /B8 ,& AB# G ,,< !(,< 'l i J,< [ình "K #S# #?,< Juấ h/S#

,/%u !(,< /î <i%, 1b 8/".

HQ68 ]~ HŸ6 8{a F**<5O+,6 >3 ;O+<a<pO6 +<67 >, zR67

Tig8 /*(P ' '7,/ h/uấ& b°C ~ 7( hg $% !™,< [ình "z. d%u P '&

–G# 5 0bbb l,<„8/"P !(,< 1b 8/"P !i !c% '7i oi ,Ao# h/c i(, 3 'a,P ¦i 'a,

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- Tx hg ue h/e( JS #?,< JuấP #/, #?,< Juấ Gi Au ~ h/e( JS /î <i%,.

T/î <i%, AB# h/e( JS ' 6 8/"P 1b 8/" 16 8/".

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Vi@# /n,/ /,/ ,/‡,< /7 ,%,( β-#&#'()*+!i,2%'<i,%* +e& !% !(,< 8/% ,Ao#

h/?,< # Jc )=,< ,/‡,< #/ấ 5# /7i.

K#/ /Ao# /7 AB# S,/ <iS fi dEM. H7 ,%,( ƒ,< /B8 AB# # h#/ /Ao#

,/r /, 1bb , h#/ /Ao# /7 h/S ,< Fu.

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K/uấ& x 3b 8/" –G# 5 1bbl,<—P )u,< )_#/ <*' !(,< JuG

K/uấ& ig8 1 <iˆP )u,<

)_#/ <*'P u !™,<!(,<

Du,< )_#/ C%C'

Du,< )_#/ %'<i,%* –h/e( JS† '@ β-#&#'()*+!i,‰%'<i,%*—

Du,< )_#/ β-#&#'()*+!i, –h/e(JS † '@ β-#&#'()*+!i,‰%'<i,%*—

TS#/ '& P !c% '7i 3

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Ri ,/r ig8 )u,< )_#/ β-#&#'()*+!i, –P0 < β-#&#'()*+!i,„L ,Ao#— (

/¦, /B8 !s,P ig8 =# h/uấ& /s :b 8/" –G# 5 1bb l,<„8/"—. L"# ,& /u AB#

)u,< )_#/ <*' !(,< JuG ,< ,/ấ [ình 8wa. Du,< )_#/ ,& AB# ~ u% s –~&s,—P )u,< )_#/ # )7,< ,/A hình 8wF.





\]\ T„67 8{a 606< F**<5O+,6“07,60+O“;O+<a<pO6

K#/ /Ao# /7 ,%,( β-#&#'()*+!i,2%'<i,%*2h*(8!(•*, j ƒ,< /B8 AB# +S#

_,/ fp,< dEM TEM. H7 # h#/ /Ao# :b->b , h#/ /Ao# /7 h/S ,<

Fu. H 'AB,< h*(8!(•*, AB# +S# _,/ fp,< HLC.

Qy trình tYng h($ nano β -cyclodextrin–alginate–Geto$roben

K/uấ& x 3b 8/" –G# 5 1bbl,<—P )u,< )_#/ <*' !(,< JuG

Du,< )_#/ C%C'

Du,< )_#/ h*(8!(•*, –h/e(JS ,,< 5 h*(8!(•*,—

1b L )u,< )_#/ %'<i,%* –h/e(JS † '@ β-#&#'()*+!i,‰%'<i,%*—





N/r x x 'AB,< h/?,< ƒi )u,< )_#/ h*(8!(•*, –3P316 < h*(8!(•*,„L

%'#(/('‰,Ao# ¹ 1‰1— ( )u,< )_#/ C%C' –1bPb6 < C%C'„L ,Ao#—. d%u P ,/r

)u,< )_#/ /¦, /B8 !s, ( )u,< )_#/ J()iu %'<i,%* –Pb < %'<i,%*„L ,Ao#—Ph/uấ& !s, S& h/uấ& x 3b 8/" –G# 5 1bb l,<„8/"—P /ấ& +uấ /i@, )u,< )_#/

)7,< <*'P u !™,< !(,< [ình 81.

HQ68 \ M˜. 07,60+O >3 ;O+<a<pO6 +-6 dX ;8.J +u





HQ68 \] M˜. 606< F**<5O+,6“07,60+O“;O+<a<pO6 z0. ;8, ;8.J

Mu ,& AB# ~ &s, u% sP !i S#/ '& 'a, au ~ '(7i fr ,/‡,< /%

#/ấ #l, )A ', !(,< u. d%u P * !c% '7i oi ,Ao# h/c i(, 3 'a,P ¦i 'a, '&

!(,< 1b 8/"P G# 5 0bbb l,<„8/". Mu ,& AB# * ?,< h/? /u AB# Je, 8/ ,%,( β-#&#'()*+!i,2%'<i,%*2h*(8!(•*, ' #/ấ +G8P ,/¢P u !™,<.





----------

N/n, '7i =# isu f%, au #$% F i‰ |mghin c% v %ng dUng β -cyclodextrin

l* chất *ang th/c Geto$roben}P 5 JG hg ue oi 'uq, ¡, j 7 AB# # /~

™ ,/A J%u‰

4Gi oi 8/9# β-#&#'()*+!i,„h*(8!(•*, AB# iFu #/g fp,< 8/A,< 8/S8

h/uấ& xP † '@ Gi Au ~ β-#&#'()*+!i, 7( 8/9# oi h*(8!(•*, 'h*(8!(•*,‰β-#&#'()*+!i, ¹ 1‰. Hi@u Juấ 8/9# ,/ /*( ƒ,< h/Gi 'AB,< #$%

β-#&#'()*+!i, h*(8!(•*, ' P6 /î <i%, 8/e, 9,< b 8/" ,/i@ 5

1b°C.

4Gi oi 8/9# β-#&#'()*+!i,„h*(8!(•*, AB# iFu #/g fp,< 8/A,< 8/S8 iJ,<P /i@u Juấ Je, 8/ ,/ /*( ƒ,< h/Gi 'AB,< #$% β-#&#'()*+!i, h*(8!(•*,

' 1P6 #?,< Juấ 3bb š /î <i%, 8/e, 9,< 1b 8/".

] 4Gi oi ,%,( β-#&#'()*+!i,2%'<i,%*P /i@u Juấ ,%,( ,/ /*( ƒ,< h/Gi

'AB,< #$% β #&#'()*+!i, %'<i,%* ' b b6 A,< 9,< oi † '@





s XS# _,/ AB# ,/i@ #/u&~, 8/% #$% 8/9# β-#&#'()*+!i,„h*(8!(•*, ,%,(

β-#&#'()*+!i,2%'<i,%*2h*(8!(•*, x #ấu !"# i,/ /~ J%,< ? _,/ /n,/ fp,<

8/A,< 8/S8 8/, #/ ,/i@ uk i J%i DdC.~ XS# _,/ AB# / 'AB,< h*(8!(•*, !(,< ,%,( β-#&#'()*+!i,2%'<i,%*2

h*(8!(•*, ƒ,< /B8 AB# fp,< 8/A,< 8/S8 8/, #/ HLC.

[ XS# _,/ AB# h/e ,¡,< 8/,< /#/ /uG# x ,%,( β-#&#'()*+!i,2%'<i,%*2

h*(8!(•*, ƒ,< /B8 AB# !(,< ?i !Aˆ,< 8H ¹ 6Pb 8H ¹ >P0. Kg ue 8/, #/h/e ,¡,< 8/,< /#/ /uG# #$% #S# u ,%,( #/( /ấ& 'AB,< h*(8!(•*, j 8/,<

/#/ !% 8H ¹ 6Pb J%u 0 <iˆ ' : !(,< #W,< /î <i%, 'AB,< h*(8!(•*,

8/,< /#/ 8H ¹ >P0 7 6>. 4iFu ,& #/9,< r 'AB,< h*(8!(•*, 8/,< /#/

8H ¹ 6Pb ,/iFu /, 8H ¹ >P0.







TÀI LIỆU THAM KHẢ$

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T3, ,k. +,i67 V,k+

–1— T!a, T/_ y#/ Qu&s, –Y—P mghin c% tYng h($ nanochitoanP Luq, ¡,

T/7# J` H% /#P T!Aˆ,< 47i /# Ca, T/.

T3, ,k. +,i67 A68–— ^. º. T/(*P R. y. u8%P Por*ation ob nano$article ob a hydro$hilic drg

ing $ercritical carFon dioxide and *icroenca$lation bor tained

releaeP N%,(*#/. yi('(<& M*)i#i,*P oP 1P 6-b.

–3— ^. M. D. di'*i!%P . (,#/*'P …. uiJi*u+P D. Du#/*,*P Co*Fined

$olyioFtylcyanoacrylate and cyclodextrin nano$article bor enhancing

the enca$lation ob li$o$hilic drgP /%!%#*ui#%' R*J*%!#/P YY[P 17

–>—.

–0— ^. š(,<*hi%P d. Y(J/i%JuP Y. T(¤uh%P K. M(!if*P K. Y%%((P





–— C. M. di'%P ^. º. Rif*i!(P I. V. …i<u*i!*)(P ^. R. (,#%'*JP …. V*i<%P

flginate *icro$here $re$ared Fy internal gelationq +evelo$*ent and

ebbect on inlin taFilityP I,*!,%i(,%' º(u!,%' (• /%!%#*ui#JP sP

"11P 1-1b.

–1b— C. . R*iJP R.º. N*u•*')P ^.º. Rif*i!(P …. V*i<%P manoenca$lation ~. 9ethod

bor $re$aration ob drg-loaded $oly*eric nano$articleP N%,(*)i#i,*P

sP 2P -1.

–11— C. d#/i)P manocarrier in drg delivery-deign6 *anbactre and

$hyicoche*ical $ro$ertieP N%,(/*!%8*ui#J D!u< D*'i*!& C(,#*8J i,

N%,(J#i*,#*.

–1— D. Du#/*,*P Cyclodextrin and their indtrial eP %!iJP Y[~P 1->3.

–13— D. Du#/*,*P . (,#/*'P D. š(u*JJi)*˜*P Cyclodextrin in targetingq

f$$lication to nano$articleP ^)%,#*) D!u< D*'i*!& R*i*˜JP YYYP "M P

-0b.

–10— D. L. L*J'i*-*'*#h&P V. L%f/%J*˜%!P R. H. º. K!%uJP manoFio*agnetic in




LU“N VN THmC d› H}^ HœC b1b

–b— E. R**!#/(,P R. ^)%iP mano*aterial and $ercritical blid6 The €ornal

ob D$ercritical PlidP sP "K P 1-.

–1— E. d#/,*i)*!%,P .̂ M. d%'#u8P Cyclodextrinq f veratile tool in e$aration cienceP º C/!(%(<! yP P K87P 3-1b.

–— …. Hi!%&%%P K. U*h%%P 9ethod ob invetigating and $re$aring inclion

co*$ondP %!iJP Y[~P 131->.

–3— . ^J!%&P C. (,¤%'*¤-y%!!*i!(P º. C. M*u(P R. Ri%'-O*!(P º. di%'-%,)%!%P f revie] on the e ob cyclodextrin in boodP …(() H&)!(#(''(i)JP YP

2"P 1:31-1:0b.

–0— . u<'iJiP M. …!*J%P . i%(,%P C. ^. V*,u!%P ~nblence ob the

$re$aration condition on $olyethylcyanoacrylate nanoca$le bor*ationP

I,. º. /%!P YYoP 127P 3->.

–6— . d#/i)P Cyclodextrin glcanotranbere $rodctionq yield enhance*ent Fy

overex$reion ob cloned geneP T!*,)J yi(*#/,('P Y[YP K P 00-.

–:— . d˜%iP M. K. K(J/&P M. %,)*&P d. ^. d%!%•P @re$aration and





–31— º. ºu,-1.

–3— º. L. ̂˜(()P º. E. D. D%i*JP D. D. M. Ni#('P ~nclion co*$ondP ^#%)*i#!*JJP L(,)(,P Y[\P 2P 0>-:>.

–33— º. . R(''%,)P y. š. M%&,(!P L. E. Eu'iJJP ^. E. E+,*!P . M. D*,iJ(,P º. M. D.

di(,*P +irect baFrication and harveting ob *onodi$ere6 ha$e-$ecibic

nanoFio*aterialP º. ^. C/*. d(#.P oP 12K P 1bb:-1b1bb.

–30— º. i/%P T. H(J/i,(P bbect ob ethanol on bor*ation ob inclion co*$lexe ob

hydroxy$ro$ylcyclodextrin ]ith tetoterone or ]ith *ethyl organeP I, º

/%!P YYP zwP 03-61.

–36— º. d¤*'iP ~ntrodction and general overvie] ob cyclodextrin che*itryP C/*

R*P YY[P 5zP 1>03-1>63.

–3:— L. Du•(JJ*P I. d(u#/(,P . …*!(,P ^. L%!%JJ*P H.E. d8i,,'*!P ~n it

detoxi‚cation ob the ber*entation *edi* dring ga**a-decalactone

$rodction ]ith the yeat D$oridioFol al*onicolor P yi(*#/,(' !(<P





–0— M. d%u#*%uP E. R()i*!P º. …%<*JP @re$aration ob ~nclion Co*$lex ob

@iroxica* ]ith Cyclodextrin Fy ƒing D$ercritical CarFon +ioxideP

º(u!,%' (• du8*!#!ii#%' …'ui)JP [P 2P 3:-33.

–03— M. »%f%u+P …. y(,,*%u+P R. !*• P . M%i,#*,P E. D*''%#/*!i*P M. ^'(,J(P

. L%f!u)*P C. Vi<,*!(,P ~nblence ob ex$eri*ental $ara*eter on the

characteritic ob $olylactic acid nano$article $re$ared Fy doFle

e*lion *ethod P º. C(,!('. R*'*%J*P YY[P 7wP 31-0b.

–00— N. …uiJ/i%P K. KuJ%h%P T. Ui,(P T. U!uJ/i,%%P K. T*!uiP Plor Faed

bood containing highly Franched cyclodextrinP º%8%,*J* %*, º P .

–06— . LiP Y. D%iP º. »/%,<P ̂ . š%,<P Q. š*iP Chitoan–flginate mano$article a

a movel +rg +elivery Dyte* bor mibedi$ine P I, º yi(*) d#iP [P 8 –3—P

1-.

–0:— Q. .̂ %,h/u!JP º. C(,,(''&P d.K. º(,*JP º. D(fJ(,P f$$lication ob *agnetic

nano$article in Fio*edicineP º. /&J ^88'. /&J.P ]P "M .

–0>— Q. »/%,<P ». d/*,P T. N%<%iP @rolonged hy$oglyce*ic ebbect ob inlin-loaded






“ m œ

–:0— T. I!i*P K. š%h%%JuP H. ^!i%P H. ^!i(iP K. U*h%%P nhancing bbect ob

cyclodextrin on naal aFor$tion ob inlin in ratP I, º /%!P YYP z8P

1-13.

–:6— T. ºu,<P š. K%P ^. y!*i*,f%#/P E. K%iJ*!'i,-1:b.

–::— T. L(•JJ(,P y. º. O'%•J)(i!P H. …!i)!ihJ)(i!P d. º(,J)(i!P Cyclodextrin

co*$lexation ob mDf~+Dq $hyicoche*ical characteriticP Eu! º /%!

d#iP YY]P 1P 6-1b1.

–:>— T. L(•JJ(,P D. Du#/*,*P Cyclodextrin and their $har*acetical a$$licationP

I,**!,%i(,%' º(u!,%' (• /%!%#*ui#JP ~P "25P 1-11.

–:— T. L(•JJ(,P D. d. **!J*,P D!u< D*. ^,) I,)uJ. /%!%#&P YY[P 28 –0—P

3:6-3>b.

–:— T. L(•JJ(,P M. E. y!*˜J*!P M. M%JJ(,P _ole ob Cyclodextrin in ~*$roving




“ m œ

–>6— U. y. K(8*''%P N. y%,)iP d. . ^&%'%J(%&%u'%P @olylactic acid

nano$article bor tained releae ob FdeonideP D!u< D*'i. T*#/,('P

P 1P 1->.

–>:— ƒltraond-aited ynthei ob cyclodextrin-Faed nano$ongeP Eu!(8*%,

%*, d8*#i•i#%i(,P Y.

–>>— V. .̂ d%/%!%,P V. Kuhh%!P M. K%%!i%P M. *!%P . K. C/(u)/u!&P +ioltion

nhance*ent ob +rgP I,*!,%i(,%' º(u!,%' (• H*%'/ R*J*%!#/P YP 2

–—P 1b>-10.

–>— V. º. M(/%,!%P Y. C/*,P mano$article – f _evie]P T!(8 º /%! R*JP sP 7

–1—P 6:1-6>3.

–>— V. R. di,/% et al.P @hyicoche*ical characteriation and in vitro dioltion

Fehavior ob celecoxiF-β -cyclodextrin inclion co*$lexeP ^#% /%!P

~P 7K P 0>-:b.

–b— š. LuP Q. »/%,— /8‰„„*,.˜ihi8*)i%.(!<„˜ihi„I,#'uJi(,Æ#(8(u,)

–— /8‰„„*,.˜ihi8*)i%.(!<„˜ihi„K*(8!(•*,

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–3— /8‰„„˜˜˜./u(#fi*)u(#.#(.,„/u(#„/u(#-<(#6b.%J8+


http://en.wikipedia.org/wiki/Dendrimer

http://en.wikipedia.org/wiki/Inclusion_compound

http://en.wikipedia.org/wiki/Ketoprofen

http://en.wikipedia.org/wiki/Nanoparticle

http://en.wikipedia.org/wiki/Quantum_dot

http://en.wikipedia.org/wiki/Scanning_electron_microscope

http://www.pharmainfo.net/reviews/nanoparticles-and-its-applications-field-pharmacy


http://www.thuocbietduoc.com.vn/thuoc/thuoc-goc509.aspx

http://en.wikipedia.org/wiki/Dendrimer

http://en.wikipedia.org/wiki/Inclusion_compound

http://en.wikipedia.org/wiki/Ketoprofen

http://en.wikipedia.org/wiki/Nanoparticle

http://en.wikipedia.org/wiki/Quantum_dot

http://en.wikipedia.org/wiki/Scanning_electron_microscope



http://www.thuocbietduoc.com.vn/thuoc/thuoc-goc509.aspx


















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Nghiên cứu và ứng dụng bêta-cyclodextrin làm chất mang thuốc ketoprofen