每月一例 2015 September

• 49 y/o • Pap smear • Clinical history:

– Breast cancer with wide metastases • Figure 1-4

Your interpretation ?

Positive or Negative ? Squamous lesion or Other ?

Primary or Metastatic ?

Cytology findings

• Dissociated cells in loose clusters or single cells • Very clean background indicating extra-uterine

origin (probable from malignant ascites) • Indian files noted • Compatible with provided history of breast

cancer with wide metastases • Special stain for GATA-3 was performed on de-

stained Pap smear

GATA-3: Positive

Final diagnosis

• Pap smear: – Positive for malignant cells – Extra-uterine carcinoma (compatible with

history of breast cancer)