October 2015

HLA Typing with NGS TechnologyMake the Switch

Introduction to OmixonMarcello Scala, Sales Manager EMEA & AP,

Tim Hague, CEO

Empowering clinical labs with technologies to improve patient

outcomes.

Mission Statement

Corporate Statement

Global biotechnology company– Budapest, Headquarters, Software R&D– Cambridge, MA, Operations and Manufacturing

World leader in HLA Typing by NGS– Best in class Assay– Best in class Software

Existing Products– Holotype HLA (Assay + Software)– HLA Twin (Software)– HLA Explore (Software)

Current stage of the company

Two UK SBRI awards $1.2m

Outsourced manufacturing (US based) ISO-13485

Flagship Product Holotype HLA

Existing customers HLA labs and hospitals

CE marked In Vitro Diagnostic

Proprietary HLA Typing software developed in-house

Exclusively in-licensed HLA assay from CHOP

Early Access Program completed in 24 labs, 13 countries

Customer Challenges

High cost per test for high-resolution tests– Cheaper low resolution test are

insufficient for bone marrow transplants

NGS solves all these challenges

Ambiguous results– Intensive interpretation to resolve– Frequently requires retesting with alternative technology

Labour intensive workflows, low throughput

Customer Adoption

Innovators Early Adopters Early Majority

Believe the Data - Holotype HLA

ASHI validation study at CHOP 253 samples

Double blind alpha study 16 samples, 6 labs each

Clinical routine 2000+ clinical samples at CHOP

Product evaluation study

200 samples99.9% accuracy98.4% sensitivity 99.2% reproducibility

Worldwide Early Access Program 2400+ samples, 24 labs

Early Access Program

Holotype HLA NGS is new technology - for the HLA clinic. Demonstrating that the technology works

reproducibly is key – ‘believe the data’. Early Access Program ran from 11/2014 to 6/2015. 24 labs, 13 countries, 2400 samples, 26000 alleles. > 99.7% accuracy and reproducibility.

Product Positioning

Only whole gene NGS product in the world currently in routine clinical practice

Lowest hands-on time of any of the available NGS HLA typing products

Only product reliably scalable for genotyping 240 samples at 5 loci in a single MiSeq run

HLA Twin has the best analysis results of any of the NGS HLA software tools on the market

HLA Twin is the only software providing reliable, complete, contiguous whole gene consensus sequences

HLA Twin is focused on high-throughput, automated genotyping that is ideal for routine and registry typing

Questions

Tim Hague tim.hague@omixon.comPeter Meintjes peter.meintjes@omixon.com