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Personal Information
Academic Positions
Name: Laila A. Abou Zeid
Academic
Position: Associate Professor of Pharmaceutical Chemistry
Administrative
Position: -
Faculty:
Faculty of Pharmacy, University of Delta, Mansoura, Egypt
Department: Department of Pharmaceutical Chemistry
Major Specialty: Drug Design & Synthesis
Minor Specialty:
Current position: Associate Professor of Pharmaceutical Chemistry
Office address: 115
Work phone:
Edu-Mail: [email protected]
Demonstrator
Organization Country From To
Department of Medicinal chemistry, Faculty of Pharmacy
Mansoura 1986 1991
Assistant Lecturer
Organization Country From To
Department of Physiology and Endocrinology, Medical College of Georgia
, Augusta, GA, USA
1992 1995
Assistant Professor
Organization Country From To
Department of
Biochemistry; Wright State University,
Dayton, Ohio, USA
1997 2000
Associate Professor
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Publications
Organization Country From To
Faculty of Pharmacy, University of Delta,
Mansoura, Egypt
2018 current
1. Tamer R. Kosbar, Laila Abou-Zeid Combating telomerase as a hallmark of
cancer: Synthesis, biological evaluation and molecular docking studies
of novel pyrazolo[3,4-d]pyrimidines as potential telo
Journal of Heterocyclic Chemistry 54 (onlinelibrary.wiley.com), DOI:
10.1002 …
1. Laila Abou-zeid; K. M. Attallah, A. M. Gouda, I. T. Ibrahim Design, Synthesis, 99mTc Labeling, and Biological Evaluation of a Novel Pyrrolizine Derivative as Potential Anti-Inflammatory Agent
Radiokhimiya 59 (No. 6), pp. 630-638
2. 3. Adel S. El-Azab, Abdullah Al-Dhfyan, Alaa A.-M. Abdel-Aziz, Laila A.
Abou-Zeid, Hamad M. Alkahtani, Abdulrahman M. Al-Obaid , Manal A.
Al-Gendy Synthesis, anticancer and apoptosis-inducing activities of
quinazoline-isatin conjugates: Epidermal growth factor receptor-
tyrosine kinase assay and molecular docking studies Journal of
enzyme inhibition and medicinal chemistry . 2017, 32(1) 935-944
4. Lamiaa Osama, Laila A. Abou-Zeid, Magda N. A. Nasr and Atif S.
Tantawy Synthesis and molecular modeling of new quinoline
derivatives as antitumor agents. Der Pharma Chemica, 2016,
8(14):100-110
5. Alaa A.-M. Abdel-Aziz, Laila A. Abou-Zeid, Kamal Eldin H. ElTahir,
Menshawy A. Mohamed, Mohamed A. Abu El-Enin, Adel S. El-Azab
Design, synthesis of 2,3-disubstitued 4(3H)-quinazolinone derivatives
as anti-inflammatory and analgesic agents: COX-1/2 inhibitory
activities and molecular docking studies Bioorganic & Medicinal
Chemistry 2016; 24: 3818–3828
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6. Alaa A.-M. Abdel-Aziz, Laila A. Abou-Zeid, Kamal Eldin H. ElTahir,
Menshawy A. Mohamed, Mohamed A. Abu El-Enin, Adel S. El-Azab
Design, synthesis of 2,3-disubstitued 4(3H)-quinazolinone derivatives
as anti-inflammatory and analgesic agents: COX-1/2 inhibitory
activities and molecular docking studies Bioorganic & Medicinal
Chemistry 2016; 24: 3818–3828
7. Alaa A.-M. Abdel-Aziz, , Laila A. Abou-Zeid, Kamal Eldin H. ElTahir, Rezk
R. Ayyad; Magda A.-A. El-Sayed, Adel S. El-Azab Synthesis, anti-
inflammatory, analgesic, COX-1/2 inhibitory activities and molecular
docking studies of substituted 2-mercapto-4(3H)-quinazolinones; .
European Journal of Medicinal Chemistry 2016; 121 : 410-421
8. Alaa A.-M. Abdel-Aziz, Adel S. El-Azab; Laila A. Abou-Zeid, Kamal Eldin
H. ElTahir, Naglaa I. Abdel-Aziz, Rezk R. Ayyad, Abdulrahman M.
Al-Obaid Synthesis, anti-inflammatory, analgesic and COX-1/2
inhibition activities of anilides based on 5,5-diphenylimidazolidine-2,4-
dione scaffold: Molecular docking European Journal of Medicinal
Chemistry 2016; 115; 121-131
9. Laila A Abou-Zeid, Mohammed Hefnawy Molecular Modeling study of the
Chiral Recognition of Celiprolol Enantiomers by a β- Cyclodextrin.
The Pharmaceutical and Chemical Journal, 2015, 2(3):16-23
10. Laila A. Abouzeid, Hussein I. El-Subbagh DNA binding of Ethyl 2-
substituted aminothiazole-4-carboxylate analogues: A molecular
modeling approach to predict their antitumor activity; Future Journal
of Pharmaceutical Sciences, 2015, 1; 1-7.
11. Deema A. Al-Turki, Mohamed A. Al-Omar, Laila A. Abou-zeid , Ihsan A.
Shehata, Mohammed S. Al-Awady Design, synthesis, molecular
modeling and biological evaluation of novel diaryl heterocyclic
analogs as potential selective cyclooxygenase-2 (COX-2) inhibitors
Saudi Pharm J. 2017, 25(1): 59-69
12. Gerald M. Alter, Laila Abou-Zeid. Molecular Dynamic Simulation of Malate Dehydrogenase. SMU Medical Journal 2015; 2; 270-280.
13. Tamer R. Kosbar, Mamdouh A. Sofan, Laila Abou-Zeid, Erik B. Pedersen Thermal stability of G-rich anti-parallel DNA triplexes upon insertion of LNA and α-L-LNA
. Org. Biomol. Chem., 2015, 13; 5115.
14. Morkos A. Henen, Laila Abou-Zeid, Alaa El-Din Barghash and Hassan
Eisa. 19F-NMR as a powerful tool for measuring binding of synthesized
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small combinatorial dynamic library components with the armadillo repeat domain of human ß-catenin. Current Topics in Peptide & Protein R e s e a r c h 2014; 15: 35-39
15. Sherin M. El-Feky, Laila A. Abou-Zeid, Mohamed A. Massoud, Shady K.
George and Hassan M. Eisa. Computational design, molecular modeling and synthesis of new 1,2,4-triazole analogs with potential antifungal activities. SMU Medical Journal 2014, 1, 224 – 242
16. Laila Abou-zeid, Hany N. Baraka. Combating oxidative stress as a hallmark of cancer & Aging: Computational modeling and Synthesis of phenylene diamine analogs as potential antioxidant. Saudi Pharm. J. 2014, 22(3): 264–272.
17. Morkos A. Henen, Laila Abou-Zeid, Alaa El-Din Barghash and Hassan M. Eisa. Nuclear magnetic resonance as a breakthrough frontier in
fragment-based drug design. Journal of American Science 2013; 9(11) 459-
466.
18. Mostafa Shuhnna, Ali Dauood, Laila Abouzeid, Osama Khudro Analytical Method Validation and Stability Study for Novel Derivative of Benzodiazepines. Research J. Aleppo University, 2013, 88.45-48
19. Mostafa Shuhnna, Ali Dauood, Laila Abouzeid, Osama Khudro Synthesis
and Molecular Modeling for Novel Derivative of Benzodiazepines and Determine the Structure Using Spectrum Methods. Research J. Aleppo University, 2013, 88.49-53
20. Tamer Kosbar, Mohamed Waly, Laila Abou-Zeid, Mamdouh Sofan, Jesper Wengel, Erik Pedersen. Highly Efficient Synthesis of Allopurinol LNA via C6 Deamination of 8-Aza-7-bromo-7-deazaadenine
LNA. Synthesis, 2013, 45(23): 3259-3262
21. Said M. Bayomi, Hassan A. El-Kashef, Mahmoud B. El-Ashmawy, Magda
N. A. Nasr, Magda A. El-Sherbeny, Farid A. Badria, Laila A. Abou-zeid, Mariam A. Ghaly, Naglaa I. Abdel-Aziz. Synthesis and biological evaluation of new curcumin derivatives as antioxidant and antitumor agents, Medicinal Chemistry Research 2013, 22(3), 1147-1162.
22. Waleed A. Bayoumi, Magda A. Elsayed, Hany N. Baraka and Laila Abou-
zeid. Computational Modeling, Synthesis and Antioxidant Potential of Novel Phenylcarbamoylbenzoic Acid Analogs in Combating Oxidative Stress. Archiv der Pharmazie 2012, 345, 902-910.
23. Magda A.-A. El Sayed , Mohamed A. Massoud , Atif S. Tantawy, Magda N.
A. Nasr, Alaa El-Dine M. Barghash, Laila A. Abou-Zeid Synthesis and biological evaluation of new unsaturated derivatives of cyclic compounds as potent antioxidant agent. Der Pharma Chemica, 2012, 4(5):1785-1797.
24. Mohamed Attia Waly, Laila Abou-zeid, Sameh Ramadan El-Gogary, Mona
Abbas Shalaby. One-pot Synthesis, Molecular Modeling and In Vitro Antibacterial Activity of Novel 3-(1,3,4-Oxadiazol-2-yl) Quinoxaline 1,4-Dioxide and Pyrazolyl Analogs Acta Chim. Slov. . 2012, 59, 32–41
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25. Khairia M. Youssef, Mohamed A. Al-Omar, Hussein I. El-Sabbagh, Laila A.
Abou-Zeid, Abdel-Galil M. Abdel-Gader, Nadia G. Haress, Ali S. Al-Tuwaijri. Synthesis, Antiplatelet Aggregation Activity, and Molecular Modeling Study of Novel Substituted-Piperazine Analogues. Medicinal Chemistry Research 2011, 20, 898–911.
26. Deema A. Al-Turki, , Laila A. Abou-Zeid, Ihsan A. Shehata, Mohamed A.
Al-Omar Therapeutic and toxic effects of New NSAIDs and related compounds : A review and prospective study International Journal of Pharmacology, 2010. 6, 813-825.
27. Fatmah A. M. Al-Omary, Laila A. Abou-Zeid, Mahmoud N. Nagi, El-Sayed
E. Habib, Alaa A.-M. Abdel-Aziz, Adel S. El-Azab, Sami G. Abdel-Hamide, Mohamed A. Al-Omar, Abdulrahman M. Al-Obaid, Hussein I. El-SubbaghNonclassical Antifolates, Part 2.# Synthesis, Biological Evaluation and Molecular Modeling Study of Some New 2,6-Substituted-quinazolin-4-ones. Bioorganic & Medicinal Chemistry. 2010; 18, 2849–2863
28. Sherin M. El-Feky, Laila A. Abou-Zeid, Mohamed A. Massoud, Shady K.
George and Hassan M. Eisa. Synthesis, Molecular modeling of novel 1,2,4-triazole derivatives with potential antimicrobial and antiviral activities. Acta Pharmaceutica Sciencia. 2010, 52:3, 353-364
29. Fatma E. Goda, Atif S. Tantawy, Laila A. Abou-Zeid, Sahar M. Badr and
Khalid B. Selim Synthesis, Biological Evaluation and Molecular Modeling Investigation of Some New Benzimidazole Analogs as Antiviral Agents. Saudi Pharm. J., 2008, 16, 103-111.
30. Laila A. Abou-Zeid, A. M. El-Mowafy, D.Eikel,
H. Nau , and M. El-Mazar Computational characteristics of valproic acid binding to Histone deacetylase. Saudi Pharm. J., 2007 15, 183-189.
31. Laila A. Abou-Zeid, A. M. El-Mowafy, D.Eikel,
H. Nau , and M. El-Mazar Mechanism of butyrate binding to histone deacetylase (HDAC): correlation with chemopreventive effects and ligand selectivity. J.Basic and Applied Sciences, 2007, 3, 73-85.
32. S. T. Al-Rashood, I. A. Aboldahab, M. N. Nagi, L. A. Abou-Zeid, A. M.
Abdel-Aziz, S. G. Abdel-hamide, K. M. Youssef, A. M. Al-Obaid and H. I. El-Subbagh Synthesis, dihydrofolate reductase inhibition, antitumor testing, and molecular modeling study of some new 4(3H)-quinazolinone analogs. Bioorganic & Medicinal Chemistry, 2006, 14, 8608–8621.
33. Laila A. Abou-Zeid and A.M. El-Mowafy Differential Recognition of
Resveratrol Isomers By Human Estrogen Receptor-α: A Molecular Dynamics Evaluation of Stereoselective Ligand Binding. Chirality, 2004, 16 (3), 190-195.
34. Laila A. Abou-Zeid and A.M. El-Mowafy: Molecular dynamics simulation
characteristics of resveratrol interaction with human estrogen receptor-Struct. Theochem, 2002 593 (1-3), 39-48.
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Conferences & Workshop:
35. A.M. El-Mowafy, L.A. Abou-Zeid and I. Edafiogho: Recognition of
Resveratrol by the human estrogen receptor-approach to understand its biological actions. Med. Princ. Pract. , 2002 11 (2), 86-92.
36. Laila A. Abou-Zeid: Molecular Modeling Studies of Resveratrol as an
Estrogen Receptor Ligand. Saudi Pharmac. J., 2002, 10, 60-64.
37. Laila A. Abou-Zeid, A.M. El-Mowafy, M.M. El-Kerdawy, H. Hamza and M. E. Abdel-Hamid: Synthesis, spectroscopic characterization, stability assessment and DNA-binding of new 2,6-piperidinedione derivatives. IL Farmaco, 2001, 56, 763-770.
38. Laila A. Abou-Zeid, A.M. El-Mowafy: Antineoplastons: major players in
the biochemical defense system against cancer. Saudi Pharm. J., 2001, 9(2), 67-71.
39. Laila A. Abou-Zeid, A.M. El-Mowafy, M.B. El-Ashmawy, L. B. Hendry, A. M.
Abdelal and F. A. Badria: Novel piperidinedione analogs as inhibitors of breast cancer cell growth. Arch. Pharm. Pharm. Med. Chem., 2000, 333, 431-434.
40. F. Badria, M. Mabed, M. El-Awadi, L.A. Abou-Zeid, E. Al-Nashar and S. Hawas: Immune modulatory potentials of antineoplaston A-10 in breast cancer patients. Cancer Lett., 157, 2000, 57-63.
41. F. Badria, M. Mabed, W. Khafagy and L.A. Abou-Zeid: Potential utility of
Antineoplaston A-10 levels in breast cancer. Cancer Lett., 2000, 155, 67-70.
42. M. M. El-Kerdawy, A. S. Tantawy, M.A. Massoud and L.A. Abou-Zeid:
Synthesis and antithyroid activity of certain uracil and thiouracil derivatives Alex. J. Pharm. Sci., 1999, 13(2), 121-125.
43. M.M. El-Kerdawy, A.S.Tantawy, M.A.Massoud and L.A. Abou-Zeid:
Synthesis and antithyroid activity of certain uracil derivatives (part II). Mans. Sci. Bull. 1999, 26(2), 133-140.
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Conferences & Workshop:
1. Laila A. Abouzeid organization committee of the First International Conference of Pharmaceutical Sciences, Faculty of Pharmacy, Mansoura University, 10-11/4/2017
1. Laila A. Abouzeid Workshop: State of Art Research in
Computational Chemistry; The First PharmaSchool International Conference of Pharmaceutical Sciences, Faculty of Pharmacy, Mansoura University, 15,16/2/2016
2. Laila Abou-zeid Ghada Boustan, Magda NA Nasr (2015) Computational molecular dynamics and synthesis of novel class of Selective Cyclooxygenase-2 Inhibitors with potential apoptotic anti-inflammatory activity. 3rd FUE international conference of pharmaceutical Science.
3. Laila Abou-zeid; (2014) Annual Departmental Conference, FOP, MU:
Hands on computational pharmaceutical chemistry.
4. Laila. Abou-Zeid, (2012) “International Computational Molecular
Modeling & Drug Discovery ” Workshop at Faculty of Pharmacy, Mansoura University, Egypt
5. M. Henen, N. Coudevylle, Laila. Abou-Zeid, A. Barghash, H. Eisa and
R. Konrat (2012) Chemistry and NMR studies of the beta-catenin-tcf4 interaction - a potential antitumor target. France - Vienna University.
6. Osama Khudro, Ali Dauod, Laila Abou-Zeid, Fawaz Shehna (Dec,
2011) Molecular Modeling Design and Synthesis of Novel Analogs As Potential Benzodiazepine analogs, AEAS, 38th Annual Conference, Cairo, Egypt
7. Laila Abou-Zeid, Hany B. Nashat (Dec, 2010) Combating oxidative
stress as a hallmark of cancer, 37th, annual conference Association of Egyptian American Scholars, Cairo. Egypt.
8. Morkos Adel Henen, Laila Abou-Zeid, Alaa Barghash, Hassan Eissa and Robert Konrat (Oct, 2010) β‐Catenin & TCF4: Chemistry and structural biology NMR studies as potential anticancer targets. Max F. Perutz Laboratories, University of Vienna, Campus Vienna Biocenter 5, 1030, Vienna, Austria.
9. Khairia M. Youssef, Mohamed A. Al-Omar, Hussein I. El-Sabbagh, Laila A. Abou-Zeid, Abdel-Galil M. Abdel-Gader, Nadia G. Haress, Ali S. Al-Tuwaijri. (2010) Synthesis, Antiplatelet Aggregation Activity, and Molecular Modeling Study of Novel Substituted-Piperazine Analogues. The 3rd International Conference of The Arab Society for Medical Research, Zawia, Libya.
10. Sherin M. El-Feky, Laila A. Abou-Zeid, Mohamed A. Massoud, Shady
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K. George and Hassan M. Eisa. (2010) Computational design, molecular modeling and synthesis of new 1,2,4-triazole analogs with potential antifungal activities. The 3rd International Conference of The Arab Society for Medical Research, Zawia, Libya.
11. Fatmah A. M. Al-Omary, Laila A. Abou-Zeid, Mahmoud N. Nagi, EL-Sayed E. Habib, Alaa A.-M. Abdel-Aziz Mohamed A. Al-Omar and Hussein I. El-Subbagh. (2010) Nonclassical Antifolate Compounds as
Dihydrofolate Reductase Inhibitors: Synthesis and Biological Evaluation. 8th Spanish-Italian Symposium on Organic Chemistry. Italy
12. Deema A. Al-Turki, Mohamed A. Al-Omar, Laila A. Abou-Zeid, Ihsan A. Shehata, Mohammed S. Al-Awady. (2010) Design, Synthesis, Molecular Modeling and Biological Evaluation of Novel Diaryl Heterocyclic Analogs as Potential Selective Cyclooxygenase-2 (COX-2) Inhibitors. 8th international pharmaceutical conference, Riyadh, KSA.
13. Laila A. Abouzeid (2010). “Computer aided drug design” 4th Conference of Pharmaceutical Sciences, Faculty of Pharmacy, University of Aleppo, Syria
14. Laila A. Abouzeid (2010) “Computer aided drug design” Workshop-I at Faculty of Pharmacy, Mansoura University, Egypt
15. Laila A. Abou-Zeid (2009) Computational Prediction of Cancer Cure with Novel Telomerase Inhibitors. First International Pharmaceutical, Sciences Conference Tanta University, Tanta, Egypt
16. Waleed A.Bayoumi, Magda A.Elsayed, Laila A. Abou-Zeid and Hanny N. Baraka. (2009) Synthesis, conformational study and antimicrobial screening of 2-(phenylcarbamoyl)benzoic acid derivatives. First International Pharmaceutical, Sciences Conference Tanta University, Tanta, Egypt
17. Magda A.Elsayed, Waleed A.Bayoumi, Laila A. Abou-Zeid and Hanny N. Baraka. (2009) Synthesis, computational study of amides of phthalic acid as potential antimicrobial agents. First International Pharmaceutical, Sciences Conference Tanta University, Tanta, Egypt
18. Sherin M. El-Feky, Laila A. Abou-Zeid, Shadi George, Mohamed A. Massoud, Hassan M. Eisa, (2009) Synthesis, computational studies and biological evaluation of novel 1,2,4-triazole derivatives as antimicrobial agents. 10th International Conference on Chemistry and Its Role in Development Mansoura University Sharm El-Sheikh Egypt
19. F. A Badria, L.A. Abou-Zeid, A Mowafy, S Hawas, Y Khafagy. M Mabed. (2008) Anti-Neoplaston: Synthesis, Biological, and Clinical Evaluation in Egypt. EHRLICH II –2nd World Conference on Magic Bullets Celebrating the 100th Anniversary of the Nobel Prize Award to Paul Ehrlich Nürnberg, Germany
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20. Hussein I. El-Subbagh, S.T. Al-Rashood, I.A. Aboldahab, S.G. Abdul-hamide, L.A. Abou-Zeid and M.N. Nagi (2005): Synthesis, Molecular Modeling, and Dihydrofolate Reductase Inhibition Activity of Some
New 4(3H)-quinazolinone Analogues. The 9th
International Pharmaceutical Sciences Conference, Saudi Arabia
21. L.A. Abou-Zeid, A.M. El-Mowafy, M. El-Mazar, D. Eikel and H. Nau (2005): Mechanism of butyrate binding to histone deacetylase (HDAC): correlation with chemopreventive effects and ligand
selectivity. The 9th
International Pharmaceutical Sciences Conference, King Saud University, Saudi Arabia
22. L.A. Abou-Zeid and A.M. El-Mowafy (2005): Differential Recognition of Resveratrol Isomers By Human Estrogen Receptor-α: A Molecular
Dynamics Evidence For Stereoselective Ligand Binding. The 9th
International Pharmaceutical Sciences Conference, King Saud University, Saudi Arabia
23. L. A. Abou-Zeid, A. M. El-Mowafy and I. Edafiogho (2003): Resveratrol binding to the human estrogen receptor-dynamics approach to understand its biological actions. 7th International Symposium on Pharmaceutical Sciences. Ankara, Turkey
24. A. M. El-Mowafy, L. A. Abou-Zeid and I. Edafiogho (2002): Unique Recognition of Resveratrol By the Human Estrogen Receptor-Molecular Dynamics Evidence. HSC Poster Day, Kuwait
25. A. M. El-Mowafy, L. A. Abou-Zeid and M. E. Abdel-Hamid and F. Badria (2002): Antibreast cancer activity and DNA binding of novel antineoplastons. HSC Poster Day, Kuwait
26. Gerald M. Alter, Laila A. Abou-Zeid, and Andrzej Kazimierczuk (2001): Molecular Pathway for Pig Heart Cytoplasmic Malate Dehydrogenase Cooperativity The Protein Society Fifteenth Symposium Philadelphia, PA. USA
27. Gerald M. Alter and Laila A. Abou-Zeid (2000): Molecular Dynamics Simulation of Malate Dehydrogenase. The Protein Society Fourteenth Symposium. San Diego, CA. USA
28. M. Mabed, F. Badria, W. Khafagy, L. A. Abou-Zeid, E. Al-Nashar and S. Hawas (1998): Apoptosis, natural killers and antineoplaston A10 in normal individuals and breast cancer patients. The Second Alexandria Oncology Conference, Egypt
29. F. Badria, M. Mabed, W. Khafagy and L. A. Abou-Zeid (1998): Potential utility of antineoplaston A10 level in breast cancer. Second Arab American Cancer Foundation Conference, Egypt
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30. M. Mabed, F. A. Badria, W. Khafagy, L.A. Abou-Zeid, E. Al-Nashar and S. Hawas (1998): Apoptosis, natural killers and antineoplaston A10 in normal individuals and breast cancer patients. Int. J. Cancer Mol. Biol. Res., Egypt
31. L. A. Abou-Zeid, M. B. El-Ashmawy, L. B. Hendry and M. M. Elkerdawy (1995): Molecular Modeling and synthesis of new antiestrogens. International Conference of Pharmaceutical Sciences and Technology, Egypt
32. L. B. Hendry, C. K. Chu, V. B. Mahesh, L. A. Abou-Zeid, T. F. Ogle D. W. Brann and T. M. Mills (1994): Drug design using DNA structure leading to the discovery of novel pharmacophores to predict activity. University system symposium, Georgia State University, USA
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Thesis Supervision
Teaching Courses
Supervised PhD
Fatmah Al-Omary (Ph.D. Faculty of Pharmacy, King Saud University, KSA, (2006-2007).
Morkos Henen (Ph.D. Faculty of Pharmacy, Mansoura University, Egypt (2008-2010).
Tamer Reda, (PhD, PhD, Faculty of Science, Mansoura University, Egypt) (2011-2014).
Supervised MSc
1. Deema Al-Turky (Masters, Faculty of Pharmacy, King Saud University, KSA, (2007-2008).
2. Sherin El-Feky (Masters, Faculty of Pharmacy, Mansoura University, Egypt. (2007-2009).
3. Lamiaa Osama (Master, Faculty of Pharmacy, Mansoura University, Egypt. (2013-2017).
4. Menna Sherif (Masters, Faculty of Pharmacy, Mansoura University, EGYPT, (2015-till now).
5. Heba eisa (Masters, Faculty of Pharmacy, Mansoura University, EGYPT, (2016-till now).
6. Mohamed Zeidan (Masters, Faculty of Pharmacy, Mansoura University, EGYPT, (2016-till now).
(i) Pharmaceutical Organic Chemistry Topics:
Principles of organic chemistry.
Virtual Lab of computational chemistry (using PC software ChemDraw).
Nomenclature of organic compounds using IUPAC & PC software ISIS/Draw).
Chemical bonds: Atomic orbitals, hybridization and bonding.
Organic reaction mechanisms: Substitution, elimination, rearrangement, oxidation-reduction, and alkylation.
Alkanes and cycloalkanes: Bonding, Nomenclature, constitutional and conformational isomers, cycloalkanes: "chair" structure of 6-membered rings, configurational isomers.
Aromatic Hydrocarbons: Aromaticity, resonance and reactions.
Alkenes: Bonding, nomenclature, configurational isomers, electrophiles and nucleophiles.
Organic halogenated compounds: Bonding, nucleophilic and elimination reactions.
Stereochemistry: Chirality, enantiomers, and diastereomer.
Spectroscopy: Characterization using Infra-Red, Nuclear Magnetic Resonance and Mass spectroscopy.
(ii) Pharmaceutical Organic Chemistry Laboratory:
Stereochemistry virtual laboratory using educational software to
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elucidate the stereo features with more convincing techniques available using computational programs.
Qualitative functional group identification by color reactions.
Separation and crystallization techniques.
Isolation of compounds from mixtures.
Small-scale synthesis of pharmaceutical products.
Interpretation of IR, UV, NMR and Mass spectra of organic molecules.
(iii) Pharmaceutical Medicinal Chemistry and Drug Design Topics:
Cardiovascular drugs.
CNS stimulant depressant drugs.
Anti-inflammatory drugs.
Anesthetic drugs.
Physicochemical parameters and mechanism of drug action.
Quantitative Structure-Activity Relationships (QSAR) of drugs.
Pharmacokinetics and Pharmacodynamics.
Chemical aspects of drug discovery approach, drug design and Molecular dynamics.
(iv) Pharmaceutical Chemistry Laboratory:
Workshops and tutorials using molecular modeling software in exploring drug design and ligand-receptor interaction.
(v) Quality assurance - Vision and motions - Strategy plans - Concept of accreditations - Course specification - Self-evaluation - Internal auditing
Graduate Courses Master & PhD
- Special pharmaceutical organic course
(i) Topics Taught:
Computer-aided molecular modeling and drug design of natural and synthetic compounds.
Dynamic simulation of drug receptor interaction
Conformational analysis of lead and Pharmacophore prediction
Advanced spectroscopic identification of organic compounds.
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Committees
Prizes and Awards
Project Membership
Research Project: Funded STDF (Science & Technology Development Fund) Co-member "NMR-Unit"
Research Project: Funded by University of Mansoura 2016
Co-Author
University strategy plan committee
Director OF Quality Assurance Unit
Director E-Learning unit, Faculty of Pharmacy, Mansoura University.
Director Computational Modeling laboratory
Post Graduate & Research Committee (Member)
Community & Environmental Development Committee (Member)
Information Technology Committee (Member)
Faculty of pharmacy board (Member)
International Organization for Standardization ISO (Internal Audit) Egyptian Pharmaceutical Students' Federation" in Mansoura University."
Chairperson of top candidate committee
Faculty of Pharmacy Award of leading the Quality assurance unit and obtain the Quality assurance renewal 2017
From ELSEVIER; Bioorganic and Medicinal Chemistry. For the paper entitled: “Non-classical antifolates. Part 2: Synthesis,
biological evaluation, and molecular modeling study of some new 2,6-substituted-quinazolin-4-ones”
This paper was published in: Bioorganic and Medicinal Chemistry, Volume 18, Issue 8, 20.
Award of Distinction (Ph.D. thesis) (1995-1996):
Faculty of Pharmacy, Mansoura University, Egypt Pre-doctoral Scholarship for Ph.D. (1993-1995): To Medical College of
Georgia, Augusta, Georgia, USA from the Egyptian Cultural and Educational Bureau, Washington, DC
Fellowship for Master degree (1986-1991): Faculty of Pharmacy, Mansoura University, Egypt
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“Design and synthesis of 2-picolinic acid derivatives as novel kinase inhibitors with potential anticancer
activity”
Several novel derivatives of 2-picolinic acid to play the role of kinase inhibitors with cyctotoxic activities. This design will be performed using Sorafenib as a model to derive the pharmacophore key functions that define the essential structural features a molecule must possess in order to bind to the kinase target. Computational docking data will be derived to correlate the experimental biological data with the predicted activity of new analogs
Research Grants: Funded by University of
Mansoura-20013-2015
Principal Investigator of Project:
“Computational molecular dynamics and synthesis of novel class of Selective Cyclooxygenase-2 Inhibitors with potential apoptotic anti-inflammatory activity”
The aim of the project is to design and synthesis new class of the cyclooxygenase-2 inhibitors and biologically evaluates their anti-inflammatory activity and their antitumor activity by enhancing the apoptosis. Computational studies will be performed for the designed compounds to determine their complementarity with the key amino acids at the binding active site of the COX-2 enzyme. The selected promising compounds will be synthesized and biologically evaluated for their anti-inflammatory and antitumor activities.
II. Reviewer of Academic Journals:
Medicinal Chemistry Research
Saudi Pharmaceutical Journal
Chemical Biology & Drug Design
IV. Editorial Advisory Board Membership
Editorial Board Member at:
1- IJC : International Journal of Chemistry, Canada ;
http://ccsenet.org/journal/index.php/ijc/about/editorialTeam
2- IJPBS: International Journal of Pharma and Bio Sciences
http://www.ijpbs.net/editorial-board.html
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3- IJAPC: International Journal of Ayurveda and Pharmaceutical Chemistry
http://www.ijapc.com/editorial-board.shtml
4- IJBMSP: International Journal of Basic Medical Sciences and Pharmacy
http://www.ijbmsp.org/index.php/IJBMSP/about/editorialPolicies#custom-1
5- JAAR Journal of American Academic Research:
http://www.american-journals.com/#!about/cipy
6- JOLSC: Journal of Laboratory Science
http://www.jolsc.com/editorial-board.shtml
7- RJPBCS: Research Journal of Pharmaceutical, Biological and Chemical Sciences
http://www.rjpbcs.com/editorial.html
8- ROS: Reactive Oxygen Species
http://www.aimsci.com/ros/index.php/ros/about/displayMembership/2
9- TPCJ: The Pharmaceutical and Chemical Journal
http://tpcj.org/editorial-board
10- JMMC: Journal of Modern Medicinal Chemistry
http://www.synergypublishers.com/editorial-board-jmmc/
