Shiva Gautam Harvard

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Principal Investigator/Program Director (Last, First, Middle):

PHS 398/2590 (Rev. 09/04) Page Biographical Sketch Format Page

BIOGRAPHICAL SKETCHProvide the following information for the key personnel and other significant contributors in the order listed on Form Page 2.

Follow this format for each person. DO NOT EXCEED FOUR PAGES.

NAME

Shiva Gautam, Ph.D.

eRA COMMONS USER NAME

shivagautam

POSITION TITLE

Director, GCRC Biostatistics,

Beth Israel Deaconess Medical Center,Boston, MA 02215

EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.)

INSTITUTION AND LOCATIONDEGREE

(if applicable)YEAR(s) FIELD OF STUDY

Tribhuvan University Kathmandu,Nepal

B.B. 1978 Statistics

The University of Texas Richardson,Texas

M.S. 1987 Statistics

The University of Texas Richardson,Texas

Ph.D. 1991 Statistics

A. Positions and Honors

1983-1985 Assistant Lecturer of StatisticsMin Bhavan Campus, Kathmandu, Nepal

1983-1985 Assistant Director, Research and PlanningJute Development and Trading Corporation of Nepal

1983-1985 Section Officer, Central Bureau of Statistics, Planning Commission of NepalHis Majestys Government of Nepal

1985-1990 Graduate Teaching Assistant, Program in Mathematical SciencesUniversity of Texas at Dallas, Richardson, Texas

1990-1991 Visiting Assistant Professor, Department of BiostatisticsOklahoma State University, Stillwater, Oklahoma

1991-1992 Post-Doctoral Fellow, Department of Biostatistics/EpidemiologyMedical University of South Carolina, Charleston, South Carolina1992-1994 Assistant Professor of Biostatistics, Department of Medical Biostatistics

University of Vermont, Burlington, Vermont1994-1998 Assistant Professor of Biostatistics, Division of Community Health Sciences

Northeastern Ohio University, Rootstown, Ohio1998-2003 Assistant Professor of Biostatistics, Department of Preventive Medicine

Vanderbilt University School of Medicine, Nashville, TN1998-2003 Biostatistician, Vanderbilt-Ingram Cancer Center

Vanderbilt University School of Medicine, Nashville, TN2003 (part) Associate Professor of Biostatistics, Department of Preventive Medicine

Vanderbilt University School of Medicine, Nashville, TN2003 - Director, GCRC Biostatistics, Beth Israel Deaconess Medical Center, Boston, MA2004 - 2006 Assistant Professor, Harvard Medical School, Boston MA2006- Associate Professor, Harvard Medical School, Boston MA

B. Selected peer-reviewed publications in chronological order (selected from a total of 52).

1. Gautam S, Kimeldorf G, and Sampson A: Optimized Scoring for ordinal Data for the General LineaModel, Statistics and Probability Letters; 1996; 27: 231-239.

2. Gautam S: Test for Linear Trend in 2xK Ordered Tables with Open-ended Categories, Biometrics; 199753: 1163-1169.


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Principal Investigator/Program Director (Last, First, Middle): Govindarajulu, Usha

PHS 398/2590 (Rev. 09/04, Reissued 4/2006) Page Biographical Sketch Format Page

3. Gautam S and Kimeldorf G: Some Results on the Maximal Correlation Coefficient in 2xK ContingencyTables, The American Statistician, 1999; 53: 336-341.

4. Carpenter JS, Gautam S, Freedman RR, and Andrykowski MA: "Circadian Rhythm of Objectively RecordedHot Flashes in Postmenopausal Breast Cancer Survivors." Menopause: Journal of the North AmericanMenopause Society, 2001; 8(3): 181-188.

5. Ely W, Gautam S, Francis J, Dittus R, Bernard G, and Inouye SK: The Impact of Delirium in the IntensiveCare Unit on Hospital Length of Stay, Intensive Care Medicine, 2001; 27: 1892-1900.

6. Gautam S, Singh H, and Sampson A: Iso-Chi-Squared Testing in 2xK Ordered Tables, Canadian Journaof Statistics, 2001; 29: 1-11.

7. D'Agata EMC, Gautam S, Green WK, and Tang YW. High False Negative Rate of the Rectal Swab CultureMethod in Detecting Gastrointestinal Colonization With Vancomycin-Resistant Enterococci, ClinicaInfectious Diseases, 2002; 34:167-172.

8. Gautam S: Analysis of Mixed Categorical Data in 2xk Contingency Tables, Statistics in Medicine, 200221:1471-1484.

9. Gautam S and Ashikaga T: Assessing the Effect of an Open-Ended Category on the Trend in 2xK OrderedTables, Journal of Data Science, 2003; 1: 167-183.

10. Ely W, Truman B, Shintani A, Thomason JW, Wheeler AP, MD, Gordon S, Francis J, Speroff T, Gautam SMargolin R, Dittus R, MD, Bernard GR, and Sessler CN: Monitoring Sedation Status over Time in the ICUA Two Part Investigation of the Richmond Agitation Sedation Scale (RASS), JAMA, 2003;289(22):2983-91.

11. Mertz H, Gautam S: The learning curve for EUS-guided FNA of pancreatic cancer, Gastrointest Endosc2004;59(1):33-7.

12. Biswas S Chytil A Washington K Romero-Gallo J Gorska AE Wirth PS Gautam S Moses HL Grady WM.TGFBR2 inactivation promotes the establishment and progression of colon cancer. Cancer Research2004 Jul 15;64(14):4687-92.

13. Hulboy DL Gautam S Fingleton B Matrisian LM. The influence of matrix metalloproteinase-7 on earlymammary tumorigenesis in the multiple intestinal neoplasia mouse. Oncol Rep. 2004 Jul;12(1):13-7.

14. Morgan V, Pickens D, Gautam S, Kessler R, Mertz H. Antriptyline reduces rectal pain-related activation ofthe anterior cingulated cortex in patients with irritable bowel syndrome. Gut, 2005:54(5):601-7.

15. Petko P, Ghiassi M, Shuber A, Gorham J, Smalley W, Washington MK, Schultenover S, Gautam S,Markowitz SD, Grady WM. Aberrantly methylated CDKN2A, MGMT and MLH1 in colon polyps and in fecalDNA from patients with colorectal polyps. Clinical Cancer Research, 2005:11(3): 1203-9.

16. Romero-Gallo J, Sozeman E, Chytil A, Russell WE, Whitehead R, Parks WT, Gautam S, Magnuson M,Moses HL, Grady WM. Inactivation of TGF- signaling in hepatocytes results in an increased proliferativeresponse after partial hepatectomy. Oncogene, 2005:24(18):3028-41.

17. Eisenberg E, Craig AS, Gautam S, Khalil MM, Shakhtour B, Schaffner W, Griffin MR. Beyond screening:Identifying new barriers to early-onset group-B streptococcal disease prevention. The Pediatric InfectiousJournal, 2005:24(6): 520-4.

18. Gavrila A, Hsu W, Tsiodras S, Doweiko J, Gautam S, Martin L, Moses AC, Karchmer AW, Mantzoros CS.Improvement in highly active antiretroviral therapyinduced metabolic syndrome by treatment withpioglitazone but not with fenofibrate: A 2_2 factorial, randomized, double-blinded, placebo-controlled trial.Clinical Infectious Diseases, 2005: 40(5):745-9.

19. Duda, RB, Darko R, Adam RMK, Seffah J, Anarfi JK, Gautam S, Hill AG. HIV prevalence and risk factorsin women of Accra, Ghana: Results from the womens health study of Accra. American Journal for Tropical

Medicine and Hygiene, 2005 ;73(1):63-6.20. Grady WM, Willis JE, Trobridge P, Romero-Gallo J, Munoz N, Olechnowicz J, Ferguson K, Gautam S,

Markowitz SD. Proliferation and cdk4 expression in microsatellite unstable colon cancers with TGFBR2mutations. International Journal of Cancer, 2006;118(3):600-8.

21. Nishino M, Kubo T, Kataoka ML, Gautam S, Raptopoulos VD, Hatabu H. Evaluation of thoracicabnormalities on 64-row Multi-Detector Row CT: Comparison between axial images versus coronalreformations. European Journal of Radiology. 2006; 59(1):33-41.

22. Varlotto JM, Gerszten K, Heron DE, Comerci J, Gautam S, Selvaraj R, LaLonde R, Chura JC. ThePotential Nephrotoxic Effects of Intensity Modulated Radiotherapy Delivered to the Para-aortic Area of


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Principal Investigator/Program Director (Last, First, Middle): Govindarajulu, Usha

PHS 398/2590 (Rev. 09/04, Reissued 4/2006) Page Biographical Sketch Format Page

Women with Gynecologic Malignancies: Preliminary Results. American Journal of Clinical Oncology.2006; 29(3):281-9.

23. Rooks DS, Gautam S, Romeling M, Cross ML, Stratigakis D, Evans B, Goldenberg DL, Iversen MD, Katz

JN. Group Exercise, Education, and Combination Self-Management in Women with Fibromyalgia. A

Randomized Trial. Annals of Internal Medicine. 2007 Nov 12; 167(20):2192-200.

C. Research Support

Ongoing Research Support

MO1 RR01032 Freedman (PI) 4/1/05-3/31/10NIH, NCRRGeneral Clinical Research Center.To provide infrastructure support for clinical investigators at Beth Israel Deaconess Medical Center who haveindependent funding for their investigations.

Role: Biostatistician

P50 HL060292 Saper (PI) 9/1/98-8/31/08NIH NHLBIHarvard Center on Sleep Neurobiology and Sleep ApneaThis grant consists of six Projects and four Cores all addressing various aspects of sleep, sleep apnea, or itsconsequences.Role: Biostatistician

Toshiba Medical Systems Hatabu (PI) 1/16/05-11/15/08International multicenter trial for radiation dose reduction (study 1, 2 and 3)This study explores whether or not reduction in radiation dose in PET scans will maintain the quality and

diagnostic value of the images obtained.Role: Biostatistician

Completed

R01 HL48531 White (PI) 7/1/06-6/30/11NIH NHLBIDefining Phenotypic Traits in Obstructive Sleep Apnea.The major goals of this project are to assess neural reflex, chemical and hormonal influences on thepharyngeal musculature awake and asleep in man in order to better understand the pathophysiology ofobstructive sleep apnea.Role: Biostatistician

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Shiva Gautam Harvard