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Title --AB-PCHetacillinMCI-PC--
Author(s) , ; ,
Citation (1969), 15(5): 382-392
Issue Date 1969-05
URL http://hdl.handle.net/2433/119995
Right
Type Departmental Bulletin Paper
Textversion publisher
Kyoto University
382
155
19695
ABPCHetacillinMCIPC
URINARY INFECTION OF RESISTANT GRAM NEGATIVE
BACILLI
SYNERGISTIC ACTION OF AMINOBENZYL PENICILLIN OR
HETACILLIN AND CLOXACILLIN
Hideo MiTsuyA and K6zi OBATA
From the DePartment of Urology Aragoya University School of Medicine Nagoya JaPan
ChairmanProf K Shimizu IL4 D
There is the tendency of increase of urinary tract infection with resistant gramnegative
bacjlli
AminobenzylPC and hetacillin Versapen were administrated to flve cases with various
urinarytract infections of resistant strains The effective results were obtained in three cases
but the alterations or superinfections were observed in two cases
The main strains of chronic urinary tract infection in Nagoya University Hospital were
Klebsiella and E coli that were highly resistant against the classical broad spectrum antibiotics
Ten cases of urinary infections with resistant gram negative bacilli were treated by ABPC
or hetacillin Versapen and MCIPC The synergistic action of ABPC or hetacillin and MCI
PC was found in seven cases of Klebsiella Rettgerella and Ps aeruginosa infections
Nb significant side effect was observed in this series
Candida
1
1
Table 1Staphylococcus
Ecoll2
34
2
5
2E coli
Klebsiella
383
Table 11 16
penicillin
Staphylococcus
Streptococcus
Enterococcus
Corynebacterium
E coli
Klebsiella
Cloaca
Pseudomonas
Proteus
Candida
30fe6
11
2
3
22
6
6
5
4
2
9
100
Klebsiella
point1actamasepeni
cillinasepenicillin
Pseudomonas68
Proteus7910 Klebsiel1a7911 E coli7910
8
penicillin
Sabathrc
CHCHCO
l1
HC CH CNCHCOOK o Versapen
Potassium hetacillin
Cl E
ll H N eLCH Xo
71penicillincepha
losporin
lactamase
methicillin oxacillin cloxacillin nafcillln
lactamase
activeenterb
12
ABPChetacilinVersapen
MCIPC
ABPCMCIPC
ABPCaminobenzyl penicillinampi
cillin
broad spectrumpenicillin
6Daaminophenylacetamidopenicillin acid
34
Versapen potassium salt of 622dimethy15oxo4pheny
1imidazolidinyl33dimethyl7oxo4thio1azabi
cyclo 320heptane2carboxylic acid
potassium hetaci1in
penicillinABPC
1516
ABPC
ampicillin
hetacillin
1 XgHcoNHPH lcHS X g gil
NH O CNCHCOOH ABPC Aminobenzyl penicillin
fi fi TcoNHpHLpff S?C
D
CONCHCooNaH20
Prostaphlin Cloxacillin
Fgi 1
384
Tuano heta
cillinampicillin
173
hetacillinampicillin
24617
hetacillin ampicillin
hetacillinampicillin
6hetacillinampicillin
hetacillin
13
ampicillin
penicillin
methici1inDMPC oxaciilinMPIPC
cloxacillinMCIPC dicloxacillinMDCIPC
MCIPC
Prostaphlin
Prostaphlincloxacillin
5methy13ochloropheny14isoxazolyLpenicillin
MCIPC Prostaphlinspec
trum penici1
1inase
Prostaphlin500mg1
15mcgm16
348500mg1
49mcgm16
33ABPC
89
ABPChetacillin allergy
20peni
cillin allergyPC penicillin
GBrownPCG a1
1ergy395ABPC allergy
21ABPC
ABPC
PCG
iABPC 510mg5
20cc anaphylaxy
ABPChetacillinanaphylaxy
ABPChetacillinTC
CP
GOT GPT LDH
20689
129
ABPC
10
769d1419d110u CCF
GOT 40u GPT 20u a1ph10u
ABPC
1TP599d110u
CCF GOT 14 GPT 6 alph542
TP zo9 CCF
1TP 70365
CCF GOT 16 GPT 12 alph62
ABPC 129
I ABPChetacillinVersaPen
1968Klebsiella
ABPChetacillin
Table 25
Tabe 3
tetracycline
chloramphenico1
TC CMABPC
hetacillinVersapen
Table 4
ABPCVersapen5
32
Versapen 16capE coli
2
ABPC
4E coliKlebsiella5
Pseudomonas aeruginosaE coliCloaca
Versapen
Ecoli
385
Table 2 ABPChetacillinVersapen
6Q E cQli
i65 TUR Micrococcus141 E coli
53 TUR E coli5 28
1 pseudorpfpas aeruginesa
Table 3 Table 2
pc SM TC cp 1 KM NA cER CL
1 E coli
2 Micrococcus
3 1 E coii
4 E coli
5 Pseudomonas aeruginosa
Table 4
1 lE coli lVersapnap1
1
2 1 MicrococcusPC Ig1 1 1
3 E coli1Versapen L25g1
2Versapen lg
2
7
39
1
4 IE coli 1 ABpclg 12
5 Pseudomonas aeruginosa DABPC lgQABPC500mg
1
P
3
Ecoli Cloaca
3 41
1400C
Ecoli
30010492001133
mm68mgd1 BUN 11Omgd1
O9mgd139N
Versapen 1000mg5500cc
6250rag
236C
Versapen 11000mg3
12V6rsapen
2
Versapen
Fig2
Klebsiella
ABPCVer
sapen
ABPC
5
386
Versap 12so mg etsap000
Fig2 3
45
Kleb
siellaE CQli
ABPC
MCIPC
H ABPCMCIPC
1968
Table 5
ABPCe hetacillinVersapenMCI
PCTable 510
63
1
Table
5tetracyclineTC chloram
phenicolCP tetracyclihe01eandonycin
TCOL tetracyclinenovobiocin
ABPCMCIPC
1 64
TUR
KlebsiellaStreptococcus faecalis TC OL CP
TUIK1b11 TC NB ABPC
3
4
62
17
VUR
Pseudomonas aeruginosaCloaca
RettgerellaStreptococcus faecalis
TC CP ABPC
TC CP ABPC
1 54K1bll 1 Tc NB oL cp
628 1 b11 Tc NB oL cp
764Klb11 TGABPC865IK1ba11
92 Klb11
CP
1 TC oL cp cER
10 58 lKlebsiella HStreptococcufaeca1s
TC OL
Table 6
387
i
2
3
4
5
6
7
8
9
10
Klebsiella
Klebsiella
Pseudomonas aeruginosa
Rettgerella
Klebsiella
Klebsiella
Klebsiella
Klebsiella
Klebsiella
Klebsiella
PC SM TC
cp
KM
NA CER CL
TCNB ABPC colistinCL
2Kleb
siellaTable 6
colistinnalidixic acid
Table 7
1
2
3
4
5
6
7
8
9
10
Klebsiella
Strept faec
Klebsiella
Pseud aerug
Cloaca
Rettgerella
Strept faec
Klebsiella
Klebsiella
Klebsiella
Klebsiella
Klebsiella
Klebsiella
Strept faec
Versapen 19
Prostaphling
Versapen 159
Prostaphlin 19
Versapen 159
Prostaphlin 19
Versapen 2259
Prostaphlin 19
ABPC 15g
MCIPC 750mg
PC 300
Prostaphlin lg
Versapen 19
Prostaphlin 19
1ABPC lg 2 ABPC 1sg
MCI750mg
2
1
1
1
3
3
4
10
5
4
340 1
3TTC1
3
MCIPC104
10
310
t
TCABPC
388
ABPCVersapenMCIPC
Table 7
ABPC110159MCIPC
119ABPC
VersapenMCIPCTable 7
73
Klebsiella2
1 64
1TUR
3goC
398821nm
42010412800
tetracycline
chloramphenico1 Ver
sapen 1000mg3
Prostaphlin 500mg2
38Versapen MCIPC
5 10009
C1C 0009
Fig31
630 10009 010 000q
Fig4 9
68S
2
Fig3
9 27
Sigmamycin 159
9
KlebsiellaCloaca
10439
Kefiin 2g23
Versapen1000mg5
Prostaphlin
500mg3
Versapen Prostaphlin5
Fig4
balance
1
E coli Klebsiella
Pseudomonas Proteus Citrobactor
22
Ecoli Klebsiella
hospital infection
2324
Ecoli Kleb
siella Cloaca Citrobactor Proteus Pseudo
monas
E coli Kleb
389
siella Pseudomonas Proteus
425
1968
Klebsiella
ABPCMCI
Klebsiella
Klebsiella
tetracycline chloramphenico1
strepto
mycin kanamycin colistin gentamycin
aminosidin
262T
penicillin
urosepsisG
ABPCheta
cillinsPectrum
penicillin
ABPChetacillinpenicillinase
spectrum14
penicillinasepenicillinase
penicillinmethicillinDM
PC oxacillin MPIPC cloxacillin MCI
PC dicloxacillinMDCIPC
penicillinase
penicillinase
Gourevitch1962benzyl
penicillinstaphylococcal penicillinase
39e
penicillinasebenzy1
PCmethicillinoxacillin
HamiltonMiller
penicillinaseanti
penicillinase penicillin
1128
Penicillinasepenicillin
penicillin
1949Barber
29Tacking
penicillinase penicillin
3
penicillinpenicillinase
penicillinase
penicillinase
penicillinase
311
penicillinaseStrePtococ
cus aueusE coli7910
Proteus79le Klebsiella91 Pseudomo
nas68penicillinase
32Shirley1965sulfa tetracy
cline chloramphenicol nitrofurantoin nalidi
xic acid mandelamine colistin kanamycin
Pseudo