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Anatomy of Human Taste SystemAnatomyofHumanTasteSystem
KuoShyan LU,PhDDepartmentofAnatomyandCell
BiologyCollegeofMedicine
National Taiwan UniversityNationalTaiwanUniversity
I Morphology of the taste bud (in human /I. Morphology of the
taste bud (in human / rodents)
II. Neurotransmitters and innervation of the taste bud
III. Apoptosis of the taste bud cells
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Taste disordersTastedisordersAgeusia: complete loss of
taste;completelossoftaste;
Hypogeusia: diminished tastediminishedtaste
sensitivity;
Hypergeusia: Hypergeusia: enhancedtaste
sensitivity;sensitivity;
Dysgeusia: distortion in tastedistortionintaste
perception;
(S id 1997)
2010/5/11
(Seiden,1997).
Normaltougue surface
transientlingualpapillitis (TLP)
i fl i f h
daninflammationoftheround,mushroomshapedstructuresthathouse taste
buds called fungiformhousetastebudscalledfungiformpapillae()
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http://embryology.med.unsw.edu.au/notes/images/senses/nature05401f1.2.jpg
I Morphology of the taste bud (inI. Morphology of the taste bud
(in human/rodents)
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Filiform papillall llVallate papilla
Foliatepapillaif ill
ll
Fungiform papilla
Vallatepapilla
CTcore
trench
Tastebud
trenchVonEbners
gland
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Averagetasteporenumberperpapilla:85.6 1.67(N=4)
2003/01/08Distributiondensityoftastepore:1.89 0.5per1000m2
(N=8)
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Averagesizeofamousetastebud:
a = 65 m b= 45 ma 65m b 45m
a
bb
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Isolatedtastecells
T. E.Finger :Chem.Senses30(suppl 1):i54i55,2005
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( )
(t t t ll ) (t t b d )
()
(taste receptor cells) (taste buds) (palate)(pharynx)
(Epiglottis)(Epiglottis)
A. 2000-500050-150
B. C C.
2 D 4-5D. 4 5
i dII. Neurotransmitters and innervation of the taste
budinnervation of the taste bud
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()
()
()
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Subgemmal nerve fibers
Intragemmal nerve fibers
Perigemmal nerve fibers
Taste cells
PGP9 5PGP9.5 ++ ++ ++ ++
5HT ++ + + +
SP + + +
NOS + +
BDNF + ++
NGF + ++
++Numberof"+signindicatestherelativestainingintensityoftheimmunoreactivity,and"signindicatesnoimmunoreactivity.
PGP9.5ProteinGeneProduct9.5,CGRPCalcitoninGeneRelatedPeptide,SPSbstanceP,NOSNitricOxideSynthase,BDNF
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Brain derivedNeurotrophicFactor,NGFNerveGrowthFactor
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()
1
()
1. 5 HT substance P5-HT substance P
2 2. (CN VII, IX & X) (brainstem) (nucleus tractus
solitarius) (nucleus tractus solitarius) (erebral cortex (erebral
cortex insular cortex)
III. Apoptosis and development of the taste bud cellsthe taste
bud cells
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1dcontrol
5d 3w5d 3w
9w24w
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3daysafterglossopharyngealneurectomy
7daysafterglossopharyngealneurectomy
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() dynamic structure
() dynamic structure
(apoptosis)
PGP9 5 NGF PGP9.5 NGF BDNF
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Contributorsofthispresentation:
Ms.MingHuei Chen()
Dr.ChungLiangChien ()
Dr.HsiuChouChou()
Dr Yi Jen Huang ()Dr.YiJenHuang()
Dr.KoKaung Liao()
DepartmentofAnatomyandCellBiology
CollegeofMedicine
This work was supported in part by grants from National Science
Council
NationalTaiwanUniversity
2003/01/08
ThisworkwassupportedinpartbygrantsfromNationalScienceCouncil.
