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GUÍA 2 – Manejo de referencias bibliográficas – Mendeley

Biología del desarrollo

1)

  El uso de mendeley nos ayuda a citar o referenciar cada artículo porque nosotros

como futuros doctores no podemos hacer plagio en información

• Facilita la búsqueda de información de búsqueda con solo ingresar el código único

PMID

• Tambin se pueden citar documentos en archi!os PDF" es un programa muy

completo ya que se pueden subrayar partes del te#to" p$ginas y dem$s%

2)

• &ibros" sección de libros" cuentas" caso" programa de computador" actas de

congreso" articulo de enciclopedia" películas" audiciones" re!istas" p$ginas 'eb"

tesis( y se utili)a mendely como herramienta

3)• Para citar un artículo o búsqueda lo principal es abrir mendeley y crear una

carpeta en la cual le pedir$n unos datos obligatorios para que cuando usted lo cite

y sea utili)ado usted como persona no tengo problemas por piratear o robar 

información

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*+

• ,E- .PP/.&01EIME234 54.-TI.,6 ,I&+

7.89,26:-D;

 .myloid deposition and 'hite matter lesions 5<M&s+ in .l)heimer=s disease 5.D+ are both

considered clinically significant 'hile a larger brain !olume is thought to pro!ide greater brain

reser!e 572+ against these pathological effects% This study identified the topography sho'ing 72 in

patients 'ith mild .D and e#plored the clinical balances among 72" amyloid" and <M&s burden%

MET16D4;

Thirty patients 'ith .D 'ere enrolled" and .>/*? positron emission tomography 'as conducted to

measure the regional standardi)ed upta@e !alue ratio 54:>r+ in A cortical !olumes/of/ interests

5>6Is+% The quantitati!e <M&s burden 'as measured from magnetic resonance imaging 'hile the

normali)ed >6Is !olumes represented 72 in this study% The cogniti!e test represented maBor 

clinical correlates%

2E4:&T4;

4ignificant correlations bet'een the prefrontal !olume and global 5r C %*" p C %*+" but not

regional 5r C %G*" p C %H+ .>/*? 4:>r 'ere found% .D patients ha!ing larger regional !olume in

the superior/ 5r C %?" p C %*+" superior medial/ 5r C %**H" p C %H*+" and middle/prefrontal 5r 

C %**A" p C %H+ regions had higher global .>/*? 4:>r% For global <M& loads" the prefrontal 5r C

/%*?A" p C %J+ and hippocampal !olume 5r C /%*GJ" p C %G+ sho'ed significant correlations

'hile the prefrontal 5r C /%*" p C %*H+ or hippocampal !olume 5r C /%*" p C %*+ also

predicted better composite memory scores% There 'ere no interactions bet'een amyloid 4:>r and

<M& loads on the prefrontal !olume5+

• ,E- .PP/.&01EIME234 54.-TI.,6 ,I&+

Presenilin 5P4/" encoded by P4E-+ is a part of the gamma/ 5K/+ secretase comple#% Mutations

in P4E- cause the maBority of cases of familial .l)heimer=s disease 5F.D+% .lthough in recentyears P4/ has been implicated as a tumor enhancer in !arious cancers" nothing is @no'n

regarding its role in gastric cancer 5,8+% In the present study" 'e in!estigate the role and clinical

significance of P4/ in ,8% <e obser!ed that P4/ 'as significantly upregulated and amplified in

,8 tissues and cell lines" and its aberrant e#pression 'as positi!ely correlated 'ith lymph node

metastasis and 'ith poor o!erall sur!i!al% Furthermore" P4/ promoted tumor in!asion and

metastasis of ,8 both in !itro and !i!o 'ithout affecting the proliferation of ,8 cells 5M,8/AH and

M9-/*?+% The results of treatment 'ith the K/secretase inhibitor D.PT 'ere consistent 'ith the

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outcomes of P4/ silencing% P4/LK/secretase clea!es E/cadherin and releases its bound protein

partner" /catenin" from the actin cytos@eleton" thereby allo'ing it to translocate into the nucleus

and to acti!ate the T8FL&EF/ transcriptional acti!ator" 'hich may promote ,8 in!asion and

metastasis%In conclusion" P4/ promotes in!asion and metastasis in ,8 and may represent a no!el

prognostic biomar@er and potential therapeutic target for ,8 treatment%5+

• ,E- .PP/.&01EIME234 54.-TI.,6 ,I&+

En esta investigación se analiza el grado de adopción por parte del profesoradouniversitario delas metodologías activas: Trabajo Colaborativo y Autoaprendizaje, en las enseñanzas deradoen la universidad! En una muestra de "#$ profesores y %!&## estudiantes de la'niversidad Católica(an Antonio se aplicaron el Cuestionario de Evaluación )ocente y el Cuestionario de*rocesosde Estudio y se obtienen valoraciones sobre: Trabajo Colaborativo, Autoaprendizaje,enfo+uedeaprendizaje y resultados acadmicos! Aun+ue a-n es limitado el desarrollo de talesmetodologías,se contrasta +ue tienen una in.uencia signi/cativa sobre la calidad de los aprendizajesdelos

alumnos y sobre los resultados acadmicos!012

• ,E- .9T/4I-D26ME DE& 16M72E E&EF.-TE 54.-TI.,6 .,:I&.2+

The organi)ation of a cell emerges from the interactions in protein net'or@s% The interactome is

critically dependent on the strengths of interactions and the cellular abundances of the connected

proteins" both of 'hich span orders of magnitude% 1o'e!er" these aspects ha!e not yet been

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analy)ed globally% 1ere" 'e ha!e generated a library of 1e&a cell lines e#pressing "? ,FP/

tagged proteins under near/endogenous control" 'hich 'e used as input for a ne#t/generation

interaction sur!ey% :sing quantitati!e proteomics" 'e detect specific interactions" estimate

interaction stoichiometries" and measure cellular abundances of interacting proteins% These three

quantitati!e dimensions re!eal that the protein net'or@ is dominated by 'ea@" substoichiometric

interactions that play a pi!otal role in defining net'or@ topology% The minority of stable comple#es

can be identified by their unique stoichiometry signature% This study pro!ides a rich interaction

dataset connecting thousands of proteins and introduces a frame'or@ for quantitati!e net'or@

analysis%5*+

•  ,E- .9T/4I-D26ME DE& 16M72E E&EF.-TE 54.-TI.,6 .,:I&.2+

67NE8TI>E;

The operati!e strategies for retrograde acute type . aortic dissection 'ith a primary intimal tear 

remain contro!ersial because resection of an intimal tear !ia a median sternotomy is difficult% <e

e!aluated the fro)en elephant trun@ technique for treating this type of aortic dissection%

MET16D4;

The fro)en elephant trun@ technique 'as used for acute retrograde type . aortic dissection 'ith a

primary intimal tear in the descending aorta in ? consecuti!e patients 5G men" J 'omenO medianage" G* years+ seen bet'een JJ and at the 1iroshima 8ity .sa 1ospital% Three patients had

Marfan syndrome% Fourteen patients had ischemia of the lo'er half of the body" had stro@e" H had

coronary ischemia" and had pericardial tamponade%

2E4:&T4;

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There 'ere no hospital deaths% Postoperati!e complications occurred in patients" including stro@e

and mediastinitis% T'o late deaths occurred o!er a median follo'/up period of ?A months 5/GJ

months+" one caused by stro@e and the other by colon cancer% T'o patients needed additional

operations; one required a second operation for descending aorta replacement because of 

ulceration caused by the stent graft" and the other required an endo!ascular stent graft because of 

dilatation of the descending aorta% 8omputed tomography follo'/up scans re!ealed that the false

lumen 'as completely thrombosed and obliterated in all ? patients 'ith stent grafts%

86-8&:4I6-4;

The fro)en elephant trun@ technique for retrograde type . aortic dissection yielded

acceptable outcomes" despite the high preoperati!e morbidity" and might impro!e the prognosis of 

dissection%5?+

• ,E- .9T/4I-D26ME DE& 16M72E E&EF.-TE 54.-TI.,6 .,:I&.2+

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El paciente en el que se basa la película se llamaba Joseph Merrick (en la película John

Merrick). Un personaje real, varón, que nació en 1!" en #eicester ($n%laterra) & en cu&ahistoria obst'trica & amiliar no había nin%una alteración. En el momento el nacimiento no

 presentaba nin%una eormia con%'nita, pero a partir e los 1 meses empe*ó a

esarrollar eormiaes que irían en constante pro%resión a lo lar%o e su via hasta su

muerte a los " a+os e ea. uano contaba con "" a+os ue escubierto por -r.reerick /reves, qui'n a lo lar%o e ! a+os reali*ó un estuio etallao el paciente. En el

historial clínico el 0o&al #onon ospital se escribían así las eormaciones e Joseph

Merrick2 3(...) una enorme & eormaa cabe*a, la e4tremia superior erecha & ambase4tremiaes ineriores mu& torcias, acentuano alar%amiento e hipertroia e la ma&or 

 parte e los eos e la mano erecha, escoliosis & una pronunciaa cojera en la caera

i*quiera. 5resentaba innumerables nóulos & masas papilares, a moo e colilor,ampliamente iseminaas en la piel & tejios blanos el cuero cabelluo, parte erecha e

la cara, espala, re%ión %l6tea & e4tremiaes. -el ma4ilar superior sobresalía una masa e

hueso, creano una apariencia peculiar a moo e probóscie7 esta masa había reciivao

espu's e su resección a la ea e "8 a+os.9(!)

• ,E- 8FT2/ FI7264I4 :I4TI8. 54.-TI.,6 MEDI-.+

*aciente de se3o masculine! Embarazo y parto normalcs, peso de nacimicnto4!#$# g, cuenta de apgar 5, uno y cinco minutos despucs de nacer! A los 4&dias fue 6ospitalizado por bronconeumonia y atelectasia iz+uierda +ue se6abi7an resuelto clinica y radiologicamente 8 dias despues! *adres y "6ermanos sanos! 9ngreso a los 1 meses de edad por di/cultad respiratoriamoderada, cianosis distal leve! des6idratacion moderada, frecucncia cardi7aca%4# por minuto, frecuencia respiratoria 4# por minuto, temperatura rectal18,%C, estertores pulmonaies difusos! En la radiogra/a de tora3 se observanimagenes ;ntersticiales! ;os estudios de gases arteriales y electrolitos ensangre y orina 0tabla %2 mostraron alcalosis metabolica, 6iponatrern< e6ipo<alemia con e3creciones bajas de sodio y cloro y clevadas de potasio! ;afuncion renal era normal! =anejado inicialinente con solucioncs endovenosasde electrolitos, mostro una respuesta favorable, pero durante fa6ospitalizacion sufrio un nucvo cpisodio de bronconeumonia con multiples

atelectasias scgmentaiias +ue tambien respondio satisfactoriamente altratamiento con penicilina y ami<acina!082

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•

,E- 8FT2/ FI7264I4 :I4TI8. 54.-TI.,6 MEDI-.+

*resenilin % 0*(>%, encoded by *(E?%2 is a part of t6e gamma> 0@>2 secretasecomple3! =utations in *(E?% cause t6e majority of cases of familialAlz6eimer7s disease 0A)2! Alt6oug6 in recent years *(>% 6as been implicatedas a tumor en6ancer in various cancers, not6ing is <noBn regarding its role ingastric cancer 0C2! 9n t6e present study, Be investigate t6e role and clinicalsigni/cance of *(>% in C! e observed t6at *(>% Bas signi/cantly upregulatedand ampli/ed in C tissues and cell lines, and its aberrant e3pression Baspositively correlated Bit6 lymp6 node metastasis and Bit6 poor overallsurvival! urt6ermore, *(>% promoted tumor invasion and metastasis of Cbot6 in vitro and vivo Bit6out aDecting t6e proliferation of C cells 0=C>$#1and =?>4&2! T6e results of treatment Bit6 t6e @>secretase in6ibitor )A*TBere consistent Bit6 t6e outcomes of *(>% silencing! *(>%F@>secretase cleavesE>cad6erin and releases its bound protein partner, G>catenin, from t6e actincytos<eleton, t6ereby alloBing it to translocate into t6e nucleus and to activatet6e TCF;E>% transcriptional activator, B6ic6 may promote C invasion andmetastasis!9n conclusion, *(>% promotes invasion and metastasis in C andmay represent a novel prognostic biomar<er and potential t6erapeutic target

for C treatment! 5+

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• ,E- 8FT2/ FI7264I4 :I4TI8. 54.-TI.,6 MEDI-.+

:;<=0>U?-2 ;m&loi eposition an @hite matter lesions (AM#s) in ;l*heimerBsisease (;-) are both consiere clinicall& si%niicant @hile a lar%er brain volume is

thou%ht to provie %reater brain reserve (:0) a%ainst these patholo%ical eects. /his stu&

ientiie the topo%raph& sho@in% :0 in patients @ith mil ;- an e4plore the clinical balances amon% :0, am&loi, an AM#s buren. ME/>-C2 /hirt& patients @ith ;-

@ere enrolle, an ;DFG positron emission tomo%raph& @as conucte to measure the

re%ional stanari*e uptake value ratio (CUDr) in cortical volumeso interests (D>$s)./he quantitative AM#s buren @as measure rom ma%netic resonance ima%in% @hile the

normali*e D>$s volumes represente :0 in this stu&. /he co%nitive test represente

major clinical correlates. 0ECU#/C2 Ci%niicant correlations bet@een the prerontal volumean %lobal (r H 8.FI8, p H 8.8"F), but not re%ional (r H 8."!F, p H 8."") ;DFG CUDr @ere

oun. ;- patients havin% lar%er re%ional volume in the superior (r H 8.GI", p H 8.88F),

superior meial (r H 8.FF, p H 8.8F), an mileprerontal (r H 8.FF, p H 8.8") re%ions

ha hi%her %lobal ;DFG CUDr. or %lobal AM# loas, the prerontal (r H 8.FG, p H

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8.81K) an hippocampal volume (r H 8.F!K, p H 8.81!) sho@e si%niicant correlations

@hile the prerontal (r H 8.F1I, p H 8.8F) or hippocampal volume (r H 8.F"", p H 8.8F)also preicte better composite memor& scores. /here @ere no interactions bet@een

am&loi CUDr an AM# loas on the prerontal volume. >?#UC$>?C2 :0 o the

 prerontal re%ion mi%ht moulate the averse %lobal patholo%ical buren cause b& am&loi

eposition. Ahile prerontal volume positivel& associate @ith hippocampal volume,AM#s ha an averse impact on the hippocampal volume that preicts memor&

 perormance in mil sta%e ;-.(1)

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