Understanding The Potential Of Digestive Health Ingredients For Consumersd3hip0cp28w2tg.cloudfront.net/uploads/block_files/2014-12/samuel... · Understanding The Potential Of Digestive

Telephone: +44 (0)1256 394200 Email: [email protected] Web: www.canadean.com

Understanding The Potential Of Digestive Health Ingredients For Consumers

By

Samuel K. Laryea

Head of Ingredient Research - Canadean

1

November, 2014


Presentation Outline

• Consumer digestive health issues

• Digestive Health Consumer benefits

• Ingredients types • Key brands

• Raw materials

• Product cases and application areas

• Patents activity

• Approvals and claims

• Gut & digestive health market

• Digestive concepts & suggestions

2


The Gut

Digestion

• Efficient absorption of nutrients

• Regularity

Immunity

• Gut barrier & protection

• Largest exposure to infections

1.5

30 40

0

20

40

60

80

100

Surface Sq. Meters

*Scand J Gastroenterol. 2014 Jun;49(6):681-9. Surface area of the digestive tract - revisited. Helander HF1, Fandriks

300

3


Consumer Gut Health

WHO, World Of Gastroenterology

UK: Bowel inflammation 1/250 persons

Italy: Constipation 34% Children

60-70 million people affected by digestive diseases annually IBS affects 15.3 million Americans

Globally 1.7 billion cases of diarrheal disease every year. Prevalence of IBD in the total population of Western countries is estimated at 1/1,000.

Singapore: Constipation 4% Malaysia: Functional dyspepsia

30%

India: More than 186,000 children die every year from diarrhoea

4


Consumer Health Needs

Gut health

Feel Good

Feel Lighter

Natural defences

Protect

Better Digestion Probiotics

Prebiotics (Dietary Fibres)

Digestive Enzymes

Phenols

Isoflavones

Key Ingredient Options & Combinations

5


Dietary Fibres

Key Ingredient/Brand Ingredient type Raw Material Orafti®; Frutafit®; Frutalose®; Fibrulose®; Fibruline® Inulin; Oligofructose Chicory

BioAgave®; Oligodex®; In-fibre™ Inulin Agave; Jerusalem Artichoke

Fibregum™; Fibraclear®; Sunfiber® Prebiotic, gums Acacia; Guar beans Litesse®; PROMITOR®; Oliggo-Fiber® MaizeWise® corn bran Polydextrose; Corn, fibre Corn

Canadian Harvest® Oat Fiber Oat, fibre Oat

• Oligosaccharides (NDO) promote the growth of probiotic populations inhibiting pathogen colonisation

• Metabolites (organic acids) of fermentation supports gut barrier function

Canadean Ingredients – Ingredient Profiles

Recommendations for dietary fibre are in the range of 25 to 35 grams per day.

• Average consumption below 50% due to a decreased consumption of fruits, vegetables and whole grains.

Key Ingredient/Brand Ingredient type Raw Material FiberAid®/ ResistAid® Arabinogalactan Larch Baozene®; Baobab fruit pulp Baobab, fibre Baobab Rice bran fibre Rice, fibre Rice Fibrex® Beetroot, fibre Beetroot

Emerging Market

6


Probiotics Ingredients

A healthy and balanced diet, as well as probiotics, have been known to be helpful in preserving gastrointestinal health.

Key Ingredients/Brands Ingredient type

Probio-Tec® LA-5®; HOWARU® Dophilus; HardiStrain® L. acidophillus;

HOWARU® Bifido; BL-G101; ProFit™ B. lactis

GanedenBC30®; LactoSpore®; LactoWise® Bacillus coagulans

BB536®; BL-G30; Rosell-175 B. longum

Lactobacillus GG (LGG®); Lr-G14; Lcr Lenio® L. rhamnosus


• Some probiotic preparations have been used to prevent diarrhoea caused by antibiotics. • Studies have documented probiotic effects on a variety of gastrointestinal and extra-intestinal disorders.

Key Ingredients/Brands Ingredient type

Goldcell® CW; Lynside® Pro Saccharomyces cerevisiae

BioOptima™ S. Boulardii Saccharomyces Boulardii

Emerging Market

7


• Digestive enzymes are needed when the digestive enzyme glands cannot make or release enough.

• Act as catalysts in the digestive process.

• Kiwifruit digest appears to prime defence mechanisms in gut cells by enhancing the production of antimicrobial agents.

• Papain have a positive effect on inflammations and a stabilizing effect on the cells of the small intestine.

Key Ingredient Brand Ingredient type Raw Material

ACTAZIN®; Digesten™ Actinidain Kiwi fruit

Caricol®; PapayaFlow™ Papain Papaya

Pineapple 4000mUHb/g Bromelain Pineapple

EnzyBoost™ CT Aspergillus enzymes

Cells (Natural extract)


Plant Enzymes

8


Gut barrier is the primary line of defence against environmental stressors.

Key Ingredients/Brand Ingredient type Raw Material

Benegut® Vicenin 2 Perilla frutescens

GutGard®; Licorice 15% (ER1114) Glabridin Liquorice

NAT activ® Artichoke extract; PureValue™ Premium Artichoke Extract (E-ALC-11) Cynarin Artichoke (Cynara sp. Var.)

NAT activ® Buckthorn bark extract Glucofrangulin A

Buckthorn (Rhamnus cathartica)

Pomegrate extract 8% Ellagitannins Pomegranate; berries

Research Phase Only Prunetin; Biochanin A; Genistein;

Yoshino cherry (prunus yedoensis

• Glabridins increases the action of mucous-secreting cells protecting the gastrointestinal tract

• Ellagitannins activate immune modulators in the gut

• Genistein, Biochanins & Prunetins are potential modulators of gut barrier tightness protecting penetration of bacteria and allergens into the blood stream

Phytochemicals and Gut Health


9


Soft Drinks

Fruits & Inulin Polydextrose FOS Enzymes

Fruit Fibre (Prune & Plums) Whole grains Polyphenols & Probiotics

10

Canadean Ingredients – Product profiles


Dairy

Probiotic & Prebiotic Fibre Probiotic

Probiotic & Beta glucan

Inulin

Probiotic & fibre

11

Desk research Canadean Ingredients


Cereals

Fibre

Wholegrain Barley

Whole wheat & fruits

Whole grains

Whole wheat

12



Baked Snacks

Inulin Wheat fibre & Inulin

Whole grain

Inulin

13



Special Nutrition – Baby Foods and Formula

FOS GOS Fibre blends

Prebiotics

14



Dietary Supplements

15

Bromelain Probiotic

Probiotic yeast GOS

Enzymes & herbs

Inulin



Patent Activity 2004-2014

WIPO

SHUKLA, Triveni,P.

KONKUK UNIV.IND.

Zhang Tianping Nantong XiyunTrade Co., Ltd.

CARGILL,INCORPORATED

30

20 18

10

7

Prebiotic/ dietary fibres & Nutrition by main applicants

Applicants Patents

Cargill, Incorporated A crisp that includes a resistant starch and a puffing agent, where the crisp has a total dietary fiber content of at least 10% by weight, as well as food products that include the crisp in combination with a base food.

Nestle The composition has a fibre content of more than 2.5 g/ fibre per 100 ml of the composition. Furthermore, it has an energy content of 1.3-1.8 kcal/ ml. The composition is useful to improve and maintain gut comfort, restoring a well-balanced gut flora, especially in an elderly patient prone to malnutrition.

Unilever Daily diet of: 1750 to 2750 kilocalories > 1650 mg gallic acid equivalents of polyphenols; (i) more than 60 g fibre…

Vital Food Processors Limited

The use of actinidin as a digestive/laxative aid. Method of obtaining actinidin from fruit

Nutricia N.V. Nutritional compositions comprising Lactobacillus rhamnosus, inulin and soy polysaccharides for the treatment of diarrhoea.

NESTEC SA PROBIOTICAL

S.P.A.

ALIMENTARY

HEALTH

LIMITED

NUTRICIA N.V. Zhao Min

229

24 21 18 15

Probiotic & Nutrition by main applicants

16


Approved Patents by Regions 2004-2014

WIPO

China

23.1%

United States

19.0%

PCT

17.7%

European

Patent Office

15.7%

Canada

7.6%

Republic of

Korea

6.2%

Russian

Federation

6.0%

Other

4.7%

Probiotic

China

44.7%

United States

13.7%

PCT

11.5%

Republic of

Korea

11.0%

European

Patent Office

6.7%

Japan

4.1%

Canada

3.3%

Other

5.0%

Prebiotic/dietary fibres

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Health and Nutritional Claims

EFSA Health claim Art 13 • Barley grain fibre, Oat grain fibre, Wheat bran fibre or Sugar beet fibre contributes to an increase

in faecal bulk. • Rye fibre contributes to normal bowel function. • Live cultures in yoghurt or fermented milk improve lactose digestion of the product in

individuals who have difficulty digesting lactose. Nutrition Claim • Source of fibre: To be made where the product contains at least 3 g of fibre per 100 g or at least

1,5 g of fibre per 100 kcal. • High fibre: To be made where the product contains at least 6 g of fibre per 100 g or at least 3 g

of fibre per 100 kcal. FDA • "Fiber" claims: That the product is high in fibre, a good source of fibre, or that the food contains

"more" fibre. This claims are base on the Daily Reference Value (DRV) established for that nutrient. FDA’s daily reference value of 25 grams of fibre a day.

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Gut & Digestive Health Market

• The gastrointestinal health supplement category $1.5 billion in consumer sales in 2011, growing 14 % from the year before

• Probiotic industry is expected to reach $32 billion by 2015 Asia-Pacific represents the fastest growing market worldwide with a CAGR of 12.4%

• 13% of all supplements launched in the past three years contained digestive health claims, compared with about 1% for functional foods

• Probiotic foods and supplements to grow to approximately $42 billion in 2016. Drinkable yogurt reach $28 billion by 2016

• Enzyme side of the digestive health category is growing even faster than (2-3 times) the supplement market as a whole

• 87 % of consumers +65 years of age say maintaining a healthy digestive system is very important


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Concepts & Suggestions

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Past and Present

• Probiotics are one of the fastest growing and most reputable categories in nutritional supplements

• Prebiotic/fibres not well established (are they needed in diet?)

• Food industries are mainly focus on food safety(Strict Regulation!) and taste (Money!)

• Developing and some developed countries are still behind yet very vulnerable

Future

•Consumer education on gut health.

•Conceptual products must be driven by Key Players •New discovery categories potential to meet future demands

•Increase consumer products with polyphenols and dietary enzymes

•Probiotics to mature over next ten years in most developing `countries

•Approval of DuPont probiotic gut health claim by Swiss Authorities will impact future discovery •Marketing digestive health claims to older consumers

Telephone: +44 (0)1256 394200 Email: [email protected] Web: www.canadean.com Telephone: +44 (0)1256 394200 Email: [email protected] Web: www.canadean.com

Thank you!

Want to learn more: Telephone: +44 (0)1256 394200

Email: [email protected]

Web: www.canadean.com

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Understanding The Potential Of Digestive Health Ingredients For Consumersd3hip0cp28w2tg.cloudfront.net/uploads/block_files/2014-12/samuel... · Understanding The Potential Of Digestive