University: Alexandria Program Specifications · 2017-05-04 · fates of pyruvate, hexose monophosphate shunt, glycogen metabolism, uronic acid pathway, metabolism of galactose and

واالعتمادهيئة القومية لضمان جودة التعليم ال

University: Alexandria

Faculty: Medicine

Program Specifications

(Academic year: 2015/ 2016)

A. Basic Information:

1. Program title: Master Degree of Medical Biochemistry.

2. Program Award/Degree: Master Degree.

3. Department (s) offering the program; Medical Biochemistry.

4. Program Coordinator: Prof. Dr Iman Hassan Diab

5. External evaluator(s): Prof. Dr. Yosry Mostafa

6. Type of the program: Single.

7. Date of most recent program specifications approval:25/8/2015B. Professional Information:

1- Program Aims: The aim of this program is to:

1.1. Develop updated basic knowledge in the field of Biochemistry & Molecular Biology.

1.2. Apply different laboratory techniques in Biochemistry and Molecular Biology. Discuss diagnostic values for different diseases.

1.3 Develop the capacities of juniors to be competent teachers and skilled researchers able to conduct an independent successful scientific research and professional service in these areas.

2- Academic reference standards (ARS) & Subject benchmark statements:

Academic reference standards of Master Degree in Medical Biochemistry & Molecular Biology designed and approved by Department of Medical Biochemistry. Faculty of Medicine. Alexandria University. Based on:

Generic Academic Reference Standards (ARS): Postgraduate Medical Education, Egypt (2009). Published by National Authority for Quality Assurance and Accreditation of Education

(NAQAAE) National

[http://naqaae.org/main/php/book/index.php]

Domain Academic Reference

Standards

Ilos

A. Knowledge and

understanding

Graduate of this program

must have deep and broad

knowledge and

understanding:

1- Different metabolic

pathways in human body.

A1. Revise knowledge about

structure of different compounds

in the body.

A2. Relate structure of different

molecules to their function.


2- Basis of Molecular

Biology and applications.

3- Diseases due to abnormal

metabolic pathways

4- Information about

general principles of lab

safety.

5- Assurance of accuracy of

laboratory results.

A3. Discuss knowledge about

metabolism of macromolecules &

micro molecules and different

tissues and relation to their

function.

A4. Explain the basic mechanisms

of cell signaling.

A5. Discuss basic information in

molecular biology.

A6. Describe metabolic & genetic

defects and its relation to diseases.

A7. Discuss procedures of

laboratory safety.

A8. Discuss different methods to

assure accuracy of laboratory

results.

B. Intellectual

skills

1. Interpret and correlate

the clinical status of a

patient with the results of

biochemical & molecular

biology analysis.

2. Provide medical and

scientific direction to a

specific diagnostic

technique.

3. Undertake research and

development in various

aspects of Medical

Biochemistry & Molecular

Biology.

B1. Utilize different diagnostic

assays effectively.

B2. Evaluate and solve problem

situations related to metabolic and

genetic diseases.

B3. Choose better practical

methods for better diagnosis of

diseases.

B4. Implement the recent

information in the biochemistry and

molecular biology lab.

B5. Share in research projects.

B6. Select good papers and

research methods.

C. Professional

skills

Perform most of laboratory

methods in medical

biochemistry and molecular

biology efficiently.

Be able to perform & teach

basic biochemical

techniques to

undergraduates and

paramedical personnel.

C1. Apply perfectly basic

techniques used in clinical

biochemistry (elisa,

immunodiffusion, enzyme activity

assay, colorimetric methods and

others).

C2. Perform and interpret

commonly used molecular biology

techniques (such as nucleic acid

extraction, pcr, gel electrophoresis

and blotting techniques)


Apply the methods used in

biochemistry and molecular

biology for better diagnosis

of diseases

C3. Prepare and conduct a practical

session.

C4. Assess the performance of a

practical class.

C5. Apply safety precautions in the

lab.

C6. Explain scientific information

to students and peers

C7. Assess the accuracy of

laboratory results.

D. General and

transferrable

skills

1-Seek to maintain and

expand professional

knowledge and skills.

2-Work in teams and co-

operate with colleagues and

seniors

3- Obtain data from

multiple technologic

sources.

D1. Acquire updated knowledge

from various sources and present it

to peers in systematized manner.

D2. Co-operate efficiently in a

multi-professional team working.

D3. Recognize and respect the

views and opinions of other team

members.

D4. Use information technology to

access, evaluate, and interpret

scientific data.

E. Attitudes and

ethical behavior

Deal honestly with trainee,

colleagues, employee and all

members.

Demonstrate medical research

ethics.

E1. Promote high standards of

personal and organizational

integrity, compassion, honesty, and

respect for seniors, colleagues,

assistants, and students.

E2. Demonstrate good work habits.

E3. Treat patient data with

confidentiality.

E4. Deal with reagents,

instruments, and equipments with

caution and preservation.

E5. Demonstrate ethical choices,

values, and professional practices

implicit in multidisciplinary

decision-making.

E6. Demonstrate commitment to

lifelong learning and professional

service including active

participation in professional

organizations.

E7. Be accurate in analyzing the

results and avoid fabrication.


Program courses ILOs Matrix

ILOs

Cours

e title

A

1

A

2

A

3

A

4

A

5

A

6

A

7

A

8

B

1

B

2

B

3

B

4

B

5

B

6

C

1

C

2

C

3

C

4

C

5

C

6

C

7

D

1

D

2

D

3

D

4

E

1

E

2

E

3

E

4

E

5

E

6

E

7

Enzym

ology X X X X X X X X X X X X X X X

Molecular

Biolog

y I

X X X X X X X X X X X X X X X X X X X

Lab

safety X X X X

X

Metab

olism I-a

X X X X X X X X X X X X X X

Metab

olism I-b


Bioche

mistry

of blood

X X X X X X X X X X X X

Immun

ochemistry

X

X

X

X

X

X

X

X

X

X

X

X

Hormo

nes X X X X X X X X X X X X X X X X

Metabolism

II

(metabolism

of

macromolecu

les)

X X X X X X X X X X X

Metab

olism III (

tissue

metabolism

and

integrated

functio

ns)

X X X X X X X X X X X X X X X X X X

Metab

olism

of micro

molecu

les and minera

ls


Quality

Assurance

X X X X X X X X X X X X

Semina

r and journal

club I

X X X X


Integra

tion in energy

and

metabolism

X X X X X X X X X X X X X X X X

1. Curriculum Structure and Contents:

1- Curriculum Structure and Contents:

5.1 Program duration: This program is fulfilled in not less than 2 years with a maximum of five years.

5.2 Program structure: 40 Credit Hours

1. Basics of Research : 3 Credit Hours 2. Obligatory subjects: 27 Credit Hours 3. Elective Subjects: 1 Credit Hour Each 4. Thesis: 8 Credit Hours

Program courses: A. Obligatory:

Code Number Credit

Hours

Theoretical Practical Course

05160801 3 2 1 Enzymology

05160802 3 2 1 Molecular Biology I

05160803 2 1 1 Laboratory safety

05160804 2 1.5 0.5 Metabolism I- A

05160805 2 1.5 0.5 Metabolism I- B

05160806 1 1 - Biochemistry of blood

05160807 2 2 - Hormones

05160808 1 1 - Quality Assurance and Lab Management

05160809 4 4 - Metabolism II (metabolism of macromolecules)

05160810 3 2 1 Metabolism III ( tissue metabolism and integrated functions)

05160811 1 1 - Metabolism of minerals and water and electrolyte balance

05160812 1 1 - Seminar and Journal Club I

05160813 1 1 - Immunochemistry

05160814 2 2 - Integration in energy and Metabolism

B. Elective:

Code Number Course Credit hours

050280831 Medical Genetics 1

Basic Microbiology 1

05200801 Basic Physiology 2

0560801 Basic Pharmacology 2

05110804 Clinical Toxicology 1

05190802 Diagnostic Parasitology 1

Other -


2. Program Admission Requirements: According to the regulations of the credit hour bylaws of the Faculty of Medicine Alexandria

University (annex).

3. Regulations for Progression and Program Completion: According to the regulations of the credit hour bylaws of the Faculty of Medicine Alexandria

University (annex).

Methods of student assessment:

Methods Intended Learning outcomes to be

assessed

1. Written Exam (a1-a6) + (b2) + (e5)

2. Practical Exam (b1- b3) + (c1-5) + (d2,4,5) + (e2,3,4,5,7)

3. Assignments (a3) + (b2,5) + (c6) + (d1-4) + (e1,6).

4. Thesis (b1-5) + (c1,2) + (d1,3,4,5) + (e1,6,7).

5. Methods of program evaluation:

Evaluator Tool Sample

1. Students enrolled in the program Questionnaires.

2. Alumni --------

3. Stakeholders (Employers) Focus group

4. External Evaluator (s) -----------

5. Others:

COURSE DESCRIPTION

1 Code Credit hours (3) Course Prerequisites

05160801 Lectures Practical Enzymology -

2 1

This course is divided into 1.5 credit hours lectures and 0.5 credit hours practical. The lectures

discuss enzyme nature, nomenclature, general properties, mechanism of action, measurement of

enzyme activity, factors affecting enzymatic activity, kinetic model, Michaelis Meuter and Line

weaver burk, inhibition and activation of enzymes, allostery and allosteric enzymes, regulatory

enzymes, and regulated enzymes. The practical sessions include applications on the theoretical

subjects of the lecture.


05160802 Lectures Practical Molecular Biology I -

2 1


This course includes DNA and RNA structure and functions, chromatin and nucleotide structure,

DNA replication, DNA repair, mutations, DNA recombination and precise rearrangement. (e.g.

immunoglobulin genes), RNA synthesis and processing, degradation of cellular RNA, reverse

transcriptase and their inhibitors, protein synthesis and genetic code, post-translational modifications

and protein maturations, regulation of gene expression and Recombinant DNA technology and PCR.

The practical part includes DNA and RNA separation and differentiation, PCR, western blot and

southern blot.


05160803 Lectures Practical Laboratory Safety -

1 1

This course includes general safety precautions, precautions against physical hazards including: fire,

pressure, radiation, and non-ionizing radiation. Precautions against chemical hazards including:

corrosive and irritant substances, toxic compounds, flammability hazards, and explosives.

Precautions against biological hazards that include accidental aspiration of infectious materials,

accidental moculation with syringes and needles, animal bites, sprays from syringes, centrifuge

accidents, cuts and scratches from glassware or instruments, and spilling of pathogenic samples on

floors or other surfaces.



05160804 Lectures Practical Metabolism I-A 05160801

1.5 0.5

This course is given in 1.5 credit hours lectures and ).5 credit hour practical sessions. The lectures

include: introduction to carbohydrate structure, digestion and absorption of carbohydrates, glycolysis,

fates of pyruvate, hexose monophosphate shunt, glycogen metabolism, uronic acid pathway,

metabolism of galactose and fructose, regulation of carbohydrate metabolism, introduction for lipid

structures, digestion and absorption of lipids, oxidation of fatty acids, ketone body metabolism,

cholesterol metabolism, fatty acid synthesis, metabolism of acyl glycerols, phospholipids and

glycolipid synthesis, regulation of lipid metabolism. The practical sessions include experiments used

as applications of the lectures with reports and interpretation of the results.


05160805 Lectures Practical Metabolism I-B 05160801

1.5 0.5

This course is given in 2 credit hours lectures and 1 credit hour practical sessions. Introduction for

protein structure, digestion and absorption of proteins, removal of amino acid ammonia and

catabolism of amino acids. Introduction to structure and functions of purine and pyrimidine base

nucleosides and nucleotides, Do novo synthesis and salvage of purine and pyrimidine nucleotides,

degradation of purine and pyrimidine nucleotides The practical sessions include experiments used as

applications of the lectures with reports and interpretation of the results.


05160806

Lectures Practical Biochemistry of Blood -

1 -

This course is given in one credit hour lectures. The lectures include:

Functions, osmotic pressure, clotting of blood, plasma proteins (types, separation, and change

in diseases), haemoglobin (normal and abnormal forms).



05160807 Lectures Practical Hormones -

2 -

This course includes classification of hormones according to their synthesis, chemistry and

elimination into: peptides and protein hormones, steroids and amino acid derivatives. It also includes

classification of hormones according to their mechanism of action and signal transduction into: group

I hormones in which the ligand-receptor complex is their signal, group II hormones which have

membrane receptors and use intracellular messengers e.g. cAMP, cGMP, calcium or phosphatidyl-

inositol or both or phosphatasecascade.


05160808 Lectures Practical Quality Assurance in Biochemistry and Lab

Management I

-

1 -

This course ensures laboratory staff and patients that laboratory results are reliable and relevant. It is

given as one credit hour as alternating lectures and practical sessions. The lectures include:

Measurement of the precision and accuracy of the lab, check the methods and reagents, calibration of

the instruments and performance, criteria of the control material, establishment of mean and standard

deviation and plotting of control data on a chart, identification of the source of analytic error,

assessment errors, precautions for sample collection, sample storage, transportation, and waste

disposal, storages of quality assurance (pre-analytic, analytic, post-analytic). The practical sessions

are applications on the lectures, with training on attaining accuracy and precision of the laboratory

results. The practical work is done through group work or single and concluded by discussion and

grading of the best performing group in each session.


05160809 Lectures Practical Metabolism II Metabolism of

Macromolecules

05160805

4 -

This course includes: biosynthesis and regulation of oligosaccharides and glycoproteins, fundamental

aspects of glycoprotein construction and flexibility of the system for generating variation in

oligosaccharides’ structure in different cell types, molecular mechanisms of protein-protein

interaction, structure-function relationships in proteins, prediction of folding, stability and structure

of protein from amino acid sequence, flavo-proteins, iron-sulfur proteins, three-dimensional structure

of proteins implicated in cancer, genetic analysis of human disease, classification of genetic diseases

and cyotgenetic diseases.



05160810 Lectures Practical Metabolism III Tissue Metabolism and

Integrated Tissue Functions

05160805 05160809

3 1

This course includes special metabolism of adipose tissue, skeletal muscles, and cytoskeleton, cardiac

muscles, red blood cells, white blood cells, liver, kidney, lung, extracellular matrix and skin. It

includes also explanations of integrated tissue functions and inter-relations.

The practical sessions are applications on the lecture subjects.


05160811 Lectures Practical Metabolism of minerals and

water and electrolyte balance 05160810

1 -

This course is given in one credit hour lectures and one credit hour practical sessions. The lectures

include: classification of minerals, major elements (sodium, potassium, calcium, magnesium, sulphur,

phosphorus, and chloride) as regards to their sources, daily requirements, absorption, tissue

distribution, metabolism, functions, excretion, and disease states; Essential trace elements (iron,

copper, zinc, manganese, cobalt, selenium, chromium, molybdenum, iodine, and fluoride) as regards

to their sources, daily requirements, absorption, tissue distribution, metabolism, functions, excretion,

and disease states; Possibly essential trace elements (aluminum, lead, cadmium, arsenic, mercury,

antimony, boron, bismuth, titanium, silver, and gold) and their possible effect on humans due to air,

water, soil, and diet pollution; Mineral interactions, correction of deficiencies, and toxicities in

humans; use of mineral supplements in a specific human diet.

The practical sessions include: experiments for extraction of trace elements from different tissues

and blood and their measurement using flame and flameless atomic absorption spectrophotometry.


05160812 Lectures Practical Seminar and Journal Club I

-

1 -

This course includes special topics current to the field of biochemistry. Topics and format for the

course may vary. Study presentation is done by each student under supervision of a faculty member.


05160813 Lectures Practical Immunochemistry -

1 -

This course is given in one credit hour lectures. The lectures include:

Types of immunity, immune response, structure of immunoglobulins, electrophoretic determination

of immunoglobulins, quantitative determinations, antigenetic determinations, structural bases of Ag

receptor, Ag receptor coupling to intracellular signaling pathway, structural basis of inhibitory signal

transduction, role of T-cell Ag receptor in fate decision, contribution of peptide to recognition by T-

cells, immunopotency, immunologically important cell surface molecules (β-cell or T-cell receptors

and adhesion molecules), complements, hypersensitivity, and autoimmunity, cloning, expression,

and genetic modification of recombinant antibody domains.



05160814 Lectures Practical Integration in energy and Metabolism

-

2 -

This course explores the relationships between cellular and energy metabolism. Biochemical

pathways of carbohydrate, lipid, protein and nucleotide metabolism are discussed in the context of

their impact on human organ systems in inborn and acquired metabolic derangements, and integrated

with analysis of human disease states.

Program director: Professor /Dr. Sabah Abdel Hady

Signature:

Program coordinator: Professor /Dr. Iman Hassan Diab

Signature:

Course Specifications


Faculty: Medicine

Department: Medical Biochemistry

Course Information

Course Code: 05160803 Course Name: Laboratory Safety

Program in which the Course is Given within the course assigned to the master degree of medical

biochemistry

Number of Credit Hours 1 Theoretical Clinical/Practical

Course Aims: The student must get deep knowledge about:

1.Precautions against physical hazards

2.Precautions against chemical hazards

3.Precautions against biological hazards

4.Precautions against mechanical hazards

5.Precautions against electrical hazards

Intended Learning Outcomes (ILOs)

Program ILO (refer to program

matrix) Course ILOs

A. Knowledge

and

Understanding

A7. Discuss procedures of

laboratory safety.

a1. Revise knowledge about the

responsibility of different laboratory

personnel.

a2. Mention the safety

equipments.

a3. Describe labeling of reagents.

Explain precautions must be taken to

avoid physical, chemical, biological

and electrical hazards

B. Intellectual

skills

C.Professional

and Practical

Skills

C5. Apply safety precautions in

the lab.

c1. Implement safety precautions in the

lab. .

1

D. General

Skills

E. Attitudes and ethical behavior

E2. Demonstrate good work

habits.


values, and professional

practices implicit in

multidisciplinary decision-

making.



e1. Demonstrate good work habits.

e2. Demonstrate ethical choices, values,

and professional practices implicit in

multidisciplinary decision-making.

e3. Be accurate in analyzing the results

and avoid fabrication.

Course Content (Units/Topics)

Teaching/Learning Methods

Lectures self

learning

Practical/

Clinical

Small

group

discussion

Others

Assignment

This course includes general safety precautions,

precautions against physical hazards including:

fire, pressure, radiation, and non-ionizing

radiation. Precautions against chemical hazards

including: corrosive and irritant substances,

toxic compounds, flammability hazards, and

explosives. Precautions against biological

hazards that include accidental aspiration of

infectious materials, accidental moculation with

syringes and needles, animal bites, sprays from

syringes, centrifuge accidents, cuts and

scratches from glassware or instruments, and

spilling of pathogenic samples on floors or other

surfaces.

✓ ✓ ✓ ✓ ✓

Please check (✓) the appropriate method.

Student Assessment

Methods of Assessment

Essay Objective questions

Case OSCE/OSPE

Assignment Logbook fulfillment

Others

Schedule of Assessment

Mid-term %

End of term 100%

Distribution of Marks

Written Exam 80 %

Practical/Clinical Exam

Others (Assignment) 20 %

List of Textbooks and References

Lecture Notes

Course Text Books

1-Clinical chemistry

2-Fundamentals of clinical chemistry

Suggested Extra Reading

Fundamentals of clinical Chemistry. Titz

Journals and Periodicals, others

Relevant journals

Course Instructor

Name: Dr. Wahid Aziz El-Delgawy Signature:

Program Coordinator

Name: Pr. Dr: Iman Hassan Diab Signature:

Program Director (Head of Department)

Name: Prof.Dr: Sabah Abdel Hady Signature:

✓ ✓

✓

✓ ✓

✓

✓



Faculty: Medicine


Course Information

Course Code: 05160801 Course Name: Enzymology

Program in which the Course is Given within the courses assigned to the master degree of medical

Biochemistry


Course Aims: the students must get basic and advanced knowledge of:

1- Mechanism of action of enzymes.

2- Factors affecting enzymatic activity.

3- Clinical Significance of enzymes.



matrix) Course ILOs

A. Knowledge

and

Understanding



in the body.







function.

a1. Revise basic nature of enzymes.

a2. Relate the structure of enzymes to

their mechanism of action.

a3. Discuss the factors affecting enzyme

activity.

B. Intellectual

skills


assays effectively.



genetic diseases.

b1. Perform different diagnostic assays

in efficient manner.

b2. Acquire the ability to solve problem


genetic diseases.

1 2



diseases.

b3. Select good practical methods for

better diagnosis of diseases.

C.Professional

and Practical

Skills






others).

C3. Prepare and conduct a

practical session.


the lab.


to students and peers.

c1. Do basic techniques used in clinical

biochemistry perfectly.

c2. Prepare and conduct a practical

session in enzymology.

c3. Use safety precautions in the lab

effectively.

c4. Explain scientific information in

enzymology to students and peers.

D. General

Skills




d1. Acquire updated knowledge from

various sources and present it to

peers in systematized manner.

E. Ethics and

Attitudes



integrity, compassion, honesty,

and respect for seniors, colleagues,



habits.




e1. Promote high standards of personal

and organizational integrity,

compassion, honesty, and respect for

seniors, colleagues, assistants, and

students.


e3. Use reagents, instruments, and

equipments carefully.




decision-making.


and professional practices implicit in

multidisciplinary decision-making.



Lectures self

learning

Practical/

Clinical

Small

group

discussion

Others

Assignment

This course includes: enzyme nature,

nomenclature, general properties, mechanism

of action, measurement of enzyme activity,

factors affecting enzymatic activity, kinetic

model, Michaelis Menten and Line weaver burk,

inhibition and activation of enzymes, allostery

and allosteric enzymes, regulatory enzymes, and

regulated enzymes. The practical sessions

include applications on the theoretical subjects

of the lecture.

✓ ✓ ✓ ✓ ✓


Student Assessment



Case OSCE/OSPE


Others


Mid-term

End of term 100%


Written Exam 70%

Practical/Clinical Exam 10%

Others (Assignment) 20%

✓ ✓

✓

✓ ✓


Lecture Notes

-

Course Text Books

1. Biochemistry. Harpers

2. Lehninger Biochemistry




Relevant journals in enzymology.

Course Instructor

Name: Prof. Dr: Ahmed Nagdy Abdel-Aal Signature:

Program Coordinator

Name: Dr: Iman Hasan Diab Signature:





Faculty: Medicine


Course Information

Course Code: 05160802 Course Name: Molecular Biology-I

Master degree Medical Biochemistry


Biochemistry



1- structure and functions of purine and pyrimidine base nucleosides and nucleotides, Do novo

synthesis and salvage of purine and pyrimidine nucleotides, degradation of purine and

pyrimidine nucleotides, causes, manifestations and principles for the treatment of

hyperuricemia.

2- DNA and RNA structure and functions, chromatin and nucleotide structure, DNA

replication, DNA repair, mutations.

3- DNA recombination and precise rearrangement. (e.g. immunoglobulin genes), RNA

synthesis and processing, degradation of cellular RNA, reverse transcriptase and their

inhibitors.

4- protein synthesis and genetic code, post-translational modifications and protein

maturations.

5- regulation of gene expression and Recombinant DNA technology and PCR.



matrix) Course ILOs

A. Knowledge

and

Understanding



in the body.





function.

a1. Revise basic structure of purines and

pyrimidine bases nucleosides and

nucleotides.

a2. Discuss the Denovo synthesis and

salvage of purine and pyrimidine

nucleotides.

a3. Explain degradation of purine and

pyrimidine nucleotides.

1 2

A5. Discuss basic information in

molecular biology.



a4. Describe DNA and RNA structure

and functions, chromatin and

nucleotide structure.

a5. State causes, manifestations and

principles for the treatment of

hyperuricemia.

a6. Explain types, causes and effects of

gene mutations.

B. Intellectual

skills



genetic diseases.



diseases.


information in the biochemistry

and molecular biology lab.


b1. Evaluate and solve problem situations

related to genetic diseases.

b2. Choose better practical methods for

diagnosis of genetic problems.

b3. Use the recent information in the

molecular biology lab.

b4. Share in research projects e.g. stem

cell project and genomic projects.

C.Professional

and Practical

Skills

C2. Perform and interpret

commonly used molecular biology


extraction, pcr, gel electrophoresis



practical session.



c1. Carry out molecular biology


extraction, PCR, gel electrophoresis


c2. Prepare and conduct a practical session

about

- nucleic acid extraction.

- PCR.

- gel electrophoresis and blotting

techniques.

c3. Explain scientific information related

to the field of molecular biology to

students and peers.

D. General

Skills



scientific data.

d1. Develop efficient writing and

presentation skills in the molecular

biology field.

d2. Acquire the capability of retrieving

scientific information and evaluate

different data related to genetic

diseases.

E. Ethics and

Attitudes







habits.


confidentiality.







decision-making.





organizations.






all staffs he/she dealing with in the

molecular biology field.

e2. Demonstrate good work habits

throughout the working hours.

e3. Treat genetic patient data with

confidentiality and respect of his

privacy.

e4. Deal with reagents , instruments, and

equipments use in the molecular

biology lab.with caution.


and professional practices decision-

making in respect to genetic

disorders.

e6. Demonstrate commitment to lifelong

learning and professional service

including active participation in

professional organizations in



of genetic patients.



Lectures self

learning

Practical/

Clinical

Small

group

discussion

Others

Assignment

This course includes introduction to

structure and functions of purine and pyrimidine

base nucleosides and nucleotides, Do novo

synthesis and salvage of purine and pyrimidine

nucleotides, degradation of purine and

pyrimidine nucleotides, DNA and RNA structure

and functions, chromatin and nucleotide

structure, DNA replication, DNA repair,

mutations, DNA recombination and precise

rearrangement. (e.g. immunoglobulin genes),

RNA synthesis and processing, degradation of

cellular RNA, reverse transcriptase and their

inhibitors, protein synthesis and genetic code,

post-translational modifications and protein

maturations, regulation of gene expression and

Recombinant DNA technology and PCR..The

practical part includes DNA and RNA separation

and differentiation, PCR, western blot and

southern blot.

✓ ✓ ✓ ✓ ✓


Student Assessment



Case OSCE/OSPE


Others


Mid-term 20%

End of term 80%


Written Exam 60%



✓ ✓

✓

✓ ✓


Lecture Notes

Course Text Books



3. Molecular cell Biology. Lodish


1. Cell and Molecular biology.


journals of molecular biology

Course Instructor

Name: Prof. Dr: Iman Hassan Diab Signature:

Program Coordinator

Name: Dr: Iman Hasan Diab Signature:


Name: Prof.Dr: Sabah Abdel-Hady Mahmoud Signature:



Faculty: Medicine


Course Information

Course Code: 051608151 Course Name: Haematology

Program in which the Course is Given


Course Aims:

1. Identify general metabolism of carbohydrate,lipid and proteins

2. Identify the structure of haemoglobin and explain types of Hb.

3. Evaluate the relation between structure and funcution of normal Hb.

4. Identify the abnormal types of Hb and how can they be managed.

5. Identify the function of plasma proteins and how can they be separated

6. Identify types and function of water soluble vitamins



matrix) Course ILOs

A. Knowledge

and

Understanding

A1. Revise, upgrade knowledge

about

A2. general metabolism of

carbohydrate,lipid and

proteins


about the the structure and

function of Hb and about

the types and function of

plasma proteins.

A4. Identify knowledge about

molecular biology

a1. Discuss general metabolism of

carbohydrate,lipid and proteins

a2. Revise and discuss the general types

of Hb and plasma protein

a3. Discuss the different types of

abnormal Hb

---- 1

B. Intellectual

skills

B1. Review recent publications

in the field of haematology

B2. Interpret, evaluate and

apply information from

different resources.

b1. Utilize information’s of diagnostic

assays.

b2. Evaluate and solve problems related

to metabolic and genetic diseases

Choose the better assay method for

better diagnosis

C.Professional

and Practical

Skills

C1 Promote good relations

with seniors, colleagues

and students

c1. Explain techniques used for

separation of plasma proteins and

hemoglobin(electrophoresis and

immunelectrophoreses

c2. Interpret the commonly used

techniques can prepare and conduct

practical session)

D. General

Skills

D1 Develop the capability of

retrieving scientific

information and evaluate

different data.

D2 Develop efficient writing and

presentation skills




d2. Co-operate efficiently in a multi-

professional team working.

d3. Use information technology to


scientific data.



Lectures self

learning

Practical

Clinical

Small group

discussion

Others

Assignment

General metabolism

of,carbohydrate,lipid and proteins

The structure of Hb,the biological

function,normal and abnormal Hb .

The catabolism of Hb.jaundice and

porphyria .

The types of plasma proteins ,the

biological function .

√ √ √ √

Student Assessment



Case OSCE/OSPE


Others


Mid-term - %

Assignment 20 %

Self learning, commitment & attitude 10 %

End of term %


Written Exam 70 %

Practical/Clinical Exam - %

√ √


Lecture Notes

Lectures on medical biochemistry

Course Text Books

Text Books of Biochemistry (Devlin)

Biochemistry (LEHNINGER)

Lippincotte biochemistry


Any related recent text book


Relevant journals & periodicals

Course Instructor

Name: Pr. Mohamed Zeidan Signature:

Program Coordinator

Name: Dr: Iman Hassan Diab Signature:


Prof. Dr: Sabah Abdel-Hady Mahmoud Signature:



Faculty: Medicine


Course Information

Course Code: 05160804 Course Name: Metabolism I-A


Biochemistry


Course Aims: To introduce the candidate to structure, digestion and metabolism of carbohydrates,

lipid and protein. The practical sessions include experiments used as applications of the lectures

with reports and interpretation of the results.


Program ILO (refer to

program matrix) Course ILOs

A. Knowledge

and

Understanding


structure of different

compounds in the body.

a1. Revise basic structure of carbohydrate

and lipids



a2. Explain the function of carbohydrates

and lipids in the body.


metabolism of macromolecules

& micro molecules and

different tissues and relation to

their function.

a3. Describe digestion and absorption of

carbohydrates, lipids.

a4. Discuss different types of oxidation of

glucose. glycolysis, fates of pyruvate,

hexose monophosphate shunt and uronic

acid pathway

a5. Describe the synthetic pathways of

carbohydrates, glycogen metabolism and

gluconeogenesis

a6. Discuss metabolism of galactose and

fructose

a7. Explain regulation of carbohydrate

metabolism.

0.5 1.5

a8. Describe oxidation of fatty acids.

a9. Explain ketone body metabolism and

cholesterol metabolism.

a10. Discuss fatty acid synthesis, metabolism

of acyl glycerols, phospholipids and

glycolipid synthesis, regulation of lipid

metabolism

A6. Describe metabolic &

genetic defects and its relation

to diseases.


principles for the treatment of metabolic

abnormalities related to carbohydrate and

lipid metabolism.

B. Intellectual

skills


situations related to metabolic

and genetic diseases.



research methods.

b1. Solve problems related to metabolic

diseases.

b2. Acquire the ability to share in research

projects.

b3. Evaluate the papers and choose good

papers and research methods.

C.Professional

and Practical

Skills


practical session.

C6. Explain scientific

information to students and

peers


about Estimation of metabolite

concentrations in biological fluids.

c2. Diagnosis of different metabolic

abnormalities.

c3. Explain scientific information related to

the field of metabolism to students and

peers

D. General

Skills

D1. Develop efficient writing

and presentation skills.

D2. Acquire the capability of

retrieving scientific information

and evaluate different data.

D4. Use information technology

to access, evaluate, and

interpret scientific data.

d1. Acquire the ability for efficient

writing and presentation skills.

d2. Develop the ability of obtaining


different data.

d3. Implement information technology to


scientific data.

E. Ethics and

Attitudes


instruments, and equipments

with caution and preservation.




equipments with caution.

e2. Analyze the results accurately and

avoid fabrication.



Lectures self

learning

Practical/

Clinical

Small

group

discussion

Others

Assignment

This course is given in 2

credit hours lectures and 1 credit

hour practical sessions. The lectures

include: introduction to carbohydrate

structure, digestion and absorption

of carbohydrates, glycolysis, fates of

pyruvate, hexose monophosphate

shunt, glycogen metabolism, uronic

acid pathway, metabolism of

galactose and fructose, regulation of

carbohydrate metabolism,

introduction for lipid structures,

digestion and absorption of lipids,

oxidation of fatty acids, ketone body

✓ ✓ ✓ ✓ ✓

metabolism, cholesterol metabolism,

fatty acid synthesis, metabolism of

acyl glycerols, phospholipids and

glycolipid synthesis, regulation of

lipid metabolism, introduction for

protein structure, digestion and

absorption of proteins, removal of

amino acid ammonia and catabolism

of amino acids. The practical

sessions include experiments used as

applications of the lectures with

reports and interpretation of the

results.


Student Assessment



Case OSCE/OSPE


Others


Mid-term

End of term 100%


Written Exam 70%



✓ ✓

✓

✓ ✓


Lecture Notes

-

Course Text Books




Stryer’s Biochemistry


Relevant journals in metabolism.

Course Instructor

Name: Prof. Dr: Ahmed Nagdy Abdel-Aal Signature:

Program Coordinator

Name: Prof. Dr: Iman Hasan Diab Signature:


Name: Prof. Dr: Sabah Abdel-Hady Signature:



Faculty: Medicine


Course Information

Course Code: 05160805 Course Name: Metabolism I- B


Biochemistry


Course Aims: To introduce the candidate to structure, digestion and metabolism of carbohydrates,

lipid and protein. The practical sessions include experiments used as applications of the lectures

with reports and interpretation of the results.



program matrix) Course ILOs

A. Knowledge

and

Understanding




a1. Revise basic structure of proteins and

nucleotides



a2. Explain the function of proteins and

nucleotides in the body.



& micro molecules and

different tissues and relation to

their function.

a3. Describe digestion and absorption of

proteins and nucleotides.

a4. Explain removal of amino acid ammonia.

a5. Describe synthesis and catabolism of

individual amino acids.

a6. Describe synthesis and catabolism of

nucleotides.


genetic defects and its relation

to diseases.


principles for the treatment of metabolic

abnormalities related to amino acids and

nucleotide metabolism.

0.5 1.5

B. Intellectual

skills






research methods.

b1. Solve problems related to metabolic

diseases.

b2. Acquire the ability to share in research

projects.

b3. Evaluate the papers and choose good

papers and research methods.

C.Professional

and Practical

Skills


practical session.



peers


about

- Estimation of metabolite

concentrations in biological fluids.

- Diagnosis of different metabolic

abnormalities.

c2. Explain scientific information related to

the field of metabolism to students and

peers

D. General

Skills


and presentation skills.

D2. Acquire the capability of

retrieving scientific information

and evaluate different data.


to access, evaluate, and

interpret scientific data.

d1. Acquire the ability for efficient

writing and presentation skills.

d2. Develop the ability of obtaining


different data.



scientific data.

E. Ethics and

Attitudes







equipment’s with caution.

e2. Analyze the results accurately and avoid

fabrication.



Lectures self

learning

Practical/

Clinical

Small

group

discussion

Others

Assignment

This course is given in 2 credit

hours lectures and 1 credit hour practical

sessions. The lectures include:

introduction to carbohydrate structure,

digestion and absorption of

carbohydrates, glycolysis, fates of

pyruvate, hexose monophosphate shunt,

glycogen metabolism, uronic acid

pathway, metabolism of galactose and

fructose, regulation of carbohydrate

metabolism, introduction for lipid

structures, digestion and absorption of

lipids, oxidation of fatty acids, ketone

body metabolism, cholesterol

metabolism, fatty acid synthesis,

metabolism of acyl glycerols,

phospholipids and glycolipid synthesis,

regulation of lipid metabolism,

introduction for protein structure,

digestion and absorption of proteins,

removal of amino acid ammonia and

catabolism of amino acids. The

practical sessions include experiments

used as applications of the lectures with

reports and interpretation of the results.

✓ ✓ ✓ ✓ ✓


Student Assessment



Case OSCE/OSPE


Others


Mid-term

End of term 100%


Written Exam 70%




Lecture Notes

-

Course Text Books




Stryer’s Biochemistry


Relevant journals in metabolism.

Course Instructor

Name: Prof. Dr: Mohamed Zeidan Signature:

Program Coordinator

Name: Prof. Dr: Iman Hasan Diab Signature:


Name: Prof. Dr: Sabah Abdel-Hady Signature:

✓ ✓

✓

✓ ✓



Faculty: Medicine


Course Information

Course Code:05160806 Course Name: Biochemistry of blood

Program in which the Course is Given within courses assigned to the master degree of medical

biochemistry


Course Aims: The student must have good knowledge about

1- Function and methods of separation of plasma proteins

2- Structure of normal and abnormal hemoglobins and hemoglobin metabolism



program matrix)

Course ILOs

A. Knowledge

and

Understanding



in the body.





& micro molecules and different


function.


genetic defects and its relation to

diseases

a1. Describe structure of hemoglobin

a2. Relate structure of hemoglobin to

it’s function

a3. Discuss hemoglobin metabolism in

tissues.

a4. Decscribe metabolic and genetic

defects for hemoglobin and its

relation to disease

B. Intellectual

skills






research methods.

b1. Solve problems related to blood

and immunoglobulins.

b2. Take part in research projects.

b3. Choose better research methods

and good papers.

- 1

C.Professional

and Practical

Skills

D-General

and

transferrable

skills

D1. Acquire updated

knowledge from various

sources and present it to

peers in systematized

manner.

D2. Use information

technology to access,

evaluate, and interpret

scientific data.

d1. Get updated knowledge from

different sources and present it to

peers perfectly.

d1. Implement information technology

to access, evaluate, and choose

scientific data.

E-Attitudes

and ethical

behavior


habits.


confidentiality.





organizations.


e2. Treat patient data with

confidentiality.

e3. Demonstrate commitment to




organizations.



Lectures self

learning

Practical/

Clinical

Small

group

discussion

Others

Assignment

This course includes:

Blood: Functions, osmotic pressure,

clotting of blood, plasma proteins

(types, separation, and change in

diseases), haemoglobin (normal and

abnormal forms).

✓ ✓ ✓ ✓


Student Assessment



Case OSCE/OSPE


Others


Mid-term %

End of term

100 %


Written Exam 80 %

Practical/Clinical Exam -


✓ ✓

✓

✓

Course Instructor

Name: Prof. Dr: Mohamed Zeidan Signature:

Program Coordinator



Name: Prof.Dr: Sabah Abdel-Hady Signature:


Lecture Notes

Course Text Books

1-Harper’s illustrated biochemistry

2-Lehninger biochemistry


1- Text book of Biochemistry (Devlin)


Relevant journals in blood



Faculty: Medicine


Course Information

Course Code: 0516807 Course Name: Hormones

Program in which the Course is Given: Master of Medical Biochemistry



1-Classification of hormones.

2- Mechanism of action of hormones.



matrix) Course ILOs

A. Knowledge

and

Understanding








& micro molecules and different


function.

A4. Explain the basic

mechanisms of cell signaling.


genetic defects and its relation to

diseases.

a1. Revise structure of hormones.

a2. Relate the structure of hormone to its

function.

a3. Discuss synthesis and catabolism of

hormones.

a4. Explain mechanism of action of

hormones

a5. Describe metabolic & genetic defects

and its relation to hormonal defects.

- 2

B. Intellectual

skills


assays effectively.






research methods.

b1. Perform different diagnostic assays

efficiently.

b2. Solve problem situations related to

metabolic and genetic diseases.

b3. Take part in research projects.

b4. Choose research methods and good

papers.

C.Professional

and Practical

Skills






others).


practical session.

c1. Perform efficiently basic techniques

used in clinical biochemistry.

c2. Prepare and conduct a practical

session.

D. General

Skills






scientific data.





evaluate, and criticize scientific data.

E. Attitudes

and ethical

behavior










students.





organizations.






professional organizations.





Lectures self

learning

Practical/

Clinical

Small

group

discussion

Others

Assignment

This course includes

classification of hormones according

to their synthesis, chemistry and

elimination into: peptides and

protein hormones, steroids and

amino acid derivatives. It also

includes classification of hormones

according to their mechanism of

action and signal transduction into:

group I hormones in which the

ligand-receptor complex is their

signal, group II hormones which

have membrane receptors and use

intracellular messengers e.g. cAMP,

cGMP, calcium or phosphatidyl-

inositol or both or phosphatase

cascade.

✓ ✓ ✓ ✓


Student Assessment



Case OSCE/OSPE


Others


Mid-term

End of term 100%


Written Exam 80 %




Lecture Notes

Course Text Books






Relevant journals in biochemistry anf.

Course Instructor

Name: Safaa Hussein Mohy El Dine Abou Deya Signature:

Program Coordinator

Name: Dr. Iman Hassan Diab Signature:



✓ ✓

✓



Faculty: Medicine


Course Information

Course Code: 0516808 Course Name: Quality and lab management



Course Aims:

the students must get basic and advanced knowledge of assurance of the laboratory results to be

reliable and accurate



matrix) Course ILOs

A. Knowledge and

Understanding

A8 Discuss different methods

to assure accuracy of

laboratory results.

a1 Discuss different methods to assure

accuracy of laboratory results.

B. Intellectual skills


assays effectively.


methods for better diagnosis

of diseases.

b1. Utilize different diagnostic assays

effectively.

b2. Choose better practical methods

for better diagnosis of diseases.

C.Professional and

Practical Skills

C7. Assess the accuracy of

laboratory results.

c1. Assess the accuracy of laboratory

results

D. General Skills

D2. Co-operate efficiently in a

multi-professional team

working.



1


views and opinions of other

team members.


to access, evaluate, and interpret

scientific data.

d2. Recognize and respect the views

and opinions of other team

members.



scientific data.

A. Attitudes

and ethical

behavior


habits.


confidentiality.




E5. Demonstrate ethical

choices, values, and

professional practices implicit

in multidisciplinary decision-

making.




e2. Treat patient data with

confidentiality.

e3. Deal with reagents, instruments,

and equipments with caution and

preservation.

e4. Demonstrate ethical choices,



decision-making.

e5. Be accurate in analyzing the




Lectures self

learning

Practical/

Clinical

Small

group

discussion

Others

Assignment

This course ensures laboratory

staff and patients that laboratory

results are reliable and relevant. The

lectures include: Measurement of the

precision and accuracy of the lab, check

the methods and reagents, calibration

of the instruments and performance,

✓ ✓ ✓ ✓ ✓

criteria of the control material,

establishment of mean and standard

deviation and plotting of control data

on a chart, identification of the source

of analytic error, assessment errors,

precautions for sample collection,

sample storage, transportation, and

waste disposal, storages of quality

assurance (pre-analytic, analytic, post-

analytic).


Student Assessment



Case OSCE/OSPE


Others


Mid-term 20 %

End of term 80%


Written Exam 70 %

Practical/Clinical Exam 10 %


✓ ✓

✓

✓


Lecture Notes

Course Text Books

1. Fundamentals of clinical Chemistry. Titz

2. Varley. Biochemical methods


1. Recent publications.

2. Any specialized text books


Relevant journals.

Course Instructor

Name: Pr. Dr. Ihsan Abdel Rahman Signature:

Program Coordinator

Name: Pr.Dr. Iman Hassan Diab Signature:


Name: Prof.Dr: Sabah Abdel Hadt Signature:



Faculty: Medicine


Course Information

Course Code:0560809 Course Name: Metabolism ІІ(metabolism of

macromolecules)

Program in which the Course is Given within the master degree of medical biochemistry


Course Aims: The student must get deep and advanced information about

1.Biosynthesis of glycoproteins

2.Flavoproteins,iron sulfur proteins

3.Protein-protein interaction

4.Proteins implicated in cancer and genetic diseases



matrix) Course ILOs

A. Knowledge

and

Understanding

Graduate of this program must have

deep and broad knowledge and

understanding :

A1 structures of macromolecules

and its relation to function

metabolism of

macromolecules

A2 Revise knowledge about

structure of different vitamins

in the body.

A3 Diseases related to abnormal

metabolism.

a1. Relate structure of different molecules to

their function.

a2. Discuss knowledge about metabolism of

macromolecules .

a3. Revise and upgrade their knowledge

about the metabolism and function of

different water soluble and fat soluble

vitamins in the body.

a4. State general properties of water soluble

vitamins and fat soluble vitamins.

a6. Describe metabolic & genetic defects

and its relation to their function

B. Intellectual

skills

B1 Interpret, evaluate and


different resources.

b2. Evaluate and solve problem situations

related to metabolic and genetic diseases

4

B2 Critically appraise

published relevant

literature.

b6. Select good papers and research

methods.

C.Professional

and Practical

Skills

C1 Perform laboratory

efficiently.

C2 Be able to perform & teach

basic biochemical techniques

to undergraduates and

paramedical personnel.

C3 Apply the methods used in

biochemistry for better

diagnosis of diseases

c1. Apply perfectly basic techniques used in

clinical biochemistry

D. General

Skills

D1. Obtain and collect data

from multiple sources


various sources and present it to peers in

systematized manner

d2. Use information technology to access,

evaluate, and interpret scientific data.

E.Attitudes and ethical behavior

E1. Deal honestly with trainee,

colleagues, employee and all

members.

E2. Demonstrate medical research

ethics.

e1. Promote high standards of personal and

organizational integrity, compassion, honesty,

and respect for seniors, colleagues, assistants,

and students.



Lectures self

learning

Practical/

Clinical

Small

group

discussion

Others

Assignment

This course ensures laboratory staff and

patients that laboratory results are

reliable and relevant. It is given as one

credit hour as alternating lectures and

practical sessions. The lectures include:

Measurement of the precision and

accuracy of the lab, check the methods

and reagents, calibration of the

✓ ✓ ✓ ✓

instruments and performance, criteria of

the control material, establishment of

mean and standard deviation and

plotting of control data on a chart,

identification of the source of analytic

error, assessment errors, precautions for

sample collection, sample storage,

transportation, and waste disposal,

storages of quality assurance (pre-

analytic, analytic, post-analytic). The

practical sessions are applications on

the lectures, with training on attaining

accuracy and precision of the laboratory

results. The practical work is done

through group work or single and

concluded by discussion and grading of

the best performing group in each

session.


Student Assessment



Case OSCE/OSPE


Others


Mid-term %

Assignment 20 %


End of term 70 %%


Written Exam 70 %


Others 30 %

✓ ✓

✓

✓

✓

✓

✓

✓

✓

✓

✓


Lecture Notes

Course Text Books

Harper’s illustrated biochemistry

Fundmentals of clinical chemistry.Titz

Lehninger Biochemistry


1.Recent publications

2.ANY SPECIALIZED TEXT BOOK


Relevant journals

Course Instructor

Name:Mohammed Naguib Dessokey Signature:

Program Coordinator

Name: Dr:Iman Hassan Diab Signature:


Name: Prof. Dr: Sabah Abdel-Hady Mahmoud Signature:



Faculty: Medicine


Course Information

Course Code: 05160810 Course Name: Metabolism III

Tissue Metabolism and Integrated Tissue

Functions

Program in which the Course is Given : Master degree of Medical Biochemistry


Course Aims:

1. Identification of metabolism of different tissues.

2. Integration of different tissue metabolic pathways.



matrix) Course ILOs

A. Knowledge

and

Understanding



in the body.







function.



a1 Revise basic structure of

carbohydrates, lipids and proteins.

a2 Relate the function and structure of

different substances.

a3 Discuss the metabolic pathways for

carbohydrates, lipids and proteins.

a4 Discuss different functions and

metabolism of different

micromolecules.

a5 State causes of inborn errors of

metabolism and their enzyme

defects.

1 2

B. Intellectual

skills



genetic diseases.



diseases.





research methods.

b2. Assess and solve problem situations

related to metabolic and genetic diseases.

b3. Select better practical methods for better

diagnosis of diseases.

b4. Use the recent information in the

biochemistry lab.

b6. Select good papers and research

methods.

C.Professional

and Practical

Skills






others).


the lab.



peers

c1. Perform efficiently basic techniques

used in clinical biochemistry (ELISA,

immunodiffusion, enzyme activity assay,

colorimetric methods and others).

c5. Use safety precautions in the lab.

c6. Describe scientific information to

students and peers

D. General

and

transferrable

Skills






members.



scientific data.

d1. Search for updated knowledge from


peers in organized manner.

d2. Respect the views and opinions of

other team members.

d3. Implement the information

technology evaluate, and criticize

scientific data.

E. Ethics and

Attitudes













organizations.







students.


equipments carefully.









Lectures self

learning

Practical/

Clinical

Small

group

discussion

Others

Assignment

This course includes: special

metabolism of adipose tissue,

skeletal muscles, and cytoskeleton,

cardiac muscles, red blood cells,

white blood cells, liver, kidney,

lung, extracellular matrix and skin.

It includes also explanations of

integrated tissue functions and inter-

relations.

√ √ √ √ √


Student Assessment



Case OSCE/OSPE


Others


Mid-term

End of term 80 %


Written Exam 70 %

Practical/Clinical Exam 10 %



Lecture Notes

Course Text Books

1- Biochemistry. Stryer

2- Lehninger Biochemistry

3- Molecular cell Biology. Lodish


Fundmentals of clinical chemistry.Titz


Relevant journals in metabolism of tissues and

integration of metabolism.

Course Instructor

Name: Pr. Dr. Nadia Ahmed Barghash Signature:

Program Coordinator




√ √

√

√



Faculty: Medicine


Course Information

Course Code: 05160811 Course Name: Metabolism of minerals and water

and electrolyte balance




1-Classification of Minerals.

2-Metabolic functions of minerals.

3- Causes and manifestations of deficiency of minerals.



matrix) Course ILOs

A. Knowledge

and

Understanding





function.



a1. Discuss metabolism of minerals.

a2. Discuss metabolic functions of

minerals in the body.

a3. Describe metabolic & genetic defects and its relation to diseases.

B. Intellectual

skills



genetic diseases.



research methods.

b1. Assess and Solve problem situations

related to metabolic and genetic

diseases.

b2. Share in research projects.

b3. Choose better research methods and

papers.

1

C.Professional

and Practical

Skills

D. General

Skills






scientific data.

d1. Develop updated knowledge from

various sources and explain it to



evaluate, and interpret scientific data.

E. Attitudes

and

ethical

behavior










organizations.





students.







Lectures self

learning

Practical/

Clinical

Small

group

discussion

Others

Assignment

This course includes: classification of

minerals, major elements (sodium,

potassium, calcium, magnesium,

sulphur, phosphorus, and chloride) as

regards to their sources, daily

requirements, absorption, tissue

distribution, metabolism, functions,

excretion, and disease states;

Essential trace elements (iron,

copper, zinc, manganese, cobalt,

✓ ✓ ✓ ✓

selenium, chromium, molybdenum,

iodine, and fluoride) as regards to

their sources, daily requirements,

absorption, tissue distribution,

metabolism, functions, excretion, and

disease states; Possibly essential

trace elements (aluminum, lead,

cadmium, arsenic, mercury,

antimony, boron, bismuth, titanium,

silver, and gold) and their possible

effect on humans due to air, water,

soil, and diet pollution; Mineral

interactions, correction of

deficiencies, and toxicities in humans;

use of mineral supplements in a

specific human diet.


Student Assessment



Case OSCE/OSPE


Others


Mid-term -------

End of term 100%


Written Exam 80%

Practical/Clinical Exam -----


✓ ✓

✓


Lecture Notes

Course Text Books




Fundamentals of clinical chemistry.Titz


Relevant journals.

Course Instructor

Name: Prof.Dr: Ahmed Nagdy Abdel-Aal Signature:

Program Coordinator:

Name:Prof Dr. Iman Hassan Diab Signature:


Name: Prof.Dr: Sbah Abdel-Hady Signature:



Faculty: Medicine


Course Information

Course Code: 05160812 Course Name: Seminar and Journal Club I

Program in which the Course is Given Master Degree in Medical biochemistry


Course Aims: 1-Collect and analize recent scientific knwolage

2-Demonstrate these knwolage in group discussion



matrix) Course ILOs

A. Knowledge

and

Understanding

A1. Revise, upgrade

knowledge about the

general principles of

biochemical basic

knowlage

a1. Revise the general biochemical

knwolage

a2. Discuss the most recent biochemical

knwolage.

B. Intellectual

skills


apply information from different

resources.

B2. Critically appraise published

relevant literature.

b1 Evaluate different published

literature

b2 Compare the recent with previous

basic knowlage.

b3 Explanation of old facts by recent

scientific knowlage

b4 Design for further scientific

application of scientific knowledge

C.Professional

and Practical

Skills

C1 Collection of scientific

data.

C2 Presentation of scientific

data

C3 Discuss the recent

knowlage in group

discussion.

c1. Collection of scientific data.

c2. Presentation of scientific data

c3. Discuss the recent knowlage in group

discussion

D. General

Skills

D1. Obtain and collect data

from multiple sources

D2. Develop the capability of



different data.


and presentation skills

d1. Develop the capability of retrieving


different data.

d2. Develop efficient writing and

presentation skills



Lectures self

learning

Practical/

Clinical

Small

group

discussion

Others

Assignment

(✓) (✓)


Student Assessment



Case OSCE/OSPE


Others


Mid-term

Assignment 100%

Self learning, commitment & attitude

End of term


Written Exam


Others

✓

(✓)


Lecture Notes

Course Text Books

1. Clinical Chemistry

2. Fundamentals of clinical

Chemistry. Titz

Varley. Biochemical methods


Any related recent text book



Course Instructor

Name: Professor Dr .Mohammad Naguib Dessouky Signature:

Program Coordinator



Name: Prof Dr: Sabah Abdel-Hady Mahmoud Signature:



Faculty: Medicine


Course Information

Course Code: 05160813 Course Name : Immunochemistry

Program in which the Course is Given

Number of Credit Hours Theoretical Clinical/Practical

Course Aims:

1. Identify the system of immune response.

2. Identify types of immune response.

3.Identify the role of complements in immune response.

4. Identify Autoimmunity and immunosupression.

5. Identify the types of plasma proteins and immunoglobulin and their biological significance



matrix) Course ILOs

A. Knowledge

and

Understanding


about the system of

immune response,types of

immune response and the

structure and function of

immunoglobulins

a1. Revise the general types of immune

response, and immunoglobulins

a2. Discuss Autoimmunity and

immunosupression

a3. Discuss the different types of plasma

protein and their separation

B. Intellectual

skills

B1. Review recent publications

in the field of Immunology

and immunoglobulins



different resources

b1. Evalute and solve problems related

to immune diseases

b2. Choose the better assay method for

better diagnosis.

C.Professional

and Practical

Skills

C1 Promote good relations

with seniors, colleagues

and students

c1. Explain techniques used for

separation of plasma proteins and

immunoglobulins(electrophoresis

and immunelectrophoreses

c2. Interpret the commonly used

techniques

- 1

D. General

Skills

D1. Develop the capability of



different data.


and presentation skills








scientific data.



Lectures self

learning

Practical

Clinical

Small group

discussion

Others

Assignment

The structure of Hb,the biological

function,normal and abnormal Hb . the

catabolism of Hb.jaundice and

porphyria .Plasma proteins

The structure of immunoglobulins ,the

biological function .The complements

√ √ √ √


Student Assessment



Case OSCE/OSPE



Assignment 20 %


End of term %


Written Exam 70 %


√ √

√


Lecture Notes

Lectures on medical biochemistry

Course Text Books

Immunology_Goldsby

Text Books of Biochemistry (Devlin)

Biochemistry (LEHNINGER)


Fundamental Immunology



Course Instructor

Name: Samy Hussein Galal Signature:

Program Coordinator






Faculty: Medicine


Course Information

Course Code: 05160814 Course Name: Integration in energy and

metabolism

Program in which the Course is Given Master Degree in Medical Biochemistry

Number of Credit Hours Theoretical Clinical/Practical

Course Aims: explores the relationships between cellular and energy metabolism. Biochemical

pathways of carbohydrate, lipid, protein and nucleotide

metabolism are discussed in the context of their impact on human organ systems in inborn and

acquired metabolic derangements, and integrated with analysis of human disease states



matrix) Course ILOs

A. Knowledge

and

Understanding

Graduate of this course must have

deep and broad knowledge and

understanding:


structure of different compounds in

the body.





micro molecules and different tissues

and relation to their function.



a1. Describe key metabolic pathways in

human cells at the molecular level

a2. Study Energy metabolism

a3. Discuss the impact of acquired and

genetically-determined human

diseases on key metabolic pathways

a4. Identify the most recent advances in

the molecular mechanisms involved

in regulation of energy and metabolic

pathways

- 2

B. Intellectual

skills



genetic diseases.



diseases.





research methods.

b1. Integrate cellular metabolism with

organ homeostasis in human biology;

b2. Apply clinical thinking in solving

problems of patients with metabolic

diseases and understand approaches

to their diagnosis and therapy

b3. Critically appraise published relevant

literature.

C.Professional

and Practical

Skills



c1. Develop skills in the analysis,

assimilation, understanding, and

effective communication of new and

discovered knowledge in

metabolism.

D. General

Skills






members.



scientific data.

d1. Perform interactive discussions and

assignment presentation

E. Attitudes

and ethical

behavior












students.

e2. Demonstrate good work habits

throughout the working hours.






organizations.



e3. Treat genetic patient data with

confidentiality and respect of his

privacy. Deal with reagents ,

instruments, and equipments use in

the molecular biology lab with

caution.


and professional practices decision-

making in respect to genetic

disorders.




professional organizations in



of genetic patients.

Course Content

(Units/Topics)


Lectures self learning Practica

l/

Clinical

Small group

discussion

Others

Assignment

- Metabolism:

definition, stages,

and metabolic

pathways

- Energy sources

and metabolism

- Supply of ATP

and glucose by

making storage

molecules

(glycogen, fat,

protein) when

food is available

and by retrieving

ATP and glucose

from storage when

they are needed

✓

✓ ✓ ✓

- Integration of

tissue metabolism

in health and

disease

- Metabolic

problems and

approaches to their

diagnosis and

therapy

-

- Each student

prepares an

assignment

supervised by the

instructors and

writes and

presents a review.


Student Assessment



Case OSCE/OSPE


Others


Mid-term 20 %

Assignment 20 %


End of term 40 %%


Written Exam 60 %


Others 40 %


Lecture Notes

Course Text Books

1. Harper’s illustrated Biochemistry.

2. Devlin’s textbook of Biochemistry.

3. Lehninger Biochemistry.

Stryer’s Biochemistry.


- Any related recent text book.


- Relevant journals & periodicals.

Course Instructor


Program Coordinator



Name: Sabah Abdel-Hady Mahmoud Signature:

Documents

University: Alexandria Program Specifications · 2017-05-04 · fates of pyruvate, hexose monophosphate shunt, glycogen metabolism, uronic acid pathway, metabolism of galactose and