v.s

49554059 49554064 49554066 49554092 49554909**

AmgenGI**

AmgenGI19801980 600-NeupogenInfergenEPOGENM-CSFinterleukin-3interleukin-111996

19871029 Amgen19871030 GI 1988 1 Amgen(ITC) GI19891 AmgenEPO **

19871029Amgen GIGI EPO()Amgen

**

1988 1 Amgen (ITC)(Chugai) GI GI Amgen ITC EPO

**

1988

Amgen GI 1 ITC EPO Amgen

**

EPO EPO DNA EPO EPOEPO**

**

4,703,008(Amgen)4,677,195(GI)

EPO EPOEPOEPO

GI Amgen()GI Amgen

GI EPO Amgen**

GI AmgenEPO DNA GI

AmgenGI GIAmgenGI Amgen**

GI Amgen EPO Obvious to tryAmgen **

(non-obvious)

**

Obvious to try()

**

-**

AmgenDNA AmgenDNAEPOGI GI EPOGIEPOEPODNAEPO Amgen

-CAFC**

GIEPO16IU/AUGIEPOGIEPO19935Amgen1,400200

**GI

AmgenAmgenAmgen GIEPOAmgen

**

**