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Výsledky farmaekonomických štúdií na Slovensku a ich implementácia v praxi. Viliam Foltán, Farmaceutická fakulta UK Slovenská spoločnosť pre farmakoekonomiku. Základný rámec problematiky farmakoekonomiky - PowerPoint PPT Presentation
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Vsledky farmaekonomickch tdi na Slovensku a ich implementcia v praxi
Viliam Foltn,Farmaceutick fakulta UK Slovensk spolonos pre farmakoekonomiku
Farmakoekonomika predstavuje jednu z monost, ako
njs objektivizujce kritrium pre zhodnotenie nielen
terapeutickho efektu konkrtneho lieku, ale terapeutickho efektu lieebnej metdy:
predstavuj plnohodnotn sas rozhodovacch procesov pri terapeutickom oceovan novch lieiv a liekov v registranom konan (AUSTRLIA, KANADA)
- v rmci stanovovania hrad za lieky (Holandsku,Fnsku,
Taliansku) a vaka zavedeniu NICE (National Institute for Clinical Excellence) aj vo Vekej Britnii).
Zkladn rmec problematiky farmakoekonomiky
Makroekonomick vchodisk (HDP, inflcia, stabilita meny, verejn financie, ttny dlh, zahranin zadenos)Programov vyhlsenie vldy
Zdravotn politika
Liekov politika
FarmakoekonomikaRacionlna farmakoterapia
Vvojov trendy vo svete IKadorone viac ako 1 000 evidovanch prc na tmu farmakoekonomika v PubMed-e ISPOR - Medzinrodn spolonos pre farmakoekonomiku a klinick vstupy a ) 7 eurpskych kongresov (posledn- okt. 2004, Hamburg) b ) 9 medzinrod. kongresov (posledn- mj 2005, Washington)OECD (zdroj Clearinghouse for Pharmacoeconomics) - 55 centier pre farmakoekonomiku - 20 asopisov - 32 knh - 19 databz - 14 periodickch bulletinov farmakoekonomickch subjektov - 16 profesnch zdruen
Farm.Hosp.,28,2004,5, 375-383Trnovec, Farmakoekonomika V., 2003
Vvojov trendy vo svete IIPokroky vo vvoji liekov s spojen s ich vyou klinickou hodnotou, ale aj vyou cenou
Zdvodnenie ceny v podstate jedin spsob ponka farmakoekonomika
Farmakoekonomika: interdisciplinrny vedn odbor, ktor sa zaober ekonomickmi aspektami farmakoterapie pri poskytovan zdravotnej starostlivosti,obvykle vo vzahu kjej innosti.
Cie: o najvyia odborn rove pri veobecnej dostupnosti a najniej nkladovosti.Bielik, ttna liekov politika, november 2004
Reflexia ich vvoja na Slovensku1995 prv pecificky orientovan lnok2001 prv farmakoekonomick konferencia2001 prv farmakoekonomick tdia o M.Crohn 2003 prv samostatn as v knihe (Foltn, Tesa:Lieky-Liekov politika- Farmakoekonomika)2004 prv kniha (Holom, Foltn, Bielik: Zklady farmakoekonomiky2005 asopis Farmakoekonomika aliekov politika (vydavate SSFE)
Bielik, Sedlkov:ttna liekov politika, november 2004
Farmakoekonomika me dokza, e cena lieku je iba jeden faktor, ktor m vo farmakoterapeutickom aspekte iba sekundrnu lohu. Pravdepodobnos spechu a cena nespenej lieby s dleitejie komponenty, ako je len ekonomick obraz farmakoterapie.
Farmakoekonomika nie je len nstrojom farmaceutickch firiem, alebo iba vednou disciplnou, ale ak je sprvne aplikovan, me sa sta jednm z najdleitejch nstrojov reformy zdravotnckeho systmu a skvalitovaniu jeho sluieb.
tdieDo r. 2004: 1- 2 tdie rone v SR (retrospektvne)
Od r. 2005: zujem o 3- 4 tdie
Predpoklad: pri aplikcii novho kategorizanho procesu al nrast
Tomek, FELP: Smernice a odporania pre farmakoekonomick tdie v Slovenskej republike (2004)
Farmakoekonomick analza lieby hypolipidemikami
Epidemiolgia OOS- Farmakoekonomika a jej vchodisk Lieky a ich spotreba Lieky pouvan pri OOS HypolipidemikFE hypolipidemk
Zvery
Mortalita cca 25 000 obyv./rok
ICHS 50%CMP 20%Komplikcie AS 16%Komplikcie hypertenzie 4%Ostatn 10%
PN cca 40 dn
Mortalita a PN na OOS v SR
Spotreba liekov poda zdruench ATC (daje s v DDD/1000/de)
ATC11_prehlad
2001
AALIMENTARY TRACT AND METABOLISM26,880,8082,238,840618,189,048313.64ATC skupina1995199619971998199920002001200220032004
BBLOOD AND BLOOD FORMING ORGANS10,157,8451,033,476188,488,28295.63ALieiv na zavac trakt a metab.210295368322303307313307282247
CCARDIOVASCULAR SYSTEM30,013,0604,090,824653,318,551331.47BLieiv na krv a krvotvor. orgny6682929694899610310098
DDERMATOLOGICALS7,409,327514,093348,171,670176.65CLieiv KVS152218235260279292331376381388
GGENITO URINARY SYSTEM AND SEX HORMONES3,293,774915,277126,831,51364.35DDermatologika111148152184146160177187178163
HSYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES1,479,410365,74231,508,69615.99GLieiv na urogen. trakt a sex. hor.28435356636864676261
JANTIINFECTIVES FOR SYSTEMIC USE9,854,1212,167,77361,483,81531.19HHormny na celk.pou.mimo sex10191315141416181920
LANTINEOPLASTIC AND IMMUNOMODULATING AGENTS1,075,814982,88252,500,91826.64JAntiinfekn na celkov pouitie23293228302731282926
MMUSCULO-SKELETAL SYSTEM12,013,4021,172,796263,783,778133.83LCytostatika a imunomodulan ltky321025764657127283032
NNERVOUS SYSTEM30,897,4152,435,016220,611,317111.93MLieiv na muskuloskelet. systmu90138147148146123134147137123
PANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENT362,44824,8314,954,8532.51NLieiv na nervov systm84107112107113105112122123146
RRESPIRATORY SYSTEM16,537,6491,698,720195,737,09399.31PAntiparazitika3433222,5221,4
SSENSORY ORGANS3,289,358232,93037,942,91319.25RLieiv na respiran systm709910699979699102111133
VVARIOUS4,086,581471,70548,234,4740SLieiv na ochorenia zmysl orgnov15182120191919202225
1422.39VRozlin lieiv0000000000
SPOLU902132214101402137113751422151014771488
20021476
AALIMENTARY TRACT AND METABOLISM26,918,0472,476,099605,981,248307.45
BBLOOD AND BLOOD FORMING ORGANS11,065,2261,295,039203,319,015103.16
CCARDIOVASCULAR SYSTEM32,246,3445,155,325741,682,799376.30
DDERMATOLOGICALS7,678,614554,358369,363,213187.40
GGENITO URINARY SYSTEM AND SEX HORMONES3,464,1361,075,597131,468,66866.70
HSYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES1,685,305437,71636,426,09218.48
JANTIINFECTIVES FOR SYSTEMIC USE9,003,0932,216,26056,153,23928.49
LANTINEOPLASTIC AND IMMUNOMODULATING AGENTS1,122,5531,233,42955,641,89428.23
MMUSCULO-SKELETAL SYSTEM12,734,9571,339,584290,284,664147.28
NNERVOUS SYSTEM31,101,8223,105,928240,518,043122.03
PANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENT352,15224,4044,376,4652.22
RRESPIRATORY SYSTEM15,538,0841,901,618200,221,706101.58
SSENSORY ORGANS3,290,075264,33340,248,13320.42
VVARIOUS3,501,998493,63137,569,6080
1509.73
ATC 2003
AALIMENTARY TRACT AND METABOLISM24,416,4102,461,374555,256,034281.71
BBLOOD AND BLOOD FORMING ORGANS11,093,2341,434,959197,350,542100.13
CCARDIOVASCULAR SYSTEM30,795,2375,665,824751,730,797381.40
DDERMATOLOGICALS7,243,328555,480351,110,505178.14
GGENITO URINARY SYSTEM AND SEX HORMONES3,229,0131,064,705122,925,19362.37
HSYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES1,660,422471,57837,840,06219.20
JANTIINFECTIVES FOR SYSTEMIC USE9,197,7892,260,66357,985,60129.42
LANTINEOPLASTIC AND IMMUNOMODULATING AGENTS1,152,7311,410,91258,970,11529.92
MMUSCULO-SKELETAL SYSTEM12,048,2391,381,618270,024,309137.00
NNERVOUS SYSTEM30,455,0233,354,021243,123,331123.35
PANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENT273,04521,2313,343,5631.70
RRESPIRATORY SYSTEM15,417,6882,063,767218,443,533110.83
SSENSORY ORGANS3,051,037276,82843,839,83522.24
VVARIOUS3,082,450535,03729,864,4000
Spolu1477.39
3Q 2004
AALIMENTARY TRACT AND METABOLISM16,003,7721,579,948356,621,256240.15
BBLOOD AND BLOOD FORMING ORGANS8,217,9201,011,753143,031,34296.32
CCARDIOVASCULAR SYSTEM22,294,8533,235,141560,041,415377.13
DDERMATOLOGICALS5,119,902398,987238,952,277160.91
GGENITO URINARY SYSTEM AND SEX HORMONES2,254,071715,52590,665,79561.05
HSYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES1,302,368286,34829,198,65319.66
JANTIINFECTIVES FOR SYSTEMIC USE5,724,6821,339,77036,784,44324.77
LANTINEOPLASTIC AND IMMUNOMODULATING AGENTS808,9351,220,34845,876,02430.89
MMUSCULO-SKELETAL SYSTEM8,526,381933,364176,895,015119.12
NNERVOUS SYSTEM20,707,5042,128,813214,673,499144.56
PANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENT201,13614,4222,047,2421.38
RRESPIRATORY SYSTEM10,260,9871,294,574187,716,537126.41
SSENSORY ORGANS2,283,128200,94138,426,64825.88
VVARIOUS1,907,934335,30521,311,7810
1428.24
Spotreba liekov pouvanch pri ochoreniach OOS BaleniaHodnota *000 Sk
c10_7
C10 2000
bal*000 SkDDDddd/1000/day
C10AA01Simvastatin13453817519053586182.72
C10AA03Pravastatin13405610525132242201.64
C10AA04Fluvastatin747284965517001600.86
C10AA05Atorvastatin641467297321024001.07
C10ABFibrates173717300.00
C10AB02Bezafibrate2442152154698030.24
C10AB03Aluminium clofibrate780369156000.01
C10AB04Gemfibrozil1359731142558210.13
C10AB05Fenofibrate29012613024786987954.41
C10AB08Ciprofibrate1049373837531481101.60
C10AB09Etofibrate27717900.00
C10AC01Colestyramine49922871310.00
C10AC02Colestipol40325000.00
C10AD06Acipimox1464821900.00
C10AXOther cholesterol and triglyceride reducers866632452173280.11
12.79
C10 20010.0
C10AA01Simvastatin23109526461288464144.49
C10AA03Pravastatin12661210404132554351.65
C10AA04Fluvastatin627104305515063020.76
C10AA05Atorvastatin13028615608745339602.30
C10AA06Cerivastatin292463183012001920.61
C10ABFibrates2991129900.00
C10AB02Bezafibrate2453646624087630.21
C10AB04Gemfibrozil1784745853766410.19
C10AB05Fenofibrate31373514241095109704.83
C10AB08Ciprofibrate1031143771930934201.57
C10AB09Etofibrate1138200.00
C10AC01Colestyramine55825579720.00
C10AC02Colestipol34274250.00
C10AD06Acipimox1241800.00
C10AXOther cholesterol and triglyceride reducers822734102453530.12
16.74
C10 20020.0
C10AA01Simvastatin471879435709181585169.21
C10AA02Lovastatin1033592218730.01
C10AA03Pravastatin591004841715128850.77
C10AA04Fluvastatin672845208319483520.99
C10AA05Atorvastatin19860724918372956103.70
C10AA06Cerivastatin17197140.00
C10ABFibrates2741027400.00
C10AB02Bezafibrate1439427352398040.12
C10AB04Gemfibrozil1299035102902890.15
C10AB05Fenofibrate344376165352111079915.64
C10AB08Ciprofibrate970403549729112001.48
C10AC01Colestyramine790361112840.01
C10AXOther cholesterol and triglyceride reducers707629442122800.11
22.18
C10 20030.0
C10AA01Simvastatin6131745324232363742311.99
C10AA02Lovastatin782056712155650.11
C10AA03Pravastatin20911176325580600.28
C10AA04Fluvastatin868179119538627961.96
C10AA05Atorvastatin21285028526986475604.39
C10AA07Rosuvastatin22560.00
C10ABFibrates90900.00
C10AB02Bezafibrate728713851214010.06
C10AB04Gemfibrozil523914621233250.06
C10AB05Fenofibrate418985202862142001857.20
C10AB08Ciprofibrate730092670721902701.11
C10AC01Colestyramine774353110530.01
C10AXOther cholesterol and triglyceride reducers1564651469200.02
C10AX09Ezetimibe400551112000.01
27.21
C10 20040.0
C10AA01Simvastatin8110742929223157557616.02
C10AA02Lovastatin1025826242341360.12
C10AA03Pravastatin554387161700.01
C10AA04Fluvastatin820488037643637722.21
C10AA05Atorvastatin14481713239366133503.36
C10AA07Rosuvastatin398473965012016760.61
C10AB02Bezafibrate1856727823093260.16
C10AB04Gemfibrozil2641544588130.03
C10AB05Fenofibrate501983161154166335328.44
C10AB08Ciprofibrate32868101949860400.50
C10AC01Colestyramine886405126520.01
C10AXOther cholesterol and triglyceride reducers26811180400.00
C10AX09Ezetimibe26913704753480.04
31.50
C10_5
hypolipidemika 2000
bal*000 SkDDDddd/1000/day
C10AAStatiny407468403070123853986.28
C10ABFibraty434061177334125916496.39
C10ACDeriv.lovch kyseln53926076310.00
C10ADDerivty kys.nikotnovej1464821900.00
C10AXOstatn zniujce cholesterol866632452173280.11
8508805839572520419612.79
hypolipidemika 20010.0
0.0
C10AAStatiny579949599626193423039.81
C10ABFibraty459542189391133936046.80
C10ACDeriv.lovch kyseln59228283970.00
C10ADDerivty kys.nikotnovej1241800.00
C10AXOstatn zniujce cholesterol822734102453530.12
10483227927133298983716.74
hypolipidemika 20020.0
0.0
C10AAStatiny7979207860032893795114.68
C10ABFibraty469074207105145520247.38
C10ACDeriv.lovch kyseln790361112840.01
C10AXOstatn zniujce cholesterol707629442122800.11
12748609964134371353922.18
hypolipidemika 20030.0
0.0
C10AAStatiny9415749321923692146018.73
C10ABFibraty504529232415166352718.44
C10ACDeriv.lovch kyseln774353110530.01
C10AXOstatn zniujce cholesterol19641201581200.03
144884111661615362590427.21
hypolipidemika 20040.0
0.0
C10AAStatiny10885985483524400468022.33
C10ABFibraty556059174674179877119.13
C10ACDeriv.lovch kyseln886405126520.01
C10AXOstatn zniujce cholesterol29593815833880.04
16485027272466208843122.18
vyvoj_kvart
Kardiovaskulrne vvoj poda tvrrokovHypolipidemika vvoj poda tvrrokov
kvartlbaleniatis.SkDDDddd/1000/daykvartlbaleniatis.SkDDDddd/1000/day
2000/16827514737902137159734282.222000/1199201132153578208611.90
2000/27355509837354150760001310.212000/2219869149941653064513.44
2000/36543015758286134641631277.042000/3195574133561578883611.91
2000/47172207885619149551210307.722000/4236236168303710263014.61
2001/17481589978006159974100329.162001/1258818190440801373716.49
2001/278325331052161169606993348.992001/2272562207051854228617.58
2001/37151252970388156244747321.492001/3235893179521733122415.08
2001/475476861090270167492711344.642001/4281049215701910259018.73
2002/176837211148879172057695354.032002/1292295225873971738819.99
2002/279856591255948182836573376.212002/23091172399991045849721.52
2002/379562751273383183498827377.572002/32989982353031027578821.14
2002/486206891477116203289705418.292002/43744502952371326186527.29
2003/181927231446410196752229404.842003/13793453017021374334228.28
2003/280594681494925197609843406.602003/23866923115171425820629.34
2003/368976631304984170000101349.792003/33265542672941218764525.08
2003/476453831419506187368624385.532003/43562502856491343671127.65
2004/171799661022938177493509365.212004/13627151645491360836828.00
2004/274977761107931188280574387.412004/23995631830411480858330.47
2004/376171111104271194267332399.732004/34134361803221535161231.59
2004/479083131170951204832112421.472004/44727881993341831986937.70
kardio_1roky
Kardio 2000
balenia*000 SkDDDddd/1000/day
C01CARDIAC THERAPY6832035414144121139422
C02ANTIHYPERTENSIVES4960301127238428899
C03DIURETICS18471486274055572939
C04PERIPHERAL VASODILATORS290704520116441165957
C05VASOPROTECTIVES337239817877466790762
C07BETA BLOCKING AGENTS251171927392963150094
C08CALCIUM CHANNEL BLOCKERS387293966188278294526
C09AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM5208051729849112365782
C10SERUM LIPID REDUCING AGENTS85088058395725204196
278982453219162572112577
0.0
kardio 20010.0
0.0
C01CARDIAC THERAPY6934381466870127475417
C02ANTIHYPERTENSIVES64526518103513349011
C03DIURETICS20156556986759779875
C04PERIPHERAL VASODILATORS282837521231542344743
C05VASOPROTECTIVES366088923136874082245
C07BETA BLOCKING AGENTS296067935317472162694
C08CALCIUM CHANNEL BLOCKERS411894383199291359455
C09AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM580055195149013977527520002001200220032004
C10SERUM LIPID REDUCING AGENTS104832279271432989837C01KARDIOLOGIKA68320356934381713300464918275929124
300130604090825653318552C02ANTIHYPERTENZIVA496030645265771462821900852568
0.0C03DIURETIKA18471482015655222102421862042240802
kardio 20020.0C04PERIFER.VASODILATANCIA29070452828375285281324262962111531
0.0C05VAZOPROTEKTIVA33723983660889405206839124353568337
C01CARDIAC THERAPY7133004538806136744469C07BETABLOKATORY25117192960679340769634610923693671
C02ANTIHYPERTENSIVES77146223852217635939C08BLOKTORY KALCIOVHO VSTUPU38729394118943444208942144394342819
C03DIURETICS22210247996064686580C09ACE-INHIBTORY52080515800551609132858322035815812
C04PERIPHERAL VASODILATORS285281322435643593992C10HYPOLIPIDEMIKA8508801048322127486014488411648502
C05VASOPROTECTIVES405206828965982122584CSPOLU2789824530013060322463443079523730203166
C07BETA BLOCKING AGENTS340769644923082612514
C08CALCIUM CHANNEL BLOCKERS44420891093775109232702
C09AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM60913281244605161340481
C10SERUM LIPID REDUCING AGENTS12748609964124371353820002001200220032004
322463445155325741682799C01KARDIOLOGIKA414144466870538806549551499506
0.0C02ANTIHYPERTENSIVA112723181035238522267614199981
kardio 20030.0C03DIURETIKA6274069867799608460796650
0.0C04PERIFER.VASODILATANCIA201164212315224356211512186990
C01CARDIAC THERAPY6491827549551130630927C05VASOPROTEKTIVA178774231368289659304855267562
C02ANTIHYPERTENSIVES82190026761419926590C07BETABLOKATORY273929353174449230495273410088
C03DIURETICS21862048460764116087C08BLOKTORY KALC.KANLOV66188283199210937751166599758738
C04PERIPHERAL VASODILATORS242629621151240683501C09ACE-INHIBTORY729849951490124460514196531259332
C05VASOPROTECTIVES391243530485579304736C10HYPOLIPIDEMIKA5839577927149964121166161727246
C07BETA BLOCKING AGENTS346109249527382786031CSPOLU32191624090825515532556658254406093
C08CALCIUM CHANNEL BLOCKERS42144391166599113349691
C09AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM58322031419653167307331
C10SERUM LIPID REDUCING AGENTS1448841116616153625904
30795237566582575173079820002001200220032004
kardio 20040.0C01KARDIOLOGIKA61.4664.6869.3866.2865.50
0.0C02ANTIHYPERTENSIVA4.286.778.9510.1110.72
C01CARDIAC THERAPY5929124499506129095205C03DIURETIKA28.2030.3332.8232.5331.67
C02ANTIHYPERTENSIVES85256819998121121215C04PERIFER.VASODILATANCIA20.8921.4822.1220.6419.63
C03DIURETICS22408029665062425536C05VASOPROTEKTIVA33.8937.5941.6740.2434.23
C04PERIPHERAL VASODILATORS211153118699038688729C07BETABLOKATORY32.0436.6141.9142.0042.78
C05VASOPROTECTIVES356833726756267469814C08BLOKTORY KALC.KANLOV39.7246.3555.4257.5163.25
C07BETA BLOCKING AGENTS369367141008884319099C09ACE-INHIBTORY57.0170.9281.8684.8888.79
C08CALCIUM CHANNEL BLOCKERS4342819758738124657188C10HYPOLIPIDEMIKA12.7916.7422.1827.2131.50
C09AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM58158121259332175008309CSPOLU290.27331.47376.30381.40388.06
C10SERUM LIPID REDUCING AGENTS164850272724662088431
302031664406093764873526
lieky_ATC1_vyv
lieky 20002001200220032004
bal*000 SkDDDddd/1000/daybal*000 SkDDDddd/1000/daybal*000 SkDDDddd/1000/daybal*000 SkDDDddd/1000/daybal*000 SkDDDddd/1000/day
AALIMENTARY TRACT AND METABOLISM271398042070521625353722317.28268808082238840618189048313.64269180472476099605981248307.45244164102461374555256034281.71215723872171686487047622247.11
BBLOOD AND BLOOD FORMING ORGANS967117079597417721701589.9110157845103347618848828295.63110652261295039203319015103.16110932341434959197350542100.1310871614134338919395841798.41
CCARDIOVASCULAR SYSTEM278982453219161572112576290.27300130604090824653318551331.47322463445155325741682799376.30307952375665824751730797381.40302031664406092764873527388.06
DDERMATOLOGICALS6940872452892321936781163.347409327514093348171670176.657678614554358369363213187.407243328555480351110505178.146806880529875321840040163.29
GGENITO URINARY SYSTEM AND SEX HORMONES296764972800911305989457.36329377491527712683151364.353464136107559713146866866.703229013106470512292519362.37301624497698712198752161.89
HSYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES13600342381742869577014.5614794103657423150869615.9916853054377163642609218.4816604224715783784006219.2017559814025433941187020.00
JANTIINFECTIVES FOR SYSTEMIC USE926712119062805846697329.66985412121677736148381531.19900309322162605615323928.49919778922606635798560129.42840545619221305275608626.77
LANTINEOPLASTIC AND IMMUNOMODULATING AGENTS9811178642344805797924.3810758149828825250091826.64112255312334295564189428.23115273114109125897011529.92114600516716716465315632.80
MMUSCULO-SKELETAL SYSTEM118032881053739272761400138.39120134021172796263783778133.83127349571339584290284664147.28120482391381618270024309137.00116344261284052244321692123.96
NNERVOUS SYSTEM306136841933210202290090102.63308974152435016220611317111.93311018223105928240518043122.03304550233354021243123331123.35287712002902115288642640146.44
PANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENT3561772397447853562.433624482483149548532.513521522440443764652.222730452123133435631.702751501981129407451.49
RRESPIRATORY SYSTEM16174630139670618007720191.3616537649169872019573709399.31155380841901618200221706101.58154176882063767218443533110.83143422811763727262544669133.20
SSENSORY ORGANS29625601811023434534617.4332893582329303794291319.2532900752643334024813320.4230510372768284383983522.2430148842672655110694025.93
VVARIOUS34597273664994554741923.1140865814717054823447424.4735019984936323756960819.0630824505350452986440015.1526704974831802901024414.72
15159607815230475268470752213621573510121834490528517569211447159702406215733223013254787152915311564622958005294180782014931444861712014452329250951691484
20002001200220032004
bal*000 Skbal*000 Skbal*000 Skbal*000 Skbal*000 Sk
ALIMENTARY TRACT AND METABOLISMA271398042070521268808082238840269180472476099244164102461374215723872171686
BLOOD AND BLOOD FORMING ORGANSB9671170795974101578451033476110652261295039110932341434959108716141343389
CARDIOVASCULAR SYSTEMC278982453219161300130604090824322463445155325307952375665824302031664406092
DERMATOLOGICALSD69408724528927409327514093767861455435872433285554806806880529875
GENITO URINARY SYSTEM AND SEX HORMONESG2967649728009329377491527734641361075597322901310647053016244976987
SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONESH13600342381741479410365742168530543771616604224715781755981402543
ANTIINFECTIVES FOR SYSTEMIC USEJ9267121190628098541212167773900309322162609197789226066384054561922130
ANTINEOPLASTIC AND IMMUNOMODULATING AGENTSL9811178642341075814982882112255312334291152731141091211460051671671
MUSCULO-SKELETAL SYSTEMM118032881053739120134021172796127349571339584120482391381618116344261284052
NERVOUS SYSTEMN306136841933210308974152435016311018223105928304550233354021287712002902115
ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTP3561772397436244824831352152244042730452123127515019811
RESPIRATORY SYSTEMR161746301396706165376491698720155380841901618154176882063767143422811763727
SENSORY ORGANSS29625601811023289358232930329007526433330510372768283014884267265
VARIOUSV34597273664994086581471705350199849363230824505350452670497483180
List1
bal. (mil.)Sk (mld)DDD/1000/den
200015.1615.231362
200115.7418.341447
200215.9721.571529
200315.3122.961493
200414.4520.141484
balenia*000 Sk
C015929124499506
C02852568199981
C03224080296650
C042111531186990
C053568337267562
C073693671410088
C084342819758738
C0958158121259332
C101648502727246
List1
00
00
00
00
00
&A
Page &P
bal. (mil.)
Sk (mld)
00
00
00
00
00
00
00
00
00
&A
Page &P
balenia
*000 Sk
c10_7
C10 2000
bal*000 SkDDDddd/1000/day
C10AA01Simvastatin13453817519053586182.72
C10AA03Pravastatin13405610525132242201.64
C10AA04Fluvastatin747284965517001600.86
C10AA05Atorvastatin641467297321024001.07
C10ABFibrates173717300.00
C10AB02Bezafibrate2442152154698030.24
C10AB03Aluminium clofibrate780369156000.01
C10AB04Gemfibrozil1359731142558210.13
C10AB05Fenofibrate29012613024786987954.41
C10AB08Ciprofibrate1049373837531481101.60
C10AB09Etofibrate27717900.00
C10AC01Colestyramine49922871310.00
C10AC02Colestipol40325000.00
C10AD06Acipimox1464821900.00
C10AXOther cholesterol and triglyceride reducers866632452173280.11
12.79
C10 20010.0
C10AA01Simvastatin23109526461288464144.49
C10AA03Pravastatin12661210404132554351.65
C10AA04Fluvastatin627104305515063020.76
C10AA05Atorvastatin13028615608745339602.30
C10AA06Cerivastatin292463183012001920.61
C10ABFibrates2991129900.00
C10AB02Bezafibrate2453646624087630.21
C10AB04Gemfibrozil1784745853766410.19
C10AB05Fenofibrate31373514241095109704.83
C10AB08Ciprofibrate1031143771930934201.57
C10AB09Etofibrate1138200.00
C10AC01Colestyramine55825579720.00
C10AC02Colestipol34274250.00
C10AD06Acipimox1241800.00
C10AXOther cholesterol and triglyceride reducers822734102453530.12
16.74
C10 20020.0
C10AA01Simvastatin471879435709181585169.21
C10AA02Lovastatin1033592218730.01
C10AA03Pravastatin591004841715128850.77
C10AA04Fluvastatin672845208319483520.99
C10AA05Atorvastatin19860724918372956103.70
C10AA06Cerivastatin17197140.00
C10ABFibrates2741027400.00
C10AB02Bezafibrate1439427352398040.12
C10AB04Gemfibrozil1299035102902890.15
C10AB05Fenofibrate344376165352111079915.64
C10AB08Ciprofibrate970403549729112001.48
C10AC01Colestyramine790361112840.01
C10AXOther cholesterol and triglyceride reducers707629442122800.11
22.18
C10 20030.0
C10AA01Simvastatin6131745324232363742311.99
C10AA02Lovastatin782056712155650.11
C10AA03Pravastatin20911176325580600.28
C10AA04Fluvastatin868179119538627961.96
C10AA05Atorvastatin21285028526986475604.39
C10AA07Rosuvastatin22560.00
C10ABFibrates90900.00
C10AB02Bezafibrate728713851214010.06
C10AB04Gemfibrozil523914621233250.06
C10AB05Fenofibrate418985202862142001857.20
C10AB08Ciprofibrate730092670721902701.11
C10AC01Colestyramine774353110530.01
C10AXOther cholesterol and triglyceride reducers1564651469200.02
C10AX09Ezetimibe400551112000.01
27.21
C10 20040.0
C10AA01Simvastatin8110742929223157557616.02
C10AA02Lovastatin1025826242341360.12
C10AA03Pravastatin554387161700.01
C10AA04Fluvastatin820488037643637722.21
C10AA05Atorvastatin14481713239366133503.36
C10AA07Rosuvastatin398473965012016760.61
C10AB02Bezafibrate1856727823093260.16
C10AB04Gemfibrozil2641544588130.03
C10AB05Fenofibrate501983161154166335328.44
C10AB08Ciprofibrate32868101949860400.50
C10AC01Colestyramine886405126520.01
C10AXOther cholesterol and triglyceride reducers26811180400.00
C10AX09Ezetimibe26913704753480.04
31.50
C10_5
hypolipidemika 2000
bal*000 SkDDDddd/1000/day
C10AAStatiny407468403070123853986.28
C10ABFibraty434061177334125916496.39
C10ACDeriv.lovch kyseln53926076310.00
C10ADDerivty kys.nikotnovej1464821900.00
C10AXOstatn zniujce cholesterol866632452173280.11
8508805839572520419612.79
hypolipidemika 20010.0
0.0
C10AAStatiny579949599626193423039.81
C10ABFibraty459542189391133936046.80
C10ACDeriv.lovch kyseln59228283970.00
C10ADDerivty kys.nikotnovej1241800.00
C10AXOstatn zniujce cholesterol822734102453530.12
10483227927133298983716.74
hypolipidemika 20020.0
0.0
C10AAStatiny7979207860032893795114.68
C10ABFibraty469074207105145520247.38
C10ACDeriv.lovch kyseln790361112840.01
C10AXOstatn zniujce cholesterol707629442122800.11
12748609964134371353922.18
hypolipidemika 20030.0
0.0
C10AAStatiny9415749321923692146018.73
C10ABFibraty504529232415166352718.44
C10ACDeriv.lovch kyseln774353110530.01
C10AXOstatn zniujce cholesterol19641201581200.03
144884111661615362590427.21
hypolipidemika 20040.0
0.0
C10AAStatiny10885985483524400468022.33
C10ABFibraty556059174674179877119.13
C10ACDeriv.lovch kyseln886405126520.01
C10AXOstatn zniujce cholesterol29593815833880.04
16485027272466208843122.18
vyvoj_kvart
Kardiovaskulrne vvoj poda tvrrokovHypolipidemika vvoj poda tvrrokov
kvartlbaleniatis.SkDDDddd/1000/daykvartlbaleniatis.SkDDDddd/1000/day
2000/16827514737902137159734282.222000/1199201132153578208611.90
2000/27355509837354150760001310.212000/2219869149941653064513.44
2000/36543015758286134641631277.042000/3195574133561578883611.91
2000/47172207885619149551210307.722000/4236236168303710263014.61
2001/17481589978006159974100329.162001/1258818190440801373716.49
2001/278325331052161169606993348.992001/2272562207051854228617.58
2001/37151252970388156244747321.492001/3235893179521733122415.08
2001/475476861090270167492711344.642001/4281049215701910259018.73
2002/176837211148879172057695354.032002/1292295225873971738819.99
2002/279856591255948182836573376.212002/23091172399991045849721.52
2002/379562751273383183498827377.572002/32989982353031027578821.14
2002/486206891477116203289705418.292002/43744502952371326186527.29
2003/181927231446410196752229404.842003/13793453017021374334228.28
2003/280594681494925197609843406.602003/23866923115171425820629.34
2003/368976631304984170000101349.792003/33265542672941218764525.08
2003/476453831419506187368624385.532003/43562502856491343671127.65
2004/171799661022938177493509365.212004/13627151645491360836828.00
2004/274977761107931188280574387.412004/23995631830411480858330.47
2004/376171111104271194267332399.732004/34134361803221535161231.59
2004/479083131170951204832112421.472004/44727881993341831986937.70
kardio_1roky
Kardio 2000
balenia*000 SkDDDddd/1000/day
C01CARDIAC THERAPY6832035414144121139422
C02ANTIHYPERTENSIVES4960301127238428899
C03DIURETICS18471486274055572939
C04PERIPHERAL VASODILATORS290704520116441165957
C05VASOPROTECTIVES337239817877466790762
C07BETA BLOCKING AGENTS251171927392963150094
C08CALCIUM CHANNEL BLOCKERS387293966188278294526
C09AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM5208051729849112365782
C10SERUM LIPID REDUCING AGENTS85088058395725204196
278982453219162572112577
0.0
kardio 20010.0
0.0
C01CARDIAC THERAPY6934381466870127475417
C02ANTIHYPERTENSIVES64526518103513349011
C03DIURETICS20156556986759779875
C04PERIPHERAL VASODILATORS282837521231542344743
C05VASOPROTECTIVES366088923136874082245
C07BETA BLOCKING AGENTS296067935317472162694
C08CALCIUM CHANNEL BLOCKERS411894383199291359455
C09AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM580055195149013977527520002001200220032004
C10SERUM LIPID REDUCING AGENTS104832279271432989837C01KARDIOLOGIKA68320356934381713300464918275929124
300130604090825653318552C02ANTIHYPERTENSIVA496030645265771462821900852568
0.0C03DIURETIKA18471482015655222102421862042240802
kardio 20020.0C04PERIFER.VASODILATANCIA29070452828375285281324262962111531
0.0C05VASOPROTEKTIVA33723983660889405206839124353568337
C01CARDIAC THERAPY7133004538806136744469C07BETABLOKATORY25117192960679340769634610923693671
C02ANTIHYPERTENSIVES77146223852217635939C08BLOKTORY KALC.KANLOV38729394118943444208942144394342819
C03DIURETICS22210247996064686580C09ACE-INHIBTORY52080515800551609132858322035815812
C04PERIPHERAL VASODILATORS285281322435643593992C10HYPOLIPIDEMIKA8508801048322127486014488411648502
C05VASOPROTECTIVES405206828965982122584CSPOLU2789824530013060322463443079523730203166
C07BETA BLOCKING AGENTS340769644923082612514
C08CALCIUM CHANNEL BLOCKERS44420891093775109232702
C09AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM60913281244605161340481
C10SERUM LIPID REDUCING AGENTS12748609964124371353820002001200220032004
322463445155325741682799C01KARDIOLOGIKA414144466870538806549551499506
0.0C02ANTIHYPERTENZIVA112723181035238522267614199981
kardio 20030.0C03DIURETIKA6274069867799608460796650
0.0C04PERIFER.VASODILATANCIA201164212315224356211512186990
C01CARDIAC THERAPY6491827549551130630927C05VASOPROTEKTIVA178774231368289659304855267562
C02ANTIHYPERTENSIVES82190026761419926590C07BETABLOKATORY273929353174449230495273410088
C03DIURETICS21862048460764116087C08BLOKTORY KALCIOVHO VSTUPU66188283199210937751166599758738
C04PERIPHERAL VASODILATORS242629621151240683501C09ACE-INHIBTORY729849951490124460514196531259332
C05VASOPROTECTIVES391243530485579304736C10HYPOLIPIDEMIKA5839577927149964121166161727246
C07BETA BLOCKING AGENTS346109249527382786031CSPOLU32191624090825515532556658254406093
C08CALCIUM CHANNEL BLOCKERS42144391166599113349691
C09AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM58322031419653167307331
C10SERUM LIPID REDUCING AGENTS1448841116616153625904
30795237566582575173079820002001200220032004
kardio 20040.0C01KARDIOLOGIKA61.4664.6869.3866.2865.50
0.0C02ANTIHYPERTENSIVA4.286.778.9510.1110.72
C01CARDIAC THERAPY5929124499506129095205C03DIURETIKA28.2030.3332.8232.5331.67
C02ANTIHYPERTENSIVES85256819998121121215C04PERIFER.VASODILATANCIA20.8921.4822.1220.6419.63
C03DIURETICS22408029665062425536C05VASOPROTEKTIVA33.8937.5941.6740.2434.23
C04PERIPHERAL VASODILATORS211153118699038688729C07BETABLOKATORY32.0436.6141.9142.0042.78
C05VASOPROTECTIVES356833726756267469814C08BLOKTORY KALC.KANLOV39.7246.3555.4257.5163.25
C07BETA BLOCKING AGENTS369367141008884319099C09ACE-INHIBTORY57.0170.9281.8684.8888.79
C08CALCIUM CHANNEL BLOCKERS4342819758738124657188C10HYPOLIPIDEMIKA12.7916.7422.1827.2131.50
C09AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM58158121259332175008309CSPOLU290.27331.47376.30381.40388.06
C10SERUM LIPID REDUCING AGENTS164850272724662088431
302031664406093764873526
lieky_ATC1_vyv
lieky 20002001200220032004
bal*000 SkDDDddd/1000/daybal*000 SkDDDddd/1000/daybal*000 SkDDDddd/1000/daybal*000 SkDDDddd/1000/daybal*000 SkDDDddd/1000/day
AALIMENTARY TRACT AND METABOLISM271398042070521625353722317.28268808082238840618189048313.64269180472476099605981248307.45244164102461374555256034281.71215723872171686487047622247.11
BBLOOD AND BLOOD FORMING ORGANS967117079597417721701589.9110157845103347618848828295.63110652261295039203319015103.16110932341434959197350542100.1310871614134338919395841798.41
CCARDIOVASCULAR SYSTEM278982453219161572112576290.27300130604090824653318551331.47322463445155325741682799376.30307952375665824751730797381.40302031664406092764873527388.06
DDERMATOLOGICALS6940872452892321936781163.347409327514093348171670176.657678614554358369363213187.407243328555480351110505178.146806880529875321840040163.29
GGENITO URINARY SYSTEM AND SEX HORMONES296764972800911305989457.36329377491527712683151364.353464136107559713146866866.703229013106470512292519362.37301624497698712198752161.89
HSYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES13600342381742869577014.5614794103657423150869615.9916853054377163642609218.4816604224715783784006219.2017559814025433941187020.00
JANTIINFECTIVES FOR SYSTEMIC USE926712119062805846697329.66985412121677736148381531.19900309322162605615323928.49919778922606635798560129.42840545619221305275608626.77
LANTINEOPLASTIC AND IMMUNOMODULATING AGENTS9811178642344805797924.3810758149828825250091826.64112255312334295564189428.23115273114109125897011529.92114600516716716465315632.80
MMUSCULO-SKELETAL SYSTEM118032881053739272761400138.39120134021172796263783778133.83127349571339584290284664147.28120482391381618270024309137.00116344261284052244321692123.96
NNERVOUS SYSTEM306136841933210202290090102.63308974152435016220611317111.93311018223105928240518043122.03304550233354021243123331123.35287712002902115288642640146.44
PANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENT3561772397447853562.433624482483149548532.513521522440443764652.222730452123133435631.702751501981129407451.49
RRESPIRATORY SYSTEM16174630139670618007720191.3616537649169872019573709399.31155380841901618200221706101.58154176882063767218443533110.83143422811763727262544669133.20
SSENSORY ORGANS29625601811023434534617.4332893582329303794291319.2532900752643334024813320.4230510372768284383983522.2430148842672655110694025.93
VVARIOUS34597273664994554741923.1140865814717054823447424.4735019984936323756960819.0630824505350452986440015.1526704974831802901024414.72
15159607815230475268470752213621573510121834490528517569211447159702406215733223013254787152915311564622958005294180782014931444861712014452329250951691484
20002001200220032004
bal*000 Skbal*000 Skbal*000 Skbal*000 Skbal*000 Sk
ALIMENTARY TRACT AND METABOLISMA271398042070521268808082238840269180472476099244164102461374215723872171686
BLOOD AND BLOOD FORMING ORGANSB9671170795974101578451033476110652261295039110932341434959108716141343389
CARDIOVASCULAR SYSTEMC278982453219161300130604090824322463445155325307952375665824302031664406092
DERMATOLOGICALSD69408724528927409327514093767861455435872433285554806806880529875
GENITO URINARY SYSTEM AND SEX HORMONESG2967649728009329377491527734641361075597322901310647053016244976987
SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONESH13600342381741479410365742168530543771616604224715781755981402543
ANTIINFECTIVES FOR SYSTEMIC USEJ9267121190628098541212167773900309322162609197789226066384054561922130
ANTINEOPLASTIC AND IMMUNOMODULATING AGENTSL9811178642341075814982882112255312334291152731141091211460051671671
MUSCULO-SKELETAL SYSTEMM118032881053739120134021172796127349571339584120482391381618116344261284052
NERVOUS SYSTEMN306136841933210308974152435016311018223105928304550233354021287712002902115
ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTP3561772397436244824831352152244042730452123127515019811
RESPIRATORY SYSTEMR161746301396706165376491698720155380841901618154176882063767143422811763727
SENSORY ORGANSS29625601811023289358232930329007526433330510372768283014884267265
VARIOUSV34597273664994086581471705350199849363230824505350452670497483180
List1
bal. (mil.)Sk (mld)DDD/1000/den
200015.1615.231362
200115.7418.341447
200215.9721.571529
200315.3122.961493
200414.4520.141484
balenia*000 Sk
C015929124499506
C02852568199981
C03224080296650
C042111531186990
C053568337267562
C073693671410088
C084342819758738
C0958158121259332
C101648502727246
List1
00
00
00
00
00
&A
Page &P
bal. (mil.)
Sk (mld)
00
00
00
00
00
00
00
00
00
&A
Page &P
balenia
*000 Sk
DDD 1000 deSpotreba liekov pouvanch pri ochoreniach OOS
c10_7
C10 2000
bal*000 SkDDDddd/1000/day
C10AA01Simvastatin13453817519053586182.72
C10AA03Pravastatin13405610525132242201.64
C10AA04Fluvastatin747284965517001600.86
C10AA05Atorvastatin641467297321024001.07
C10ABFibrates173717300.00
C10AB02Bezafibrate2442152154698030.24
C10AB03Aluminium clofibrate780369156000.01
C10AB04Gemfibrozil1359731142558210.13
C10AB05Fenofibrate29012613024786987954.41
C10AB08Ciprofibrate1049373837531481101.60
C10AB09Etofibrate27717900.00
C10AC01Colestyramine49922871310.00
C10AC02Colestipol40325000.00
C10AD06Acipimox1464821900.00
C10AXOther cholesterol and triglyceride reducers866632452173280.11
12.79
C10 20010.0
C10AA01Simvastatin23109526461288464144.49
C10AA03Pravastatin12661210404132554351.65
C10AA04Fluvastatin627104305515063020.76
C10AA05Atorvastatin13028615608745339602.30
C10AA06Cerivastatin292463183012001920.61
C10ABFibrates2991129900.00
C10AB02Bezafibrate2453646624087630.21
C10AB04Gemfibrozil1784745853766410.19
C10AB05Fenofibrate31373514241095109704.83
C10AB08Ciprofibrate1031143771930934201.57
C10AB09Etofibrate1138200.00
C10AC01Colestyramine55825579720.00
C10AC02Colestipol34274250.00
C10AD06Acipimox1241800.00
C10AXOther cholesterol and triglyceride reducers822734102453530.12
16.74
C10 20020.0
C10AA01Simvastatin471879435709181585169.21
C10AA02Lovastatin1033592218730.01
C10AA03Pravastatin591004841715128850.77
C10AA04Fluvastatin672845208319483520.99
C10AA05Atorvastatin19860724918372956103.70
C10AA06Cerivastatin17197140.00
C10ABFibrates2741027400.00
C10AB02Bezafibrate1439427352398040.12
C10AB04Gemfibrozil1299035102902890.15
C10AB05Fenofibrate344376165352111079915.64
C10AB08Ciprofibrate970403549729112001.48
C10AC01Colestyramine790361112840.01
C10AXOther cholesterol and triglyceride reducers707629442122800.11
22.18
C10 20030.0
C10AA01Simvastatin6131745324232363742311.99
C10AA02Lovastatin782056712155650.11
C10AA03Pravastatin20911176325580600.28
C10AA04Fluvastatin868179119538627961.96
C10AA05Atorvastatin21285028526986475604.39
C10AA07Rosuvastatin22560.00
C10ABFibrates90900.00
C10AB02Bezafibrate728713851214010.06
C10AB04Gemfibrozil523914621233250.06
C10AB05Fenofibrate418985202862142001857.20
C10AB08Ciprofibrate730092670721902701.11
C10AC01Colestyramine774353110530.01
C10AXOther cholesterol and triglyceride reducers1564651469200.02
C10AX09Ezetimibe400551112000.01
27.21
C10 20040.0
C10AA01Simvastatin8110742929223157557616.02
C10AA02Lovastatin1025826242341360.12
C10AA03Pravastatin554387161700.01
C10AA04Fluvastatin820488037643637722.21
C10AA05Atorvastatin14481713239366133503.36
C10AA07Rosuvastatin398473965012016760.61
C10AB02Bezafibrate1856727823093260.16
C10AB04Gemfibrozil2641544588130.03
C10AB05Fenofibrate501983161154166335328.44
C10AB08Ciprofibrate32868101949860400.50
C10AC01Colestyramine886405126520.01
C10AXOther cholesterol and triglyceride reducers26811180400.00
C10AX09Ezetimibe26913704753480.04
31.50
C10_5
hypolipidemika 2000
bal*000 SkDDDddd/1000/day
C10AAStatiny407468403070123853986.28
C10ABFibraty434061177334125916496.39
C10ACDeriv.lovch kyseln53926076310.00
C10ADDerivty kys.nikotnovej1464821900.00
C10AXOstatn zniujce cholesterol866632452173280.11
8508805839572520419612.79
hypolipidemika 20010.0
0.0
C10AAStatiny579949599626193423039.81
C10ABFibraty459542189391133936046.80
C10ACDeriv.lovch kyseln59228283970.00
C10ADDerivty kys.nikotnovej1241800.00
C10AXOstatn zniujce cholesterol822734102453530.12
10483227927133298983716.74
hypolipidemika 20020.0
0.0
C10AAStatiny7979207860032893795114.68
C10ABFibraty469074207105145520247.38
C10ACDeriv.lovch kyseln790361112840.01
C10AXOstatn zniujce cholesterol707629442122800.11
12748609964134371353922.18
hypolipidemika 20030.0
0.0
C10AAStatiny9415749321923692146018.73
C10ABFibraty504529232415166352718.44
C10ACDeriv.lovch kyseln774353110530.01
C10AXOstatn zniujce cholesterol19641201581200.03
144884111661615362590427.21
hypolipidemika 20040.0
0.0
C10AAStatiny10885985483524400468022.33
C10ABFibraty556059174674179877119.13
C10ACDeriv.lovch kyseln886405126520.01
C10AXOstatn zniujce cholesterol29593815833880.04
16485027272466208843122.18
vyvoj_kvart
Kardiovaskulrne vvoj poda tvrrokovHypolipidemika vvoj poda tvrrokov
kvartlbaleniatis.SkDDDddd/1000/daykvartlbaleniatis.SkDDDddd/1000/day
2000/16827514737902137159734282.222000/1199201132153578208611.90
2000/27355509837354150760001310.212000/2219869149941653064513.44
2000/36543015758286134641631277.042000/3195574133561578883611.91
2000/47172207885619149551210307.722000/4236236168303710263014.61
2001/17481589978006159974100329.162001/1258818190440801373716.49
2001/278325331052161169606993348.992001/2272562207051854228617.58
2001/37151252970388156244747321.492001/3235893179521733122415.08
2001/475476861090270167492711344.642001/4281049215701910259018.73
2002/176837211148879172057695354.032002/1292295225873971738819.99
2002/279856591255948182836573376.212002/23091172399991045849721.52
2002/379562751273383183498827377.572002/32989982353031027578821.14
2002/486206891477116203289705418.292002/43744502952371326186527.29
2003/181927231446410196752229404.842003/13793453017021374334228.28
2003/280594681494925197609843406.602003/23866923115171425820629.34
2003/368976631304984170000101349.792003/33265542672941218764525.08
2003/476453831419506187368624385.532003/43562502856491343671127.65
2004/171799661022938177493509365.212004/13627151645491360836828.00
2004/274977761107931188280574387.412004/23995631830411480858330.47
2004/376171111104271194267332399.732004/34134361803221535161231.59
2004/479083131170951204832112421.472004/44727881993341831986937.70
kardio_1roky
Kardio 2000
balenia*000 SkDDDddd/1000/day
C01CARDIAC THERAPY6832035414144121139422
C02ANTIHYPERTENSIVES4960301127238428899
C03DIURETICS18471486274055572939
C04PERIPHERAL VASODILATORS290704520116441165957
C05VASOPROTECTIVES337239817877466790762
C07BETA BLOCKING AGENTS251171927392963150094
C08CALCIUM CHANNEL BLOCKERS387293966188278294526
C09AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM5208051729849112365782
C10SERUM LIPID REDUCING AGENTS85088058395725204196
278982453219162572112577
0.0
kardio 20010.0
0.0
C01CARDIAC THERAPY6934381466870127475417
C02ANTIHYPERTENSIVES64526518103513349011
C03DIURETICS20156556986759779875
C04PERIPHERAL VASODILATORS282837521231542344743
C05VASOPROTECTIVES366088923136874082245
C07BETA BLOCKING AGENTS296067935317472162694
C08CALCIUM CHANNEL BLOCKERS411894383199291359455
C09AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM580055195149013977527520002001200220032004
C10SERUM LIPID REDUCING AGENTS104832279271432989837C01KARDIOLOGIKA68320356934381713300464918275929124
300130604090825653318552C02ANTIHYPERTENSIVA496030645265771462821900852568
0.0C03DIURETIKA18471482015655222102421862042240802
kardio 20020.0C04PERIFER.VASODILATANCIA29070452828375285281324262962111531
0.0C05VASOPROTEKTIVA33723983660889405206839124353568337
C01CARDIAC THERAPY7133004538806136744469C07BETABLOKATORY25117192960679340769634610923693671
C02ANTIHYPERTENSIVES77146223852217635939C08BLOKTORY KALC.KANLOV38729394118943444208942144394342819
C03DIURETICS22210247996064686580C09ACE-INHIBTORY52080515800551609132858322035815812
C04PERIPHERAL VASODILATORS285281322435643593992C10HYPOLIPIDEMIKA8508801048322127486014488411648502
C05VASOPROTECTIVES405206828965982122584CSPOLU2789824530013060322463443079523730203166
C07BETA BLOCKING AGENTS340769644923082612514
C08CALCIUM CHANNEL BLOCKERS44420891093775109232702
C09AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM60913281244605161340481
C10SERUM LIPID REDUCING AGENTS12748609964124371353820002001200220032004
322463445155325741682799C01KARDIOLOGIKA414144466870538806549551499506
0.0C02ANTIHYPERTENSIVA112723181035238522267614199981
kardio 20030.0C03DIURETIKA6274069867799608460796650
0.0C04PERIFER.VASODILATANCIA201164212315224356211512186990
C01CARDIAC THERAPY6491827549551130630927C05VASOPROTEKTIVA178774231368289659304855267562
C02ANTIHYPERTENSIVES82190026761419926590C07BETABLOKATORY273929353174449230495273410088
C03DIURETICS21862048460764116087C08BLOKTORY KALC.KANLOV66188283199210937751166599758738
C04PERIPHERAL VASODILATORS242629621151240683501C09ACE-INHIBTORY729849951490124460514196531259332
C05VASOPROTECTIVES391243530485579304736C10HYPOLIPIDEMIKA5839577927149964121166161727246
C07BETA BLOCKING AGENTS346109249527382786031CSPOLU32191624090825515532556658254406093
C08CALCIUM CHANNEL BLOCKERS42144391166599113349691
C09AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM58322031419653167307331
C10SERUM LIPID REDUCING AGENTS1448841116616153625904
30795237566582575173079820002001200220032004
kardio 20040.0C01KARDIOLOGIKA61.4664.6869.3866.2865.50
0.0C02ANTIHYPERTENSIVA4.286.778.9510.1110.72
C01CARDIAC THERAPY5929124499506129095205C03DIURETIKA28.2030.3332.8232.5331.67
C02ANTIHYPERTENSIVES85256819998121121215C04PERIFER.VASODILATANCIA20.8921.4822.1220.6419.63
C03DIURETICS22408029665062425536C05VASOPROTEKTIVA33.8937.5941.6740.2434.23
C04PERIPHERAL VASODILATORS211153118699038688729C07BETABLOKATORY32.0436.6141.9142.0042.78
C05VASOPROTECTIVES356833726756267469814C08BLOKTORY KALC.KANLOV39.7246.3555.4257.5163.25
C07BETA BLOCKING AGENTS369367141008884319099C09ACE-INHIBTORY57.0170.9281.8684.8888.79
C08CALCIUM CHANNEL BLOCKERS4342819758738124657188C10HYPOLIPIDEMIKA12.7916.7422.1827.2131.50
C09AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM58158121259332175008309CSPOLU290.27331.47376.30381.40388.06
C10SERUM LIPID REDUCING AGENTS164850272724662088431
302031664406093764873526
lieky_ATC1_vyv
lieky 20002001200220032004
bal*000 SkDDDddd/1000/daybal*000 SkDDDddd/1000/daybal*000 SkDDDddd/1000/daybal*000 SkDDDddd/1000/daybal*000 SkDDDddd/1000/day
AALIMENTARY TRACT AND METABOLISM271398042070521625353722317.28268808082238840618189048313.64269180472476099605981248307.45244164102461374555256034281.71215723872171686487047622247.11
BBLOOD AND BLOOD FORMING ORGANS967117079597417721701589.9110157845103347618848828295.63110652261295039203319015103.16110932341434959197350542100.1310871614134338919395841798.41
CCARDIOVASCULAR SYSTEM278982453219161572112576290.27300130604090824653318551331.47322463445155325741682799376.30307952375665824751730797381.40302031664406092764873527388.06
DDERMATOLOGICALS6940872452892321936781163.347409327514093348171670176.657678614554358369363213187.407243328555480351110505178.146806880529875321840040163.29
GGENITO URINARY SYSTEM AND SEX HORMONES296764972800911305989457.36329377491527712683151364.353464136107559713146866866.703229013106470512292519362.37301624497698712198752161.89
HSYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES13600342381742869577014.5614794103657423150869615.9916853054377163642609218.4816604224715783784006219.2017559814025433941187020.00
JANTIINFECTIVES FOR SYSTEMIC USE926712119062805846697329.66985412121677736148381531.19900309322162605615323928.49919778922606635798560129.42840545619221305275608626.77
LANTINEOPLASTIC AND IMMUNOMODULATING AGENTS9811178642344805797924.3810758149828825250091826.64112255312334295564189428.23115273114109125897011529.92114600516716716465315632.80
MMUSCULO-SKELETAL SYSTEM118032881053739272761400138.39120134021172796263783778133.83127349571339584290284664147.28120482391381618270024309137.00116344261284052244321692123.96
NNERVOUS SYSTEM306136841933210202290090102.63308974152435016220611317111.93311018223105928240518043122.03304550233354021243123331123.35287712002902115288642640146.44
PANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENT3561772397447853562.433624482483149548532.513521522440443764652.222730452123133435631.702751501981129407451.49
RRESPIRATORY SYSTEM16174630139670618007720191.3616537649169872019573709399.31155380841901618200221706101.58154176882063767218443533110.83143422811763727262544669133.20
SSENSORY ORGANS29625601811023434534617.4332893582329303794291319.2532900752643334024813320.4230510372768284383983522.2430148842672655110694025.93
VVARIOUS34597273664994554741923.1140865814717054823447424.4735019984936323756960819.0630824505350452986440015.1526704974831802901024414.72
15159607815230475268470752213621573510121834490528517569211447159702406215733223013254787152915311564622958005294180782014931444861712014452329250951691484
20002001200220032004
bal*000 Skbal*000 Skbal*000 Skbal*000 Skbal*000 Sk
ALIMENTARY TRACT AND METABOLISMA271398042070521268808082238840269180472476099244164102461374215723872171686
BLOOD AND BLOOD FORMING ORGANSB9671170795974101578451033476110652261295039110932341434959108716141343389
CARDIOVASCULAR SYSTEMC278982453219161300130604090824322463445155325307952375665824302031664406092
DERMATOLOGICALSD69408724528927409327514093767861455435872433285554806806880529875
GENITO URINARY SYSTEM AND SEX HORMONESG2967649728009329377491527734641361075597322901310647053016244976987
SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONESH13600342381741479410365742168530543771616604224715781755981402543
ANTIINFECTIVES FOR SYSTEMIC USEJ9267121190628098541212167773900309322162609197789226066384054561922130
ANTINEOPLASTIC AND IMMUNOMODULATING AGENTSL9811178642341075814982882112255312334291152731141091211460051671671
MUSCULO-SKELETAL SYSTEMM118032881053739120134021172796127349571339584120482391381618116344261284052
NERVOUS SYSTEMN306136841933210308974152435016311018223105928304550233354021287712002902115
ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTP3561772397436244824831352152244042730452123127515019811
RESPIRATORY SYSTEMR161746301396706165376491698720155380841901618154176882063767143422811763727
SENSORY ORGANSS29625601811023289358232930329007526433330510372768283014884267265
VARIOUSV34597273664994086581471705350199849363230824505350452670497483180
List1
bal. (mil.)Sk (mld)DDD/1000/den
200015.1615.231362
200115.7418.341447
200215.9721.571529
200315.3122.961493
200414.4520.141484
balenia*000 Sk
C015929124499506
C02852568199981
C03224080296650
C042111531186990
C053568337267562
C073693671410088
C084342819758738
C0958158121259332
C101648502727246
List1
00
00
00
00
00
&A
Page &P
bal. (mil.)
Sk (mld)
00
00
00
00
00
00
00
00
00
&A
Page &P
balenia
*000 Sk
Hypolipidemik - skupina statnovStatny maj: 1) rovnak mechanizmus inku 2) podobn fyziklno-chemick a farmakokinetick vlastnosti 3) v terapeutickej dvke je dostatone dokzaten innos (znenie celkovho cholesterolu a LDL-cholesterolu) 4) niektor z nich (simvastatn, pravastatn, lovastatn) preukzatene ovplyvuj mortalitu a morbiditu
Podiel populcie uvajcej hypolipidemik
*IMS Data June 2003 (mio. MOT/number of inhabitants)
0,0%
1,0%
2,0%
3,0%
4,0%
5,0%
6,0%
7,0%
8,0%
9,0%
FRANCE
BELGIUM
CZECH
REPUBLIC
HUNGARY
SLOVAK
REPUBLIC
POLAND
EU AVERAGE
Fiona Read - Dans l'anglais fourni par Fournier : "Directly established in 29 countries". A vrifier.
Photograph: reading of code bars (robot)
Efektvnos pouitia statnov
Cena prpravkuPotrebn vekos dvkyNklady na jednotku (%) poklesu cholesteroluZnanlivos a compliance pacientaZmeny HDL cholesterolu a alch lipidovch parametrov
CENA ZA DDD (Sk)
Chart1
11.100397400611.405141854811.405147537211.40847274738.9937476966
12.172573791812.173395886312.091398571811.85485505789.2496556884
14.972993385914.973236168314.885860098414.28587021939.6885015161
12.189853594712.193300618712.193253641112.19347386410.3383229889
31.97307530531.986954340231.99220134731.937030670432.0107492886
14.931348008513.898342388313.868475598313.874680306913.8059701493
00049.196428571449.1585708977
2000
2001
2002
2003
2004
c10_7
C10 2000
bal*000 SkDDDddd/1000/day
C10AA01Simvastatin13453817519053586182.7232.69
C10AA03Pravastatin13405610525132242201.6432.64
C10AA04Fluvastatin747284965517001600.8629.21
C10AA05Atorvastatin641467297321024001.0734.71
C10ABFibrates173717300.004.05
C10AB02Bezafibrate2442152154698030.2411.10
C10AB03Aluminium clofibrate780369156000.0123.65
C10AB04Gemfibrozil1359731142558210.1312.17
C10AB05Fenofibrate29012613024786987954.4114.97
C10AB08Ciprofibrate1049373837531481101.6012.19
C10AB09Etofibrate27717900.003.91
C10AC01Colestyramine49922871310.0031.97
C10AC02Colestipol40325000.0064.00
C10AD06Acipimox1464821900.0021.92
C10AXOther cholesterol and triglyceride reducers866632452173280.1114.93
12.790.00
C10 20010.00.00
C10AA01Simvastatin23109526461288464144.4929.91
C10AA03Pravastatin12661210404132554351.6531.96
C10AA04Fluvastatin627104305515063020.7628.58
C10AA05Atorvastatin13028615608745339602.3034.43
C10AA06Cerivastatin292463183012001920.6126.52
C10ABFibrates2991129900.003.68
C10AB02Bezafibrate2453646624087630.2111.41
C10AB04Gemfibrozil1784745853766410.1912.17
C10AB05Fenofibrate31373514241095109704.8314.97
C10AB08Ciprofibrate1031143771930934201.5712.19
C10AB09Etofibrate1138200.003.66
C10AC01Colestyramine55825579720.0031.99
C10AC02Colestipol34274250.0063.53
C10AD06Acipimox1241800.0022.22
C10AXOther cholesterol and triglyceride reducers822734102453530.1213.90
16.740.00
C10 20020.00.00
C10AA01Simvastatin471879435709181585169.2123.99
C10AA02Lovastatin1033592218730.0127.07
C10AA03Pravastatin591004841715128850.7732.00
C10AA04Fluvastatin672845208319483520.9926.73
C10AA05Atorvastatin19860724918372956103.7034.16
C10AA06Cerivastatin17197140.0026.61
C10ABFibrates2741027400.003.65
C10AB02Bezafibrate1439427352398040.1211.41
C10AB04Gemfibrozil1299035102902890.1512.09
C10AB05Fenofibrate344376165352111079915.6414.89
C10AB08Ciprofibrate970403549729112001.4812.19
C10AC01Colestyramine790361112840.0131.99
C10AXOther cholesterol and triglyceride reducers707629442122800.1113.87
22.180.00
C10 20030.00.00
C10AA01Simvastatin6131745324232363742311.9922.52
C10AA02Lovastatin782056712155650.1126.31
C10AA03Pravastatin20911176325580600.2831.60
C10AA04Fluvastatin868179119538627961.9623.61
C10AA05Atorvastatin21285028526986475604.3932.99
C10AA07Rosuvastatin22560.0035.71
C10ABFibrates90900.000.00
C10AB02Bezafibrate728713851214010.0611.41
C10AB04Gemfibrozil523914621233250.0611.85
C10AB05Fenofibrate418985202862142001857.2014.29
C10AB08Ciprofibrate730092670721902701.1112.19
C10AC01Colestyramine774353110530.0131.94
C10AXOther cholesterol and triglyceride reducers1564651469200.0213.87
C10AX09Ezetimibe400551112000.0149.20
27.210.00
C10 20040.00.00
C10AA01Simvastatin8110742929223157557616.029.28
C10AA02Lovastatin1025826242341360.1211.21
C10AA03Pravastatin554387161700.0123.93
C10AA04Fluvastatin820488037643637722.2118.42
C10AA05Atorvastatin14481713239366133503.3620.02
C10AA07Rosuvastatin398473965012016760.6133.00
C10AB02Bezafibrate1856727823093260.168.99
C10AB04Gemfibrozil2641544588130.039.25
C10AB05Fenofibrate501983161154166335328.449.69
C10AB08Ciprofibrate32868101949860400.5010.34
C10AC01Colestyramine886405126520.0132.01
C10AXOther cholesterol and triglyceride reducers26811180400.0013.81
C10AX09Ezetimibe26913704753480.0449.16
31.50
C10_5
hypolipidemika 2000
bal*000 SkDDDddd/1000/day
C10AAStatiny407468403070123853986.28989.2132.54
C10ABFibraty434061177334125916496.39408.5514.08
C10ACDeriv.lovch kyseln53926076310.00482.3734.07
C10ADDerivty kys.nikotnovej1464821900.00328.7721.92
C10AXOstatn zniujce cholesterol866632452173280.11374.4514.93
8508805839572520419612.79686.3023.17
hypolipidemika 20010.00.000.00
0.00.000.00
C10AAStatiny579949599626193423039.811033.9331.00
C10ABFibraty459542189391133936046.80412.1314.14
C10ACDeriv.lovch kyseln59228283970.00476.3533.58
C10ADDerivty kys.nikotnovej1241800.00333.3322.22
C10AXOstatn zniujce cholesterol822734102453530.12414.4913.90
10483227927133298983716.74756.1724.03
hypolipidemika 20020.00.000.00
0.00.000.00
C10AAStatiny7979207860032893795114.68985.0627.16
C10ABFibraty469074207105145520247.38441.5214.23
C10ACDeriv.lovch kyseln790361112840.01456.9631.99
C10AXOstatn zniujce cholesterol707629442122800.11416.0513.87
12748609964134371353922.18781.5922.79
hypolipidemika 20030.00.000.00
0.00.000.00
C10AAStatiny9415749321923692146018.73990.0425.25
C10ABFibraty504529232415166352718.44460.6613.97
C10ACDeriv.lovch kyseln774353110530.01456.0731.94
C10AXOstatn zniujce cholesterol19641201581200.03611.5120.66
144884111661615362590427.21804.8921.75
hypolipidemika 20040.00.000.00
0.00.000.00
C10AAStatiny10885985483524400468022.33503.7212.46
C10ABFibraty556059174674179877119.13314.139.71
C10ACDeriv.lovch kyseln886405126520.01457.1132.01
C10AXOstatn zniujce cholesterol29593815833880.041289.2945.75
16485027272466208843122.18441.1611.71
vyvoj_kvart
Kardiovaskulrne vvoj poda tvrrokovHypolipidemika vvoj poda tvrrokov
kvartlbaleniatis.SkDDDddd/1000/daykvartlbaleniatis.SkDDDddd/1000/day
2000/16827514737902137159734282.222000/1199201132153578208611.90
2000/27355509837354150760001310.212000/2219869149941653064513.44
2000/36543015758286134641631277.042000/3195574133561578883611.91
2000/47172207885619149551210307.722000/4236236168303710263014.61
2001/17481589978006159974100329.162001/1258818190440801373716.49
2001/278325331052161169606993348.992001/2272562207051854228617.58
2001/37151252970388156244747321.492001/3235893179521733122415.08
2001/475476861090270167492711344.642001/4281049215701910259018.73
2002/176837211148879172057695354.032002/1292295225873971738819.99
2002/279856591255948182836573376.212002/23091172399991045849721.52
2002/379562751273383183498827377.572002/32989982353031027578821.14
2002/486206891477116203289705418.292002/43744502952371326186527.29
2003/181927231446410196752229404.842003/13793453017021374334228.28
2003/280594681494925197609843406.602003/23866923115171425820629.34
2003/368976631304984170000101349.792003/33265542672941218764525.08
2003/476453831419506187368624385.532003/43562502856491343671127.65
2004/171799661022938177493509365.212004/13627151645491360836828.00
2004/274977761107931188280574387.412004/23995631830411480858330.47
2004/376171111104271194267332399.732004/34134361803221535161231.59
2004/479083131170951204832112421.472004/44727881993341831986937.70
kardio_1roky
Kardio 2000
balenia*000 SkDDDddd/1000/day
C01CARDIAC THERAPY683203541414412113942261.46
C02ANTIHYPERTENSIVES49603011272384288994.28
C03DIURETICS1847148627405557293928.20
C04PERIPHERAL VASODILATORS29070452011644116595720.89
C05VASOPROTECTIVES33723981787746679076233.89
C07BETA BLOCKING AGENTS25117192739296315009432.04
C08CALCIUM CHANNEL BLOCKERS38729396618827829452639.72
C09AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM520805172984911236578257.01
C10SERUM LIPID REDUCING AGENTS8508805839572520419612.79
278982453219162572112577290.27
0.0
kardio 20010.0
0.0
C01CARDIAC THERAPY693438146687012747541764.68
C02ANTIHYPERTENSIVES645265181035133490116.77
C03DIURETICS2015655698675977987530.33
C04PERIPHERAL VASODILATORS28283752123154234474321.48
C05VASOPROTECTIVES36608892313687408224537.59
C07BETA BLOCKING AGENTS29606793531747216269436.61
C08CALCIUM CHANNEL BLOCKERS41189438319929135945546.35
C09AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM580055195149013977527570.92
C10SERUM LIPID REDUCING AGENTS10483227927143298983716.74
300130604090825653318552331.47
0.0
kardio 20020.0
0.0
C01CARDIAC THERAPY713300453880613674446969.38
C02ANTIHYPERTENSIVES771462238522176359398.95
C03DIURETICS2221024799606468658032.82
C04PERIPHERAL VASODILATORS28528132243564359399222.12
C05VASOPROTECTIVES40520682896598212258441.67
C07BETA BLOCKING AGENTS34076964492308261251441.91
C08CALCIUM CHANNEL BLOCKERS4442089109377510923270255.42
C09AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM6091328124460516134048181.86
C10SERUM LIPID REDUCING AGENTS12748609964124371353822.18
322463445155325741682799376.30
0.0
kardio 20030.0
0.0
C01CARDIAC THERAPY649182754955113063092766.28
C02ANTIHYPERTENSIVES8219002676141992659010.11
C03DIURETICS2186204846076411608732.53
C04PERIPHERAL VASODILATORS24262962115124068350120.64
C05VASOPROTECTIVES39124353048557930473640.24
C07BETA BLOCKING AGENTS34610924952738278603142.00
C08CALCIUM CHANNEL BLOCKERS4214439116659911334969157.51
C09AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM5832203141965316730733184.88
C10SERUM LIPID REDUCING AGENTS144884111661615362590427.21
307952375665825751730798381.40
kardio 20040.0
0.0
C01CARDIAC THERAPY592912449950612909520565.50
C02ANTIHYPERTENSIVES8525681999812112121510.72
C03DIURETICS2240802966506242553631.67
C04PERIPHERAL VASODILATORS21115311869903868872919.63
C05VASOPROTECTIVES35683372675626746981434.23
C07BETA BLOCKING AGENTS36936714100888431909942.78
C08CALCIUM CHANNEL BLOCKERS434281975873812465718863.25
C09AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM5815812125933217500830988.79
C10SERUM LIPID REDUCING AGENTS16485027272466208843131.50
302031664406093764873526388.06
lieky_ATC1_vyv
lieky 20002001200220032004
bal*000 SkDDDddd/1000/daybal*000 SkDDDddd/1000/daybal*000 SkDDDddd/1000/daybal*000 SkDDDddd/1000/daybal*000 SkDDDddd/1000/day
AALIMENTARY TRACT AND METABOLISM271398042070521625353722317.28268808082238840618189048313.64269180472476099605981248307.45244164102461374555256034281.71215723872171686487047622247.11
BBLOOD AND BLOOD FORMING ORGANS967117079597417721701589.9110157845103347618848828295.63110652261295039203319015103.16110932341434959197350542100.1310871614134338919395841798.41
CCARDIOVASCULAR SYSTEM278982453219161572112576290.27300130604090824653318551331.47322463445155325741682799376.30307952375665824751730797381.40302031664406092764873527388.06
DDERMATOLOGICALS6940872452892321936781163.347409327514093348171670176.657678614554358369363213187.407243328555480351110505178.146806880529875321840040163.29
GGENITO URINARY SYSTEM AND SEX HORMONES296764972800911305989457.36329377491527712683151364.353464136107559713146866866.703229013106470512292519362.37301624497698712198752161.89
HSYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES13600342381742869577014.5614794103657423150869615.9916853054377163642609218.4816604224715783784006219.2017559814025433941187020.00
JANTIINFECTIVES FOR SYSTEMIC USE926712119062805846697329.66985412121677736148381531.19900309322162605615323928.49919778922606635798560129.42840545619221305275608626.77
LANTINEOPLASTIC AND IMMUNOMODULATING AGENTS9811178642344805797924.3810758149828825250091826.64112255312334295564189428.23115273114109125897011529.92114600516716716465315632.80
MMUSCULO-SKELETAL SYSTEM118032881053739272761400138.39120134021172796263783778133.83127349571339584290284664147.28120482391381618270024309137.00116344261284052244321692123.96
NNERVOUS SYSTEM306136841933210202290090102.63308974152435016220611317111.93311018223105928240518043122.03304550233354021243123331123.35287712002902115288642640146.44
PANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENT3561772397447853562.433624482483149548532.513521522440443764652.222730452123133435631.702751501981129407451.49
RRESPIRATORY SYSTEM16174630139670618007720191.3616537649169872019573709399.31155380841901618200221706101.58154176882063767218443533110.83143422811763727262544669133.20
SSENSORY ORGANS29625601811023434534617.4332893582329303794291319.2532900752643334024813320.4230510372768284383983522.2430148842672655110694025.93
VVARIOUS34597273664994554741923.1140865814717054823447424.4735019984936323756960819.0630824505350452986440015.1526704974831802901024414.72
15159607815230475268470752213621573510121834490528517569211447159702406215733223013254787152915311564622958005294180782014931444861712014452329250951691484
20002001200220032004
bal*000 Skbal*000 Skbal*000 Skbal*000 Skbal*000 Sk
ALIMENTARY TRACT AND METABOLISMA271398042070521268808082238840269180472476099244164102461374215723872171686
BLOOD AND BLOOD FORMING ORGANSB9671170795974101578451033476110652261295039110932341434959108716141343389
CARDIOVASCULAR SYSTEMC278982453219161300130604090824322463445155325307952375665824302031664406092
DERMATOLOGICALSD69408724528927409327514093767861455435872433285554806806880529875
GENITO URINARY SYSTEM AND SEX HORMONESG2967649728009329377491527734641361075597322901310647053016244976987
SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONESH13600342381741479410365742168530543771616604224715781755981402543
ANTIINFECTIVES FOR SYSTEMIC USEJ9267121190628098541212167773900309322162609197789226066384054561922130
ANTINEOPLASTIC AND IMMUNOMODULATING AGENTSL9811178642341075814982882112255312334291152731141091211460051671671
MUSCULO-SKELETAL SYSTEMM118032881053739120134021172796127349571339584120482391381618116344261284052
NERVOUS SYSTEMN306136841933210308974152435016311018223105928304550233354021287712002902115
ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTP3561772397436244824831352152244042730452123127515019811
RESPIRATORY SYSTEMR161746301396706165376491698720155380841901618154176882063767143422811763727
SENSORY ORGANSS29625601811023289358232930329007526433330510372768283014884267265
VARIOUSV34597273664994086581471705350199849363230824505350452670497483180
Sheet1
C10 2000
2000200120022003200420002001200220032004
C10AA01Simvastatin32.6929.9123.9922.529.28C10AB02Bezafibrate11.1011.4111.4111.418.99
C10AA03Pravastatin32.6431.9632.0031.6023.93C10AB04Gemfibrozil12.1712.1712.0911.859.25
C10AA02Lovastatin0.000.0027.0726.3111.21C10AB05Fenofibrate14.9714.9714.8914.299.69
C10AA04Fluvastatin29.2128.5826.7323.6118.42C10AB08Ciprofibrate12.1912.1912.1912.1910.34
C10AA05Atorvastatin34.7134.4334.1632.9920.02C10AC01Colestyramine31.9731.9931.9931.9432.01
C10AA08Rosuvastatin0.000.000.0036.7133.00C10AXOther hypolipidemics14.9313.9013.8713.8713.81
C10ABFibrates4.053.683.650.000.00C10AX09Ezetimibe0.000.000.0049.2049.16
C10AB02Bezafibrate11.1011.4111.4111.418.99
C10AB04Gemfibrozil12.1712.1712.0911.859.25
C10AB05Fenofibrate14.9714.9714.8914.299.69
C10AB08Ciprofibrate12.1912.1912.1912.1910.34
C10AC01Colestyramine31.9731.9931.9931.9432.01
C10AXOther cholesterol and triglyceride reducers14.9313.9013.8713.8713.81
C10AX09Ezetimibe0.000.000.0049.2049.16
C10 2001
C10AA01Simvastatin29.9117812031
C10AA03Pravastatin31.9591698191
C10AA04Fluvastatin28.5832455909
C10AA05Atorvastatin34.4261969669
C10ABFibrates3.6789297659
C10AB02Bezafibrate11.4051418548
C10AB04Gemfibrozil12.1733958863
C10AB05Fenofibrate14.9732361683
C10AB08Ciprofibrate12.1933006187
C10AB09Etofibrate3.6585365854
C10AC01Colestyramine31.9869543402
C10AC02Colestipol63.5294117647
C10AD06Acipimox22.2222222222
C10AXOther cholesterol and triglyceride reducers13.8983423883
C10 2002
C10AA01Simvastatin23.9947471478
C10AA02Lovastatin27.0653316875
C10AA03Pravastatin32.0030934275
C10AA04Fluvastatin26.7318225865
C10AA05Atorvastatin34.1551974407
C10AA06Cerivastatin26.6106442577
C10ABFibrates3.6496350365
C10AB02Bezafibrate11.4051475372
C10AB04Gemfibrozil12.0913985718
C10AB05Fenofibrate14.8858600984
C10AB08Ciprofibrate12.1932536411
C10AC01Colestyramine31.992201347
C10AXOther cholesterol and triglyceride reducers13.8684755983
C10 2003
C10AA01Simvastatin22.5245789272
C10AA02Lovastatin26.3076102336
C10AA03Pravastatin31.5951689782
C10AA04Fluvastatin23.6085467625
C10AA05Atorvastatin32.9883805374
C10AA07Rosuvastatin35.7142857143
C10AB02Bezafibrate11.4084727473
C10AB04Gemfibrozil11.8548550578
C10AB05Fenofibrate14.2858702193
C10AB08Ciprofibrate12.193473864
C10AC01Colestyramine31.9370306704
C10AXOther cholesterol and triglyceride reducers13.8746803069
C10AX09Ezetimibe49.1964285714
C10 2004
C10AA01Simvastatin9.2768537302
C10AA02Lovastatin11.2071616496
C10AA03Pravastatin23.9332096475
C10AA04Fluvastatin18.4189274783
C10AA05Atorvastatin20.0190523713
C10AA07Rosuvastatin32.995582836
C10AB02Bezafibrate8.9937476966
C10AB04Gemfibrozil9.2496556884
C10AB05Fenofibrate9.6885015161
C10AB08Ciprofibrate10.3383229889
C10AC01Colestyramine32.0107492886
C10AXOther cholesterol and triglyceride reducers13.8059701493
C10AX09Ezetimibe49.1585708977
Sheet1
2000
2001
2002
2003
2004
List1
2000
2001
2002
2003
2004
2000
2001
2002
2003
2004
bal. (mil.)Sk (mld)DDD/1000/den
200015.1615.231362
200115.7418.341447
200215.9721.571529
200315.3122.961493
200414.4520.141484
balenia*000 Sk
C015929124499506
C02852568199981
C03224080296650
C042111531186990
C053568337267562
C073693671410088
C084342819758738
C0958158121259332
C101648502727246
&A
Page &P
bal. (mil.)
Sk (mld)
&A
Page &P
balenia
*000 Sk
MBD000057E7.xls
List1
cenov rozmedziepriem.cena
Simvastatn199944,38 - 100,2769.98
200112,67 - 102,6435.94
Pravastatn199928,38 - 44,3736.38
200128,38 - 75,2049.68
Fluvastatn199926,61 - 39,2132.91
200126,61 - 39,2132.91
Cerivastatn199938,50 - 57,0648.05
200138,50 - 67,4652.86
Bezafibrt19995,52 - 24,4211.33
20014,97 - 5,525.25
Gemfibrozil19993,34 - 14,647.56
20013,34 - 6,804.86
Fenofibrt19997,00 - 21,7611.99
20017,00 - 29,0416.12
Cholestyramn19992,97 - 13,276.6
20012,97 - 13,276.6
In ltky zniujce19994,83 - 53,8422.7
cholest. a triglyc.20014,83 - 20,1516.12
SimvastatnPravastatnFluvastatnCerivastatnBezafibrtGemfibrozilFenofibrtCholestyramnIn ltky
199969.9836.3832.9148.0511.337.5611.996.622.7
200135.9449.6832.9152.865.254.8616.126.616.12
List1
69.9835.94
36.3849.68
32.9132.91
48.0552.86
11.335.25
7.564.86
11.9916.12
6.66.6
22.716.12
1999
2001
List2
69.9835.94
36.3849.68
32.9132.91
48.0552.86
11.335.25
7.564.86
11.9916.12
6.66.6
22.716.12
1999
2001
Sk
Primern cena
List3
Chart2
32.693130952829.911781203123.994747147822.52457892729.2768537302
32.643864252431.959169819132.003093427531.595168978223.9332096475
0027.065331687526.307610233611.2071616496
29.206074722428.583245590926.731822586523.608546762518.4189274783
34.709379756534.426196966934.155197440732.988380537420.0190523713
00036.714285714332.995582836
2000
2001
2002
2003
2004
c10_7
C10 2000
bal*000 SkDDDddd/1000/day
C10AA01Simvastatin13453817519053586182.7232.69
C10AA03Pravastatin13405610525132242201.6432.64
C10AA04Fluvastatin747284965517001600.8629.21
C10AA05Atorvastatin641467297321024001.0734.71
C10ABFibrates173717300.004.05
C10AB02Bezafibrate2442152154698030.2411.10
C10AB03Aluminium clofibrate780369156000.0123.65
C10AB04Gemfibrozil1359731142558210.1312.17
C10AB05Fenofibrate29012613024786987954.4114.97
C10AB08Ciprofibrate1049373837531481101.6012.19
C10AB09Etofibrate27717900.003.91
C10AC01Colestyramine49922871310.0031.97
C10AC02Colestipol40325000.0064.00
C10AD06Acipimox1464821900.0021.92
C10AXOther cholesterol and triglyceride reducers866632452173280.1114.93
12.790.00
C10 20010.00.00
C10AA01Simvastatin23109526461288464144.4929.91
C10AA03Pravastatin12661210404132554351.6531.96
C10AA04Fluvastatin627104305515063020.7628.58
C10AA05Atorvastatin13028615608745339602.3034.43
C10AA06Cerivastatin292463183012001920.6126.52
C10ABFibrates2991129900.003.68
C10AB02Bezafibrate2453646624087630.2111.41
C10AB04Gemfibrozil1784745853766410.1912.17
C10AB05Fenofibrate31373514241095109704.8314.97
C10AB08Ciprofibrate1031143771930934201.5712.19
C10AB09Etofibrate1138200.003.66
C10AC01Colestyramine55825579720.0031.99
C10AC02Colestipol34274250.0063.53
C10AD06Acipimox1241800.0022.22
C10AXOther cholesterol and triglyceride reducers822734102453530.1213.90
16.740.00
C10 20020.00.00
C10AA01Simvastatin471879435709181585169.2123.99
C10AA02Lovastatin1033592218730.0127.07
C10AA03Pravastatin591004841715128850.7732.00
C10AA04Fluvastatin672845208319483520.9926.73
C10AA05Atorvastatin19860724918372956103.7034.16
C10AA06Cerivastatin17197140.0026.61
C10ABFibrates2741027400.003.65
C10AB02Bezafibrate1439427352398040.1211.41
C10AB04Gemfibrozil1299035102902890.1512.09
C10AB05Fenofibrate344376165352111079915.6414.89
C10AB08Ciprofibrate970403549729112001.4812.19
C10AC01Colestyramine790361112840.0131.99
C10AXOther cholesterol and triglyceride reducers707629442122800.1113.87
22.180.00
C10 20030.00.00
C10AA01Simvastatin6131745324232363742311.9922.52
C10AA02Lovastatin782056712155650.1126.31
C10AA03Pravastatin20911176325580600.2831.60
C10AA04Fluvastatin868179119538627961.9623.61
C10AA05Atorvastatin21285028526986475604.3932.99
C10AA07Rosuvastatin22560.0035.71
C10ABFibrates90900.000.00
C10AB02Bezafibrate728713851214010.0611.41
C10AB04Gemfibrozil523914621233250.0611.85
C10AB05Fenofibrate418985202862142001857.2014.29
C10AB08Ciprofibrate730092670721902701.1112.19
C10AC01Colestyramine774353110530.0131.94
C10AXOther cholesterol and triglyceride reducers1564651469200.0213.87
C10AX09Ezetimibe400551112000.0149.20
27.210.00
C10 20040.00.00
C10AA01Simvastatin8110742929223157557616.029.28
C10AA02Lovastatin1025826242341360.1211.21
C10AA03Pravastatin554387161700.0123.93
C10AA04Fluvastatin820488037643637722.2118.42
C10AA05Atorvastatin14481713239366133503.3620.02
C10AA07Rosuvastatin398473965012016760.6133.00
C10AB02Bezafibrate1856727823093260.168.99
C10AB04Gemfibrozil2641544588130.039.25
C10AB05Fenofibrate501983161154166335328.449.69
C10AB08Ciprofibrate32868101949860400.5010.34
C10AC01Colestyramine886405126520.0132.01
C10AXOther cholesterol and triglyceride reducers26811180400.0013.81
C10AX09Ezetimibe26913704753480.0449.16
31.50
C10_5
hypolipidemika 2000
bal*000 SkDDDddd/1000/day
C10AAStatiny407468403070123853986.28989.2132.54
C10ABFibraty434061177334125916496.39408.5514.08
C10ACDeriv.lovch kyseln53926076310.00482.3734.07
C10ADDerivty kys.nikotnovej1464821900.00328.7721.92
C10AXOstatn zniujce cholesterol866632452173280.11374.4514.93
8508805839572520419612.79686.3023.17
hypolipidemika 20010.00.000.00
0.00.000.00
C10AAStatiny579949599626193423039.811033.9331.00
C10ABFibraty459542189391133936046.80412.1314.14
C10ACDeriv.lovch kyseln59228283970.00476.3533.58
C10ADDerivty kys.nikotnovej1241800.00333.3322.22
C10AXOstatn zniujce cholesterol822734102453530.12414.4913.90
10483227927133298983716.74756.1724.03
hypolipidemika 20020.00.000.00
0.00.000.00
C10AAStatiny7979207860032893795114.68985.0627.16
C10ABFibraty469074207105145520247.38441.5214.23
C10ACDeriv.lovch kyseln790361112840.01456.9631.99
C10AXOstatn zniujce cholesterol707629442122800.11416.0513.87
12748609964134371353922.18781.5922.79
hypolipidemika 20030.00.000.00
0.00.000.00
C10AAStatiny9415749321923692146018.73990.0425.25
C10ABFibraty504529232415166352718.44460.6613.97
C10ACDeriv.lovch kyseln774353110530.01456.0731.94
C10AXOstatn zniujce cholesterol19641201581200.03611.5120.66
144884111661615362590427.21804.8921.75
hypolipidemika 20040.00.000.00
0.00.000.00
C10AAStatiny10885985483524400468022.33503.7212.46
C10ABFibraty556059174674179877119.13314.139.71
C10ACDeriv.lovch kyseln886405126520.01457.1132.01
C10AXOstatn zniujce cholesterol29593815833880.041289.2945.75
16485027272466208843122.18441.1611.71
vyvoj_kvart
Kardiovaskulrne vvoj poda tvrrokovHypolipidemika vvoj poda tvrrokov
kvartlbaleniatis.SkDDDddd/1000/daykvartlbaleniatis.SkDDDddd/1000/day
2000/16827514737902137159734282.222000/1199201132153578208611.90
2000/27355509837354150760001310.212000/2219869149941653064513.44
2000/36543015758286134641631277.042000/3195574133561578883611.91
2000/47172207885619149551210307.722000/4236236168303710263014.61
2001/17481589978006159974100329.162001/1258818190440801373716.49
2001/278325331052161169606993348.992001/2272562207051854228617.58
2001/37151252970388156244747321.492001/3235893179521733122415.08
2001/475476861090270167492711344.642001/4281049215701910259018.73
2002/176837211148879172057695354.032002/1292295225873971738819.99
2002/279856591255948182836573376.212002/23091172399991045849721.52
2002/379562751273383183498827377.572002/32989982353031027578821.14
2002/486206891477116203289705418.292002/43744502952371326186527.29
2003/181927231446410196752229404.842003/13793453017021374334228.28
2003/280594681494925197609843406.602003/23866923115171425820629.34
2003/368976631304984170000101349.792003/33265542672941218764525.08
2003/476453831419506187368624385.532003/43562502856491343671127.65
2004/171799661022938177493509365.212004/13627151645491360836828.00
2004/274977761107931188280574387.412004/23995631830411480858330.47
2004/376171111104271194267332399.732004/34134361803221535161231.59
2004/479083131170951204832112421.472004/44727881993341831986937.70
kardio_1roky
Kardio 2000
balenia*000 SkDDDddd/1000/day
C01CARDIAC THERAPY683203541414412113942261.46
C02ANTIHYPERTENSIVES49603011272384288994.28
C03DIURETICS1847148627405557293928.20
C04PERIPHERAL VASODILATORS29070452011644116595720.89
C05VASOPROTECTIVES33723981787746679076233.89
C07BETA BLOCKING AGENTS25117192739296315009432.04
C08CALCIUM CHANNEL BLOCKERS38729396618827829452639.72
C09AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM520805172984911236578257.01
C10SERUM LIPID REDUCING AGENTS8508805839572520419612.79
278982453219162572112577290.27
0.0
kardio 20010.0
0.0
C01CARDIAC THERAPY693438146687012747541764.68
C02ANTIHYPERTENSIVES645265181035133490116.77
C03DIURETICS2015655698675977987530.33
C04PERIPHERAL VASODILATORS28283752123154234474321.48
C05VASOPROTECTIVES36608892313687408224537.59
C07BETA BLOCKING AGENTS29606793531747216269436.61
C08CALCIUM CHANNEL BLOCKERS41189438319929135945546.35
C09AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM580055195149013977527570.92
C10SERUM LIPID REDUCING AGENTS10483227927143298983716.74
300130604090825653318552331.47
0.0
kardio 20020.0
0.0
C01CARDIAC THERAPY713300453880613674446969.38
C02ANTIHYPERTENSIVES771462238522176359398.95
C03DIURETICS2221024799606468658032.82
C04PERIPHERAL VASODILATORS28528132243564359399222.12
C05VASOPROTECTIVES40520682896598212258441.67
C07BETA BLOCKING AGENTS34076964492308261251441.91
C08CALCIUM CHANNEL BLOCKERS4442089109377510923270255.42
C09AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM6091328124460516134048181.86
C10SERUM LIPID REDUCING AGENTS12748609964124371353822.18
322463445155325741682799376.30
0.0
kardio 20030.0
0.0
C01CARDIAC THERAPY649182754955113063092766.28
C02ANTIHYPERTENSIVES8219002676141992659010.11
C03DIURETICS2186204846076411608732.53
C04PERIPHERAL VASODILATORS24262962115124068350120.64
C05VASOPROTECTIVES39124353048557930473640.24
C07BETA BLOCKING AGENTS34610924952738278603142.00
C08CALCIUM CHANNEL BLOCKERS4214439116659911334969157.51
C09AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM5832203141965316730733184.88
C10SERUM LIPID REDUCING AGENTS144884111661615362590427.21
307952375665825751730798381.40
kardio 20040.0
0.0
C01CARDIAC THERAPY592912449950612909520565.50
C02ANTIHYPERTENSIVES8525681999812112121510.72
C03DIURETICS2240802966506242553631.67
C04PERIPHERAL VASODILATORS21115311869903868872919.63
C05VASOPROTECTIVES35683372675626746981434.23
C07BETA BLOCKING AGENTS36936714100888431909942.78
C08CALCIUM CHANNEL BLOCKERS434281975873812465718863.25
C09AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM5815812125933217500830988.79
C10SERUM LIPID REDUCING AGENTS16485027272466208843131.50
302031664406093764873526388.06
lieky_ATC1_vyv
lieky 20002001200220032004
bal*000 SkDDDddd/1000/daybal*000 SkDDDddd/1000/daybal*000 SkDDDddd/1000/daybal*000 SkDDDddd/1000/daybal*000 SkDDDddd/1000/day
AALIMENTARY TRACT AND METABOLISM271398042070521625353722317.28268808082238840618189048313.64269180472476099605981248307.45244164102461374555256034281.71215723872171686487047622247.11
BBLOOD AND BLOOD FORMING ORGANS967117079597417721701589.9110157845103347618848828295.63110652261295039203319015103.16110932341434959197350542100.1310871614134338919395841798.41
CCARDIOVASCULAR SYSTEM278982453219161572112576290.27300130604090824653318551331.47322463445155325741682799376.30307952375665824751730797381.40302031664406092764873527388.06
DDERMATOLOGICALS6940872452892321936781163.347409327514093348171670176.657678614554358369363213187.407243328555480351110505178.146806880529875321840040163.29
GGENITO URINARY SYSTEM AND SEX HORMONES296764972800911305989457.36329377491527712683151364.353464136107559713146866866.703229013106470512292519362.37301624497698712198752161.89
HSYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES13600342381742869577014.5614794103657423150869615.9916853054377163642609218.4816604224715783784006219.2017559814025433941187020.00
JANTIINFECTIVES FOR SYSTEMIC USE926712119062805846697329.66985412121677736148381531.19900309322162605615323928.49919778922606635798560129.42840545619221305275608626.77
LANTINEOPLASTIC AND IMMUNOMODULATING AGENTS9811178642344805797924.3810758149828825250091826.64112255312334295564189428.23115273114109125897011529.92114600516716716465315632.80
MMUSCULO-SKELETAL SYSTEM118032881053739272761400138.39120134021172796263783778133.83127349571339584290284664147.28120482391381618270024309137.00116344261284052244321692123.96
NNERVOUS SYSTEM306136841933210202290090102.63308974152435016220611317111.93311018223105928240518043122.03304550233354021243123331123.35287712002902115288642640146.44
PANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENT3561772397447853562.433624482483149548532.513521522440443764652.222730452123133435631.702751501981129407451.49
RRESPIRATORY
