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2. Treatmentofbreastcancer Surgeryforbreastcancer Localversussystemictherapy Local Mastectomy y Modifiedradicalmastectomy(MRM) Breastconservingsurgery(BCS) Breastreconstructivesurgery Breastimplant TRAM h d L Lymphnodesurgery Axillarylymphnodedissection(ALND) Sentinellymphnodebiopsy(SLNB) Surgery Radiationtherapy Systemic Chemotherapy H th Hormonetherapy Targettherapy adjuvantversusneoadjuvant therapy Breastsurgery Axillarylymphnodesdissection (ALND) i i I III II I 2

3. Thoracodorsal n. ,art. & vein Intercostobrachial n. Axillary vein y Long thoracic n. Serratus collateral artery Sentinellymphnodebiopsy (SLNB) Breastreconstruction 3

4. Radiationtherapy Chemotherapy Jugular vein J l i Subclavian vein Cephalic vein 4

5. Chemotherapyinducedperipheral neuropathy(CIPN) Chemobrain Weightgain Sequelae oftheupperquarter afterbreastcancertreatment Prognosisofthefollowingsurgeryand radiationforbreastcancer included32studiestoanalyze shoulderrestriction