22A20130012771
(%) 40% 30% 30%
()
)
) Reproductive Physiomics Future-oriented Creative Research & Education Center
of Excellence
KyuBum Kwack
()
4('16.3~'17.2) 5('17.3~'18.2)
245 247
2013.9.1. ~ 2020.8.31.(84)
2016.3.1. ~ 2018.2.28.(24)
BK21 .
,
.
2018 07 13
()
()
()
BK21 ()
1-248
()
(reproduction ) ,
. 2010
15~39 13.5% . 8 1 ,
635000 . 45 140 .
.
(reproductive rate ) , ,
. ,
.
10 (organ system ) , , , ,
, , , , ,
.
,
.
(reproductive physiology )
(mechanism ) () , , ,
, (emergent property )
.
(ome ) . (omics
) () DNA, RNA, ,
(genomics),
(transcriptomics), (proteomics), (metabolomics) .
(Human Genome Project), 1,000
(1000 Genome Project) ,
(next generation sequencing) (ENCODE Project) .
-omics
. omics
(multi-level omics study) .
25 ,
. -omics
.
.
, ,
, ,
unmet-need
.
" "
,
, ,
.
--
-
multi-level omics
2-248
I)
II) , -omics
III)
IV) ,
.
.
I) Global Top 5
.
1)
.
2)
.
3)
4)
5)
II)
1) : , SCI impact factor
.
2) , :
, .
3) :
.
4) (impact factor) : (impact factor)
, impact
.
5) :
.
6) : BK21
, ,
,
I) --
1) stress
2) - ENCODE
II) , ,
1)
III) ,
" "
.
,
.
.
, ,
.
.
3-248
(Institutional Review Board IRB),
,
.
.
, , , , ,
, , , , , , ,
, , ,
, , ,
, -- , ENCODE( )
Journal club ), (next
generation sequencing NGS) .
.
,
,
, , , workshop
IF
" "
.
.
.
.
-- ,
, , ,
.
--
.
.
1. -omics
ENCODE NGS
database
.
4-248
2.
, , ,
-omics .
, , , -
omics .
, , , ,
.
1.
----
2.multi-level omics
, , , ,
multi-level omics
multi-level omics
database
ENCODE data
3.
TGF-b
DNA
7 .
1)
2)
3)
4) , R&D ,
5) ,
.
6) .
.
7)
, ,
.
1)
2)
3) .
4)
5)
5-248
6-248
.
1.
1.1
KyuBum Kwack
1.2
(: )
()
'16.3.1~'18.2.28 4.9166 0 4.9166
(: )
()
'16.3.1~'18.2.28 20 11 27 58
7-248
. -
1.
1.1
" "
I) ,
II)
III) , ,
.
I)
II) , -omics
III)
IV) , .
.
I) Global Top 5
.
1) .
2) .
3)
4)
5)
II)
1) : , SCI impact factor .
2) , : ,
.
3) : .
4) (impact factor) : (impact factor) ,
impact .
5) :
.
6) : BK21 ,
, , .
I) --
1) stress
2) - ENCODE
II) , ,
1)
III) ,
()
8-248
()
9-248
- , ,
.
I) ( )
-omics . II)
.
III)
.
IV) ,
.
.
I) , NGS microRNA SNP
.
II) 2 44 148
75 .
III) .
10-248
2.
2.1 /
( 2)
.
() (: )
2016 11.5 8.5 11.5 31.5
2017 10.5 8 13.5 32
22 16.5 25 63.5
2016 0 1 1
2017 7 2 9
2018 6 0 6
13 3 16
11-248
4 3 0 3
5 8 1 9
6 5 8 13
7 5 6 11
8 0 1 1
21 16
(: )
1) 4 (, )
- 4 8, / 12
.
-
.
- T/O () 1 1,
1.5 1 .
- 2016 2 3 (3) ,
.
4 201603 5 3 201608 0 0
201609 0 0 201702 3 0
5 201703 5 2 201708 3 0
201709 0 3 201802 5 1
6 201803 5 0 201808 0 1
201809 0 2 201902 5 7
7 201903 5 3 201908 0 0
201909 0 0 201002 5 6
8 202003 5 5 201008 0 0
12-248
.
- .
- 15
.
- .
/ 2-4
. /
.
- , , " " ""
. .
- , , , ,
.
- .
.
- .
- " "
.
-
.
.
- .
- (, , , )
.
- IF , ,
.
.
()
13-248
()
14-248
[ ]
,
.
.
. 2018
. ,
(KOBIC)
,
.
2016 10 13 21 WISET
8 10 LA
. 6 3,4 Grand rapids, Chicago,
Salt lake city, LA
.
ASRM(American Society Reproductive Medicine) . ASRM
. 6
. , LA
. 2016 71
3,4 2107 6
BK ,
, .
,
.
, ,
.
15-248
. 2
2017 , 2018
. ,
,
,
. ,
, 3,4 .
2017 Genomics 2018 PLoS One 1
C. elegans
SIC . 2018
.
.
4 3 0 3 4 1 5
5 8 1 9 9 2 11
4(2016 03 ~ 2017 2) 4 (2017 2 4)
1(2016 8 1) 5
1
2 5(2017 3 ~ 2018 2)
9 (2016 8 3, 2018 2 6) 2
(2017 8 2) 2 .
.
16-248
2.2
() (: , %)
,
(%)
(D/E)100
(%)
(C/F)100
(G)
(B)
(C)
(D)
(E=G-B-C)
(F=G-B-D)
2017 2
3 0 0 0 2 3 1
66.67 0
0 0 0 0 0
2017 8
3 0 0 0 1 3 2
60 0
2 0 2 2 0
8 0 0 0 5 8 3 62.5 0
17-248
()
18-248
[ ]
BK21 2018 2017
. 2017 2 3 8
3, 2 2017 8 62.5%
0%. , 5 3, 2
60%, 40%.
, , .
(2016)1)
, ,
14,170 61.09%, 21.26%2). 62.5%
,
.
1) 2017 (2017. 12. 31) 2018 12 .
2) .
(%) = / {-(++++)} 100
(%) = / 100
19-248
( )
. /
1)
.
, , ,
.
2)
.
() . .
. .
3)
, BMS .
4)
.
spec .
* . .
* .
* , , , .
. T/O .
.
.
/ ()
20-248
/ ()
21-248
[ ]
1)
/ ,
. 1:1
, ,
.
2)
,
, , . ,
full funding ,
.
-
.
3)
.
, , KOBIC
.
GDA , -
BIT
. -
2 . ,
,
R-WeSET
22-248
.
4)
2017
,
. 2016 2 2017 2
,
2017 8
. 2016 2017
KIST , 2017
. 2018 2 ,
.
23-248
.
24-248
[ ]
. /
, .
,
.
.
Home coming day
,
.
25-248
3.
3.1 ( 2)
1
2
2016 2017 2018
19 19 5 43
1 0.7413
3.7302 7.9373 1.665 13.3325
1 0.2298
58
26-248
SCI(E) (SSCI ) IF
1 SCI(E) (SSCI) IF
2
2016 2017 2018
3.7302 7.9373 1.665 13.3325
IF 1.81391 4.68314 1.26705 7.7641
1 IF 0.48627 0.59001 0.76099 0.58234
1 IF 0.13386
58
27-248
1 Eigenfactor Score IF
2
2016 2017 2018
Eigenfactor
Score
3.7302 7.9373 1.6650 13.3325
ES 1.77351 4.93746 0.614 7.32497
1 ES 0.47544 0.62205 0.36876 0.5494
1 ES 0.12629
Impact Factor
3.7302 7.9373 1.6650 13.3325
IF 1.81391 4.68314 1.26705 7.76410
1 IF 0.48627 0.59001 0.76099 0.58234
1 IF 0.13386
58
28-248
1 Eigenfactor Score IF
29-248
[ ]
4 5
.1)
4
(16.03-17.02)
5
(17.03-18.02)
(C) 5.6564 7.6761 13.3325 136%
1
(C/T)0.0992 0.1301 0.2299 131%
IF(X) 3.0841 4.6801 7.7641 152%
1
IF(X/C)0.5452 0.6097 0.5823 112%
1
IF(X/T)0.0541 0.0793 0.1339 147%
ES(Y) 3.6221 3.7029 7.3250 102%
1
ES(Y/C)0.6404 0.4824 0.5494 75%
1
ES(Y/T)0.0635 0.0628 0.1263 99%
(T)57 59 58 29
13.3325 Eigenfactor Score( ES)
7.3250, Impact Factor( IF) 7.7641. 5
7.6761 4 36% 1
0.1301 31% .
4
.
5 1 IF 0.6097 12% ES
0.4824 25% . ES ,
5
ES 2%
. 1
IF ES IF 47%, ES 1%
30-248
.
/
.
1) BK21 .
[ 2] .
ES, IF, [ 6] .
31-248
[ ]
Impact Factor Eigen
Factor Score Eigen Factor Score
Journal of Pineal Research(IF 10.391), BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON
CANCER(IF 9.452), Cellular and Molecular Life Sciences(IF 5.788), Scientific reports(IF
4.259) SCOPUS SJR
25% (Q1) ,
72% IF ES
.
32-248
1
1
2
2016 2017
38 31 69 41 42 83 79 73 152
47.5798 21.9432 69.5230 62.0250 25.0069 87.0319109.604
846.9501 156.5549
1 2.6992
58
33-248
3.2
( )
4 5 6 7 8
1
1.2 1.2 1.2 1.3 1.3 2.77
1 SCI, SCIE (SSCI,
A&HCI ) IF0.7 0.8 0.8 0.9 0.9 8.92
1 IF 0.6328 0.6644 0.6977 0.7325 0.7692 4.99
1
0.8 0.9 0.9 1 1 7.87
BK21plus 3 2
3 2
1 0.5673 0.1891 0.4456 0.2228 17.8%
1 IF 0.25159 0.08386 0.25999 0.13000 55.0%
1 IF 0.44347 0.14812 0.58345 0.29173 97.0%
* ,
.
* .
.
* 1 IF BK21plus 2 0.57532
10% 0.6328 5% .
*
.
34-248
( )
4 5 6 7 8
1
0.0665 0.0652 -1.95
1 SCI, SCIE (SSCI,
A&HCI ) IF0.0614 0.0803 30.78
1 IF 0.5460 0.6004 9.96
1
1.1987 1.5006 25.19
35-248
36-248
[ ]
6 BK21
.
1
(2.77%), 1 SCI, SCIE (SSCI, A&HCI )
IF(8.92%), 1 IF(4.99%), 1
(7.87%). 4 5
1 (98%), 1 SCI, SCIE (SSCI, A&HCI
) IF(131%), 1 IF(110%),
1 (125%)
.
.
37-248
( )
.
. .
1) : / .
2) :
.
3) :
.
4) : / , (SCI) .
1)
2) 1 2 . , 1
, 3-5: 300, 6-
10: 500, 11 700 .
3) , ,
, BK21 .
1): SCI IF>3 1 , , .
2) : SCI IF>3 1 , , .
()
38-248
()
39-248
1) / 148
2016~2018 2 72 , 76, 148 / .
( 31 / 31 )
( 0 / 15 )
( 7 / 8 )
( 20 / 20 )
( 14 / 2 )
2016 2017 International conference of theGenetics Society of Korea 21 2016
The 9th Congress of the Asia-Pacific Society on Thrombosis and Hemostasis 4,
International Society on Thrombosis and Hemostasis 2017 Congress
4 2017 International KOGO Annual
Conference 2 . 2016 12
WinterCamp 2, 29
4, 30 3 70
2, 71 6
. 2017 6 1, 72
2, 73 2, 72
4,32 3
.
2016 2017 InternationalConference of the Genetics Society of Korea 14
. 2017 Congress of the European Menopause and Andropause
Society .
2016 15th The Human ProteomeOrganization 1, 2016 International Conference of the Korean
Society for Molecular and Cellualr Biology KSBMB International Conference 2016
1 2017 4th World Congress of
Reproductive Biology 1, International conference of the
Genetics Society of Korea 2 , 2018 1 8th
International Conference on Bioscience, Biochemistry and Bioinformatics 2
. 2017 4,
3 .
2016 2017
40-248
Experimental Biology Meeting 17 . 2016
Joint Natural Products Conference 1 ,
2017 4 International Conference on Clinical Nutrition 1
. 2016 2017
19 .
2017 2018 5 2017 5
2 10
1 . 2017 6
2, 6 2, 8
KALAS 1
.
2)
, 6
2017
2017
.
International Conference of the Genetics Society of Korea 2016
.
2016
.
2017 6
72
.
3)
. , 1
.
.
1 SCI IF 5
, .
4) BK21
41-248
BK21 ,
. BK21 6
,
, .
42-248
.
Impact Factor ,
.
1) : , SCI
( IF ) IF 3-5: 300, IF 5-8: 500 , IF 8
1,000 .
2) ,
3) (SCI ) ,
. ()
43-248
. ()
44-248
2017
SCI, SCIE 1, 1
. 2017
-
.
.
6 BK21
,
.
45-248
3.3
-
, .
- .
- ,
,
.
- .
-
, ,
.
.
- 2 BK21
.
,
.
2 .
- . .
- .
- ( 250)
.
- BK21plus
- .
, , . 2015 SGER (Small Grant for Exploratory
Research) 1 .
, ,
.
()
46-248
()
47-248
2016
C. elegans
BK21
. 2017 Raj Kumar
Mongre 6 .
. Raj Kumar Mongre 6
.
.
.
BK21
.
.
48-248
1
1
2
2016 2017 2018
0 0 0 0
1 0
0.0000 0.0000 0.0000 0.0000
1 0.0000
0.3333
49-248
SCI(E) (SSCI ) IF
1 SCI(E) (SSCI) IF
2
2016 2017 2018
0.0000 0.0000 0.0000 0.0000
IF 0.00000 0.00000 0.00000 0.00000
1 IF 0.00000 0.00000 0.00000 0.00000
1 IF 0.00000
0.3333
50-248
1 Eigenfactor Score IF
2
2016 2017 2018
Eigenfactor
Score
0.0000 0.0000 0.0000 0.0000
ES 0.00000 0.00000 0.00000 0.00000
1 ES 0.00000 0.00000 0.00000 0.00000
1 ES 0.00000
Impact Factor
0.0000 0.0000 0.0000 0.0000
IF 0.00000 0.00000 0.00000 0.00000
1 IF 0.00000 0.00000 0.00000 0.00000
1 IF 0.00000
0.3333
51-248
1 Eigenfactor Score IF
52-248
.
53-248
.
54-248
4.
4.1
,
1)
( 33.3% (5/15)).
2) , 1 93.3%
(14/15) .
3) ( ; 6 1 )
,
-
, / ,
. .
4) ,
- CHA San Pedro MOU ,
Peru 1 .
- Tsukuba School of Integrative and Global Majors (SIGMA)
.
- Case Western Reserve .
- .
5)
- .
.
6)
-
.
,
.
-
.
- .
()
55-248
()
56-248
[ , ]
1)
.
2)
. Li Lan North China
University of Sciences and Technology Suresh
Ramakrishna .
Madhuri 2016 2 2017 1
.
Raj Kumar Mongre
,
.
3)
/ BK21
2016 2017 5 .
- 2016.07.27. Purinergic receptor, P2Y12 on platelet induces tumor growth in ovarian cancer(Min
Soon Cho, MD Anderson Cancer Center)
- 2016.08.03.
Genetic studies on regulator of calcineurin (RCAN-1) and thioredoxin reductases(TRXR-1 and TRXR
-2) in C. elegans(Weixun Li, Hugel Inc.)
- 2016.10.19.Cancer Genomics toward Precision Medicine (Ju-Seog Lee, MD Anderson Cancer
Center)
- 2017.06.26. Role of ADP receptors on platelets in the growth of ovarian cancer
(Min Soon Cho, MD Anderson Cancer Center)
- 2017.10.25. Melatonin:Applications to Reproductive Physiology
(Russel J. Reiter, Editor-in-Chief, Journal of Pineal Research)
57-248
4.2 ( 2)
2
2016 2017
6 10 16
6 10 16
(%) 100.00 100.00 100
58-248
5.
5.1
- (reproduction; ) ,
. 2010 15~39 13.5%
. 8 1 , 635000 . 45 140
.
.
- (reproductive rate; ) , ,
.
,
.
- (reproductive physiology; ) (mechanism; )
, (ome;) (reproductive
physiomics; ) () , , , ,
(emergent property; ) omics .
- , ,
, , , , , .
.
1.
- jump . , ,
, PCR , NGS . (HGP), (NGS),
ENCODE . , ,
2
- , NGS , ChIA-PET,
- , , microRNA SNP
- TGF-beta
- , ubiqitination
- ,
2.
-
. system
3.
- .
- IF journal club
.
4.
-
5.
- . .
.
()
59-248
6.
- .
60-248
()
61-248
- 4 ,
. ( ) simulated
annealing, entropy, mutual information , (machine
learning) .
- NGS EMR(electronic medical
records) , .
- ,
, ,
.
- , CMG , 10
()
.
-
.
.
- 4 ,
.
.
62-248
6.
6.1
(YYYYMM-YYYYMM)
1 201309-201802
63-248
1) ,
- () ,
, , QC
Iowa .
- . New
England , NEBS
.
-
. ,
. .
- 10 ,
. , IRB
.
40% .
2)
-
. , ,
3-40 .
- , , ,
(; unit-level omics) , , , ,
(; multi-level omics) . (Next
Generation Sequencing;NGS) 2012 DNA(ENCyclopedia Of DNA Elements; ENCODE)
CHIA-PET (10^15) , ,
data (significant) .
- (bigdata)
, . .
- // , , , ,
, NGS,
ENCODE .
-
, , , ,
.
- , , (,,
), (), (, , ), (, , , ),
(, , , ), (, ), (, , ),
(), omics (, ), omics (), ENCODE (),
(, , , , ).
()
64-248
()
65-248
- ,
.
. , ,
, , . 2016
, ,
.
.
, ,
, .
66-248
7.
7.1
1.
1.
1)
- TGF-beta
. TGF-beta TGF-beta Smad TGF-
beta . ,
, , , TGF-beta Smad TGF-beta .
TGF-beta
TGF-beta . , TGF-beta
,
.
- Smad3 linker Smad3 c-tail
. Smad3 Linker Rutgers Fang Liu Smad3
(NCI, NIH) Lalage Wakefield .
.
- TGF-beta (NIDDK, NIH) Sushil G. Rane
Jeffrey E. Green
Smad3 linker
TGF-beta
.
- Smad3 conditional knockout TGF-beta Smad3
top-tier journal ,
( 1)
- ,
. ,
. 2014 12
UBC P. Sorensen, A* STAR N. Barker
.
- .
NIH Tsukuba Univ. .
2)
University of Texas and MD Anderson Cancer Center Ju-Seog Lee
MOU .
()
67-248
()
68-248
[ ]
1)
BK21
. ,
.
.
2015 / 10
.
(ASRM,
PSRM) 2014 2016 .
2017 11 pineal gland, neuroscience, melatonin, physiology
Journal of Pineal Research (Impact Factor 10.391)
.
2)
,
. 2016 3 2018 2
20 SCI 24 .
3)
MD Anderson Cancer Center Systems Biology
MOU . 2015
Bioinformatics
.
69-248
7.2 ( 2)
70-248
1)
/
-
-
- Human Proteome Organisation
-
-
- 8
- Medical Research Council Grant
2005- Editorial Advisory Board Member for Current Protein & Peptide Science
2005- Associate Editor for Journal of Biological Sciences
2007- Editorial Board Member for The Open Biochemistry Journal
2007- Editorial Board Member for International Journal of Medical Sciences
2008- Editorial Board Member for Molecular Medicine Reports Journal
2010- Editorial Board Member for Journal of Chinese Clinical Medicine
2010- International Advisory Board Member for British Journal of Pharmaceutical and Medical
Research
2012- Editorial Board Member for World Journal of Obstetrics and Gynecology
2012- Academic Editor for PLoS One
2013- Editorial Board Member for Open Access Journal of Science and Technology
2014- Editorial Board Member for Journal of Translational Proteomics Research
2014- Editorial Board Member for The Open Analytical Chemistry Journal
2014- Editorial Board Member for Aperito Journal of Endocrine System and Enzymology
2015-2016 Editorial Board Member for International Journal of Immunotherapy and Cancer
Research
2015- Editorial Board Member for International Journal of Oncology
2015- Editorial Board Member for ARC Journal of Diabetes and Endocrinology
2016-2017 Editorial Board Member for Journal of Molecular Medicine
2016- Editorial Board Member for ARC Annals of Obesity & Disorders
2016- Editorial Board Member for SRL Stem Cell & Research
2016- Editorial Board Member for Journal of Stem Cell Therapy & Transplantation
2016- Editor-in-Chief for International Journal of Immunotherapy and Cancer Research
2016-2017 Editorial Board Member for SciFed Journal of Protein Science
2017- Editorial Board Member for Annals of Stem Cell Research & Therapy
2017- Editorial Board Member for Current Advances in Cell Stem Cells
2017- Editorial Board Member for International Journal of Stem Cells & Research
2017- Editorial Board Member for Biochemistry and Molecular Biology
71-248
2017-2017 Editorial Board Member for Cancer International Journal
2017- Editorial Board Member for Journal of Molecular Cancer
Li, L., and Baek, K.-H.. (2016). Genetics of Polycystic Ovary Syndrome: How Far Have We Come?
In "Polycystic Ovary Syndrome (PCOS): Clinical Aspects, Potential Complications and Dietary
Management".
Nova Science Publishers, (ISBN: 978-1-63485-955-4)
2)
/ - (2015-2017)
-
-
-
-
-
2017- Editorial board member for Journal of Pineal Research
2016- First scientific program prize poster at 72nd American Society for Reproductive Medicine
Symposium (ASRM)
3)
/
-
2014 - Editorial board member for Gene & Genomics
4)
/
- (2017)
- (2018)
72-248
2017 - Editorial board member for Gene & Genomics
73-248
2
/
(YYYYMM-YYYYMM)
(,
)
1
/UT-MD
Anderson Cancer
Center
Bioinformatics
201504-202003
74-248
2
75-248
University of Texas and MD Anderson Cancer Center MOU
2015 Bioinformatics
.
.
76-248
77-248
2015 MD Anderson
Cancer Center Systems Biology
BK21 5 2016
Endometriosis, PCOS
.
78-248
8.
8.1 ( 2)
2 1 , , (: )
()
'16.3.1'17.2.28 '17.3.1'18.2.28
904,281 772,849 1,677,130
() 0 25,000 25,000
0 0 0
1 183,924 162,276 346,200
4.9166
79-248
8.2 ( 2)
1
1
2
2016 2017 2018
39 31 4 74
1 15.051
10.8150 10.4375 1.4675 22.7200
1 4.621
4.9166
80-248
IF
2 1 SCI, SCIE (SSCI ) IF
2
2016 2017 2018
10.8150 10.4375 1.4675 22.7200
IF 4.58679 5.71263 0.95358 11.253
1 IF 0.42411 0.54731 0.64979 0.49529
1 IF 2.28877
4.9166
81-248
1 Eigenfactor Score IF
2
2016 2017 2018
Eigenfactor
Score
10.8150 10.4375 1.4675 22.7200
ES 10.40820 9.06281 0.27152 19.74253
1 ES 0.96238 0.86829 0.18502 0.86894
1 ES 4.01548
Impact Factor
10.8150 10.4375 1.4675 22.7200
IF 4.58679 5.71263 0.95358 11.25300
1 IF 0.42411 0.54731 0.64979 0.49529
1 IF 2.28877
4.9166
82-248
1 Eigenfactor Score IF
83-248
1 Eigenfactor Impact factor
.
22.7200 2017 10.4375 2016
3% . Eigenfactor Score( ES) 19.7425
Impact Factor( IF) 11.2530 2016 2017
ES 13% IF 25% . 2017 1 ES 0.8683
10% IF 2016 0.4241 2017 0.5473 29%
. ES IF , 4
2016
Eigenfactor Score
Impact Factor .
,
.
84-248
SCI(E) ES IF
SJR
. 2 74
Impact Factor Eigen Factor Score ES
Journal of Pineal Research(IF 10.391), BIOCHIMICA ET BIOPHYSICA ACTA-
REVIEWS ON CANCER(IF 9.452), Cellular and Molecular Life Sciences(IF 5.788)
SCOPUS SJR
25% (Q1) , 73% IF ES
.
85-248
8.3 ( , )
.
1.
- .
- n n n
.
- .
.
2.
- , , , database
.
3. ( )
()
86-248
()
87-248
, ,
. , ,
.
1)
2015 UT-MD Anderson Cancer Center
2016
.
. . 2018
.
2)
2016 (Poor Ovarian Responder)
ovary follicle
2017 mouse ovary
.
.
2016 10 (Michigan State University,
Department of Obstetrics and Gynecology) ,
Endometriosis, PCOS
.
3)
Whole Exome Sequencing( WES) NGS
.
C. elegans
. ,
. 2018 ,
, .
4)
2014 2017
.
2017 Bioinformatics
.
88-248
WES -
. ,
. 2018 6 ,
.
89-248
.
- , .
-
.
-
-
.
. ()
90-248
. ()
91-248
- 6 BK21
,
.
- , ,
.
1)
2014-2017 :
2016- : miRNA
2017- :
2017- :
2018- : 2018 6 ,
2)
2016- : ,
3)
2016-2016 :
.
.
92-248
9.
9.1 ( 2)
1
2
2016 2017
1 1 2
0.2000 0.5000 0.7000
0 0 0
0 0 0
1 1 2
0.2 0.5 0.7
1 0.1423
4.9166
93-248
1
( : )
2 ()
2016 2017
0 0 0
1 0
0 0 0
1 0
0 0 0
1 0
Know-how
0 0 0
1 0
0 0 0
1 0
4.9166
94-248
9.2 /
2 4
1. ( ) // 3 "
NK cell " .
- The Autologous
Killer Cell" , /, , 20150082369 2015 7 16
.
- activated NK (ANK) GMP , QC
. protocol ANK protocol #1" . , ,
.
- 4 ( )
. NK
protocol , NK
GMP . cancer genomic database
.
- ANK protocol #1 (tumor heterogeneity)
cancer profile ANK activation protocol ANK protocol
#2" .
- ANK protocol #2
NK cell therapy .
/ ()
95-248
/ ()
96-248
1)
, ,
. 5 50 SCI
150 .
.
2 .
2)
2016 mouse uterus
microbiome . mouse uterus bacterial strain injection
birth rate uterus microbiome .
(in vitro fertilization, IVF) swap metagenome IVF
biomarker .
3)
2017
.
97-248
9.3
1) 2(2013.9.1~2015.8.31)
- ,
.
.
-
2013. 9. 13.
2013.12. 16.
2013.12. 20.
2015. 5. 22. ,
2015. 6. 17. ,
2015. 6. 24. ,
2015. 7. 15. ,
2) 4
- .
()
98-248
()
99-248
1) 2(2016.3.1~2018.2.28)
,
. .
2016.06.29.
2016.07.16.
2017.07.07.
2017.07.18.
2)
2017 , , , , , , ,
. , ,
.
.
100-248
[ 1] ()
()
//
/ /
(YYYYMMDD~
YYYYMMDD)
(A)
(A/24)
'16.3.1~'
18.2.28
KyuBum
Kwack
20160301-
2018022824 1
'16.3.1~'
18.2.28
Nam Keun
Kim
20160301-
2018022824 1
'16.3.1~'
18.2.28
Seong-
Jin Kim
20160301-
201606304 0.1666
'16.3.1~'
18.2.28
Kwang-
Hyun
BAEK
20160301-
2018022824 1
'16.3.1~'
18.2.28
BooYong
Lee
20160301-
2018022824 1
'16.3.1~'
18.2.28
Youngsok
Choi
20160901-
2018022818 0.75
(, , )
6
(, , )
4.9166
0 0
6 4.9166
101-248
[ 2]
()
(YYYYMMDD)
2016 1 SeulKi Kwon 3
2016 1 Soo-Yeon Kim 3
2016 1 Kim Eunseon 3
2016 1 Kim hana 1
2016 1 ryu chang su 1
2016 1 Myeong A
yeong 1
2016 1 Sagong
Jeonghyeon 2
2016 1 Yujung Lee 2
2016 1 leehyuna 2
2016 1 Kim Jeongo 5
2016 1 Park
Yeongjun 3
102-248
2016 1 Yuna Park 3
2016 1 Park
Jeonghyeon 1
2016 1 Lee Jisu 3
2016 1 Lee Jihui 3
2016 1 Ko Eunjeong 5
2016 1 PYOUNGGANGKI
M 7
2016 1 KIM HYEON
WOO 1
2016 1 YoungJin Seo 3
2016 1 Song Jihyeon 3
2016 1 An Hui Jeong 7
2016 1 Yang Jinmo 3
2016 1 LEE YEONJOO 7
103-248
2016 1 Choi Seongu 1
2016 1 JIA CHOI 5
2016 1 KYOUNGWHA
PANG 6
2016 1 Ji-hyun
Hwang 7
2016 1 CHOEJINNY CHOEJINNY 7
2016 2 SeulKi Kwon 4
2016 2 Soo-Yeon Kim 4
2016 2 Choi Seongu 4
2016 2 Kim hana 2
2016 2 ryu chang su 2
2016 2 Choi Seongu 3
2016 2 Yoon Hyemin 4
104-248
2016 2 Lee Dahye 1
2016 2 Yujung Lee 3
2016 2 leehyuna 3
2016 2 JoonYeon
Hwang 1
2016 2 Kim Jeongo 6
2016 2 Park
Yeongjun 4
2016 2 Park
Jeonghyeon 2
2016 2 Lee Jisu 4
2016 2 Saindane
Madhuri
Saindane
Madhuri 1
2016 2 Ko Eunjeong 6
2016 2 KIM HYEON
WOO 2
2016 2 Moon So
Hyeon 2
105-248
2016 2 YoungJin Seo 4
2016 2 Song Jihyeon 4
2016 2 An Hui Jeong 8
2016 2 Yang Jinmo 4
2016 2 Lee Sangho 2
2016 2 LEE YEONJOO 8
2016 2 Choi Seoyun 1
2016 2 Choi Seongu 2
2016 2 JIA CHOI 6
2016 2 Ji-hyun
Hwang 8
2017 1 KIM EUN-GYO 1
2017 1 Kim hana 3
106-248
2017 1 ryu chang su 3
2017 1 park jun-
hyeok 1
2017 1 Sagong
Jeonghyeon 4
2017 1 Lee Dahye 2
2017 1 Yujung Lee 4
2017 1 leehyuna 4
2017 1 Jihye Choi 1
2017 1 Hwang
Youngjae 1
2017 1 JoonYeon
Hwang 2
2017 1 Kim Jeongo 7
2017 1 Park
Yeongjun 5
2017 1 Han Sung
Park 1
107-248
2017 1 Lee Jisu 5
2017 1 SAINDANEMADH
URI
SAINDANEMADH
URI 2
2017 1 Ko Eunjeong 7
2017 1 KIM HYEON
WOO 3
2017 1 Moon So
Hyeon 3
2017 1 park min ki 1
2017 1 YoungJin Seo 5
2017 1 Song Jihyeon 5
2017 1 Juwon Ahn 1
2017 1 An Hui Jeong 9
2017 1 Lee Sangho 3
2017 1 LEE YEONJOO 9
108-248
2017 1 HaeJong Lee 1
2017 1 Cho Minha 1
2017 1 Choi Seoyun 2
2017 1 Choi Seongu 3
2017 1 JIA CHOI 7
2017 1 Ji-hyun
Hwang 9
2017 2 KIM EUN-GYO 2
2017 2 Kim hana 4
2017 2 ryu chang su 4
2017 2 park jun-
hyeok 2
2017 2 Lee Dahye 3
2017 2 HaeJong Lee 2
109-248
2017 2 Jihye Choi 2
2017 2 Hwang
Youngjae 2
2017 2 JoonYeon
Hwang 3
2017 2 Kim Jeongo 8
2017 2 Park
Yeongjun 6
2017 2 Han Sung
Park 2
2017 2 ChangZhu Pei 1
2017 2 Lee Kippeum 1
2017 2 Lee Jisu 6
2017 2 Ko Eunjeong 8
2017 2 KIM HYEON
WOO 4
2017 2 Moon So
Hyeon 4
110-248
2017 2 YoungJin Seo 6
2017 2 Song Jihyeon 6
2017 2 Juwon Ahn 2
2017 2 An Hui Jeong 10
2017 2 Lee Sangho 4
2017 2 Cho Minha 2
2017 2 Choi Seoyun 3
2017 2 Choi Seongu 4
2017 2 JIA CHOI 8
()
20
11
27
58
111-248
[ 3]
()
(YYYYMMDD~YYYYMMDD) (B) (B/24)
160301-
180228
YONGSOON
KIM20160301-20160430 2 0.0833
160301-
180228
Raj Kumar
Mongre
Raj
Kumar
Mongre
20170401-20171011 6 0.25
2 0.3333
112-248
[ 4] 2 (/ )
/
(YYYYMMDD)
2016 4 1 1
2016 4 1 2
2016 4 1 3
2016 4 1 4
2016 4 1 5
2016 4 1 6
2016 4 1 7
2016 4 1 8
113-248
2016 4 1 9
2016 4 1 10
2016 4 1 11
2016 4 1 12
2016 4 1 13
2016 4 1 14
2016 4 1 15
2016 4 1 16
2016 4 1 17
2016 4 1 18
2016 4 1 19
2016 4 1 20
114-248
2016 4 1 21
2016 4 1 22
2016 4 1 23
2016 4 1 24
2016 4 1 25
2016 4 1 26
2016 4 1 27
2016 4 1 28
2016 4 1 29
2016 4 1 30
2016 4 1 31
2016 10 1 1
115-248
2016 10 1 2
2016 10 1 3
2016 10 1 4
2016 10 1 5
2016 10 1 6
2016 10 1 7
2016 10 1 8
2016 10 1 9
2016 10 1 10
2016 10 1 11
2016 10 1 12
2016 10 1 13
116-248
2016 10 1 14
2016 10 1 15
2016 10 1 16
2016 10 1 17
2016 10 1 18
2016 10 1 19
2016 10 1 20Saindane
Madhuri
2016 10 1 21
2016 10 1 22
2016 10 1 23
2016 10 1 24
2016 10 1 25
117-248
2016 10 1 26
2016 10 1 27
2016 10 1 28
2016 10 1 29
2016 10 1 30
2016 10 1 31
2016 10 1 32
2017 4 1 1
2017 4 1 2
2017 4 1 3
2017 4 1 4
2017 4 1 5
118-248
2017 4 1 6
2017 4 1 7
2017 4 1 8
2017 4 1 9
2017 4 1 10
2017 4 1 11
2017 4 1 12
2017 4 1 13
2017 4 1 14
2017 4 1 15
2017 4 1 16
2017 4 1 17
119-248
2017 4 1 18
2017 4 1 19
2017 4 1 20
2017 4 1 21
2017 4 1 22
2017 4 1 23
2017 4 1 24
2017 4 1 25
2017 4 1 26
2017 4 1 27
2017 4 1 28
2017 4 1 29
120-248
2017 4 1 30
2017 4 1 31
2017 4 1 32
2017 4 1 33
2017 4 1 34
2017 10 1 1
2017 10 1 2
2017 10 1 3
2017 10 1 4
2017 10 1 5
2017 10 1 6
2017 10 1 7
121-248
2017 10 1 8
2017 10 1 9
2017 10 1 10
2017 10 1 11
2017 10 1 12
2017 10 1 13
2017 10 1 14
2017 10 1 15
2017 10 1 16
2017 10 1 17
2017 10 1 18
2017 10 1 19
122-248
2017 10 1 20
2017 10 1 21
2017 10 1 22
2017 10 1 23
2017 10 1 24
2017 10 1 25
2017 10 1 26
2017 10 1 27
2017 10 1 28
2017 10 1 29
2017 10 1 30
123-248
()
2016 23
2016 23
2017 21 2017 27
22 25
2016 17
(
)
2016 31.5
2017 16 2017 32
16.5 63.5
124-248
[ 5] 2 (, )
(YYYYMM)
2013.9~
2016.2
2016.3~
2018.2
(YYYYMMDD)
2016 8 1 Kye-yoon
Yoon
2017 2 1 Seul-Ki
Kwon
2017 2 2 Soo-Yeon
Kim
2017 2 3 Yang
Jinmo
2017 2 4 kim Eun
Sun
2017 8 1 Yeon-Joo
LEE
2017 8 2 leehyuna
2017 8 3 Ji-Hyun
Hwang
2017 8 4
Sakong
Jung
Hyun
2017 8 5 Yujung
Lee
125-248
2018 2 1 hyemin
Yoon
2018 2 2 Sangho
Lee
2018 2 3 Kim hana
2018 2 4
KIM
HYEON
WOO
2018 2 5 ryu
chang su
2018 2 6 Sohyeon
Moon
2016
0
2017
7
2018
6
13
1 2 0 3
1 9 6 16
2017 2
3
0
2017 8
3
0
0 0
0 0
2 1
0 0
2 0
0 2
126-248
[ 6] 2
/
(U)
Impact
Factor
Eigen Factor
Score
Q-
Va
lu
e
ISSN
(YYYY
MM)
(m)
(n)
(T)
IF
(I)
IF
(F)
IF(X
)=(U
xF)
ES
(E)
ES
(Y)
ES(z
)=(U
xY)
(A)
(B)
2016
1
Caffeine
prevents
LPS-
induced
inflammat
ory
responses
in
RAW264.7
cells and
zebrafish
Chemic
o-
Biolog
ical
Intera
ctions
SCI(E)0009-
2797
24
81
20160
32 2 4
1 0 1 0.4
3.1
43
0.56
511
0.22
604
0.0
106
1
0.6
187
5
0.24
75Q2
2016
2
Melatonin
prevents
cisplatin
-induced
primordia
l
follicle
loss via
suppressi
on of
PTEN/AKT/
FOXO3a
pathway
activatio
n in the
mouse
Journa
l of
Pineal
Resear
ch
SCI(E)0742-
309860 3 336
20160
31 9 10 0
1 1
0.0
555
10.
391
1.49
799
0.08
313
0.0
080
2
0.3
040
8
0.01
687Q1
127-248
ovary.
2016
3
Polymorph
isms in
tumor
necrosis
factor-
alpha (-
863C>A, -
857C>T
and
+488G>A)
are
associate
d with
idiopathi
c
recurrent
pregnancy
loss in
Korean
women.
Human
immuno
logy
SCI(E)0198-
885977 6 506
20160
62 7 9 0
1 1
0.0
285
2.3
11
0.21
754
0.00
619
0.0
076
4
0.1
353
4
0.00
385Q3
2016
4
The
associati
on of-
429T>C
and -
374T>A
polymorph
isms in
the RAGE
gene with
polycysti
c ovary
syndrome
Intern
ationa
l
Journa
l of
Medica
l
Scienc
es
SCI(E)1449-
190713 6 451
20160
61 3 4
1 0 1 0.5
2.3
99
0.21
435
0.10
717
0.0
060
6
0.0
790
5
0.03
952Q1
128-248
2016
5
Ubiquitin
specific
protease
19
involved
in
transcrip
tional
repressio
n of
retinoic
acid
receptor
by
stabilizi
ng CORO2A
Oncota
rgetSCI(E)
1949-
25537 23
347
59
20160
62 7 9
1 0 1 0.4
5.1
68
0.40
316
0.16
126
0.0
786
6
1.3
746
1
0.54
984Q1
2016
6
Associati
on of
miR-146a,
miR-149,
miR-
196a2,
and miR-
499
Polymorph
isms with
Ossificat
ion of
the
Posterior
Longitudi
nal
Ligament
of the
Cervical
Spine.
PloS
oneSCI(E)
1932-
620311 7
e01
597
56
20160
72 12 14 0
1 1
0.0
166
2.8
06
0.23
892
0.00
396
1.9
217
6
3.2
807
2
0.05
446Q1
129-248
2016
7
Associati
on of
miR-
146aC>G,
miR-
149C>T,
miR-
196a2T>C,
and miR-
499A>G
polymorph
isms with
risk of
recurrent
implantat
ion
failure
in Korean
women.
Europe
an
Journa
l of
Obstet
rics &
Gyneco
logy
and
Reprod
uctive
Biolog
y
SCI(E)0301-
2115
20
214
20160
72 10 12 0
1 1
0.0
2
1.6
66
0.36
508
0.00
73
0.0
147
1
0.5
665
0.01
133Q3
2016
8
Associati
on of
miR-34a,
miR-130a,
miR-150
and miR-
155
polymorph
isms with
the risk
of
ischemic
stroke.
Intern
ationa
l
journa
l of
molecu
lar
medici
ne
SCI(E)1107-
375638 1 345
20160
72 8 10 0
1 1
0.0
25
2.3
41
0.29
586
0.00
739
0.0
136
0.2
918
3
0.00
729Q3
2016
9
Altered
Gelidium
elegans
extract-
Journa
l of
Food
and
SCI(E)1336-
86724 7 448
20160
82 2 4
1
1 2 0.5
1.9
5
0.51
201
0.25
6
0.0
008
4
0.0
363
7
0.01
818Q2
130-248
stimulate
d beige-
like
phenotype
attenuate
s
adipogene
sis in
3T3-L1
cells
Nutrit
ion
Resear
ch
2016
10
Genetic
Variation
of
Methylene
tetrahydr
ofolate
Reductase
(MTHFR)
and
Thymidyla
te
Synthase
(TS)
Genes Is
Associate
d with
Idiopathi
c Korean
women.
PloS
oneSCI(E)
1932-
620311 8
e01
608
84
20160
82 7 9
0 0 0 0
2.8
06
0.23
8920
1.9
217
6
3.2
807
2
0 Q1
2016
11
Pterostil
bene
activates
the
GRP78-
elF2-ATF3
Journa
l of
Functi
onal
Foods
SCI(E)1756-
464626 10 394
20160
82 3 5
1
1 2
0.4
666
3.1
44
0.82
552
0.38
518
0.0
117
8
0.5
101
8
0.23
805Q1
131-248
cascade
of ER
stress
and
subsequen
tly
induces
apoptosis
in HCT116
cells
2016
12
Silibinin
suppresse
s
mediators
of
Inflammat
ion
through
the
inhibitio
n of
TLR4-TAK1
pathway
in LPS-
induced
RAW264.7
cells
Journa
l of
Food
and
Nutrit
ion
Resear
ch
SCI(E)1336-
86724 8 515
20160
82 - 2
1 0 1 0.5
1.9
5
0.51
201
0.25
6
0.0
008
4
0.0
363
7
0.01
818Q2
2016
13
Associati
on of the
Single
Nucleotid
e
Polymorph
isms in
microRNAs
130b,
PloS
oneSCI(E)
1932-
620311 9
e01
625
19
20160
91 7 8 0
1 1
0.0
714
2.8
06
0.23
892
0.01
705
1.9
217
6
3.2
807
2
0.23
424Q1
132-248
200b, and
495 with
Ischemic
Stroke
Susceptib
ility and
Post-
Stroke
Mortality
.
2016
14
miRNA
polymorph
isms
(miR146a,
miR149,
miR196a2
and
miR499)
are
associate
d with
the risk
of
coronary
artery
disease.
Molecu
lar
medici
ne
report
s
SCI(E)1791-
299714 3
232
8
20160
92 11 13 0
1 1
0.0
181
1.6
92
0.21
383
0.00
387
0.0
205
1
0.4
401
0.00
796Q3
2016
15
Variation
in the
Dicer and
RAN Genes
Are
Associate
d with
Survival
in
PloS
oneSCI(E)
1932-
620311 9
e01
622
79
20160
91 7 8 0
1 1
0.0
714
2.8
06
0.23
892
0.01
705
1.9
217
6
3.2
807
2
0.23
424Q1
133-248
Patients
with
Hepatocel
lular
Carcinoma
.
2016
16
Evaluatio
n of the
genotoxic
ity of
Gelidium
elegans
extract
in vitro
and in
vivo
Journa
l of
Food
and
Nutrit
ion
Resear
ch
SCI(E)1336-
86724 10 653
20161
01 2 3 0
1 1
0.2
5
1.9
5
0.51
201
0.12
8
0.0
008
4
0.0
363
7
0.00
909Q2
2016
17
Next
generatio
n
sequencin
g
identifie
s
abnormal
Y
chromosom
e and
candidate
causal
variants
in
premature
ovarian
failure
patients
Genomi
csSCI(E)
0888-
7543
10
85 209
20161
03 2 5
1
1 2
0.3
571
2.8
01
0.33
02
0.11
791
0.0
089
0.1
787
0.06
381Q2
134-248
2016
18
Fucoxanth
in
Suppresse
s Lipid
Accumulat
ion and
ROS
Productio
n During
Different
iation in
3T3-L1
Adipocyte
s
Phytot
herapy
Resear
ch
SCI(E)0951-
418X30
180
2
20161
12 4 6 0
1 1
0.0
5
3.0
92
0.60
825
0.03
041
0.0
097
5
0.3
820
5
0.01
91Q2
2016
19
Associati
on of
Plasminog
en
Activator
Inhibitor
-1 (PAI-
1) Gene
Polymorph
isms with
Osteoporo
tic
Vertebral
Compressi
on
Fractures
(OVCFs)
in
Postmenop
ausal
Women.
Intern
ationa
l
journa
l of
molecu
lar
scienc
es
SCI(E)1422-
006717 12
E20
62
20161
22 8 10
0 0 0 0
3.2
26
0.36
8860
0.0
714
8
0.9
705
2
0 Q2
135-248
2017
1
Ginsenosi
de Rg1
suppresse
s early
stage of
adipocyte
developme
nt via
activatio
n of
C/EBP
homologou
s
protein-
10 in
3T3-L1
and
attenuate
s fat
accumulat
ion in
high fat
diet-
induced
obese
zebrafish
Journa
l of
Ginsen
g
Resear
ch
SCI(E)1226-
845341 1 23
20170
12 41 43
1
1 2
0.4
048
4.0
82
1.26
354
0.51
148
0.0
022
6
0.1
310
2
0.05
304Q1
2017
2
RNPS1 is
modulated
by
ubiquitin
-specific
protease
4.
FEBS
LETTER
S
SCI(E)0014-
5793
59
12 369
20170
11 2 3
1 0 1 0.5
3.6
23
0.48
648
0.24
324
0.0
499
8
1.1
184
9
0.55
924Q1
2017
3
Ubiquitin
-specific
protease
Bioche
mical
and
SCI(E)0006-
291X
48
24
144
3
20170
13 3 6
,
2 0 20.5
714
2.4
66
0.33
112
0.18
92
0.0
803
2
1.7
974
7
1.02
707Q3
136-248
21
regulatin
g the
K48-
linked
polyubiqu
itination
of NANOG.
Biophy
sical
Resear
ch
Commun
icatio
ns
2017
4
6-
gingerol
suppresse
s
adipocyte
-derived
mediators
of
inflammat
ion in
vitro and
in figh-
fat diet-
induced
obese
zebra
fish
Planta
medicaSCI(E)
0032-
094383 3 245
20170
22 4 6
1
1 2
0.4
5
2.3
42
0.72
494
0.32
622
0.0
080
2
0.4
649
8
0.20
924Q1
2017
5
Ecklonia
cava-
derived
Polysacch
aride
Prevent
Hydro
Peroxide-
induced
Oxidative
Stress
Journa
l of
Food
and
Nutrit
ion
Resear
ch
SCI(E)1336-
86725 3 187
20170
32 2 4
,
2 0 2 0.81.9
5
0.51
201
0.40
961
0.0
008
4
0.0
363
7
0.02
91Q2
137-248
and
Neurotoxi
city in
Human
Microglia
l HMO6
Cells
2017
6
Gelidium
elegans
Regulates
the AMPK-
PRDM16-
UCP-1
Pathway
and Has a
Synergist
ic Effect
with
Orlistat
on
Obesity-
Associate
d
Features
in Mice
Fed
Nutrie
ntsSCI(E)
2072-
66439 4 342
20170
32 2 4
1
1 2 0.5
3.5
5
0.64
077
0.32
038
0.0
219
6
0.7
487
2
0.37
436Q2
2017
7
Gelidium
elegans
Regulates
Blood
Glucose
Homeostas
is in ICR
Mice
Journa
l of
Food
and
Nutrit
ion
Resear
ch
SCI(E)1336-
86725 ` 274
20170
42 3 5
1
,
2 30.5
333
1.9
5
0.51
201
0.27
305
0.0
008
4
0.0
363
7
0.01
94Q2
138-248
2017
8
miR-27a
and miR-
449b
polymorph
isms
associate
d with a
risk of
idiopathi
c
recurrent
pregnancy
loss
PLoS
OneSCI(E)
1932-
620312 5
e01
771
60
20170
42 7 9 0
1 1
0.0
285
2.8
06
0.23
892
0.00
68
1.9
217
6
3.2
807
2
0.09
35Q1
2017
9
Crude
Ecklonia
cava
Flake
Extracts
Attenuate
Inflammat
ion
through
the
Regulatio
n of TLR4
Signaling
Pathway
in LPS-
Induced
RAW264.7
Cells
Molecu
lesSCI(E)
1420-
304922 5 777
20170
52 1 3
1 0 1 0.4
2.8
61
0.47
781
0.19
112
0.0
491
9
0.7
551
4
0.30
205Q2
2017
10
Modulatio
n of HO-1
by
Ferulic
Acid
Molecu
lesSCI(E)
1420-
304922 5 745
20170
52 3 5
1
,
2 30.5
333
2.8
61
0.47
781
0.25
481
0.0
491
9
0.7
551
4
0.40
271Q2
139-248
Attenuate
s
Adipocyte
Different
iation in
3T3-L1
Cells
2017
11
Hespereti
n
inhibits
lipid
accumulat
ion and
ROS
productio
n during
adipocyte
different
iation in
3T3-L1
cells
Journa
l of
food
bioche
mistry
SCI(E)0145-
888441 3
e12
348
20170
61 4 5
1 0 1 0.5 1
0.26
257
0.13
128
0.0
013
2
0.0
571
6
0.02
858Q3
2017
12
Polymorph
isms of
miR-146a,
miR-149,
miR-
196a2,
and miR-
499 Are
Associate
d With
Osteoporo
tic
Vertebral
Compressi
on
JOURNA
L OF
ORTHOP
AEDIC
RESEAR
CH
SCI(E)0736-
026636 1 244
20170
82 7 9
0 0 0 0
2.6
92
0.74
4110
0.0
176
7
0.6
526
3
0 Q1
140-248
Fractures
in Korean
Postmenop
ausal
Women
2017
13
Spirulina
maxima
Extract
Prevents
Neurotoxi
city via
Promoting
Activatio
n of
BDNF/CREB
Signaling
Pathways
in
Neuronal
Cells and
Mice
Molecu
lesSCI(E)
1420-
304922 8
136
3
20170
82 5 7
,
2
1 3
0.8
4
2.8
61
0.47
781
0.40
136
0.0
491
9
0.7
551
4
0.63
431Q2
2017
14
Anti-
adipogene
sis
mechanism
of
pterostil
bene
through
the
activatio
n of heme
oxygenase
-1 in
3T3-L1
cells
Phytom
edicin
e
SCI(E)0944-
711333 7
20170
92 3 5
1
,
2 30.5
333
3.5
26
1.09
143
0.58
206
0.0
094
2
0.5
461
5
0.29
126Q1
141-248
2017
15
Interplay
between
3- UTR
polymorph
isms in
the
methylene
tetrahydr
ofolate
reductase
(MTHFR)
gene and
the risk
of
ischemic
stroke
Scient
ific
report
s
SCI(E)2045-
23227 1
124
64
20170
91 7 8
0
,
2 20.1
428
4.2
59
0.36
263
0.05
178
0.3
873
6
0.6
612
7
0.09
443Q1
2017
16
Associati
on
between
vascular
endotheli
al growth
factor
promoter
polymorph
isms and
the risk
of
recurrent
implantat
ion
failure
Experi
mental
and
Therap
eutic
Medici
ne
SCI(E)1792-
0981
152
210
9
20171
12 7 9
0
,
2 20.0
571
1.2
61
0.15
936
0.00
909
0.0
111
7
0.2
396
8
0.01
368Q4
2017
17
Spirulina
maxima
Extract
Ameliorat
Intern
ationa
l
Journ
SCI(E)1422-
006718
240
1
20171
13 5 8
,
2
1 3 0.6
3.2
26
0.36
886
0.22
132
0.0
714
8
0.9
705
2
0.58
231Q2
142-248
es
Learning
and
Memory
Impairmen
ts via
Inhibitin
g GSK-3
Phosphory
lation
Induced
by
Intracere
broventri
cular
Injection
of
Amyloid-
142 in
Mice
al of
Molecu
lar
Scienc
es
2017
18
The Role
of RNF213
4810G>A
and
4950G>A
Variants
in
Patients
with
Moyamoya
Disease
in Korea
Intern
ationa
l
Journa
l of
Molecu
lar
Scienc
es
SCI(E)1422-
006718 11
E24
77
20171
11 7 8 0
,
2 20.1
428
3.2
26
0.36
886
0.05
267
0.0
714
8
0.9
705
2
0.13
859Q2
2017
19
p53
stability
is
regulated
BIOCHI
MICA
ET
BIOPH
SCI(E)0304-
419X
18
682 404
20171
22 1 3
1 0 1 0.4
9.4
52
1.26
918
0.50
767
0.0
094
5
0.2
114
8
0.08
459Q1
143-248
by
diverse
deubiquit
inating
enzymes.
YSICA
ACTA-
REVIEW
S ON
CANCER
2018
1
Anti-
inflammat
ory
effects
of moutan
cortex
radicis
extract,
paeoniflo
rin and
oxypaeoni
florin
through
TLR
signaling
pathway
in
RAW264.7
cells
Journa
l of
Food
and
Nutrit
ion
Resear
ch
SCI(E)1336-
86726 1 119
20180
11 5 6 0
,
2 2 0.21.9
5
0.51
201
0.10
24
0.0
008
4
0.0
363
7
0.00
727Q2
2018
2
Associati
on of
MicroRNA
Biogenesi
s Genes
Polymorph
isms with
Ischemic
Stroke
Susceptib
ility and
Journa
l of
stroke
SCI(E)2287-
639120 1 110
20180
11 8 9
0
1 1
0.0
625
5.5
76
0.78
26
0.04
891
0.0
023
9
0.0
724
2
0.00
452Q1
144-248
Post-
Stroke
Mortality
.
2018
3
Cellular
functions
of stem
cell
factors
mediated
by the
ubiquitin
-
proteasom
e system
Cellul
ar and
Molecu
lar
Life
Scienc
es
SCI(E)1420-
682X75 11
194
7
20180
12 0 2
1 0 1 0.5
5.7
88
0.66
181
0.33
09
0.0
425
9
0.5
782
7
0.28
913Q1
2018
4
Korean
ginseng
extract
ameliorat
es
abnormal
immune
response
through
the
regulatio
n of
inflammat
ory
constitue
nts in
Sprague-
Dawley
rat
subjected
to
Journa
l of
Ginsen
g
Resear
ch
SCI(E)1226-
845326
20180
25 1 6
,
,
3 0 30.5
454
4.0
82
1.26
354
0.68
913
0.0
022
6
0.1
310
2
0.07
146Q1
145-248
environme
ntal heat
stress
2018
5
Spirulina
maxima
extract
prevents
neuronal
cell
death
through
BDNF
activatio
n due to
amyloid
beta 1-42
(A1-42)
induced
neurotoxi
city in
PC12
cells
Neuros
cience
Letter
s
SCI(E)0304-
3940
67
333
20180
23 2 5
1
1 2
0.3
571
2.1
8
0.26
802
0.09
571
0.0
350
1
0.6
766
4
0.24
162Q3
146-248
2016 19
2016 3.7302
2017 19 2017 7.9373
2018 5 2018 1.6650
43 13.3325
IF
(ZERO)
2016 3.7302
IF
2016 58.4480
IF
2016 8.39746
IF
2016 1.81391
20177.9373 10.77022 2017 4.683142017 2017 59.9940
2018 20181.6650 2018 19.5760 3.48798 2018 1.26705
13.3325 138.0180 22.65566 7.76410
ES
(ZERO)
2016 3.7302
ES
2016 7.95128
ES
2016 19.08370
ES
2016 1.77351
2017 14.18897 2017 4.937467.9373 2017 2.812902017
2018 20181.6650 2018 0.08309 1.49472 2018 0.61400
13.3325 10.84727 34.76739 7.32497
147-248
[ 7] 2
(YYYYMMDD)
(T)
(P)
(P/T)*A (A)
/
2016 1
29
20160430
A study on
association
between t-
PA, PAI-1,
REN
polymorphism
s and
recurrent
spontaneous
abortion
(RSA) in
Korean women
8
,
,
,
,
,
6 1 0.75
/
2016 2
29
20160430
Association
between
potentially
functional
Tissue
inhibitor of
metalloprote
inase (TIMP)
genetic
polymorphism
s and
primary
ovarian
insufficienc
y (POI)
8
,
,
,
,
,
6 1 0.75
148-248
/
2016 3
29
20160430
Interplay
between 3'-
UTR
polymorphism
s in the
thymidylate
synthase
(TS) gene
and the risk
of ischemic
stroke
prevalence
and silent
brain
infarction
(SBI) in
Koreans.
9
,
,
,
,
,
,
7 1 0.7777
/
2016 4
29
20160430
Mucin
(MUC2A>G,
MUC2C >T,
MUC4A>G, and
MUC4G>T)
polymorphism
s are
associated
with
recurrent
pregnancy
loss in
Korean women
9
,
,
,
,
,
,
7 1 0.7777
/
2016 5
70
20160528
Association
of PAI-1, t-
PA, REN
8
,
,
6 1 0.75
149-248
polymorphism
s with risk
of
idiopathic
recurrent
pregnancy
loss(RPL) in
Korean women
,
,
,
/
2016 6
70
20160528
Genetic
variations
and risk of
recurrent
pregnancy
loss (RPL):
Whole exome
sequencing
and follow-
up chip
assay and a
casecontrol
study
7
,
,
,
,
5 1 0.7142
/
2016 771
20160810
Association
between
miRNA
machinery
gene
polymorphism
s and
recurrent
implantation
failure
(RIF) in
Korean women
10
,
,
,
,
,
6 1 0.6
150-248
/
2016 871
20160810
Association
of miR-34a,
miR-130a,
miR-150 and
miR-155
Polymorphism
s with the
Risk of
Ischemic
Stroke
9
,
,
,
,
,
6 1 0.6666
/
2016 971
20160810
Association
Study
between
miRNA (miR-
27a, miR-
423, miR-
449b and
miR-604)
Polymorphism
s and
Recurrent
Implantation
Failure in
Korean Women
10
,
,
,
,
,
,
7 1 0.7
/
2016 1071
20160810
Association
study of
miRNA
polymorphism
s with
recurrent
pregnancy
loss (RPL)
in Korean
women
10
,
,
,
,
,
,
7 1 0.7
151-248
/
2016 1171
20160810
Identificati
on of novel,
rare and
splicing
variants
using whole
exome
sequencing
(WES) in
Korean women
with
recurrent
pregnancy
loss (RPL)
8
,
,
,
,
5 1 0.625
/
2016 1271
20160810
The
Relevance
Study of
between Ring
Finger
Protein213
(RNF213)
Polymorphism
s and the
risk of
Ischemic
Stroke in
Korean
11
,
,
,
,
,
,
7 1 0.6363
/
2016 13
30
20160902
Polymorphism
s of miR-
34a, miR-
130a, miR-
150 and miR-
155 are
associated
with the
9
,
,
,
,
,
6 1 0.6666
152-248
risk of
Ischemic
Stroke in a
Korean
population.
/
2016 14
30
20160902
The
Associationb
etweenRing
Finger
Protein213
(RNF213)
Polymorphism
s and
Ischemic
Strokeriskin
Koreanpatien
ts
12
,
,
,
,
,
,
7 1 0.5833
/
2016 15
30
20160902
The miRNA
machinery
gene
polymorphism
s are
associated
with
recurrent
implantation
failure
(RIF) in
Korean women
10
,
,
,
,
,
6 1 0.6
/
2016 16
2016 KFN
International
Symposium and
Annual
Meeting.
20161031
A
synergistic
anti-obesity
effect by
9
,
,
,
,
8 1 0.8888
153-248
combination
of Gelidium
elegans
extract and
orlistat in
high fat
diet induced
obese mice.
,
,
,
/
2016 17
2016 KFN
International
Symposium and
Annual
Meeting.
20161031
Anti-
inflammatory
Effect of
Ecklonia
cava Extract
Flakes by
Regulating
TLR4 pathway
in RAW264.7
cells.
9
,
,
,
,
,
,
,
8 1 0.8888
/
2016 18
2016 KFN
International
Symposium and
Annual
Meeting.
20161031
Black
ginseng
derivatives
suppress
heat stress-
induced
apoptosis in
a
hippocampal
neuronal
cell line.
11
,
,
,
,
,
,
,
8 1 0.7272
154-248
/
2016 19
2016 KFN
International
Symposium and
Annual
Meeting.
20161031
Effect of
Gelidium
elegans
extract on
blood
biochemistry
in high fat
diet induced
obese mice.
9
,
,
,
,
,
,
,
8 1 0.8888
/
2016 20
2016 KFN
International
Symposium and
Annual
Meeting.
20161031
Evaluation
of the
genotoxicity
of a
Gelidium
elegans
extract in
vitro and in
vivo.
9
,
,
,
,
,
,
,
8 1 0.8888
/
2016 21
2016 KFN
International
Symposium and
Annual
Meeting.
20161031
Gelidium
elegans
regluate
blood
glucose
homeostasis
in ICR
mice.
10
,
,
,
,
,
,
,
8 1 0.8
/
2016 22
2016 KFN
International
Symposium and
Annual
Meeting.
20161031
Ginsenoside
Rg1
suppresses
early stage
of adipocyte
development
9
,
,
,
,
,
,
8 1 0.8888
155-248
via
activation
of CHOP10 in
3T3-L1 and
attenuates
fat
accumulation
in high fat
diet-induced
obese
zebrafish.
,
/
2016 23
2016 KFN
International
Symposium and
Annual
Meeting.
20161031
Neuroprotect
ive Effect
of Spirulina
maxima
Extract
against
Trimethyltin
-Induced
Cognitive
Disorders in
HT-22 Cells.
9
,
,
,
,
,
,
,
8 1 0.8888
/
2016 24
2016 KFN
International
Symposium and
Annual
Meeting.
20161031
Spirulina
Extract
Protects
against TMT-
induced
Neuronal
Damage in
SH-SY5Y
cells.
9
,
,
,
,
,
,
,
8 1 0.8888
156-248
/
2016 25
2016 KFN
International
Symposium and
Annual
Meeting.
20161031
The Effects
of Korean
Ginseng
Extracts in
Protection
Against the
Environmenta
l Heat
Stress in
Sprague
Dawley Rats.
11
,
,
,
,
,
,
,
8 1 0.7272
/
2016 26
2016 KFN
International
Symposium and
Annual
Meeting.
20161031
The
Protective
Effect of
Ecklonia
cava Extract
Flakes
against
Oxidative
Stress in
Human
Microglial
Cell Line.
9
,
,
,
,
,
,
,
8 1 0.8888
/
2016 27
12
Winter Camp
20161221
A study on
association
between t-
PA, PAI-1,
REN
polymorphism
s and
recurrent
spontaneous
abortion
(RSA) in
10
,
,
,
,
,
6 1 0.6
157-248
Korean women
/
2016 28
12
Winter Camp
20161221
Polymorphism
s of the
mucin (MUC2
and MUC4)
are
associated
with
idiopathic
recurrent
pregnancy
loss Korean
women
10
,
,
,
,
,
,
7 1 0.7
/
2016 29
20170215
Hippo
signaling
Kinase,
TAOK1 is
expressed in
primordial
follicles of
mouse ovary
8
,
,
3 1 0.375
/
2016 30
20170215
Role of
Prkar2b in
mouse oocyte
maturation
11
,
,
3 1 0.2727
/
2016 31
20170215
The
transcriptio
nal co-
repressor
TLE3 is
expressed
9
,
,
3 1 0.3333
158-248
in growing
follicle in
the ovary
/
2016 1
Experimental
Biology
Meeting
20160402
Experiment
al Biology
Meeting
Anti-
diabetic
effect of
SeapolynolTM
in 3T3-L1
adipocytes
and
C57BL/KsJ-
db/db mice.
7
,
,
,
,
,
6 2 1.7142
/
2016 2
Experimental
Biology
Meeting
20160402
Experiment
al Biology
Meeting
Anti-
inflammatory
effect of
caffeine by
regulating
NF-&[kappa]B
activation
in murine
macrophage.
7
,
,
,
,
,
6 2 1.7142
/
2016 3
Experimental
Biology
Meeting
20160402
Experiment
al Biology
Meeting
Ferulic acid
suppresses
adipogenesis
via
activation
of HO-1 in
3T3-L1
cells.
7
,
,
,
,
,
6 2 1.7142
/
2016 4
Experimental
Biology
Meeting
20160402
Experiment
al Biology
Meeting
Gelidium
elegans, a
Metabolite
of red alga,
7
,
,
,
,
6 2 1.7142
159-248
inhibits
adipocyte
differentiat
ion in 3T3-
L1 cells.
,
/
2016 5
Experimental
Biology
Meeting
20160402
Experiment
al Biology
Meeting
Inhibitory
Effects of
Silibinin on
Inflammation
via
Attenuation
of HO-1 in
Murine
Macrophage
Cell.
7
,
,
,
,
,
6 2 1.7142
/
2016 6
Experimental
Biology
Meeting
20160402
Experiment
al Biology
Meeting
Pterostilben
e Inhibits
Mitotic
Clonal
Expansion
and
Subsequent
Decreases
Adipogenic
Factors in
3T3-L1.
7
,
,
,
,
,
6 2 1.7142
/
2016 7
Experimental
Biology
Meeting
20160402
Experiment
al Biology
Meeting
Pterostilben
e Inhibits
Mitotic
Clonal
Expansion
and
Subsequent
Decreases
7
,
,
,
,
,
6 2 1.7142
160-248
Adipogenic
Factors in
3T3-L1.
/
2016 8
Experimental
Biology
Meeting
20160402
Experiment
al Biology
Meeting
Seapolynol
attenuates
lipid
accumulation
during
adipocyte
differentiat
ion in 3T3-
L1 and
decreases
body fat
accumulation
invivo.
7
,
,
,
,
,
6 2 1.7142
/
2016 9
KSBMB
International
Conference
2016
20160518
Apoptoic
protein Bax
is regulated
by multiple
deubiquitina
ting enzymes
4 1 2 0.5
/
2016 10
Joint Natural
Products
Conference
2016
20160724
Joint
Natural
Products
Conference
Gelidium
elegans
ethanol
extract
increase
energy
expenditure
in 3T3-L1
adipocyte.
7
,
,
,
,
,
6 2 1.7142
/
2016 11
15th Human
Proteome
Organisation
20160918 HUPO
Apoptotic
protein Bax
is
5
,2 2 0.8
161-248
World
Congress
regulated by
multiple
deubiquitina
ting enzymes
in response
to DNA
damage.
/
2016 12
The 9th
Congress of
the Asia-
Pacific
Society on
Thrombosis
and
Hemostasis
20161006 APSTH
ASSOCIATION
STUDY
BETWEEN
mucin (MUC2
AND MUC4)
POLYMORPHISM
S AND
IDIOPATHIC
RECURRENT
PREGNANCY
LOSS IN
KOREAN WOMEN
10
,
,
,
,
,
,
7 2 1.4
/
2016 13
The 9th
Congress of
the Asia-
Pacific
Society on
Thrombosis
and
Hemostasis
20161006 APSTH
ASSOCIATION
STUDY OF t-
PA, PAI-1,
REN
POLYMORPHISM
S WITH RISK
OF
IDIOPATHIC
RECURRENT
PREGNANCY
LOSS(RPL).
10
,
,
,
,
,
6 2 1.2
/
2016 14
The 9th
Congress of
the Asia-
Pacific
Society on
20161006 APSTH
Polymorphism
s in tissue
inhibitor of
8
,
,
,
,
6 2 1.5
162-248
Thrombosis
and
Hemostasis
metalloprote
inase (TIMP)
are
associated
with primary
ovarian
insufficienc
y POI
,
/
2016 15
The 9th
Congress of
the Asia-
Pacific
Society on
Thrombosis
and
Hemostasis
(APSTH)
20161006 APSTH
Polymorphism
s of the TS
gene
(1100T>C,
1170A>G and
1494del6)
are
associated
with
ischemic
stroke
prevalence
and silent
brain
infarction
(SBI) in
Koreans
11
,
,
,
,
,
,
7 2 1.2727
/
2016 16
International
Conference of
Korean
Society for
Molecular and
Cellular
Biology 2016
20161012
Bax-
dependent or
UV-induced
apoptosis is
regulated by
Bax-DUB1
5
,2 2 0.8
163-248
/
2016 17
International
Conference of
Korean
Society for
Molecular and
Cellular
Biology 2016
20161012
Deubiquitina
ting enzyme
Bax-DUB4
regulates an
apoptotic
protein Bax
7 1 2 0.2857
/
2016 18
International
Conference of
Korean
Society for
Molecular and
Cellular
Biology 2016
20161012
Protease A
involved in
the
pathogenesis
of recurrent
pregnancy
loss
3 1 2 0.6666
/
2016 19
International
Conference of
Korean
Society for
Molecular and
Cellular
Biology 2016
20161012
Ubiquitin-
specific
protease-R
regulates
SR45 in RNA
splicing
2 1 2 1
/
2016 20
International
Conference of
the Korean
Society for
Molecular and
Cellular
Biology 2016
20161012
Associationo
f the miR-
605, miR-
608, miR-
631, miR-
938and miR-
1302-3
polymorphism
s with risk
of recurrent
implantation
failure
10
,
,
,
,
,
,
7 2 1.4
164-248
in Korean
women
/
2016 21
International
Conference of
the Korean
Society for
Molecular and
Cellular
Biology 2016
20161012
Identificati
on of novel,
rare and
splicing
variants
using whole
exome
sequencing
(WES) in
ischemic
stroke
patients
9
,
,
,
,
5 2 1.1111
/
2016 22
International
Conference of
the Genetics
Society of
Korea 2016
20161109
A Novel Role
of
F52H2.6/DHCR
24 on C.
elegans
Reproduction
and Life
Span
11
,
,
,
,
,
6 2 1.0909
/
2016 23
International
Conference of
the Genetics
Society of
Korea 2016
20161109
AGENT:
Analysis
Using Gene
Expression
Data for
Niche of
Tumor
15
,
,
,
,
,
6 2 0.8
/
2016 24
International
Conference of
the Genetics
Society of
20161109
Association
analysis of
the
plasminogen
activator
5
,
,
,
,
5 2 2
165-248
Korea 2016
inhibitor-1
(PAI-1)
polymorphism
with
prevalent
osteoporotic
vertebral
compression
fracture
(OVCF) in
postmenopaus
al women
with
osteoporosis
/
2016 25
International
Conference of
the Genetics
Society of
Korea 2016
20161109
Association
study
between
mucin (MUC2
and MUC4)
ploymorphism
s and
idiopathic
recurrent
pregnancy
loss Korean
women
10
,
,
,
,
,
,
7 2 1.4
/
2016 26
International
Conference of
the Genetics
Society of
Korea 2016
20161109
Association
study of
miRNA
polymorphism
s with
recurrent
pregnancy
loss (RPL)
in Korean
10
,
,
,
,
,