H+E d4 -catenin d4 c-Myc d6 lysozyme d6 Grimelius d4 p21CIP1/WAF1 d4 H2AX d4

a

b

c

d

g

f

i

h

k

j

Cre

+A

pcfl/

fl P53

+/+

Cre

+A

pcfl/

fl P53

-/-

e

p q

l

Cre+Apcfl/fl p53-/-Cre+Apcfl/fl p53+/+

Cre+ Apc+/+ p53-/-

Cre+Apc+/+ p53+/+

Cre+Apcfl/fl p53-/-Cre+Apcfl/fl p53+/+

Cre+ Apc+/+ p53-/-

Cre+Apc+/+ p53+/+

m

n

*

*

*