Pt # 2

Pre-treatment

Pt # 3

EGFR-L858R EGFR-L858R-T790M

EGFR-del19 EGFR-del19-T790M

III IV

EGFR-L858R EGFR-L858R-T790M

Pt # 4

Supplementary Figure S2. Expression of β-catenin in pre- and post-EGFR TKIs lung biopsies.

(4.0%) (20.7%)

(3.8%) (34.4%)

(35.0%) (38.9%)

VIV

VII VIII

EGFR-del19 EGFR-del19-T790M

Pt #1

(Nuclear β-catenin 21.8%) (51.3%)

Post-treatment

III