The Next Challenges
in Biotechnology of Japan
Mitsuru Miyata,
The excutive leader writer,
Nikkei Business Publications,Inc.
宮田 満 日経BP社
Global Forum on Biotechnology, OECD, Nov.12,2012
Outline
Current status of BT and Pharma in Japan
History :National Policy to promote BT
Top down Policy does not go well now.
The Next Challenges of BT in Japan
For Last minutes, critical problems in
Biotechnology in Japan
5.3 trillion yen *Instruments/Reagents(3.1)
*Bioinformatics (2.2)
Tools/Informatics
8.4 trillion yen
*Pharmaceuticals
*Medical devices
Medical
6.3 trillion yen
*Functional Foods (3.2)
*Others (3.1)
4.2 trillion yen *Bio-process (3.6)
*Biomass (0.2)
*Bioremediation (0.4)
Environment/Energy
Foods
Total
25 trillion yen
Expected market in 2010 on “National BT Strategy ”
21 25 trillion yen = 220 bil. dollars
Pharma in Japan are failing down
Patent expiration of Major Product
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1150Byen in 2010,
Import surplus of Therapeutics
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Lost decade of Japanese
Biophartherapeutics
(山口ら、09年)
Reasons of the first failure
in Biotechnology in Japan
Conservative culture
Bad and Poor Science Policy
Gap between industry and Academy
Poor venture financing and activity
Poor Public Acceptance especially to GMO
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The New strategy for
national growth by DPJ
Dec.39,09 Av.3% GDP Growth until 2020
GDP 650 T Yen in 2020 (473T Yen,2009)
Unemployment rate less than 4%
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Goal :Job Creation for Brain workers
No one believes the policy in Japan
Energy/Environment Health/Medical/Care
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Research Institutes of Big Pharma.
Disappeared in Japan
New type of biotechnological research based on Japanese culture ----Full Length cDNA Project
not enough money and human resources for whole human
genome analysis in Japan From 1997, focusing research on full length cDNA due to less than 1% of genome
Now, We have about 30,000 cDNA Applying to Targeted Proteomics to find the function of genes and make them patentable.
Full Length cDNA Project leads to
Innovation of iPS Cell
20th Nov,2007 Human iPS Cell
2006, Murine iPS Cell Established
4Genes Introduced Oct3/4、Sox2、(c-
Myc)、Klf4 ,selected from cDNA Database
New type of biotechnological research based on
Japanese culture Personalized Medicine
Hap- map Program
Genomic Cohort study
From 2003,
the national program
collecting DNA and MR
from 300,000 patients
Poteligeo Launched
29 May in 2012 Kyow Kirin
antiCCR4 Mab with modified Sugar chains/
Adult T Cell Leukemia
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The only one commercial plant
for recombinant hAlbumin
Oct. 2007 operation
Pichia based Fermentation plant
New type of biotechnological research based on Japanese culture Bioelectronics/Nanobiology
Bio Computer
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Super Computer “KEI” began
operation in Sept. of 2012
Molecular Dynamics
Protein/Ligand Simulation with KEI
Virtual Drug Discovery
3.5PFLOPSの京コンピュータ上で、1.315PFLOPSの性能を達成 効率 37%
細胞混雑下でのタンパク質動態シミュレーション
1.8億原子、 カットオフ
これまで行われたタンパ
ク質の分子動力学シミュ
レーションで最高の性能
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※本成果は、グランドチャレンジプロジェクト「次世代生命体統合シミュレーション」の一環であり、早期の成果創出の要求に基づきマシン割り当てに特別な配慮をいただいて実現したものです。
New type of biotechnological research based on Japanese culture
----Functional Food
Food for enhancing health , based on research of traditional dishes in Japan
Our longevity is partly due to Japanese food
More than 2000M$ for functional food market Modern Biotechnology is applied to study and to understand healthy element in food at molecular level
March 11th ,2011
East Japan Earthquake and Tsunami
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Big Money to RecoverTohoku area
Some in Advanced Medicine
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Tohoku Medical Megabank
15.8Byen(2011)+5.6Bye(2012)
3Generation Genome Cohort、150,000people
Multi Omics Research Center
Fukushima Drug Discovery Platform
25.8Bye for 10years from 2012
Multi Omics Research Center
Fukushima Pref. Med. Examination 2Mpeople
Multi Omics Research Center
in Fukusima
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Multi Omics Research Center
will complete this month.in Fukushima
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Failure to Get Public Acceptance
to GMO in last 2decades
Almost everyone believe no GMO in Japan
The largest importer of GMO on the globe is
Japan
Japanese travelers love to eat rPapaya
in Hawaii
nether in Japan
Future of Japanese Bioindustry
Hoping Bright Future
By Continuous Scientific Innovation
By Fusing BT,ICT, NT and ET
By Combining Innovation , Precise
Manufacturing and Design
By Creating and Financing Smart Bioventure
Companies
BY Alliance with Global Talent and Brain
The Last Critical Question:
Can we pay for Next Biotechnological
Inovation?
10.0% of GDP for Healthcare
1000TYen National Debt
The fastest aging society on the globe.
The Final Option →VAT or DEAD/Debt Austria 20.0 1%
France 20.6 1%
Italy 20.0 1 %
Germany 16.0 1%
England 17.5%