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FAST DISSOLVING ORAL FILMS
PRESENTED BY B.JAGADEESH BABUM.Pharm
OVER VIEWINTRODUCTIONSPECIAL FEATURESGENERAL PROPERTIESFORMULATIONMETHOD OF PREPARATIONEVALUATION TESTSADVANTAGES & DISADVANTAGESCONCLUSION
INTRODUCTION These are the drug delivery systems
which fastly disintegrate in mouth with H2O.
It was first developed in 1970’s alternative to tablets & capsules.
It consists of very thin oral strip which is placed on tongue & upon hydration it fastly releases drug into oral cavity.
Thin elegant film Available in various sizes & shapes Unobstrusive Excellent mucoadhesion Rapid release
GENERAL PROPERTIES
Thickness ranges from 1-10mm & it’s surface area is 1-20 cm².
Its low dry tack allows for ease of handling & application.
Its rapid hydration rate facilitates fast softening & absorption.
2mm thickness of film will take 5-10sec to start its disintegration.
FORMULATIONFORMULATIONDRUGWATER SOLUBLE POLYMERSUPER DISINTEGRANTSPLASTISIZERSURFACTANTSFLAVOURSCOLOURSSWEETENING AGENTSSALIVA STIMIULATING AGENTS
SOLVENT CASTING* SEMI-SOLID CASTING HOT MELT EXTRUSION SOLID DISPERSION EXTRUSION ROLLING METHOD
EVALUATION TESTSMORPHOLOGY STUDYSWELLING PROPERTYCONTACT ANGLEDISINTEGRATIONMECHANICAL PROPERTIES 1. Tensile strength 2.Elastic modulus 3.% Elongation 4. Folding endurance
Convenient dosing
No water needed
No risk of chocking
Taste masking
Enhanced stability
First pass metabolism can be avoided
Easily fragile & brittle.
Special package for protection during storage
& transportation.
These are having several advantages over conventional dosage forms like
ODT, TABLETS, CAPSULES ,IV etc., so they are of great importance during the emergency cases such as allergic reations & asthamatic attacks.