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2PHARMACOLOGY OF RECEPTORS- ADRENERGIC RECEPTORSPRESENTED BY- AMEENA MEHABOOB

INTRODUCTIONAdrenoceptors are membrane bound receptors located throughout the body on neuronal and non-neuronal tissues where they mediate a diverse range of responses to the endogenous catecholamines- noradrenaline and adrenaline. They are G protein coupled receptors. Binding of catecholamine to the receptor is responsible for fight or flight response.

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CLASSIFICATION4

5RECEPTOR NAMETYPICAL LOCATIONS1Vascular smooth muscle, visceral smooth muscle, radial smooth muscle of iris, CNS neurons2Some presynaptic terminals, pancreatic islets, platelets, ciliary epithelium, smooth muscles, CNS neurons1Myocardium, JG cells, some presynaptic terminals, CNS neurons2Visceral smooth muscle, vascular smooth muscle, liver, myocardium, skeletal muscle, some presynaptic terminals, CNS neurons

1. ADRENERGIC RECEPTORA) 1 ADRENERGIC RECEPTOR (Gq)

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B) 2 ADRENERGIC RECEPTOR (Gi)9

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2. ADRENERGIC RECEPTORSA) 1 ADRENERGIC RECEPTOR (Gs)

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B) 2 ADRENERGIC RECEPTORS-

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C) 3 ADRENERGIC RECEPTORS- They are involved in the epinephrine and norepinephrine induced activation of adenylyl cyclase through the action of the G proteins of the type Gs.

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REFERENCES20Adrenoceptor Pharmacology, Emma Robinson and Alan Hudson, Psychopharmacology Unit, Department of Pharmacology, School of Medical Sciences, University of Bristol.www.cvpharmacology.com/vasodilator/alphawww.ncbi.nih.gov/pubmed/6098436www.wikipedia.com

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