Bacterial Infection (แพทย์)

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  1. 1. Ratirath Samol, MD. BACTERIAL DISEASE RATIRATH SAMOL,MD
  2. 2. Content
    • Pyogenic gram positive cocci
    • Bacterial infection of childhood
    • Sexually transmitted bacterial disease
    • Enteropathogenic bacteria
    • Clostridial infection
    • Bacterial infection with animal reservoirs or insect vectors
    • Bacterial infection with immunocompromised host
    • Filamentous bacteria
    • Mycobacterial infection
    • Clamydia infection
    • Mycoplasma infection
    • Rickettsia infection
  3. 3. Pyogenic gram positive cocci
  4. 4. Pyogenic gram positive cocci
    • Staphylococcal infection
    • - coagulase positive (S. aureus)
    • - coagulase negative (S. epidermidis,
    • S. saprophyticus )
    • Streptococcal infection
    • - S. pyogenes
    • - S. agalactiae
    • - S. pneumoniae
    • - S. mutans
  5. 5. Staphylococcus spp.
  6. 6. Streptococcus spp.
  7. 7. Staphylococcus aureus
    • Furuncles
    • - infection in and around hair follicles
    • - common in scalp, face, axillary
    • Carbuncles
    • - infection around hair follicle and produce
    • draining sinuses
    • Hydradenitis suppurativa
    • - infection in sweat gland
  8. 8. carbuncles furuncles
  9. 9. Staphylococcus aureus
    • Osteomyelitis
    • - infection in bone
    • Toxic shock syndrome (TSS)
    • - infection in surgical wound, tampons produce high fever, nausea, vomiting and shock
  10. 10. Staphylococcus aureus
    • Food poisoning
    • - diarrhea, nausea, vomiting
    • - symptom present < 6 hours after
    • contaminated food
  11. 11. Staphylococcus aureus
    • Staphylocoocal scalded skin syndrome (SSSS)
    • - severe skin infection
    • - organism produce exfoliatin that destroys
    • desmogelin-1 (granulosa) of epidermis
    • bullae, rupture, skin scald
    • - other organs : lung, heart valve, bone
  12. 12. SSSS
  13. 14. Staphylococcus epidermidis
    • causes opportunistic infections in catheterized patients, patients with prosthetic cardiac valves, and drug addicts.
  14. 15. Staphylococcus saprophyticus
    • common cause of urinary tract infections in young women.
  15. 16. Streptococcal infection
    • 3 types
    • -hemolytic streptococci
    • eg. S. pneumoniae, S. viridans, S. mutans
    • -hemolytic streptococci
    • eg. S. pyogenes (group A), S. agalactiae (group B)
    • -hemolytic streptococci (non-hemolytic)
    • eg. S. faecalis (group D)
  16. 17. -hemolytic streptococci
    • S. pneumoniaeis a common cause of community-acquired pneumonia and meningitis in adults
    • S. viridansare part of the normal oral flora but are also a common cause of endocarditis
    • S. mutansis the major cause of dental caries
  17. 18. -hemolytic streptococci
    • S. pyogenes (group A)
    • - pharyngitis
    • - scarlet fever
    • - erysipelas
    • - impetigo
    • - cellulitis
  18. 19. Pharyngitis
    • Infection in throat (tonsillitis)
    • Clinical: high grade fever, sore throat
    • Complication :
    • - glomerulonephritis, rheumatic fever
    • - cross reaction of immune system to M
    • protein of bacteria
  19. 20. Tonsillitis
  20. 21. Scarlet fever
    • Common in childhood
    • Erythematous rash at trunk, extremities and faceexceptaround the mouth (circumoral pallor), strawberry tongue
    • Cause by erythrogenic toxin
  21. 22. Scarlet fever strawberry tongue circumoral pallor
  22. 23. Erysipelas
    • Erythematous rash, rapid distribution at face, particullary both cheek
    • Rash at trunk, extremities (uncommon)
  23. 24. Erysipelas
  24. 25. Impetigo
    • Infection in epidermis
    • Erythematous papulepustule
    • May be caused by S. pyogenes or S. aureus
  25. 26. Cellulitis
    • Infection in deep dermis
    • S. pyogenes invade through wound
    • Pustule in deep dermis
    • Clinical : fever, erythematous skin lesion
  26. 27. Cellulitis
  27. 28. -hemolytic streptococci
    • S. agalactiae (group B)
    • - meningitis
    • - chorioamnionitis
    • - septicemia
  28. 29. Bacterial infection of childhood
  29. 30. Bacterial infection of childhood
    • Diphtheria
    • Pertussis (Whooping cough)
    • Haemophilus influenzae infection
    • Neisseria meningitidis infection
  30. 31. Diphtheria
    • Caused by Corynebacterium diphtheriae (gram positive bacilli)
    • Transmitted as respiration
    • Immunization with diphtheria toxoid (formalin-fixed toxin) does not prevent colonization withC. diphtheriaebut protects immunized people from the lethal effects of the toxin.
  31. 32. Diphtheria
    • Tracheal colonization may lead to
    • - Mucosal erosion
    • - Formation of a suffocating
    • pharyngeal fibrinosuppurative exudate
    • (pseudomembrane)obstruct airway
    • Toxin-mediated damage to the heart, nerves, liver, or kidneys
    • Microscopic: necrotic tissue, neutrophil, fibrin, bacteria
  32. 33. Diphtheria
  33. 34. Pertussis
    • Bordetella pertussis infection(gram negative coccobacilli )
    • Common in childhood (