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CALMODULIN (CaM)
BY: -HUSNAIN RIAZINTERNATIONAL ISLAMIC UNIVERSITY ISLAMABAD
Calmodulin is a Calcium Binding Protein
Use to detect changes in calcium ion concentration
It is a ubiquitous protein
Calcium Ion Most abundant mineral present in body
Calcium have many roles in our body like in metabolism, composition of eukaryotes
Act as a secondary messenger in signal transduction pathway
Structure
Calmodulin is a small protein of about 148 amino acids
Has two globular domains joined by flexible linker region
Also has four EF hands on both domains
Binding
Calmodulin binds with four calcium ions
EF hands produces electronegative area to bind with Ca ion
After binding calmodulin undergo conformational changes
Target of Calmodulin Adenyl Cyclase – Conversion of ATP into AMP
Protein Kinase – Many signaling cascades and is thought to be an important mediator of learning and memory, immune signaling
Ca Mg ATPase – regulating the amount of Ca2+ with in the cell
Glycogen synthase – involved in converting glucose to glycogen
Myosin Kinase – important in contraction in muscle