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Circadian rhythms also known as "The Body Clock" is the physical, mental and behavioral changes that follow roughly 24 hrs. cycle responding to light and darkness in the organism.
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Circadian rhythms
&
Human health
Presented by Dr. Sudhakar KokateDirector PPRC, India
Circadian rhythms .…
Also known as the “Body clock”
Physical, mental and behavioural changes that
follow a roughly 24 hrs. cycle responding to light
and darkness in the organism
Found in living things, plants, animals and even
among tiny microbesPPRC/INDIA 01
Circadian rhythms .…
PPRC/INDIA 02
Circadian rhythms ….
Related to biological cycle
Study of Circadian rhythms and health is known
as “Chronobiology”
Biological cycle controls Circadian rhythms –
governing of interacting molecules in cells
throughout the bodyPPRC/INDIA 03
Master clock ….
Master clock: Brain
A group of nerve cells ‘Suprachiasmatic nucleus’
(SCN) containing 20,000 nerve cells are located
in hypothalamus
Location: above optic nerves from eyes cross
PPRC/INDIA 04
Brain
PPRC/INDIA 05
Suprachiasmatic nucleus
PPRC/INDIA 06
About CR ….
Circadian rhythms influence sleep wake cycles,
hormone release and other bodily functions
CR – linked to sleep disorders e.g. Insomnia,
Obesity, Diabetes, Depression, Bipolar disorders
and Seasonal Affective Disorder (SAD)
PPRC/INDIA 07
Insomnia
PPRC/INDIA 08
Obesity
PPRC/INDIA 09
Diabetes
PPRC/INDIA 10
Depression
PPRC/INDIA 11
Bipolar disorders
PPRC/INDIA 12
Seasonal Affective Disorder (SAD)
PPRC/INDIA 13
About CR ….
CR tells our body when to sleep and regulate
many other physiological processes
This internal body clock is affected by
environmental cues like sunlight and
temperature
When CR is disrupted, sleeping & eating
patterns can run amokPPRC/INDIA 14
Physiological disruption leads to ….
PPRC/INDIA 15
Research ….
A growing body of research is examining the
adverse health effects like increasing cardio-
vascular events, observing neurological problems
like depression and bipolar disorders.
It also affects immune and metabolic systems
PPRC/INDIA 16
Immune system
PPRC/INDIA 17
Metabolic system
PPRC/INDIA 18
Research ….
Scientists are looking into:
1. How brain-neuro system works in disorder?
2. What are effective remedies without side effects
with minimum duration of time span?
3. Behaviour of Human being in disrupted CR
positionPPRC/INDIA 19
Research ….
4. Treatment of sleep disorders, Jet lag and other
health related issues
5. Do Ayurvedic plants control Circadian rhythms
in plants, animals and microbes? If so how and
at what level of output?
PPRC/INDIA 20
Research ….
6. Are there any natural control for strengthening
nerves and muscle? If so how and what
mechanism does it possess?
PPRC/INDIA 21
Remedies ….
Change or modify lifestyle
Ideal diet plan – implementation
Yoga, exercises and meditation
Use of herbal technology
Well disciplinary actions in exact time
Strengthen and calm – nerves and musclesPPRC/INDIA 22
Yoga
PPRC/INDIA 23
Exercise
PPRC/INDIA 24
Meditation
PPRC/INDIA 25
Cryobiology
Study of cell preservation technology with low
temperature
Applied science
Rule: Every 10°C reduction in temperature
= 50 % decrease in oxygen consumption
PPRC/INDIA 26
Cryobiology
Temperature ranges 32 to 37°C
and -80 to -196°C
Many Journals, Societies study Cryobiology
PPRC/INDIA 27
Neurochemicals ….
Organic molecules participating in Neural activity
Neuropeptide: Oxytocin signifies maternal
behaviour, stress wound healing
Glutamate
GABA: Inhibits neurotransmission
PPRC/INDIA 28
Neurochemicals
PPRC/INDIA 29
Neuropeptide
PPRC/INDIA 30
Oxytocin
PPRC/INDIA 31
Glutamate
PPRC/INDIA 32
GABA
PPRC/INDIA 33
Neurochemicals ….
Organic molecules participating in Neural activity
Dopamine: Function of the limbic system,
emotional function and control
Serotonin: Mood, sleep and alertness, sensation
of pleasure
PPRC/INDIA 34
Dopamine
PPRC/INDIA 35
Serotonin
PPRC/INDIA 36
Neurochemicals ….
Organic molecules participating in Neural activity
Acetylcholine: Memory
Nitric oxide
Endocannabinoids: Eicosanoids
PPRC/INDIA 37
Acetylcholine
PPRC/INDIA 38
Nitric oxide
PPRC/INDIA 39
Endocannabinoids
PPRC/INDIA 40
Foods for healthy nerves ….
₪ Milk
₪ Yogurt
₪ Honey
₪ Apple
₪ Mangoes
PPRC/INDIA 41
₪ Potatoes
₪ Bananas
₪ Herbal tea
₪ Whole grain
₪ Sweet potatoes
Foods for healthy nerves ….
PPRC/INDIA 42
Foods for healthy nerves ….
₪ Pineapples
₪ Beet salad
₪ Grape fruits
₪ Oranges
₪ Almonds
PPRC/INDIA 43
₪ Green salad
₪ Dates
₪ Cashew nuts
₪ Coconut water
PPRC/INDIA 44
₪ Tulsi
₪ Sunflower
₪ Papaya
₪ Peppermint
PPRC/INDIA 45
₪ Avocado
₪ Cabbage
₪ Cauliflower
₪ Asparagus
Tulsi (Ocimum sanctum)
PPRC/INDIA 46
Sunflower
PPRC/INDIA 47
Papaya
PPRC/INDIA 48
Peppermint
PPRC/INDIA 49
Avocado
PPRC/INDIA 50
Cabbage
PPRC/INDIA 51
Cauliflower
PPRC/INDIA 52
Asparagus
PPRC/INDIA 53
₪ Alfalfa
₪ Parsley
₪ Garlic
₪ Beet
PPRC/INDIA 54
₪ Kale
₪ Hemp
₪ Fenugreek
₪ Lime
Alfalfa
PPRC/INDIA 55
Parsley
PPRC/INDIA 56
Garlic
PPRC/INDIA 57
Beet
PPRC/INDIA 58
Kale
PPRC/INDIA 59
Hemp
PPRC/INDIA 60
Fenugreek
PPRC/INDIA 61
Lime
PPRC/INDIA 62
Thank You !!
“BE WITH US”